Ademetionine disulfate tosylate

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.

Ademetionine disulfate tosylate Chemical Structure

Ademetionine disulfate tosylate Chemical Structure

CAS: 97540-22-2

Purity & Quality Control

Batch: S451501 DMSO] 79 mg/mL] false] Water] 79 mg/mL] false] Ethanol] Insoluble] false Purity: 99.85%
99.85

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Biological Activity

Description Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.
In Vivo
In vivo Continuous oral administration of ademetionine for 7 days may induce the activities of CYP450 isoforms CYP1A2 of rats, while it may inhibit the activities of CYP2D6, CYP3A4, CYP2C19 and CYP2C9[1].
Animal Research Animal Models Sprague-Dawley rats
Dosages 50 mg/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 766.80 Formula

C22H34N6O16S4

CAS No. 97540-22-2 SDF Download Ademetionine disulfate tosylate SDF
Smiles C[S+](CCC(N)C([O-])=O)CC1OC(C(O)C1O)[N]2C=NC3=C(N)N=CN=C23.CC4=CC=C(C=C4)[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 79 mg/mL ( (103.02 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 79 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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