Home Transmembrane Transporters Potassium Channel inhibitor Gliclazide For research use only.

Gliclazide

Synonyms: S1702, SE1702

Gliclazide(S1702, SE1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.

Gliclazide Chemical Structure

Gliclazide Chemical Structure

CAS: 21187-98-4

Selleck's Gliclazide has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 100.0%
100.0

Gliclazide Related Products

Signaling Pathway

Potassium Channel Signaling Pathways

Potassium Channel Signaling Pathway

Choose Selective Potassium Channel Inhibitors

Biological Activity

Description Gliclazide(S1702, SE1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
Targets
Potassium channel [1]
184 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04198948 Completed
Diabetes Mellitus Type 2
University of Sarajevo|General Hospital Prim. Dr. Abdulah Nakas|University of Dundee|Wellcome Trust
 March 4 2019 Phase 1
NCT03705195 Completed
Type 2 Diabetes Mellitus
University of Dundee|NHS Tayside
 August 3 2018 Not Applicable
NCT03467971 Completed
Healthy
Merck KGaA Darmstadt Germany
 March 6 2018 Phase 1
NCT02643329 Completed
Healthy
Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited|Chinese University of Hong Kong
 January 2016 Phase 1

Chemical Information & Solubility

Molecular Weight 323.41 Formula

C15H21N3O3S
CAS No. 21187-98-4 SDF Download Gliclazide SDF
Smiles CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 65 mg/mL ( (200.98 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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