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Moxidectin Parasite inhibitor

Name: Moxidectin
Brand: Selleck Chemicals
SKU: S3713
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3713

Moxidectin (Milbemycin B) is a potent, broad-spectrum endectocide with activity against a wide range of nematodes, insects and acari.

Chemical Structure

Molecular Weight: 639.82

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Quality Control

Batch: Purity: 99.23%

99.23

Related Targets	Integrase Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Reverse Transcriptase HIV HCV Protease
Other Parasite Inhibitors	Diminazene Aceturate Oxibendazole Arteether Diclazuril Oxfendazole Fenbendazole α-santonin Nicarbazin Pyrantel Pamoate Carica Papaya Fruit Extract

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (156.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (7.81mM)
	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (7.81mM)
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	639.82	Formula	C₃₇H₅₃NO₈	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	113507-06-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Milbemycin B			Smiles	CC1CC(=CCC2CC(CC3(O2)CC(=NOC)C(C(O3)C(=CC(C)C)C)C)OC(=O)C4C=C(C(C5C4(C(=CC=C1)CO5)O)O)C)C

Mechanism of Action

In vivo	In human, MOX is generally safe and well tolerated, with a slightly higher incidence of transient, mild, and moderate central nervous system AEs as the dose increased. The PKs of MOX are dose proportional within the dose range studied, and the elimination half-life (t1/2 elim) is long (mean: 20.2-35.1 days).
References	[1] https://pubmed.ncbi.nlm.nih.gov/23133688/ [2] https://pubmed.ncbi.nlm.nih.gov/14517193/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03876262	Active not recruiting	Onchocerciasis	Medicines Development for Global Health	May 3 2021	Phase 3
NCT03962062	Completed	Onchocerciasis	Medicines Development for Global Health	March 29 2021	Phase 1
NCT03905265	Completed	Scabies	Medicines Development for Global Health	January 13 2020	Phase 2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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