Catalog No.S3079

Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.

Price Stock Quantity  
USD 130 In stock
USD 97 In stock
USD 310 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Atovaquone Chemical Structure

Atovaquone Chemical Structure
Molecular Weight: 366.84

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Atovaquone is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Description Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.
In vitro Atovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity.[1] Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. [2]
In vivo Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. [3]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Looareesuwan S, et al. Am J Trop Med Hyg, 1996, 54(1), 62-66.

[2] Kessl JJ, et al. J Biol Chem, 2003, 278(33), 31312-31318.

view more

Clinical Trial Information( data from, updated on 2015-11-14)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02564471 Not yet recruiting Rabies State University of New York - Upstate Medical University  ...more State University of New York - Upstate Medical University|Walter Reed Army Institute of Research (WRAIR)|Kansas State University October 2015 Phase 4
NCT02297477 Recruiting Malaria Armed Forces Research Institute of Medical Sciences, Thai  ...more Armed Forces Research Institute of Medical Sciences, Thailand|National Centre for Parasitology, Entomology and Malaria Control, Cambodia|Naval Medical Research Center, Asia (NMRC-A) December 2014 Phase 4
NCT02098590 Active, not recruiting Malaria Radboud University|Bill and Melinda Gates Foundation October 2014 --
NCT02080026 Completed Malaria Radboud University|Bill and Melinda Gates Foundation June 2014 --
NCT01858831 Completed Malaria GlaxoSmithKline April 2012 Phase 1

view more

Chemical Information

Download Atovaquone SDF
Molecular Weight (MW) 366.84


CAS No. 95233-18-4
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms Atavaquone
Solubility (25°C) * In vitro DMSO 5 mg/mL (13.62 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1,4-Naphthalenedione, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Others Products

  • CB-839

    CB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. Phase 1.

  • GKT137831

    GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Phase 2.

  • LB-100

    LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.

  • Puromycin 2HCl

    Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

  • Cyclosporin A

    Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

  • Cyclophosphamide Monohydrate

    Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

  • Calcitriol

    Calcitriol is the hormonally active form of vitamin D.

  • Ganciclovir

    Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.

  • Ribavirin

    Ribavirin, a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.

  • N6-methyladenosine (m6A)

    N6-methyladenosine (m6A) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.

Recently Viewed Items

Tags: buy Atovaquone | Atovaquone ic50 | Atovaquone price | Atovaquone cost | Atovaquone solubility dmso | Atovaquone purchase | Atovaquone manufacturer | Atovaquone research buy | Atovaquone order | Atovaquone mouse | Atovaquone chemical structure | Atovaquone mw | Atovaquone molecular weight | Atovaquone datasheet | Atovaquone supplier | Atovaquone in vitro | Atovaquone cell line | Atovaquone concentration | Atovaquone nmr
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us