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Nitrofurantoin Bacterial chemical

Cat.No.S4536

Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections. It inhibits bacterial DNA, RNA, and cell wall protein synthesis.
Nitrofurantoin Bacterial chemical Chemical Structure

Chemical Structure

Molecular Weight: 238.16

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Quality Control

Batch: S453601 DMSO]47 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.82%
99.82

Solubility

In vitro
Batch:

DMSO : 47 mg/mL (197.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 238.16 Formula

C8H6N4O5

 Storage (From the date of receipt)
CAS No. 67-20-9 Download SDF Storage of Stock Solutions

Synonyms Macrodantin, Furadantine, Furadonine Smiles C1C(=O)NC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]

Mechanism of Action

In vitro
Nitrofurantoin is very effective against both outdoor and indoor urinary isolates and can be used empirically for uncomplicated urinary tract infections. This compound can directly injure lung parenchymal cells, probably through oxidant mechanisms.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05630833 Recruiting
Urinary Tract Infections
GlaxoSmithKline
 January 11 2023 Phase 3
NCT05817253 Completed
Clinical Audit|Quality Improvement
University of British Columbia|Ministry of Health British Columbia
 September 23 2021 Not Applicable
NCT04900571 Completed
Pain Postoperative|Irreversible Pulpitis
Altamash Institute of Dental Medicine
 January 1 2021 Phase 4
NCT02727322 Completed
Pelvic Organ Prolapse
Halina M Zyczynski MD|University of Pittsburgh
 August 2016 Phase 4
NCT00678041 Terminated
Urinary Tract Infections
University of Pittsburgh
 May 2008 Not Applicable

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