Atovaquone

Catalog No.S3079

Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.

Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 310 In stock
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Atovaquone Chemical Structure

Atovaquone Chemical Structure
Molecular Weight: 366.84

Validation & Quality Control

MSDS

Related Compound Libraries

Atovaquone is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Description Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.
In vitro Atovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity.[1] Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. [2]
In vivo Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. [3]
Features

Protocol(Only for Reference)

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Looareesuwan S, et al. Am J Trop Med Hyg, 1996, 54(1), 62-66.

[2] Kessl JJ, et al. J Biol Chem, 2003, 278(33), 31312-31318.

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Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2014-10-24)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02098590 Not yet recruiting Malaria Radboud University|Bill and Melinda Gates Foundation November 2014 --
NCT02080026 Recruiting Malaria Radboud University|Bill and Melinda Gates Foundation June 2014 --
NCT01783340 Not yet recruiting Malaria, Falciparum|Chloroquine|Azithromycin|Immunization Radboud University|Leiden University Medical Center|Medic  ...more Radboud University|Leiden University Medical Center|Medicines for Malaria Venture April 2013 Phase 1|Phase 2
NCT01858831 Completed Malaria GlaxoSmithKline April 2012 Phase 1
NCT01479361 Completed HIV|PCP|Toxoplasmosis National Institutes of Health Clinical Center (CC) October 2011 Phase 1

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Chemical Information

Download Atovaquone SDF
Molecular Weight (MW) 366.84
Formula

C22H19ClO3

CAS No. 95233-18-4
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Atavaquone
Solubility (25°C) * In vitro DMSO 5 mg/mL (13 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1,4-Naphthalenedione, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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