Cilengitide

Catalog No.S7077 Synonyms: EMD 121974, NSC 707544

Cilengitide Chemical Structure

Molecular Weight(MW): 702.68

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.

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In DMSO USD 454 In stock
USD 270 In stock

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6 Customer Reviews

  • WT mice were subjected to BDL and treated with either vehicle or cilengitide (10 mg/kg) daily for 6 days; adjacent liver sections were immunostained for CK19 or PCNA. Data were quantified and expressed as mean ± SD. (n = 6 per group.) *P < 0.02, **P < 0.004, Student’s t test.

    J Clin Invest, 2015, 125(5): 1886-900. Cilengitide purchased from Selleck.

    BrdU incorporation was quantified in freshly isolated primary cholangiocytes treated with BSA (4 μg/ml), CCN1 (4 μg/ml), soluble JAG1 (2 μg/ml), DAPT (10 μM), cilengitide (1 μM), NBD (25 μM), or control peptide (25 μM). Where indicated, CCN1 (4 μg/ml) was added with other inhibitors. *P < 0.04, **P < 0.01, Student’s t test.

    J Clin Invest, 2015, 125(5): 1886-900. Cilengitide purchased from Selleck.

  • (A) Comparison of blood vessel count of the linear and grafted peptides. Error bars indicate ± SD (n ≥ 6). The dotted line indicates ~50% inhibition of blood vessels. A one-way ANOVA with Dunnett's post-test using a multiple comparison test was used for statistical analysis. In addition, unpaired t-test was used to test the significance of MCoAA-02 against MCo-SST-01 and MCo-PEDF. ****p ≤ 0.0001 and ***p ≤ 0.05. All peptides were compared to 0.3 nM VEGF (highlighted in grey), which is represented as 100% blood vessel growth.

    Sci Rep, 2016, 6:35347.. Cilengitide purchased from Selleck.

    (D) The treatment more significantly inhibited cell invasion and proliferation in EGFRvIII-expressing GBM than vector cells in the environment of hypoxia and vitronectin-enrichment in vitro. All experiments were performed independently at least three times. *p < 0.05; **p < 0.01.

    Oncotarget, 2016, 7(4):4680-94.. Cilengitide purchased from Selleck.

  • Elevated β-catenin expression was observed in OPNa-, OPNb- and OPNc-expressing cells. Addition of cilengitide did not alter β-catenin expression in any of the OPN isoform-expressing cells but induced E-cadherin expression in OPNc-expressing cells. GAPDH or β-actin was included as a loading control.

    Oncotarget, 2015, 6(26):22239-57.. Cilengitide purchased from Selleck.

    Cell growth inhibition of non-small cell lung carcinoma (NSCLC) by Cilengitide. Cilengitide is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins. Interestingly, it acts differently on HTB183 and A549 cell lines. Cilengitide was more efficient on A549, lung adenocarcinoma, while in HTB183 it showed moderate inhibitory activity. This may be due to the mestastatic nature of HTB183 cells which have already lost the cell adhesion properties.

    Dr.Milica Pesic from Institute for Biological Research . Cilengitide purchased from Selleck.

Purity & Quality Control

Choose Selective Integrin Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Targets
αvβ3 receptor [1]
(Cell-free assay)
αvβ5 receptor [2]
(Cell-free assay)
4.1 nM 79 nM
In vitro

Cilengitide is a cyclized pentapeptide peptidomimetic designed to compete for the arginine-glycine-aspartic acid (RGD) peptide sequence that regulates integrin-ligand binding. Cilengitide selectively and potently blocks the ligation of theαvβ3 andαvβ5 integrins to provisional matrix proteins such as vitronectin, fibronectin, fibrinogen, von Willebrand factor, osteopontin, and others. [1] Cilegitide inhibits angiogenesis in vitro. 10 μM Cilengitide completely inhibits attachment of BAE, BME and HUVE cells on vitronectin and fibronectin. Cilengitide inhibits in vitro angiogenesis of BAE cells on three-dimensional collagen and fibrin gels pretreated with FGF-2(or VEGF-A) with IC50 of 15 μM and 8 μM, 4 μM and 3 μM, respectively. [2] Cilengitide blocks proliferation and induces apoptosis of endothelial cells as well as differentiation of human endothelial precursor cells (EPCs). 50 μg/mL Cilengitide completely inhibits the proliferation of human microvascular endothelial cell line HMEC-1 and leads to apoptosis in ~30% cells. [3] 1.0 μM Cilengitide treating for 9 days inhibits the proliferation of EPCs by nearly 40%. 1 μM Cilengitide inhibits the differentiation of EPCs by more than 80% at 14 days. [4] Cilengitide inhibits adhesion and induces apoptosis of tumor cells. 25 μg/mL Cilengitide causes detachment of DAOY cells (medulloblastoma) and U87MG cells (glioblastoma) from vitronectin and tenascin by more than 60%. 25 μg/mL Cilengitide induces a nearly 50% apoptosis rate of these cells. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LN-308  MVrGeY5kfGmxbjDBd5NigQ>? Mnz3NU8yOC9zMEFihKnPxG1? MXuyOEBp NHzNe2lFVVORwrC= M2T6ZZJm\HWlZYOgSHJGKHKncH;yeIVzKGGldHn2bZR6KGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz NYXXZ3BUOjZ3MECwOVY>
ZH-161 NUXWTo1ZTnWwY4Tpc44hSXO|YYm= M{flRVEwOTEkgJpOwI0> Moi0NlQhcA>? NGDCNItFVVORwrC= NYHDfZg3emWmdXPld{BFWkVicnXwc5J1\XJiYXP0bZZqfHl? MmHtNlY2ODByNU[=
S-24 Mo\pSpVv[3Srb36gRZN{[Xl? NGLGO|kyNzFy4pEJ{txu M2Lhc|I1KGh? MVnEUXNQyqB? M2KxWZJm\HWlZYOgSHJGKHKncH;yeIVzKGGldHn2bZR6 MmnjNlY2ODByNU[=
HaCaT  M2XpR2Z2dmO2aX;uJGF{e2G7 NXzt[|RUOTEkgJpOwI0> NFXqd2Y1QCCq MWfEUXNQyqB? NWHGNlNMemWmdXPld{BVT0ZvzsKyxsBuWk6DIHX4dJJme3Orb36= NXruNolMOjZ3MECwOVY>
LN-308  MV;GeY5kfGmxbjDBd5NigQ>? MnX1NVDjiIoQvH2= NXHwd3BHOjRiaB?= MkPnSG1UV8Li MmrldoVlfWOnczDBbHIheHKxdHXpckBt\X[nbIOgZY5lKESURTDy[ZBwenSncjDhZ5Rqfmm2eR?= M1rwXlI3PTByMEW2
REN MW\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NUHaZ49[OSCwTT2yNFAh|ryP NXLlT5h7PzJiaB?= NH7sWpJl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= MoHyNlQ2QTV{N{S=
MSTO-211H NUnUcm5DS2WubDDWbYFjcWyrdImgRZN{[Xl? M1Ho[FEhdk1vMkCwJO69VQ>? NGLQTHA4OiCq NFnhVIZl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= NIm2epAzPDV7NUK3OC=>
MM05 MWDD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NVS3RWRvOSCwTT2yNFAh|ryP M3rue|czKGh? MlrG[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ M1j0UlI1PTl3Mke0
H28 Ml:wR4VtdCCYaXHibYxqfHliQYPzZZk> MnHYNUBvVS1{MECg{txO NXyyNZBbPzJiaB?= MoPs[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ M1z5WFI1PTl3Mke0
SCC25 NGD5d3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnyR2p5Pi5{NfMAl|IxOMLiwsXN MWG3NkBp M1fB[ZJme3WudIOgcY9l\XKjdHWsJIRwe2VvZHXw[Y5l\W62IHfyc5d1cCCrbnjpZol1cW:w M4T3WFI1PTV5MEW2
CAL27 M1jCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz5O3hsPi5{NfMAl|IxOMLiwsXN NV6yZ4RkPzJiaB?= MlL6doV{fWy2czDtc4RmemG2ZTyg[I9{\S2mZYDlcoRmdnRiZ4Lve5RpKGmwaHnibZRqd25? M3;ORlI1PTV5MEW2
FaDu  MkDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{iwSVYvOjYkgKOyNFDDqML3TR?= NVfVT4xMPzJiaB?= NYjFVmR2emW|dXz0d{Bud2SncnH0[Uwh\G:|ZT3k[ZBmdmSnboSg[5Jwf3SqIHnubIljcXSrb36= NIjRVWczPDV3N{C1Oi=>
SCC25 Mon5RZBweHSxc3nzJGF{e2G7 NGjjXGEzPcLiwsXNxsA> NVS5OZpkPDkEoHlCpC=> NG\mSFZqdmS3Y3XzJIFxd3C2b4Ppdy=> MYiyOFU2PzB3Nh?=
CAL27 M1PFfmFxd3C2b4Ppd{BCe3OjeR?= NUjHTIE4OjYEoNM1UeKh Mnj2OFjDqGkEoB?= Mm\0bY5lfWOnczDhdI9xfG:|aYO= MnnVNlQ2PTdyNU[=
FaDu  MWDBdI9xfG:|aYOgRZN{[Xl? MlHaNlXDqML3TdMg M4\TeFQ5yqCqwrC= MYfpcoR2[2W|IHHwc5B1d3Orcx?= NIDhTWIzPDV3N{C1Oi=>
T-47D NVLvd4ZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nuZlAuOjBizszN NGLlZYo6PiCq NEXZenpqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MXKyOFE2OzFyMh?=
MCF-7  NWLrdZh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j4d|AuOjBizszN MUO5OkBp NGXvTHlqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? Ml7zNlQyPTNzMEK=
T-47D M1naS2Fxd3C2b4Ppd{BCe3OjeR?= NUi1XZYxOC1{MDFOwG0> NHe2Slc1QCCq NHrGRndqdmS3Y3XzJIFxd3C2b4Ppdy=> NFrMSHAzPDF3M{GwNi=>
MCF-7  NUS4OmJTSXCxcITvd4l{KEG|c3H5 M{W4RVAuOjBizszN MlWxOFghcA>? NVrwW284cW6mdXPld{BieG:ydH;zbZM> MlLhNlQyPTNzMEK=
U87MG M{P2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrkXlIxNTJ3IN88US=> NVn1dXR1OjRxNEigbC=> M33RPIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51KG2jbn7ldi=> MnjtNlM{PTR6MEe=
U251MG M1LBe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLLNE0zPSEQvF2= NX7h[WoyOjRxNEigbC=> MWrpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= NGfQc5IzOzN3NEiwOy=>
U87MG MnPnRZBweHSxc3nzJGF{e2G7 MWCxJOK2VQ>? NWq3XYJvPDhiaB?= NIPLRVNqdmS3Y3XzJIFxd3C2b4Ppdy=> NHzKUIYzOzN3NEiwOy=>
U251MG NUXXfIpWSXCxcITvd4l{KEG|c3H5 NInZSJgyKML3TR?= NHj4fpk1QCCq NXe4[ZFmcW6mdXPld{BieG:ydH;zbZM> NEnoSlgzOzN3NEiwOy=>
U251 M{m4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HxTlAuOjVizsznM41N MX2wMVQ5KGh? MUTpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= NHno[oQzOTd6OEO0Ny=>
U87  M1\jNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjnZpoxNTJ3IN88[{9uVA>? NXPqR2dGOC12ODDo M1qx[IlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51KG2jbn7ldi=> NVnIV2o1OjF5OEizOFM>
U251 MlPyRZBweHSxc3nzJGF{e2G7 M3W1elI2KM7:Zz;tUC=> NGDUbGIzPC92ODDo MW\pcoR2[2W|IHHwc5B1d3OrczDheEA1QCCqIIPp[45q\mmlYX70cJk> MV2yNVc5QDN2Mx?=
U87  NWXQZpdYSXCxcITvd4l{KEG|c3H5 NEC1ZWUzPSEQvHevcWw> NX7ncFk3OjRxNEigbC=> NIfVNYhqdmS3Y3XzJIFxd3C2b4Ppd{BifCB2ODDoJJNq\26rZnnjZY51dHl? NX7UU25QOjF5OEizOFM>
U251 MVHGeY5kfGmxbjDBd5NigQ>? MonXNE0zPSEQvHevcWw> NIjtTIYyOiCqwrC= M4fLUolv\HWlZYOgZZV1d3CqYXf5JIRwe2ViZHXw[Y5l\W62bIm= M2HnOFIyPzh6M{Sz
U87  NWjTVpMxTnWwY4Tpc44hSXO|YYm= MWewMVI2KM7:Zz;tUC=> Ml7CNVIhcMLi MXzpcoR2[2W|IHH1eI9xcGGpeTDkc5NmKGSncHXu[IVvfGy7 NFLnbnczOTd6OEO0Ny=>
U87MG NIe1UXVHfW6ldHnvckBCe3OjeR?= MnLQNE4yNzFxMUCg{txO NIriWFczPCCq NH3tRoNqdXCjaYLzJJRp\SCjZHjld4lwdiCxZjDj[YxteyC2bzD2bZRzd26nY4TpckBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldi=> NYKxXY9[OTl{MkGxO|E>
LN-308 MYPGeY5kfGmxbjDBd5NigQ>? NVzrNoZHOC5zL{GvNVAh|ryP NWjZ[nZvOjRiaB?= M4XZeYlueGGrcoOgeIhmKGGmaHXzbY9vKG:oIHPlcIx{KHSxII\peJJwdmWldHnuJIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy MY[xPVIzOTF5MR?=
LN-18 MUTGeY5kfGmxbjDBd5NigQ>? NUPIXmJNOC5zL{GvNVAh|ryP NXeyPJZ2OjRiaB?= MVXpcZBicXK|IITo[UBi\Ginc3nvckBw\iClZXzsd{B1dyC4aYTyc45m[3SrbjDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= MVGxPVIzOTF5MR?=
T98G M{TYWmZ2dmO2aX;uJGF{e2G7 M3vXc|AvOS9zL{GwJO69VQ>? MoHBNlQhcA>? M2rrSYlueGGrcoOgeIhmKGGmaHXzbY9vKG:oIHPlcIx{KHSxII\peJJwdmWldHnuJIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy NWfHOGxkOTl{MkGxO|E>
LNT-229  NUfqeW5vTnWwY4Tpc44hSXO|YYm= M3LzO|AvOS9zL{GwJO69VQ>? Mof2NlQhcA>? NXLUOpFncW2yYXnyd{B1cGViYXTo[ZNqd25ib3[gZ4VtdHNidH:geol1em:wZXP0bY4hcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> M4nkXFE6OjJzMUex
HMEC-1  NWT0U44zTnWwY4Tpc44hSXO|YYm= MVqxM|UwPTBizsznM41t NFzydmEzPCCq M4HafIlv\HWlZYOgZUBld3OnIHTldIVv\GWwdDDk[ZRi[2ivZX70xsA> MXKxPVEyPDByNR?=
HMEC-1  Mnf6VJJwdGmoZYLheIlwdiCDc4PhfS=> M3uyN|EwPS93MDFOwIcwdWx? M4XxRVI1NzR6L{eyJIg> NYLoXXJ4cW6qaXLpeJMheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= MVSxPVEyPDByNR?=
HMEC-1  NH\zbWdCeG:ydH;zbZMhSXO|YYm= NWL6[JVrOS93L{WwJO69\y:vbB?= NYCxZnZpOjRiaB?= M3PpXYlv\HWlZYOgZZBweHSxc3nz M1nJNlE6OTF2MEC1
G28 MlO2VJJwdGmoZYLheIlwdiCDc4PhfS=> M1fQdVEwPS93MDFOwIcwdWx? MVyyOE81QC95MjDo MX\pcohq[mm2czDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz MVKxPVEyPDByNR?=
G44 MXPQdo9tcW[ncnH0bY9vKEG|c3H5 MYSxM|UwPTBizsznM41t MX:yOE81QC95MjDo NHi0[ndqdmirYnn0d{Bxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ MoHsNVkyOTRyMEW=
G28 NXLUUGY2SXCxcITvd4l{KEG|c3H5 MnPYNU82NzVyIN88[{9udA>? NGLBWlMzPCCq NGrLUJBqdmS3Y3XzJIFxd3C2b4Ppdy=> M1TPe|E6OTF2MEC1
G44 M4T3emFxd3C2b4Ppd{BCe3OjeR?= NVL5N3A6OS93L{WwJO69\y:vbB?= NWWz[WM{OjRiaB?= NVzqbWM3cW6mdXPld{BieG:ydH;zbZM> MV:xPVEyPDByNR?=
HMEC-1  M33LfGZ2dmO2aX;uJGF{e2G7 M2LTUFIxNzRyL{[wJO69\y:vbB?= M4LkSIlvcGmkaYTzJGZCUyCjbnSgV5JkyqB? MXexPVEyPDByNR?=
G28 NWDkbJVkTnWwY4Tpc44hSXO|YYm= M{jFUlUxKM7:Zz;tcC=> NXj6T3BJOzBxNkCvNVIxKG2rbh?= MVHpcohq[mm2czDwbI9{eGixconsZZRqd25ib3[gSmFMNCCVcnOgZY5lKEGtdB?= NGHFeGgyQTFzNECwOS=>

... Click to View More Cell Line Experimental Data

In vivo Cilengitide is activity against tumor growth and angiogenesis as single-agent. 100 μg Cilengitide induces a significant decrease in the number of CD 31+ vessels seen in tumors (2/high-power field) compared with control tumors (56/high-power field). 100 μg Cilengitide increases cellular apoptosis in the brain tumors of animals (2.2% apoptotic cells/high-power field) compared with those receiving the inactive peptide (1.7% cells/high-power field). Cilengitide treatment results in prolonged survival of the mice bearing melanoma xenografts M21 compared with control treatment group. (36.5 vs 17.3 days). [5] Cilengitide can augment the therapeutic benefit associated with cytotoxic agents including chemotherapy and radiation therapy in tumor models. Cilengitide (250 mg/dose) alone does not alter tumor growth of breast cancer xenografts when compared with untreated mice, but combined modality RIT (CMRIT) using RIT and six doses of Cilengitide (250 mg/dose) increases efficacy of treatment, with the cure rate for mice that receives only RIT increasing from 15 to 53%. CMRIT significantly increases apoptosis of tumor and endothelial cells 5 days, and decreases tumor proliferation. [6]

Protocol

Kinase Assay:[2]
+ Expand

Integrin-binding competition assay:

Recombinant soluble integrins are immobilized, and peptides, which are serially diluted in Tris-buffered saline (TBS++) (0.1% (w/v) BSA, 150 mM NaCl, 1 mM CaCl2, 1 mM MgCl2 10 μM MnCl2, 20 mM Tris-HCl; pH 7.4), are added in parallel with biotinylated vitronectin (to 1μg/mL). After a 3-h incubation at 37℃ and washing with Tris–buffered saline, bound ligand is detected by incubation with an antibiotin alkaline phosphatase-conjugated antibody (BioRad) followed by development with p-nitrophenyl phosphatase substrate. The reaction is stopped by the addition of NaOH and the color intensity read at 405 nm.
Cell Research:[3]
+ Expand
  • Cell lines: Human microvascular endothelial cell line HMEC-1
  • Concentrations: 1-50 μg/mL
  • Incubation Time: 3 days
  • Method: HMEC-1 (1×104 per well) are seeded on uncoated 48 well plates and incubated in medium containing 4% FCS with Cilengitide. After incubation for 72 hours at 37℃, cells are trypsinized and counted.
    (Only for Reference)
Animal Research:[5]
+ Expand
  • Animal Models: Human glioblastoma xenografts U87 MG
  • Formulation: PBS
  • Dosages: 100μg
  • Administration: Daily i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (142.31 mM)
Water 8 mg/mL (11.38 mM)
Ethanol <1 mg/mL
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 702.68
Formula

C29H41F3N8O9

CAS No. 199807-35-7
Storage powder
in solvent
Synonyms EMD 121974, NSC 707544

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01782976 Withdrawn Glioblastoma M.D. Anderson Cancer Center|Brain Tumor Trials Collaborative|EMD Serono June 2013 Phase 2
NCT01517776 Terminated Gliomas Martin-Luther-Universität Halle-Wittenberg|Merck KGaA January 2012 Phase 2
NCT01504165 Completed Renal Impairment Merck KGaA January 2012 Phase 1
NCT01276496 Completed Adult Solid Neoplasm|Estrogen Receptor Negative|HER2/Neu Negative|Male Breast Carcinoma|Progesterone Receptor Negative|Recurrent Breast Carcinoma|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Triple-Negative Breast Carcinoma National Cancer Institute (NCI) December 2010 Phase 1
NCT01165333 Completed Diffuse Intrinsic Pontine Glioma Centre Oscar Lambret August 2010 Phase 1
NCT00979862 Completed Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Neoplasm National Cancer Institute (NCI) March 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Integrin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID