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Cilengitide (EMD 121974) Integrin inhibitor

Name: Cilengitide (EMD 121974)
Brand: Selleck Chemicals
SKU: S6387
Availability: InStock
Rating: 5 (39 reviews)

Cat.No.S6387

Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-707544) is a potent and selective inhibitor of the integrins α_νβ₃ and α_νβ₅ with IC50 of 4 and 79 nM, respectively.

Chemical Structure

Molecular Weight: 588.66

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Quality Control

Batch: Purity: 99.63%

99.63

Related Targets	Akt Wnt/beta-catenin PKC HSP ROCK Microtubule Associated Bcr-Abl Actin FAK Kinesin
Other Integrin Inhibitors	SB273005 Cilengitide trifluoroacetate RGD peptide (Arg-Gly-Asp) ATN-161 Cyclo(RGDyK) TFA Cyclo(-RGDfK) TFA Leukadherin-1 A-205804 RGD peptide (GRGDNP) Pyrintegrin

Q&A of Cilengitide (EMD 121974): Insights Rooted in Extensive Publications, Every Answer Cited

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Solubility in DMSO or Water

In vitro
Batch:

DMSO : 100 mg/mL (169.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 5 mg/mL (超声加热十分钟，60℃)

Ethanol : Insoluble

The solubility data above are all experimental results (not literature values).

DMSO : 100 mg/mL (169.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 20 mg/mL

Ethanol : Insoluble

The solubility data above are all experimental results (not literature values).

DMSO : 100 mg/mL (169.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

The solubility data above are all experimental results (not literature values).

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (8.49mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.250mg/ml (2.12mM)	Taking the 1 mL working solution as an example, add 50 μL of 25 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Search directly for a cell line, or select a cell line to find matched working concentrations

Cilengitide (EMD 121974) is a potent inhibitor of αvβ3 (5400 ± 814 nM) and αvβ5. Cilengitide (EMD 121974) exhibits the greatest inhibitory potency toward αvβ3 (IC50 = 5400 ± 814 nM).

Mechanism of Action

Information	Cilengitide is a potent, selective cyclic RGD peptide and integrin αvβ3/αvβ5 antagonist. It affects FAK/Src/AKT, TGF-β1/Smad, and Ras/ERK/AKT signaling pathways by blocking integrin-mediated signaling, effectively inhibiting tumor cell adhesion, migration, and proliferation, and promoting apoptosis.
Read more about Cilengitide (EMD 121974) IC50 for cell-based and cell-free assays
Primary Applications and Mechanism of Action

Chemical Information, Storage & Stability

Molecular Weight	588.66	Formula	C₂₇H₄₀N₈O₇	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	188968-51-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	EMD 121974, EMD-12192, EMD-85189, NSC-707544			Smiles	CC(C)C1N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCCNC(N)=N)NC1=O

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cilengitide (EMD 121974) Integrin inhibitor

Molecular Weight: 588.66

Quality Control

Solubility in DMSO or Water

Molarity Calculator

In vivo Formulation Calculator (Clear solution)

Working Concentrations for Cell Culture Treatment

Search directly for a cell line, or select a cell line to find matched working concentrations

Selectivity & Specificity

Mechanism of Action

Chemical Information, Storage & Stability

Tech Support