Cilengitide

Catalog No.S7077 Synonyms: EMD 121974, NSC 707544

Cilengitide Chemical Structure

Molecular Weight(MW): 702.68

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.

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In DMSO USD 454 In stock
USD 270 In stock

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3 Customer Reviews

  • WT mice were subjected to BDL and treated with either vehicle or cilengitide (10 mg/kg) daily for 6 days; adjacent liver sections were immunostained for CK19 or PCNA. Data were quantified and expressed as mean ± SD. (n = 6 per group.) *P < 0.02, **P < 0.004, Student’s t test.

    J Clin Invest, 2015, 125(5): 1886-900. Cilengitide purchased from Selleck.

    BrdU incorporation was quantified in freshly isolated primary cholangiocytes treated with BSA (4 μg/ml), CCN1 (4 μg/ml), soluble JAG1 (2 μg/ml), DAPT (10 μM), cilengitide (1 μM), NBD (25 μM), or control peptide (25 μM). Where indicated, CCN1 (4 μg/ml) was added with other inhibitors. *P < 0.04, **P < 0.01, Student’s t test.

    J Clin Invest, 2015, 125(5): 1886-900. Cilengitide purchased from Selleck.

  • Cell growth inhibition of non-small cell lung carcinoma (NSCLC) by Cilengitide. Cilengitide is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins. Interestingly, it acts differently on HTB183 and A549 cell lines. Cilengitide was more efficient on A549, lung adenocarcinoma, while in HTB183 it showed moderate inhibitory activity. This may be due to the mestastatic nature of HTB183 cells which have already lost the cell adhesion properties.

    Dr.Milica Pesic from Institute for Biological Research . Cilengitide purchased from Selleck.

Purity & Quality Control

Choose Selective Integrin Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Targets
αvβ3 receptor [1]
(Cell-free assay)
αvβ5 receptor [2]
(Cell-free assay)
4.1 nM 79 nM
In vitro

Cilengitide is a cyclized pentapeptide peptidomimetic designed to compete for the arginine-glycine-aspartic acid (RGD) peptide sequence that regulates integrin-ligand binding. Cilengitide selectively and potently blocks the ligation of theαvβ3 andαvβ5 integrins to provisional matrix proteins such as vitronectin, fibronectin, fibrinogen, von Willebrand factor, osteopontin, and others. [1] Cilegitide inhibits angiogenesis in vitro. 10 μM Cilengitide completely inhibits attachment of BAE, BME and HUVE cells on vitronectin and fibronectin. Cilengitide inhibits in vitro angiogenesis of BAE cells on three-dimensional collagen and fibrin gels pretreated with FGF-2(or VEGF-A) with IC50 of 15 μM and 8 μM, 4 μM and 3 μM, respectively. [2] Cilengitide blocks proliferation and induces apoptosis of endothelial cells as well as differentiation of human endothelial precursor cells (EPCs). 50 μg/mL Cilengitide completely inhibits the proliferation of human microvascular endothelial cell line HMEC-1 and leads to apoptosis in ~30% cells. [3] 1.0 μM Cilengitide treating for 9 days inhibits the proliferation of EPCs by nearly 40%. 1 μM Cilengitide inhibits the differentiation of EPCs by more than 80% at 14 days. [4] Cilengitide inhibits adhesion and induces apoptosis of tumor cells. 25 μg/mL Cilengitide causes detachment of DAOY cells (medulloblastoma) and U87MG cells (glioblastoma) from vitronectin and tenascin by more than 60%. 25 μg/mL Cilengitide induces a nearly 50% apoptosis rate of these cells. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LN-308  MkPxSpVv[3Srb36gRZN{[Xl? M3j5dVEwOTBxMUCw5qCK|ryv MnnwNlQhcA>? NVz0Z4dnTE2VT9Mg MnPCdoVlfWOnczDEVmUhemWyb4L0[ZIh[WO2aY\peJkhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZI> NYXmNodyOjZ3MECwOVY>
ZH-161 NXPHT4N[TnWwY4Tpc44hSXO|YYm= MV6xM|Ex6oDLzszt MYqyOEBp M2C2OGROW00EoB?= M3LFepJm\HWlZYOgSHJGKHKncH;yeIVzKGGldHn2bZR6 Ml;vNlY2ODByNU[=
S-24 MXHGeY5kfGmxbjDBd5NigQ>? NVPGOphNOS9zMPMAje69dQ>? NWjNfolZOjRiaB?= M1rKOWROW00EoB?= MWry[YR2[2W|IFTSSUBz\XCxcoTldkBi[3Srdnn0fS=> MnXENlY2ODByNU[=
HaCaT  MVfGeY5kfGmxbjDBd5NigQ>? NGPPdlYyOOLCid88cS=> MoixOFghcA>? MV\EUXNQyqB? M2jzN5Jm\HWlZYOgWGdHNc7{MtMgcXJPSSCneIDy[ZN{cW:w NHPXUWkzPjVyMEC1Oi=>
LN-308  NYOwb4pZTnWwY4Tpc44hSXO|YYm= M1yyUVEx6oDLzszt NUS2d3d3OjRiaB?= NF\DS3ZFVVORwrC= M1jPW5Jm\HWlZYOgRYhTKHC{b4TlbY4hdGW4ZXzzJIFv\CCGUlWgdoVxd3K2ZYKgZYN1cX[rdIm= MYiyOlUxODB3Nh?=
REN MX\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NV;lbotiOSCwTT2yNFAh|ryP NWXCRZBIPzJiaB?= MWPk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MUiyOFU6PTJ5NB?=
MSTO-211H Mnr4R4VtdCCYaXHibYxqfHliQYPzZZk> MYqxJI5ONTJyMDFOwG0> MojUO|IhcA>? Mnvh[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ M4OzflI1PTl3Mke0
MM05 MkHHR4VtdCCYaXHibYxqfHliQYPzZZk> NEm4S|gyKG6PLUKwNEDPxE1? MUm3NkBp NH6xSlFl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= NXm3OXh1OjR3OUWyO|Q>
H28 NWjFe|hKS2WubDDWbYFjcWyrdImgRZN{[Xl? MYWxJI5ONTJyMDFOwG0> NEXKdlE4OiCq NUXPU5hY\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy MVOyOFU6PTJ5NB?=
SCC25 M2fzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjTdG9PPi5{NfMAl|IxOMLiwsXN MWO3NkBp MYHy[ZN2dHS|IH3v[IVz[XSnLDDkc5NmNWSncHXu[IVvfCCpcn;3eIghcW6qaXLpeIlwdg>? NYDmSo44OjR3NUewOVY>
CAL27 M4Xp[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHSS3RlPi5{NfMAl|IxOMLiwsXN M1\1[lczKGh? NGW4THhz\XO3bITzJI1w\GW{YYTlMEBld3OnLXTldIVv\GWwdDDndo94fGhiaX7obYJqfGmxbh?= MX2yOFU2PzB3Nh?=
FaDu  NFW3R5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfkcodKPi5{NfMAl|IxOMLiwsXN MYS3NkBp MljzdoV{fWy2czDtc4RmemG2ZTyg[I9{\S2mZYDlcoRmdnRiZ4Lve5RpKGmwaHnibZRqd25? NGjROXUzPDV3N{C1Oi=>
SCC25 NF7GWZNCeG:ydH;zbZMhSXO|YYm= NVToZZZROjYEoNM1UeKh MV60POKhcMLi NIDHTHlqdmS3Y3XzJIFxd3C2b4Ppdy=> NIrnW3IzPDV3N{C1Oi=>
CAL27 MVLBdI9xfG:|aYOgRZN{[Xl? MnnxNlXDqML3TdMg NH\DRnY1QMLiaNMg M2PrS4lv\HWlZYOgZZBweHSxc3nz MlLpNlQ2PTdyNU[=
FaDu  NV35SpdsSXCxcITvd4l{KEG|c3H5 MYeyOeKhyrWPwrC= MUS0POKhcMLi M4rmZYlv\HWlZYOgZZBweHSxc3nz M4O3cVI1PTV5MEW2
T-47D M1LCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPFcG8xNTJyIN88US=> M2TD[|k3KGh? NV7nR444cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? M37YPFI1OTV|MUCy
MCF-7  NYHYdXh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYWwMVIxKM7:TR?= MYq5OkBp NI\WT49qdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NFHJR48zPDF3M{GwNi=>
T-47D M{L5eGFxd3C2b4Ppd{BCe3OjeR?= NVfObZVIOC1{MDFOwG0> MV60PEBp NXG1cWQ{cW6mdXPld{BieG:ydH;zbZM> MnX0NlQyPTNzMEK=
MCF-7  M2LuPWFxd3C2b4Ppd{BCe3OjeR?= NYrYWIZVOC1{MDFOwG0> NGH6W3c1QCCq NGS3VJFqdmS3Y3XzJIFxd3C2b4Ppdy=> NVvaVmNTOjRzNUOxNFI>
U87MG MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHYNE0zPSEQvF2= NHTFbmMzPC92ODDo NV:wZWxncW6qaXLpeJMh[2WubDDndo94fGhiaX6g[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnRibXHucoVz NX;nVJdGOjN|NUS4NFc>
U251MG NFHYNlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH2VIYxNTJ3IN88US=> NHXUXIwzPC92ODDo NHjPPXVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfCCvYX7u[ZI> NEToWIEzOzN3NEiwOy=>
U87MG M4jNSGFxd3C2b4Ppd{BCe3OjeR?= MUCxJOK2VQ>? MYm0PEBp MonRbY5lfWOnczDhdI9xfG:|aYO= MV[yN|M2PDhyNx?=
U251MG M1nKSWFxd3C2b4Ppd{BCe3OjeR?= MXWxJOK2VQ>? MVi0PEBp M4jCTYlv\HWlZYOgZZBweHSxc3nz NYTkSmV1OjN|NUS4NFc>
U251 NVrEU4lRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXiwMVI2KM7:Zz;tUC=> Mo\CNE01QCCq NH7y[WlqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfCCvYX7u[ZI> NYP1fHF{OjF5OEizOFM>
U87  MmLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLUNE0zPSEQvHevcWw> NX3G[lNFOC12ODDo NH3ScnFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfCCvYX7u[ZI> MlfXNlE4QDh|NEO=
U251 MlHhRZBweHSxc3nzJGF{e2G7 NYPEZXdsOjVizsznM41N NGnRT3AzPC92ODDo NVH1bW9ZcW6mdXPld{BieG:ydH;zbZMh[XRiNEigbEB{cWewaX\pZ4FvfGy7 MnvaNlE4QDh|NEO=
U87  MWHBdI9xfG:|aYOgRZN{[Xl? NUHqbWQ1OjVizsznM41N M37LXVI1NzR6IHi= M4jWUYlv\HWlZYOgZZBweHSxc3nzJIF1KDR6IHigd4lodmmoaXPhcpRtgQ>? MnOyNlE4QDh|NEO=
U251 M1flcGZ2dmO2aX;uJGF{e2G7 MVGwMVI2KM7:Zz;tUC=> MXyxNkBpyqB? MmPEbY5lfWOnczDheZRweGijZ4mg[I9{\SCmZYDlcoRmdnSueR?= M2D1O|IyPzh6M{Sz
U87  M3fXO2Z2dmO2aX;uJGF{e2G7 NIfTZ2cxNTJ3IN88[{9uVA>? MXqxNkBpyqB? Mn:xbY5lfWOnczDheZRweGijZ4mg[I9{\SCmZYDlcoRmdnSueR?= NVrQVG5ROjF5OEizOFM>
U87MG M1\qc2Z2dmO2aX;uJGF{e2G7 M4\wOVAvOS9zL{GwJO69VQ>? MWKyOEBp Mn;GbY1x[Wm{czD0bIUh[WSqZYPpc44hd2ZiY3XscJMhfG9idnn0do9v\WO2aX6gbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= MYSxPVIzOTF5MR?=
LN-308 NILabYFHfW6ldHnvckBCe3OjeR?= NX25PZcyOC5zL{GvNVAh|ryP MUSyOEBp NF;ifm5qdXCjaYLzJJRp\SCjZHjld4lwdiCxZjDj[YxteyC2bzD2bZRzd26nY4TpckBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldi=> MXSxPVIzOTF5MR?=
LN-18 M{H1SmZ2dmO2aX;uJGF{e2G7 MnrwNE4yNzFxMUCg{txO MnHjNlQhcA>? MYPpcZBicXK|IITo[UBi\Ginc3nvckBw\iClZXzsd{B1dyC4aYTyc45m[3SrbjDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= MUGxPVIzOTF5MR?=
T98G MlzXSpVv[3Srb36gRZN{[Xl? M{e5e|AvOS9zL{GwJO69VQ>? MlL4NlQhcA>? NXTEeHlHcW2yYXnyd{B1cGViYXTo[ZNqd25ib3[gZ4VtdHNidH:geol1em:wZXP0bY4hcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> M{i3T|E6OjJzMUex
LNT-229  NFPmOHhHfW6ldHnvckBCe3OjeR?= M1LuPVAvOS9zL{GwJO69VQ>? M3\QTlI1KGh? MnHFbY1x[Wm{czD0bIUh[WSqZYPpc44hd2ZiY3XscJMhfG9idnn0do9v\WO2aX6gbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= MUKxPVIzOTF5MR?=
HMEC-1  MV3GeY5kfGmxbjDBd5NigQ>? NXrldGh5OS93L{WwJO69\y:vbB?= NF7zbGIzPCCq NYjRfo5qcW6mdXPld{BiKGSxc3Wg[IVx\W6mZX70JIRmfGGlaH3lcpTDqA>? M4fJN|E6OTF2MEC1
HMEC-1  MoPaVJJwdGmoZYLheIlwdiCDc4PhfS=> NGPLU|gyNzVxNUCg{txoN22u MnK1NlQwPDhxN{KgbC=> M2XER4lvcGmkaYTzJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MUKxPVEyPDByNR?=
HMEC-1  M1fGfGFxd3C2b4Ppd{BCe3OjeR?= MlLsNU82NzVyIN88[{9udA>? MmSxNlQhcA>? MV7pcoR2[2W|IHHwc5B1d3Orcx?= MYCxPVEyPDByNR?=
G28 M4r1ZXBzd2yrZnXyZZRqd25iQYPzZZk> NGPtRZEyNzVxNUCg{txoN22u M3LVelI1NzR6L{eyJIg> NV6xXXJWcW6qaXLpeJMheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= M{T6O|E6OTF2MEC1
G44 M2\yRnBzd2yrZnXyZZRqd25iQYPzZZk> NFvzcWQyNzVxNUCg{txoN22u MYmyOE81QC95MjDo MXnpcohq[mm2czDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz MljiNVkyOTRyMEW=
G28 NE\qeHhCeG:ydH;zbZMhSXO|YYm= M{nsOlEwPS93MDFOwIcwdWx? MVKyOEBp M4nFc4lv\HWlZYOgZZBweHSxc3nz NH;tVJgyQTFzNECwOS=>
G44 MnvRRZBweHSxc3nzJGF{e2G7 MXixM|UwPTBizsznM41t MWmyOEBp NXLSb4RtcW6mdXPld{BieG:ydH;zbZM> MUixPVEyPDByNR?=
HMEC-1  NX;UZpFvTnWwY4Tpc44hSXO|YYm= M4\ZN|IxNzRyL{[wJO69\y:vbB?= MlTMbY5pcWKrdIOgSmFMKGGwZDDTdoPDqA>? M4f0cFE6OTF2MEC1
G28 MX7GeY5kfGmxbjDBd5NigQ>? M2rY[FUxKM7:Zz;tcC=> MVWzNE83OC9zMkCgcYlv NUnkcotTcW6qaXLpeJMheGixc4Doc5J6dGG2aX;uJI9nKE[DSzygV5JkKGGwZDDBb5Q> MYGxPVEyPDByNR?=

... Click to View More Cell Line Experimental Data

In vivo Cilengitide is activity against tumor growth and angiogenesis as single-agent. 100 μg Cilengitide induces a significant decrease in the number of CD 31+ vessels seen in tumors (2/high-power field) compared with control tumors (56/high-power field). 100 μg Cilengitide increases cellular apoptosis in the brain tumors of animals (2.2% apoptotic cells/high-power field) compared with those receiving the inactive peptide (1.7% cells/high-power field). Cilengitide treatment results in prolonged survival of the mice bearing melanoma xenografts M21 compared with control treatment group. (36.5 vs 17.3 days). [5] Cilengitide can augment the therapeutic benefit associated with cytotoxic agents including chemotherapy and radiation therapy in tumor models. Cilengitide (250 mg/dose) alone does not alter tumor growth of breast cancer xenografts when compared with untreated mice, but combined modality RIT (CMRIT) using RIT and six doses of Cilengitide (250 mg/dose) increases efficacy of treatment, with the cure rate for mice that receives only RIT increasing from 15 to 53%. CMRIT significantly increases apoptosis of tumor and endothelial cells 5 days, and decreases tumor proliferation. [6]

Protocol

Kinase Assay
+ Expand

Integrin-binding competition assay:

Recombinant soluble integrins are immobilized, and peptides, which are serially diluted in Tris-buffered saline (TBS++) (0.1% (w/v) BSA, 150 mM NaCl, 1 mM CaCl2, 1 mM MgCl2 10 μM MnCl2, 20 mM Tris-HCl; pH 7.4), are added in parallel with biotinylated vitronectin (to 1μg/mL). After a 3-h incubation at 37℃ and washing with Tris–buffered saline, bound ligand is detected by incubation with an antibiotin alkaline phosphatase-conjugated antibody (BioRad) followed by development with p-nitrophenyl phosphatase substrate. The reaction is stopped by the addition of NaOH and the color intensity read at 405 nm.
Cell Research
+ Expand
  • Cell lines: Human microvascular endothelial cell line HMEC-1
  • Concentrations: 1-50 μg/mL
  • Incubation Time: 3 days
  • Method: HMEC-1 (1×104 per well) are seeded on uncoated 48 well plates and incubated in medium containing 4% FCS with Cilengitide. After incubation for 72 hours at 37℃, cells are trypsinized and counted.
    (Only for Reference)
Animal Research
+ Expand
  • Animal Models: Human glioblastoma xenografts U87 MG
  • Formulation: PBS
  • Dosages: 100μg
  • Administration: Daily i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (142.31 mM)
Water 8 mg/mL (11.38 mM)
Ethanol <1 mg/mL
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 702.68
Formula

C29H41F3N8O9

CAS No. 199807-35-7
Storage powder
in solvent
Synonyms EMD 121974, NSC 707544

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01782976 Withdrawn Glioblastoma M.D. Anderson Cancer Center|Brain Tumor Trials Collaborative|EMD Serono June 2013 Phase 2
NCT01517776 Terminated Gliomas Martin-Luther-Universität Halle-Wittenberg|Merck KGaA January 2012 Phase 2
NCT01504165 Completed Renal Impairment Merck KGaA January 2012 Phase 1
NCT01276496 Completed Adult Solid Neoplasm|Estrogen Receptor Negative|HER2/Neu Negative|Male Breast Carcinoma|Progesterone Receptor Negative|Recurrent Breast Carcinoma|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Triple-Negative Breast Carcinoma National Cancer Institute (NCI) December 2010 Phase 1
NCT01165333 Completed Diffuse Intrinsic Pontine Glioma Centre Oscar Lambret August 2010 Phase 1
NCT00979862 Completed Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Neoplasm National Cancer Institute (NCI) March 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    The recommend vehicle is 30% propylene glycol, 5% Tween 80, 65% D5W at 30mg/ml, can you let me know if this is a suspension or clear solution?

  • Answer:

    S7077 Cilengitide can be dissolved in 30% propylene glycol/5% Tween 80/65% D5W at 10 mg/ml as a clear solution.

  • Question 2:

    Is Cilengitide a TFA salt?

  • Answer:

    S7077 Cilengitide is actually a TFA salt, and the ratio between Cilengitide and TFA is 1:1.

Integrin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID