Catalog No.S3079 Synonyms: Atavaquone
Molecular Weight(MW): 366.84
Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.
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|Description||Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.|
Atovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. 
|In vivo||Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. |
|In vitro||DMSO||5 mg/mL (13.62 mM)|
|In vivo||Add solvents individually and in order:
5% DMSO+corn oil
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01479361||Completed||HIV|PCP|Toxoplasmosis||National Institutes of Health Clinical Center (CC)||October 31, 2011||Phase 1|
|NCT02858817||Not yet recruiting||Malaria||University Hospital Tuebingen|Sanaria Inc.||October 2016||Phase 1|
|NCT02836002||Recruiting||Malaria||Radboud University|The PATH Malaria Vaccine Initiative (MVI)|QIMR Berghofer Medical Research Institute||June 2016||Phase 1|Phase 2|
|NCT02628080||Recruiting||Carcinoma, Non-Small-Cell Lung||University of Oxford||May 2016||Early Phase 1|
|NCT02564471||Recruiting||Rabies||State University of New York - Upstate Medical University|Walter Reed Army Institute of Research (WRAIR)|Kansas State University||April 2016||Phase 4|
|NCT02297477||Completed||Malaria||Armed Forces Research Institute of Medical Sciences, Thailand|National Centre for Parasitology, Entomology and Malaria Control, Cambodia|Naval Medical Research Center, Asia (NMRC-A)||December 2014||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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