Avanafil

Catalog No.S4019

Avanafil Chemical Structure

Molecular Weight(MW): 483.95

Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
Features Highly selective for PDE5.
Targets
PDE5 [1]
1 nM
In vivo Avanafil (i.v.) potentiates penile tumescence with ED200% of 37.5 μg/kg in dogs. Furthermore, intraduodenal treatment of Avanafil potentiates pelvic nerve stimulation induced changes in intracavernous pressure and duration. [1] The cavernous injection of avanafil (1 μM) in T2DM rats results in partial improvement in erectile responses. [2]

Protocol

Animal Research
+ Expand
  • Animal Models: Male mongrel dogs
  • Formulation: 0.05N HCl (intraduodenal); Saline containing 0.01N HCl (i.v.)
  • Dosages: 1-300 μg/kg
  • Administration: Intraduodenal treatment or i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (200.43 mM)
Water <1 mg/mL
Ethanol <1 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 483.95
Formula

C23H26ClN7O3

CAS No. 330784-47-9
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02503306 Completed Sexual Function and Fertility Disorders NEC-Erectile Dysfunction Sanofi July 2015 Phase 3
NCT01768676 Completed Erectile Dysfunction VIVUS, Inc. December 2012 Phase 4
NCT01698684 Completed Erectile Dysfunction VIVUS, Inc. September 2012 Phase 4
NCT01705197 Completed Erectile Dysfunction JW Pharmaceutical February 2012 Phase 3
NCT01095601 Completed Healthy VIVUS, Inc. April 2010 Phase 1
NCT01117038 Completed Erectile Dysfunction VIVUS, Inc. April 2010 Phase 1

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PDE Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID