Atovaquone

Catalog No.S3079

Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.

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In DMSO USD 130 In stock
USD 97 In stock
USD 310 In stock
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Atovaquone Chemical Structure

Atovaquone Chemical Structure
Molecular Weight: 366.84

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Product Description

Biological Activity

Description Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.
In vitro Atovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity.[1] Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. [2]
In vivo Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. [3]
Features

Protocol(Only for Reference)

1

References

[1] Looareesuwan S, et al. Am J Trop Med Hyg, 1996, 54(1), 62-66.

[2] Kessl JJ, et al. J Biol Chem, 2003, 278(33), 31312-31318.

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Chemical Information

Download Atovaquone SDF
Molecular Weight (MW) 366.84
Formula

C22H19ClO3

CAS No. 95233-18-4
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Atavaquone
Solubility (25°C) * In vitro DMSO 5 mg/mL (13 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1,4-Naphthalenedione, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-

Research Area

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