Home GPCR & G Protein RGS inhibitor CCG 50014 For research use only.

CCG 50014

CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

CCG 50014 Chemical Structure

CCG 50014 Chemical Structure

CAS: 883050-24-6

Selleck's CCG 50014 has been cited by 1 publication

Purity & Quality Control

Batch: S290101 DMSO] 63 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.91%
99.91

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Choose Selective RGS Inhibitors

Biological Activity

Description CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.
Targets
RGS4 [1] RGS19 [1] RGS16 [1] RGS8 [1]
30 nM 0.12 μM 3.5 μM 11 μM
In vitro
In vitro CCG-50014 is highly potent at inhibiting RGS4 and it fully inhibits several other RGS proteins, including RGS8, -16, and -19, but does not have activity on RGS7. Furthermore, CCG-50014 has no activity on a mutated form of RGS4 that lacks cysteine residues in the RGS homology domain (RGS4Cys−). CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG-50014 is able to inhibit the RGS4−Gαo protein−protein interaction in a living cell. CCG-50014 represents the first of a class of small molecule RGS inhibitors that function in a cellular environment. [1] [2]

Chemical Information & Solubility

Molecular Weight 316.35 Formula

C16H13FN2O2S
CAS No. 883050-24-6 SDF Download CCG 50014 SDF
Smiles CC1=CC=C(C=C1)N2C(=O)N(C(=O)S2)CC3=CC=C(C=C3)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 63 mg/mL ( (199.14 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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