Vorinostat (SAHA, MK0683)

Catalog No.S1047

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

Price Stock Quantity  
USD 191 In stock
USD 147 In stock
USD 220 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Vorinostat (SAHA, MK0683) Chemical Structure

Vorinostat (SAHA, MK0683) Chemical Structure
Molecular Weight: 264.3

Validation & Quality Control

Cited by 99 publications:

20 customer reviews :

Quality Control & MSDS

Related Compound Libraries

HDAC Inhibitors with Unique Features

Product Information

  • Compare HDAC Inhibitors
    Compare HDAC Products
  • Research Area
  • Vorinostat (SAHA, MK0683) Mechanism
  • Combination Therapy
    Combination Therapy

Product Description

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets HDAC [1]
(Cell-free assay)
IC50 ~10 nM
In vitro Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A20M4TCfWtqdmG|ZTDBd5NigQ>?MoLpNUBpNFHmeHdFVVORMnO3ZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryPNGq0fIYyOTl4MES4PS=>
Friend leukemic cellMoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1fRZ|UxKM7:TR?=NF\OWZM4OiCqM4PFOGROW09?MUnJR|UxRTBwOUmg{txONGj3XY4yOjFyOUmxNy=>
K562NFHJd3JMcW6jc3WgRZN{[Xl?MlPuOkBpMVXEUXNQMUfJcohq[mm2aX;uJI9nKGi3bXHuJIhqe3SxbnWg[IVi[2W2eXzhd4UhMG2reIT1doUhd2ZiSFTBR|Eh[W6mIFjERWMzMSC5aYToJGlEPTBib3[gNE4xOSEQvF2=MkHLNVI1OTl|OEC=
HT1080MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUToZlVQPzJiaB?=MmHwSG1UVw>?MmXoTWM2OD1{LkSg{txOM3HxWlEzOjdyMUe1
H1299Mk[0T4lv[XOnIFHzd4F6Mn\mNlAhdWmwMUjEUXNQMY\Jcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgTGRCSyCnbor5cYUhf2m2aDDJR|UxKG:oIECuNVk1KM7:TR?=M{PFS|E1PTJzNEKy
H1299M{XYO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVO5bmI{PzJiaB?=NUDLe5dHTE2VTx?=NUDVTVNoUUN3ME23MlI1KM7:TR?=M{fqWVE1PTJzNEKy
HeLaNXrYOlhKU2mwYYPlJGF{e2G7M3Gzb|MxKG2rbh?=NXPu[pNOUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbIl{fG:wZTDk[YFk\XS7bHHz[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1?MkP0NVU3ODN7NEm=
LOX-IMVINVrSN4JpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEXKWGw1QCCqNIfB[IlKSzVyPUGuN{DPxE1?M1fiRlE2PzF3NEew
NCI-H226NYrkc3MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnvtOFghcA>?Mn;mTWM2OD1{Lk[g{txONUPLWHE4OTV5MUW0O|A>
RXF-631LMnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGLicow1QCCqNV62fpVTUUN3ME2yJO69VQ>?MUWxOVcyPTR5MB?=
SNB-78M4nYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWTZSJJ4PDhiaB?=MXPJR|UxRTF4IN88US=>MXixOVcyPTR5MB?=
St-4MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIPnWFY1QCCqNXL2ZlFFUUN3ME21MlIh|ryPNGqzcoMyPTdzNUS3NC=>
ARP1NUPpW2hGTnWwY4Tpc44hSXO|YYm=MXmyJO69VQ>?MlnTOkBpMVvJcoR2[3Srb36gc4YhWDJzV1HGNUBo\W6nIHX4dJJme3Orb36=MWqxOFc{PDhyNh?=
CEMMVPLbY5ie2ViQYPzZZk>MWmxJIg>MUnEUXNQM1f6T2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1?NUPCdIxGOTZ2MkCwOlQ>
HCT15MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIDGWlc1QCCqMmjuS2k2OD1yLkiyJO69VQ>?NVzLRoxwOTZ5MkOyNlc>
NCI-H23M4HTb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUC0PEBpNEXWcnhIUTVyPUCuPVIh|ryPM3Xwd|E3PzJ|MkK3
GM15850MXvLbY5ie2ViQYPzZZk>MoC5Nk42KM7:TR?=M4D3RVk3KGh?NVXKVZRHTE2VTx?=NXrDeoxqUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7lM1jRVlE3QTJzM{[3
GM15850NYHqTHh{U2mwYYPlJGF{e2G7MVuyMlUh|ryPNXPJVmVFQTZiaB?=NGSzVo9FVVORMYHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViNTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>?MUixOlkzOTN4Nx?=
GM15850NUTlRnF[U2mwYYPlJGF{e2G7M1LYWFIvPSEQvF2=NIj0eGc6PiCqM33KOmROW09?MVLJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMUKgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV?MWixOlkzOTN4Nx?=
GM15850NULFblRzU2mwYYPlJGF{e2G7NEPYdWIzNjVizszNNXvkenpWQTZiaB?=MVnEUXNQMleyTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV?NU\EWXlMOTZ7MkGzOlc>
GM15850MWHLbY5ie2ViQYPzZZk>NV\tV2Z6Oi53IN88US=>Mn7kPVYhcA>?NIj1ToVFVVORNWK4XnZlUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW=MnPXNVY6OjF|Nke=
GM15850NIG1V41McW6jc3WgRZN{[Xl?NFjkU5ozNjVizszNMkfBPVYhcA>?MX;EUXNQM{T3VGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?=M4fMOlE3QTJzM{[3
U937NWXqOIhCTnWwY4Tpc44hSXO|YYm=MXK1JO69VQ>?NGPZNI8zPCCqMVvEUXNQMYjD[YxtKGO7Y3zlJIFzemW|dDDifUBi[2O3bYXsZZRqd25iYYSgV{9IOi:PIIDoZZNmNUL5SYpTOTdyMES3NVg>
H661NUXMfFZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3m0S|Q5KGh?MWjJR|UxRTFizszNMlvwNVcyPTdyMEm=
U937NGjNZ25HfW6ldHnvckBCe3OjeR?=M{P4cVUh|ryPMVWyOEBpNX3xNmVCTE2VTx?=NVTHZ5RxUW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=>NF3uRXUyPzR2N{e1NC=>
U937M2OwdWZ2dmO2aX;uJGF{e2G7MVyxJO69VQ>?MWiyOEBpNVnjPYZsTE2VTx?=MWXF[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?=MnrFNVc1PDd5NUC=
RAW264.7NUX4cJk5TnWwY4Tpc44hSXO|YYm=MV:xNEDPxE1?NVLz[oo2OjSqMl:3e4F1\XJ?NV3VTY86UW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCWTl\hcJBp[SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjd4IN88US=>M170elE4PDd5NUG4
RAW264.7NYHvTXRYTnWwY4Tpc44hSXO|YYm=M3\Bc|ExKM7:TR?=NXLne5NjOjSqMnHje4F1\XJ?MXrJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFEvQDhizszNNFzwSogyPzR5N{WxPC=>
SC9MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml\BOFghcA>?Mm\uTWM2OD1yLk[wOkDPxE1?M3\OS|E4PTB5MkG5
ST14ANYPpNWprTnWwY4Tpc44hSXO|YYm=NHy0[ms2KG6PM4f6elczKGh?MkeyTY5kemWjc3WgbY4hWkWVVD;OVnNHKG2UTlGg[ZhxemW|c3nvci=>MU[xO|U3PTl7Mx?=
ST14ANHvhdZhHfW6ldHnvckBCe3OjeR?=M375VFUhdk1?MX23NkBpM{TzNmlv[3KnYYPlJIlvKEV{RkGgcXJPSSCneIDy[ZN{cW:wMl;XNVc2PjV7OUO=
PANC1MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWexJO69VQ>?Mm\yTWM2OD1yLkS1JO69VQ>?NYSycmtGOTd3OEi3OFQ>
PANC1NYKycmNUTnWwY4Tpc44hSXO|YYm=NYjEe2pFOSEQvF2=M3jCdVI1KGh?NVHWcWxsUW6lcnXhd4UhcW5icEKxW2FHOS:FSWCxJIdmdmViZYjwdoV{e2mxbh?=MXmxO|U5QDd2NB?=
PANC1NFy1b2FHfW6ldHnvckBCe3OjeR?=M4nRVlEh|ryPMWiyOEBpMmDlTY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36=MofINVc2QDh5NES=
PT45MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV;Me|E6UUN3ME20JO69VQ>?NYHEc|F3OTd3OEi3OFQ>
ACHNNHvPTYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIDzPW8zOSCqMV7HTVUxRTBwNkWg{txOMmDVNVc3PjJ4ME[=
PC3NYHCXHE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXOyNUBpNVPDRXBkT0l3ME2wMlcyKM7:TR?=MlX4NVc3PjJ4ME[=
A431NGG5[o9EgXSxdH;4bYMhSXO|YYm=MWm3NkBpM{nvRmlEPTB;ND6yJO69VQ>?NEHLemgyPzZ7MUe2Ny=>
Cal27MX7DfZRwfG:6aXOgRZN{[Xl?MWO3NkBpMWDJR|UxRTNwMjFOwG0>NUTCcnZKOTd4OUG3OlM>
CCRF-CEMNIHhSmxEgXSxdH;4bYMhSXO|YYm=Mnz0O|IhcA>?MVfJR|UxRTBwODFOwG0>MmWyNVc3QTF5NkO=
EOL1MonmR5l1d3SxeHnjJGF{e2G7Mo[3O|IhcA>?M13Ce2lEPTB;MTFOwG0>NF7BOpEyPzZ7MUe2Ny=>
Hec-1-ANECzdWpEgXSxdH;4bYMhSXO|YYm=Mny1O|IhcA>?NVfCN2RFUUN3ME2xJO69VQ>?Moq1NVc3QTF5NkO=
HeLaM1j0SWtqdmG|ZTDBd5NigQ>?NET4e44yOCEQvF2=MWGzNEBucW5?NFvmPY1FVVORMVLJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlAzKM7:TR?=MUWxO|Y6OTd4Mx?=
RKOp21MYTDfZRwfG:6aXOgRZN{[Xl?M4jTd|czKGh?NWP3WXc1UUN3ME2xMlc3KM7:TR?=NFLLfm0yPzZ7MUe2Ny=>
Saos2NUC3WoFWS3m2b4TvfIlkKEG|c3H5MYK3NkBpNY\Pe2t[UUN3ME2yMlMh|ryPNVOyelJuOTd4OUG3OlM>
SK-OV-3NV:0[o4zS3m2b4TvfIlkKEG|c3H5M4DFfFczKGh?MnvUTWM2OD1{LkKg{txOMnLLNVc3QTF5NkO=
U87MGNVHwT3ZVS3m2b4TvfIlkKEG|c3H5MoPPO|IhcA>?NW[2SHpTUUN3ME2xNUDPxE1?NFHkWnEyPzZ7MUe2Ny=>
NUGC3MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYPhU|dPPSEQvF2=MlT6NlQhcA>?M{TEVWdKPTB;Mj63PUDPxE1?NGXCPGwyPzlyNEi0Ny=>
CCD1059SKM1jXXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF71c2FKSzVyPUSzMlUh|ryPMXyxPFI1PzV3NB?=
HepG2NVW4WmZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4DMUWlEPTB;MD6wNFA3KM7:TR?=MUKxPFI1PzV3NB?=
HT1080NUO2S|A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3\qV2lEPTB;MD6wNFI1KM7:TR?=NEfBPFEyQDJ2N{W1OC=>
SKBR3M2rsT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnLxTWM2OD1yLkig{txOMlTxNVgzPDd3NUS=
SNB78MmL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUPFR|UxRTF4IN88US=>MkDZNVgzPDd3NUS=
SQ20BMVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3TpO2lEPTB;MzFOwG0>MlPQNVgzPDd3NUS=
St4NHXNT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEL3SXpGSzVyPUWuNkDPxE1?M2rzTVE5OjR5NUW0
MCF7MU\GeY5kfGmxbjDBd5NigQ>?MWKxNEDPxE1?NWKxcnh{QCCqNH;LVYJFVVORMUnJcoR2[3Srb36gc4YhfHWkdXzpckBpgXCncnHj[ZR6dGG2aX;uMYixPFI3QTJ{Nh?=
HEK293NHrBNVZMcW6jc3WgRZN{[Xl?NXq4XGY2OSCqNVTCenZ1TE2VTx?=NX;4ephJUW6qaXLpeIlwdiCxZjDISGFEOSC5aYToJGlEPTBib3[gNE4xOyEQvF2=Mm\pNVg{ODh3NkO=
HEK293NVj0O4dHU2mwYYPlJGF{e2G7NI\OTWsyKGh?M3\4UmROW09?NH3wOolKdmirYnn0bY9vKG:oIFjERWM{KHerdHigTWM2OCCxZjCwMlA2PyEQvF2=NUPpcGlsOTh|MEi1OlM>
G401M{\3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1X3ZVczKGh?NHfqUGJFVVORMYrJR|UxRTFizszNMU[xPFM4ODN5Mx?=
HeLaNHLvTJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkHyO|IhcA>?NVnSWIZKTE2VTx?=NFvUWGJKSzVyPUCuOFYh|ryPMY[xPFM4ODN5Mx?=
Human renal epithelial cellM2HIbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHfNZWM4OiCqM1\uZWROW09?NYLmc2pGUUN3ME2xOEDPxE1?NFXUTWwyQDN5MEO3Ny=>
U937NVK1S5czTnWwY4Tpc44hSXO|YYm=MlrqOUDPxE1?NFPCXIYzPCCqMX\JcoR2[3Srb36gc4YhcGm|dH;u[UBJPCCqeYDldoFk\XS7bHH0bY9vMn7TNVg{QDF{M{i=
U937MUjGeY5kfGmxbjDBd5NigQ>?M{DocFUh|ryPNGDtNoUzPCCqMXrJcoR2[3Srb36gc4Yh[WyyaHGgeJVjfWyrbjDofZBmemGlZYT5cIF1cW:wMmDNNVg{QDF{M{i=
U937MWTGeY5kfGmxbjDBd5NigQ>?M2nEdVUh|ryPMUKyOEBpM1zqbGlv\HWldHnvckBw\iCyMkGg[ZhxemW|c3nvci=>Mo\INVg{QDF{M{i=
U937NXHMOZF6TnWwY4Tpc44hSXO|YYm=M12xdlUh|ryPMXuyOEBpMmPDTY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>?Ml;nNVg{QDF{M{i=
U937M1vuPGZ2dmO2aX;uJGF{e2G7M37qZlUh|ryPMlPlNlQhcA>?Ml;4TY5lfWO2aX;uJI9nKGe{YX71cI9kgXSrYzDkbYZn\XKnboTpZZRqd25?MUixPFM5OTJ|OB?=
U937M3S0N2tqdmG|ZTDBd5NigQ>?NV;WRpp2PSEQvF2=MlLXNlQhcA>?NHGwcFZKdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOxMX[xPFM5OTJ|OB?=
U937NWfBUmoxU2mwYYPlJGF{e2G7NGToemc2KM7:TR?=NWH2VVc{OjRiaB?=MnHpTY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNB?=MnLqNVg{QDF{M{i=
HEK-TENWrQWG5qTnWwY4Tpc44hSXO|YYm=NIDJOY02KM7:TR?=NGCzbWM3cA>?MoHvSG1UVw>?NFLYU4ZKdmO{ZXHz[UBqdiCqaYP0c45mKEh|IHHj[ZR6dGG2aX;uNHvl[XEyQDR|NEG0OC=>
HPDE6c7NX6yTZo6S3m2b4TvfIlkKEG|c3H5NHj6TVc2OCEQvF2=M{jnd|czKGh?MV\EUXNQM4qyfGlEPTB;MT6zJO69VQ>?NX;mO4lIOTh2OUS0OlM>
Human microvascular epithelial cellM{nGemN6fG:2b4jpZ{BCe3OjeR?=NEDN[Jc2OCEQvF2=MYG3NkBpM3rJS2ROW09?NX[4cndzUUN3ME2xMlMh|ryPMWOxPFQ6PDR4Mx?=
Hup T3NUPxZXhmS3m2b4TvfIlkKEG|c3H5MmX6OVAh|ryPMmDSO|JpNFf2[IFFVVORM2DwNGlEPTB;MD64JO69VQ>?NIrycnAyQDR7NES2Ny=>
Mia Paca2M1jBUmN6fG:2b4jpZ{BCe3OjeR?=MkO1OVAh|ryPMl\vO|JpNIDUT|JFVVORM33VeWlEPTB;MT6xJO69VQ>?M2fweFE5PDl2NE[z
Panc 04.03M{PscGN6fG:2b4jpZ{BCe3OjeR?=M4fldlUxKM7:TR?=NV\rfmhkPzKqM{LSbmROW09?NEHXSXdKSzVyPUGuNkDPxE1?NVLUTJZPOTh2OUS0OlM>
SU 86.86M{j5eWN6fG:2b4jpZ{BCe3OjeR?=MYG1NEDPxE1?NEXJWnE4Omh?NXPuRYk1TE2VTx?=NILZPYJKSzVyPUGuN{DPxE1?NWjIbWdKOTh2OUS0OlM>
HEK293M1\ZTWtqdmG|ZTDBd5NigQ>?MXOzJIg>MWTJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFjERWM3KGW6cILld5Nqd25id3n0bEBKSzVyIH;mJFAvODF7IN88US=>NW\hdHRZOTh3NUi2Olk>
HeLaMWXLbY5ie2ViQYPzZZk>NUPMWm1oOiCqM1\Lb2lvcGmkaYTpc44hd2ZiboXjcIVieiCKRFHDJJdqfGhiSVO1NEBw\iByLkC4N{DPxE1?Mn3HNVg2PTh4Nkm=
RAW264.7MUfGeY5kfGmxbjDBd5NigQ>?MnfENkDPxE1?NI\je|Q{NjViaB?=MUPEUXNQMWLBcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBRdGG|bX;kbZVuKG[jbHPpdIFzfW1iaX7m[YN1\WRid3n0bEBKSzVyIH;mJFAvOTFizszNNH\5fY0yQDZ2NEm2PS=>
NB4Mn;EOFhpNWP5bZcyTE2VTx?=MlnrTWM2OD1yLk[g{txONXzCcWhNOTh5MkOzOFk>
HEK293MVjGeY5kfGmxbjDBd5NigQ>?NGLO[lAyOCEQvF2=Mn7ENlQhcA>?NUnacodbTE2VTx?=MUDBZ5RqfmG2aX;uJI9nKG2xdYPlJHdvfDOjIIPp[45idGmwZzDlfJBz\XO|ZXS=M1zNTlE6ODJ{Nke1
HCT116M1P0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYi3Nog>MV;EUXNQNIfMRphKSzVyPUCuN|Eh|ryPM3;hUVE6ODh2Mkm0
HeLaMmTwT4lv[XOnIFHzd4F6NIf0ZpYzKM7:TR?=M1XwTVMxKG2rbh?=NVjPNJZ2TE2VTx?=M1zrc2lvcGmkaYTpc44hd2ZiSFTBR|IhcW5iaIXtZY4hUGWOYTDj[YxteyC5aYToJGlEPTBib3[gNE4yKM7:TR?=NGHRUZcyQTB6NEK5OC=>
IGROV1M3vhV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF\ySFg4OiCqM1HuOWROW09?NITle2JKSzVyPUKuNkDPxE1?NWTvS4VxOTlyOESyPVQ>
IGROV1NHLYUllMcW6jc3WgRZN{[Xl?NWnmNlR4PSEQvF2=M1O0TFI1KGh?MlvPSG1UVw>?NHK5NXVKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNicEWzJIFk\XS7bHH0bY9vM4OwelE6ODh2Mkm0
IGROV1MV7LbY5ie2ViQYPzZZk>NE\Yc5kyOCEQvF2=NXPubGFLPCCqNWfKZlJ7TE2VTx?=M{Lu[WlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mNUh2IHHj[ZR6dGG2aX;uNYDXNnplOTlyOESyPVQ>
IGROV1NHL1UmRMcW6jc3WgRZN{[Xl?MXyxNEDPxE1?MWW0JIg>MlvvSG1UVw>?NUfJfnFKUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:wMl7nNVkxQDR{OUS=
T24M{DMNmtqdmG|ZTDBd5NigQ>?NHznOYw{KGh?NUflU5p{UW6mdXP0bY9vKG:oIHjpd5RwdmViSEOgZYNmfHmuYYTpc44hf2m2aDDFR|UxKG:oIECuNVIh|ryPNH25fmsyQTB6NEO5OS=>
T24MkTQT4lv[XOnIFHzd4F6NEfnXHA{KGh?NF75O4dKdmS3Y4Tpc44hd2ZiYXzwbIEhfHWkdXzpckBi[2W2eXzheIlwdiC5aYToJGVEPTBib3[gNE4zPSEQvF2=M3j1NlE6ODh2M{m1
HeLaNWDnXW1nU2mwYYPlJGF{e2G7NVzE[3ZkOTVibXnuNYXzTpFZTE2VTx?=MkjDTY5pcWKrdHnvckBw\iCKRFHDOkBnem:vIH71Z4xm[XJiZYj0doFkfCC5aYToJGlEPTBib3[gNE4xQDV3IN88US=>M4THeFE6ODl|OEi0
HeLaNYLhVYxsU2mwYYPlJGF{e2G7M4PVR|E2KG2rbh?=MkS4SG1UVw>?MUDJcohq[mm2aX;uJI9nKEiGQVO4JIZzd21iboXjcIVieiCneITyZYN1KHerdHigTWM2OCCxZjCxMlg3KM7:TR?=MmfQNVkxQTN6OES=
NCI-H69NXXyc2x4S3m2b4TvfIlkKEG|c3H5NFnKVmE4OiCqMmi3SG1UVw>?NInZdGVKSzVyPUKuNFYh|ryPMn\CNVkxQTN6OES=
SKMES1M{DFZWN6fG:2b4jpZ{BCe3OjeR?=NGLmSoM4OiCqNFvrPYFFVVORM4HvN2lEPTB;Mj60NkDPxE1?MkPCNVkxQTN6OES=
S2NWrIWZVyU2mwYYPlJGF{e2G7NW[5VowxOC5zLUGwJO69VQ>?MkTqNUBpM{i1NmlvcGmkaYTpc44hd2ZiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJGhFSUNzIHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOC5yNUmg{txOMmqwNVk{OTd2NUC=
SHSY5YMXLLbY5ie2ViQYPzZZk>MmfrNVAh|ryPMUe0PEBpMULEUXNQM2HOemlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61JO69VQ>?M3jqcFE6OzR2MUe1
SHSY5YNEnufmREgXSxdH;4bYMhSXO|YYm=NH:yV4kyOCEQvF2=NYXjTlFZPDhiaB?=NX;HNWc{TE2VTx?=Mm\MTWM2OD1{IN88US=>NVH6XnFYOTl|NESxO|U>
DMS114M2fjNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2TVZVQ5KGh?NEPvenlIUTVyPUKuPUDPxE1?M4TPflE6PDF7MkC1
HBC5NULVSo02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mof4OFghcA>?Ml:0S2k2OD1zNzFOwG0>NFrN[XQyQTRzOUKwOS=>
SNB78M4XL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYXifpFOPDhiaB?=M2TQUWdKPTB;MU[g{txOMYmxPVQyQTJyNR?=
HeLaMUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NI\BTZY4OiCqMWTEUXNQM{[x[GlEPTB;MD60OkDPxE1?M37B[|E6PDRzOES2
BHKMki5T4lv[XOnIFHzd4F6NVjTTYhDPSEQvF2=MorTNlQhcA>?MXrEUXNQNUjh[|BHUW6qaXLpeIlwdiCxZjDISGFEPyCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4heGyjc33hJI1mdWK{YX7lJGZl\Wy2YUWwPEBETlSUIIDyc5RmcW5?NHfnNlYyQTl4Nke4PS=>
CFBE41o-M3jEOmtqdmG|ZTDBd5NigQ>?NFLmblQ2KM7:TR?=NELCcno5KGh?MVPEUXNQNEXXN|lKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaInw[ZJi[2W2eXzheIlwdiCxZjDobZN1d26nIFizMmnnNVk6PjZ5OEm=
CFBE41o-NEn0ZW1McW6jc3WgRZN{[Xl?M3T3ZlUh|ryPNILWWZY1KGh?MXfEUXNQMUPJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5ibYX0ZY51KE[mZXz0ZVUxQCCFRmTSJJBzd3SnaX6gcIV3\Wx?NIrhPW0yQTl4Nke4PS=>
CFBE41o-MW\LbY5ie2ViQYPzZZk>MUCxJO69VQ>?MofKNUBpM3;mcWROW09?NXn6dFZmUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJGNHXFJicILveIVqdiCuZY\lcC=>MXWxPVk3Pjd6OR?=
Primary bronchial epithelial cellM2nZOWtqdmG|ZTDBd5NigQ>?M4mzfVEh|ryPM1rUflI1KGh?MlniSG1UVw>?NXz0RodzUW6qaXLpeIlwdiCxZjDISGFEPyCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhdXW2YX70JGZl\Wy2YUWwPEBETlSUIIDyc5RmcW5iYYDpZ4FtKHO3cn\hZ4UhdG:lYXzpfoF1cW:wNH3ycoQyQTl4Nke4PS=>
CFBE41o-NW\TfXpVU2mwYYPlJGF{e2G7NGL0NVIyKM7:TR?=NWDKb|R7PSCmYYnzNVfFc2ZjTE2VTx?=M{jzPGlvcGmkaYTpc44hd2ZiSFTBR|ch[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gd5Ri[mmuaYrheIlwdiCxZjDG[IVtfGF3MEigR2ZVWiCycn;0[YlvNH\nWW0yQTl4Nke4PS=>
CFBE41o-MXjLbY5ie2ViQYPzZZk>MVSxJO69VQ>?M{K2R|I1KGh?M3ntd2ROW09?NGHFVFdKdmirYnn0bY9vKG:oIFjERWM4KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJGZl\Wy2YUWwPEBETlSUIIDyc5RmcW5idILh[oZq[2urbne=MkTBNVk6PjZ5OEm=
CFBE41o-Mnf6T4lv[XOnIFHzd4F6NF7RbYI2KM7:TR?=MViyOEBpNXvON2RXTE2VTx?=M1LrdGlvcGmkaYTpc44hd2ZiSFTBR|ch[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gdoF1\SCxZjDtZZR2emG2aX;uJI9nKEOIVGKgdJJwfGWrbjD0c{BqfHNiZ3z5Z49nd3KvNYPZb2lIOTl7Nk[3PFk>
CFBE41o-MVfLbY5ie2ViQYPzZZk>NYCxUndyPSEQvF2=NHjIcHMzPCCqM1j2cWROW09?M3HJUmlvcGmkaYTpc44hd2ZiSFTBR|ch[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gd5Ri[mmuaYT5JI9nKE[mZXz0ZVUxQCCFRmTSJJBzd3SnaX6=M1HjRVE6QTZ4N{i5
CFBE41o-MWDLbY5ie2ViQYPzZZk>MWq1JO69VQ>?M1\VTFI1KGh?MV\EUXNQM2\QNmlvcGmkaYTpc44hd2ZiSFTBR|ch[XO|ZYPz[YQh[XNiY3;ydoVkfGmxbjDv[kBufXSjboSgSoRmdHSjNUC4JGNHXFJidILh[oZq[2urbnegeI8h[2WubDDzeZJn[WOnIHHzJIdtgWOxZn;ycS=>M4DxfVE6QTZ4N{i5
Primary bronchial epithelial cellM4XIUGtqdmG|ZTDBd5NigQ>?MV[1JO69VQ>?MnvLNlQhcA>?MoDVSG1UVw>?MkjkTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDteZRidnRiRnTlcJRiPTB6IFPGWHIheHKxdHXpckBieGmlYXygd5Vz\mGlZTDsc4NidGm8YYTpc44>NWfGNFl7OTl7Nk[3PFk>
Primary bronchial epithelial cellM3rQZmtqdmG|ZTDBd5NigQ>?NFO1cHQyKM7:TR?=MkDXPVYhcA>?M13LfGROW09?NFXB[FlKdmirYnn0bY9vKG:oIFjERWM4KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJNpd3K2IHPpdoN2cXRiY4XydoVvfHN?MUKxPVk3Pjd6OR?=
BxPC3NX;hWHFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4XqSFczKGh?M3HvPGlEPTB;Mj63JO69VQ>?NHu2OoEzODF2M{e3PC=>
CAL27MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFGzcIs4OiCqMV\JR|UxRTNwN{Kg{txONFPLUWgzODF2M{e3PC=>
Capan1MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEPNU2c4OiCqMVHJR|UxRTdwMzFOwG0>NUD2T4pVOjBzNEO3O|g>
HCC827NUHMb3Z5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{fWZlczKGh?NYHJT4N4UUN3ME2xMlgh|ryPM4XId|IxOTR|N{e4
LNCAPMkPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHf5Z4M4OiCqNW\SfWlrUUN3ME2wMlU5KM7:TR?=NEjGW5gzODF2M{e3PC=>
NCI-H2122NF;kSFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4Thd|czKGh?MYHJR|UxRTdwNTFOwG0>M4LtSlIxOTR|N{e4
NCI-H358M2\rc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIrMUoM4OiCqMlTnTWM2OD1{LkWg{txOM4T0bVIxOTR|N{e4
SCC15M1ntUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV63NkBpMkjSTWM2OD1{LkS5JO69VQ>?MXOyNFE1Ozd5OB?=
SCC25M13kWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4PmeVczKGh?M4LTWWlEPTB;MT65N{DPxE1?MVKyNFE1Ozd5OB?=
SKHEP1NH7IV3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXSzd5REPzJiaB?=NF3kSnJKSzVyPUOuOFYh|ryPNWTRSZBHOjBzNEO3O|g>
BJNYrNXJVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3fEWVExOCEQvF2=M4DrOlQ5KGh?NVT6ZZZOTE2VTx?=M1fO[2dzd3e2aDDpcohq[mm2aX;uJIF1KDBwMEWgeI8hOTByIIXNNFLJeYwzODF2M{i0NC=>
MUFMWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF;p[VAyODBizszNNV7VVIVbPDhiaB?=MYjEUXNQNX:4Z2xRT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0>MkL4NlAyPDN6NEC=
Caco-2M2e3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1LkXlExOCEQvF2=NIO5PI41QGh?MXfEUXNQMknCTWM2OD16LkGg{txOMornNlAyPDN6NEC=
Caco-2M1\vNWtqdmG|ZTDBd5NigQ>?NWD0VWx2PSEQvF2=M4\kNFQhcA>?NWLudXdxTE2VTx?=MYLJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszNMnfGNlAyPDN6NEC=
Caco-2NXjJ[pV1U2mwYYPlJGF{e2G7Mnq2NE4{OTZibl2geI8hOzFwNjFOwG0>MVy0JIg>MVvEUXNQM3f5T2V5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMTD3bZRpKEmFNUCgc4YhOC5zMUmg{txOMoC3NlAyPDN6NEC=
Caco-2M17E[mtqdmG|ZTDBd5NigQ>?NFLkdGExNjNzNjDuUUB1dyB|MT62JO69VQ>?M2DMcVQhcA>?MV;EUXNQMn;GSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN|IIfpeIghUUN3MDDv[kAxNjF2NzFOwG0>MlLGNlAyPDN6NEC=
Caco-2NFK5WJVMcW6jc3WgRZN{[Xl?MWG2MlMzKG6PIITvJFY{OiEQvF2=MVK0JIg>NV:0PGI3TE2VTx?=NXzxV49zTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO1JJdqfGhiSVO1NEBw\iBzMj62JO69VQ>?Ml3rNlAyPDN6NEC=
Caco-2M4faSGtqdmG|ZTDBd5NigQ>?NIGxU4E3NjN{IH7NJJRwKDZ|MjFOwG0>MWi0JIg>NUjyVVJ2TE2VTx?=MknRSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2=MVmyNFE1Ozh2MB?=
Caco-2M2H5fWtqdmG|ZTDBd5NigQ>?MX2wMlMyPiCwTTD0c{A{OS54IN88US=>NH;tVnU1KGh?MVnEUXNQNEjZSI9GgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{[=MlOzNlAyPDN6NEC=
HepG2MXHLbY5ie2ViQYPzZZk>M{L4[|Uh|ryPMn;YOog>MVHEUXNQNHzodHBKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9vNWW1bGtxOjBzNEO4OFA>
HepG2M{WwUmtqdmG|ZTDBd5NigQ>?MUO1JO69VQ>?MUC2bC=>NVm5bWtwTE2VTx?=M3\nZ2lv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgbJlx\XKjY3X0fYxifGmxbh?=NU[4enVpOjBzNEO4OFA>
HepG2NEfpc5dMcW6jc3WgRZN{[Xl?NXrhZZBFPSEQvF2=MYC2bC=>MkS1SG1UVw>?NVHZTlFLUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=>MmHnNlAyPDN6NEC=
HepG2M4j5WmtqdmG|ZTDBd5NigQ>?NIXQ[Vc2KM7:TR?=NGfpdFU3cA>?NF\jVYlFVVORNFO0Zm5KdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBJOy:KNDDobZN1d26nIHHj[ZR6dGG2aX;uNHLkN5czODF2M{i0NC=>
COLO205M2fhZ2tqdmG|ZTDBd5NigQ>?MYCxNEDPxE1?NUThdXJ{OjRiaB?=MlHMSG1UVw>?NHTBXpVKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIIfpeIghUUN3MDDv[kAzNjJizszNM3rnb|IxPDVzM{e4
SCC4M2G0XGtqdmG|ZTDBd5NigQ>?MlLxNUDPxE1?MWGyOIg>NELMOXVKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6geJVjfWyrbjDhZ4V1gWyjdHnvci=>M4PaeVIxPDV{MkK1
SCC4MULLbY5ie2ViQYPzZZk>NUjF[nAyOSEQvF2=M1;zb|I1cA>?NYeyRWxbUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44>MlnBNlA1PTJ{MkW=
SCC4NGnMdZdHfW6ldHnvckBCe3OjeR?=MX2xJO69VQ>?NYX6UGV6PSCvaX6=MkmzRYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?=NUXFRm5GOjB2NUKyNlU>
NB4MlfKSpVv[3Srb36gRZN{[Xl?NVTPV2hKPSEQvF2=M4eweVI1KGh?MXXEUXNQMWTD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOnMk[2NlA1QTF2NEC=
NB4MorPT4lv[XOnIFHzd4F6NGnzcFg2KM7:TR?=NYO5c|B5OjRiaB?=MnrvSG1UVw>?NGHHcoJKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNmfHmuYYTlJJR2[nWuaX6gcIV3\Wx?NE[zT|kzODR7MUS0NC=>
NB4M2TFbmZ2dmO2aX;uJGF{e2G7MonIOUDPxE1?NWD3Uox{OjRiaB?=NYnhdZhsTE2VTx?=MVzJcoR2[3Srb36gc4YheDJzV1HGNU9EUVBzIHX4dJJme3Orb36=M1TYdVIxPDlzNESw
NB4NUW0NZpiU2mwYYPlJGF{e2G7M1HFXFUh|ryPMmPZNlQhcA>?M2jnXGROW09?MUTJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=>Mn;oNlA1QTF2NEC=
NUGC3MonoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoC1S2k2OD1{Lkm0JO69VQ>?MmPGNlA5PTB7N{G=
A549MkDRSpVv[3Srb36gRZN{[Xl?M2XWeFUh|ryPM2r0TlMhcA>?Mlj6SG1UVw>?MWPJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hVEN|SVm=MUGyNFg2PTJyOB?=
HUT78NHL3RnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWS3NkBpM2XXNWROW09?MXfHTVUxRTBwMzFOwG0>NF73U2ozODh6NEKwPC=>
U937M1jEdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVP3TZJ4PzJiaB?=MkTBSG1UVw>?MlvVS2k2OD1yLkO5JO69VQ>?MUSyNFg5PDJyOB?=
A431NF7GXZBEgXSxdH;4bYMhSXO|YYm=MnXNO|IhcA>?NIPvZm1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2=NF3nN4czOTB6ME[yPS=>
A549MWjDfZRwfG:6aXOgRZN{[Xl?M2jITFczKGh?NFPmfmhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvQCEQvF2=NX\TWI1pOjFyOEC2Nlk>
CAL27MVHDfZRwfG:6aXOgRZN{[Xl?MVq3NkBpM1zPOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFMvOiEQvF2=MWOyNVA5ODZ{OR?=
HeLaMkfrR5l1d3SxeHnjJGF{e2G7M2qwdVczKGh?NEP4S5ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2=NELhUHQzOTB6ME[yPS=>
Sf21MkSyT4lv[XOnIFHzd4F6NXf0U2d4OyCqMYXJcohq[mm2aX;uJI9nKE[uYXegeIFo\2WmIHj1cYFvKHKnY3;tZolv[W62IFjERWM5KGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4zKM7:TR?=Mo\XNlExQDB4Mkm=
SKBR3NYTQOodQS3m2b4TvfIlkKEG|c3H5MWe3NkBpNE\hT3pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjZizszNNEXPfW0zOTB6ME[yPS=>
SKOV3MV;DfZRwfG:6aXOgRZN{[Xl?NWTObVBMPzJiaB?=MoPrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?=M2TZdVIyODhyNkK5
COR-L23NFrVU2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkLZNVAh|ryPNFLrdFY4OiCqMoL5SG1UVw>?MWLHTVUxRTFwMTFOwG0>NYTuXFhXOjFyOEC2OFc>
DU145NUP3ZpJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYqxNEDPxE1?NGnyc3M4OiCqM{T2XmROW09?M{jJS2dKPTB;MT6wOUDPxE1?NF;kZWozOTB6ME[0Oy=>
LoVoM3qyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXmxNEDPxE1?MnXLO|IhcA>?NVvkdXV3TE2VTx?=MmXSS2k2OD1zLkeg{txONXT5dG1[OjFyOEC2OFc>
MCR5-SV2NYDOcIdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlPhNVAh|ryPMmC5O|IhcA>?MljZSG1UVw>?MnrES2k2OD1{LkGg{txOMnywNlExQDB4NEe=
HCT116NHXkXW1McW6jc3WgRZN{[Xl?MlnzN|Ah|ryPMX2zNEBpNVu2Z256TE2VTx?=M4rBZmlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36=Mke2NlExQDB4NEe=
HCT116M37GTGtqdmG|ZTDBd5NigQ>?NH;Ue3M{OCEQvF2=MlzwN|AhcA>?NGCzOWxFVVORMV7Jcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizT|kh[WOndInsZZRqd25?MXeyNVA5ODZ2Nx?=
U937M1TTVmtqdmG|ZTDBd5NigQ>?NV3hT2pqPSEQvF2=MYSyOEBpMXzEUXNQNX\6U2JxUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m=NF7qe5EzOTJ7MkS5Ni=>
U937NUXaXXhwU2mwYYPlJGF{e2G7MX[1JO69VQ>?NV3nUGZZOjRiaB?=NF7DbpVFVVORNGDPfW5KdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNMUi=NVzLZlZsOjF{OUK0PVI>
U937NEntem9McW6jc3WgRZN{[Xl?NUW0NXpFPSEQvF2=Mn\6NlQhcA>?MV7EUXNQNVqxUG9kUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHCjbj3hZ4V1gWyjdHXkJIhqe3SxbnWgTFQhdGW4ZXy=MY[yNVI6OjR7Mh?=
U937NHvtR2ZMcW6jc3WgRZN{[Xl?NHnSToc2KM7:TR?=MY[xOUBucW5?NXmxc|lxTE2VTx?=Mli4TY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25ibHX2[Yw>MmXqNlEzQTJ2OUK=
A2780M{DINWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MofaPVYhcA>?MnvaSG1UVw>?NUDlWXlMUUN3ME2xMlYzKM7:TR?=MlnHNlE3OzR2M{C=
COLO205MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYq5OkBpNV[wfYd3TE2VTx?=Mn[wTWM2OD1{LkGyJO69VQ>?NEDTVoczOTZ|NESzNC=>
Hep3BMoO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVv6[ZhFPDhiaB?=NF3zUZlFVVORNUDH[nlST0l3ME2xMlIyKM7:TR?=MofENlE4OTJzNE[=
GM11272M1jNdGZ2dmO2aX;uJGF{e2G7M4Dz[VExOCCwTR?=MWW3NkBpMlPwSG1UVw>?MlPPVoVi[3SrdnH0bY9vKG:oIF3lR5AzKG23dHHueEBmgHC{ZYPzbY9vKGG2IEGwJJRwKDFyMDDuUS=>M1iwWlIyQDRyN{G2
CFBE41oMXLLbY5ie2ViQYPzZZk>MUS1JO69VQ>?MmD5SG1UVw>?MYHEc5dvKHKnZ4XsZZRqd25ib3[gTGRCSzdiYYSgNE4zKHSxIEWgeW0>M3;kSlIyQTh2OUW4
CFBE41oNV:4SWNJTnWwY4Tpc44hSXO|YYm=MmPGNUDPxE1?NIXqXZQzPCCqNYnnNZVGTE2VTx?=M3[3eXJme3SxcnH0bY9vKG:oIFPGWHIh\GWudHHGOVA5KG23dHHueEB1emGoZnnjb4lv\yC2bzDj[YxtKHO3cn\hZ4Uh[XNiZ3z5Z49nd3Kvcx?=NIjKNZozOTl6NEm1PC=>
DU145NWm1d2pjU2mwYYPlJGF{e2G7M3\5S|IvPSEQvF2=NV;jW3pJOjRiaB?=M{DvTGROW09?MkDPTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW|c3nvci=>M1TRWVIzOjZyMU[2
DU145NYXuTZJUU2mwYYPlJGF{e2G7NXjRbI56PSEQvF2=MW[yOEBpNGDwdYhFVVORMlnQTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36=MU[yNlI3ODF4Nh?=
DU145NHr0U3ZMcW6jc3WgRZN{[Xl?MWG1JO69VQ>?M1zNN|I1KGh?MlXzSG1UVw>?MVzJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9vNIP4NWUzOjJ4MEG2Oi=>
786-0MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoDuOk4zKM7:TR?=M{TuXFczKGh?NVOxZlVGTE2VTx?=MoTkS2k2OD1|LkKg{txONGDxUlMzOjR|NU[2PS=>
A498MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3PFSVYvOiEQvF2=MmjTO|IhcA>?MojGSG1UVw>?MlTxS2k2OD1zLk[g{txOMnz6NlI1OzV4Nkm=
A549/ATCCMWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWO2MlIh|ryPNWfGOlhWPzJiaB?=MmeySG1UVw>?NXS1e5B[T0l3ME2xMlYh|ryPM3O1b|IzPDN3Nk[5
ACHNNV65ZYt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIDUdVA3NjJizszNMmLSO|IhcA>?MYXEUXNQNFnGV5hIUTVyPUGuN{DPxE1?NXHhfnc5OjJ2M{W2Olk>
BT549MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{fhUlYvOiEQvF2=M1HFR|czKGh?MUPEUXNQMYXHTVUxRTFwMzFOwG0>NUjabnZROjJ2M{W2Olk>
EKVXMYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkO1Ok4zKM7:TR?=NEO1SWU4OiCqNGm2TIJFVVORMXfHTVUxRTFwMzFOwG0>NGPGcHozOjR|NU[2PS=>
HCT15NFzqdGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUTKXmF3Pi5{IN88US=>NG\lZow4OiCqM4n3O2ROW09?MlLNS2k2OD1{LkWg{txOMoXyNlI1OzV4Nkm=
HOP92MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NIPPPIk3NjJizszNMoLaO|IhcA>?NVjUb3FXTE2VTx?=NIrScIZIUTVyPUSg{txONVXI[FRrOjJ2M{W2Olk>
IGROV1NXzqVlNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVK2MlIh|ryPNES3TnA4OiCqNGHtUXRFVVORMUnHTVUxRTFwMzFOwG0>NEDGSpMzOjR|NU[2PS=>
LOXIMVINV;KW4htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2XqZ|YvOiEQvF2=NWLxcYlKPzJiaB?=NGC4UnpFVVORMYDHTVUxRTFizszNM4L6WFIzPDN3Nk[5
M14M3PQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlXiOk4zKM7:TR?=MlfEO|IhcA>?MnvFSG1UVw>?M4f2ZmdKPTB;MT6zJO69VQ>?MnO3NlI1OzV4Nkm=
MALME-3MNUfTe3VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{LDcVYvOiEQvF2=MonzO|IhcA>?M{eyVmROW09?MV3HTVUxRTBwM{Kg{txOMoDBNlI1OzV4Nkm=
MCF10AM{DCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlPQOk4zKM7:TR?=NGHpNZg1QCCqNYfObY9KTE2VTx?=NGOwdZBIUTVyPUmuOkDPxE1?M3rFeVIzPDN3Nk[5
MDA-MB-435NYnZT3l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NITQXog3NjJizszNMnjZO|IhcA>?MV7EUXNQM4\0TWdKPTB;MD61JO69VQ>?MnLtNlI1OzV4Nkm=
MDA-MB-468NXLNWGlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV64VWVwPi5{IN88US=>M{DN[lczKGh?MmS3SG1UVw>?MojoS2k2OD1yLk[zJO69VQ>?NHvPdZkzOjR|NU[2PS=>
MOLT4M2PPW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYq2MlIh|ryPMomxO|IhcA>?Mn60SG1UVw>?M1;tcmdKPTB;MD60JO69VQ>?MoXyNlI1OzV4Nkm=
NCI-ADR-RESMYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWO2MlIh|ryPMkjPO|IhcA>?MX;EUXNQMXnHTVUxRTBwMU[g{txONH\1WmYzOjR|NU[2PS=>
NCI-H23M2DHfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M32yWVYvOiEQvF2=Mn3oO|IhcA>?MmPCSG1UVw>?NHX1XVJIUTVyPUGg{txONXzYdmY{OjJ2M{W2Olk>
NCI-H322MMUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1\UeFYvOiEQvF2=NUfBWo5IPzJiaB?=MlfOSG1UVw>?M{H5TmdKPTB;MD63PUDPxE1?NWW0XlJYOjJ2M{W2Olk>
NCI-H460MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUfrSYsxPi5{IN88US=>M2m2O|czKGh?Mn7pSG1UVw>?MoDXS2k2OD1yLke5JO69VQ>?NX7NcIY1OjJ2M{W2Olk>
NCI-H522M2j6Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1XYeFYvOiEQvF2=NXjVT3lYPzJiaB?=NWXtOIsyTE2VTx?=NHfnVJlIUTVyPUCuOUDPxE1?NX7SbVltOjJ2M{W2Olk>
OVCAR3NWP2TINjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{\sdVYvOiEQvF2=MmnUO|IhcA>?NXj6UWRoTE2VTx?=NXTLSIY5T0l3ME2xMlMh|ryPNVzQ[m85OjJ2M{W2Olk>
OVCAR4NU\pPFZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGjDZow3NjJizszNNGLyWIk4OiCqNIfIbpFFVVORM1;kd2dKPTB;NDFOwG0>NWXZSWlvOjJ2M{W2Olk>
OVCAR5NVrGTldPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1XMcVYvOiEQvF2=NHvIRlc4OiCqMmG1SG1UVw>?M4fqPGdKPTB;MD63PUDPxE1?Mn7wNlI1OzV4Nkm=
OVCAR8NXu3PVQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYfBOWtYPi5{IN88US=>Ml\nO|IhcA>?NUXoOpM1TE2VTx?=NEW0UYZIUTVyPUCuOUDPxE1?MXqyNlQ{PTZ4OR?=
RXF393Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnjpOk4zKM7:TR?=MkPtO|IhcA>?NVvEcFBYTE2VTx?=NFnoPHBIUTVyPUGuN{DPxE1?NGL2eoszOjR|NU[2PS=>
SF268NInpUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmfwOk4zKM7:TR?=MXu3NkBpNXPJSnJZTE2VTx?=M3XtNGdKPTB;MT62JO69VQ>?MXSyNlQ{PTZ4OR?=
SF295M4exWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVi2MlIh|ryPMV[3NkBpM2DGRWROW09?M1fnXGdKPTB;MT62JO69VQ>?NIflc2MzOjR|NU[2PS=>
SF539M4DmVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NH35SpY3NjJizszNM13hTlczKGh?MWrEUXNQM37IfmdKPTB;MjFOwG0>NY[1eWcxOjJ2M{W2Olk>
SK-MEL-2NVTZeW5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2jL[|YvOiEQvF2=M2HPZlczKGh?M33US2ROW09?NYLpTFgyT0l3ME2xMlMh|ryPM2XQTFIzPDN3Nk[5
SK-MEL-28Mnu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NI\hXJQ3NjJizszNMWe3NkBpMnnkSG1UVw>?NIPHWGRIUTVyPUGg{txOMkP6NlI1OzV4Nkm=
SK-MEL-5M2npRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmrnOk4zKM7:TR?=MkXJO|IhcA>?NVGyT|hRTE2VTx?=NUj3PGhsT0l3ME2wMlY{KM7:TR?=MWCyNlQ{PTZ4OR?=
SKOV3NWjlR3dCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{DqRlYvOiEQvF2=NYPFeoZpPzJiaB?=M{nWSGROW09?MlLIS2k2OD1zIN88US=>M{\MblIzPDN3Nk[5
SN12CM1;PTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUe2MlIh|ryPMUS3NkBpNFPjUXRFVVORM{Drb2dKPTB;MjFOwG0>MYqyNlQ{PTZ4OR?=
SNB19NEXxblVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGC4WFg3NjJizszNMnezO|IhcA>?M4L4RWROW09?NEDETmRIUTVyPUCuOlMh|ryPM2G3N|IzPDN3Nk[5
SNB75NGLZUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NU\OdoJbPi5{IN88US=>MlTCO|IhcA>?MUTEUXNQMXvHTVUxRTBwN{mg{txONGn5cIUzOjR|NU[2PS=>
SRNXvhTnJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWm2MlIh|ryPM3;UVFczKGh?NUHvTHk5TE2VTx?=MUjHTVUxRTBwNDFOwG0>MmP6NlI1OzV4Nkm=
T47DMnXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4HYcVYvOiEQvF2=NXTMOIpFPzJiaB?=Moj0SG1UVw>?NXvMbFBpT0l3ME2wMlUh|ryPMWSyNlQ{PTZ4OR?=
TK10M1LYWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYDOSIJDPi5{IN88US=>M3\MRVczKGh?NE\QZnNFVVORMWjHTVUxRTBwNkOg{txONYXrW2tSOjJ2M{W2Olk>
UACC257NWXoTnlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmCxOk4zKM7:TR?=M4rm[|czKGh?M376S2ROW09?NFjNeHRIUTVyPUCuOUDPxE1?NYDQcYtqOjJ2M{W2Olk>
UACC62MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkLyOk4zKM7:TR?=MkjFO|IhcA>?M{nnPWROW09?MkLhS2k2OD1yLkSg{txOMVuyNlQ{PTZ4OR?=
UO31M4DFRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUS2MlIh|ryPMUK3NkBpNInxblhFVVORNFTBOIFIUTVyPUCuOUDPxE1?NUXafJlKOjJ2M{W2Olk>
Hep3BM4XnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4flflQ5KGh?MmPYSG1UVw>?MWnHTVUxRTBwNkmg{txOMkHSNlI1Ozl6NkO=
BE(2)-CNHnGU3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmTCO|IhcA>?NHTCVZNFVVORNVu2VGVCUUN5ME2yJO69VQ>?Ml;5NlI6OzJ|MU[=
Bel7402Mn3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NI\JbmM4OiCqNW\hSIdnTE2VTx?=NH;JXlNIUTlyPUG3JO69VQ>?M{f1UVI{ODZzM{e2
Bel7404MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVq3NkBpMo\RSG1UVw>?MoDrS2k6OD1zODFOwG0>NV\FNHBZOjNyNkGzO|Y>
BGC823MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2PTNFczKGh?MXfEUXNQMkXDS2k6OD15LkWg{txOMnG1NlMxPjF|N{[=
MGC803NInoPHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkLXO|IhcA>?M{e0SGROW09?MlPPS2k6OD1zMD64JO69VQ>?M{HOdlI{ODZzM{e2
SGC7901M3u3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUDReodUPzJiaB?=NYW5V2lKTE2VTx?=MkHxS2k6OD17LkSg{txOMUOyN|A3OTN5Nh?=
SKHEP1NWW5OGg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUfUTW9OPzJiaB?=M2nNT2ROW09?MVLHTVkxRTF5IN88US=>MVOyN|A3OTN5Nh?=
SMMC7721MmrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWm3NkBpNVHKNmlkTE2VTx?=NWfIOXA{T0l7ME2yNEDPxE1?MYqyN|A3OTN5Nh?=
NUGC3MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2fvdVExKM7:TR?=NE\rVHRIUT1{Lkm0JO69VQ>?MYSyN|E3OzN|Mh?=
A2780 CisRNVTTTYdYU2mwYYPlJGF{e2G7M{LIRVE5KGh?M2LkRWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1?Ml\YNlMzPTJ4MEO=
CAL27 sensMoLvT4lv[XOnIFHzd4F6MY[xPEBpNVXFUHpCUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?=MYmyN|I2OjZyMx?=
CAL27 CisRNIHSRoRMcW6jc3WgRZN{[Xl?NESyXFAyQCCqMlWzTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>?NEPCVFgzOzJ3Mk[wNy=>
KYSE-510 CisRNHnkPJdMcW6jc3WgRZN{[Xl?M3LOS|E5KGh?NFnhR2xKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOVkh|ryPNV\u[JZmOjN{NUK2NFM>
KYSE-510 sensMn[3T4lv[XOnIFHzd4F6MlvMNVghcA>?NYfsZ4pGUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlch|ryPMli4NlMzPTJ4MEO=
MDA-MB-231 sensMVnLbY5ie2ViQYPzZZk>NF7mb4IyQCCqNXf4[4pIUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?=Mlv2NlMzPTJ4MEO=
MDA-MB-231 CisRMl;oT4lv[XOnIFHzd4F6MYmxPEBpMk\WTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>?NVy3XI9LOjN{NUK2NFM>
ES2NV\0emdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYO0PEBpM{\wR2ROW09?MmXETWM2OD1zMj63JO69VQ>?MknkNlM1QTN2NEm=
MDA-MB-231M1PRZ2tqdmG|ZTDBd5NigQ>?MoX4NVAh|ryPNFLreY0{OCCvaX6=NWLjUXZoTE2VTx?=NHHwbW5KdmirYnn0bY9vKG:oIFjERWMz[Q>?MWeyN|Q6OzR2OR?=
MDA-MB-231NUPWcY5rU2mwYYPlJGF{e2G7MX[xJO69VQ>?NV7IcWJKOjRiaB?=MXLEUXNQNED2ZldKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHHj[ZR6dGG2aX;uJIxmfmWuczDv[kB1fWK3bHnuNVvlUoZHOjN2OUO0OFk>
HS68NHjFVm5EgXSxdH;4bYMhSXO|YYm=MkC0NVAh|ryPMXG3NkBpMX7EUXNQMV3JR|UxRTRwNjFOwG0>NIrpUmczOzV5MEW0Ni=>
MEFNHe1S3NEgXSxdH;4bYMhSXO|YYm=MnXZNVAh|ryPNVHqO|hWPzJiaB?=M{TpZWROW09?NUH1XoptUUN3ME20MlQh|ryPMm\uNlM2PzB3NEK=
BGC823MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2Du[GROW09?NU\5V25JT0l3ME2zMlA6KM7:TR?=MVeyN|YxOTdyNh?=
High5NHrL[GxMcW6jc3WgRZN{[Xl?M1zCb|I1KGh?MVXJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>?M4G0bVI{PjB{NUKz
High5M4j0VmtqdmG|ZTDBd5NigQ>?MVyyOEBpM{\tS2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNVIh|ryPNE\jUFMzOzZyMkWyNy=>
High5NVLPO4F7U2mwYYPlJGF{e2G7MWmyOEBpNELueGlKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?=MnrpNlM3ODJ3MkO=
A549M3Pye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVrmd5o2TE2VTx?=NFzac3VKSzVyPUGuNFc6KM7:TR?=NH\KUnUzOzZ2NEKxNC=>
HCT116MmPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmXoSG1UVw>?MlO0TWM2OD1yLke1O{DPxE1?M4HLZVI{PjR2MkGw
K562NFL0cpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NG\1d3lFVVORMoX4TWM2OD1yLk[0OUDPxE1?MnfPNlM3PDR{MUC=
GBC-SDNV3QRY5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXfveI9XPSEQvF2=MYO3NkBpNFvT[2dFVVORNYr4PGNvUUN3ME2xOE45KM7:TR?=NEXNfIIzOzdyN{K2NC=>
HGC27MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmeyOUDPxE1?MXq3NkBpNE[5Z5hFVVORNX7hVIFiUUN3ME21MlQh|ryPNWDzeVZNOjN5MEeyOlA>
HL60MkXBT4lv[XOnIFHzd4F6NGX4ZpM2KM7:TR?=M4HGUVI1KGh?NVe3OmM6TE2VTx?=NXTHWHpIUW6qaXLpeIlwdiCxZjDISGFEM3j5NVI{PzB5Mk[w
VeroMXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkXSO|IhcA>?M4DuVmROW09?NFq3Z2tKSzVyPUCuPUDPxE1?MnzrNlM4QDZ2NUK=
NCI60NXvE[lZkS3m2b4TvfIlkKEG|c3H5NW\ZeYRTPDhiaB?=M{jLUWROW09?NFTHdIFIUT1yLkWzJO69VQ>?NIjVT2YzPDBzNUOyOy=>
SW620NIiy[2xEgXSxdH;4bYMhSXO|YYm=NHLTOGk1QCCqMkC0SG1UVw>?MomwS2k:OC53NDFOwG0>NXX0foRIOjRyMUWzNlc>
U251NEHMSodEgXSxdH;4bYMhSXO|YYm=MXG0PEBpNFH4eWFFVVORNFvzO|VIUT1zLkWzJO69VQ>?M{fvZ|I1ODF3M{K3
KM12M3HOd2N6fG:2b4jpZ{BCe3OjeR?=MUK0PEBpMkLBSG1UVw>?M{m1cWdKRTFwOEig{txOM{HB[VI1ODF3M{K3
Hs578TMYPDfZRwfG:6aXOgRZN{[Xl?MkDnOFghcA>?M3;1cmROW09?MlTWS2k:PC56MzFOwG0>Moj5NlQxOTV|Mke=
MDA-MB-231M4fq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NU\vVmhlPDhiaB?=MkHYTWM2OD1yLkG2JO69VQ>?MXuyOFA6PTBzNh?=
MCF7NX\Wb|B6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFrQSXM1QCCqNUnlO4h3T0l;MD60OUDPxE1?M1fFRVI1OTF7NUW1
MDA-MB-435MlqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mmn5OFghcA>?NYfU[GNNT0l;MD64PEDPxE1?M3iwcVI1OTF7NUW1
AsPC1NH\QTIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVyzNEDPxE1?MV20PEBpM37l[2ROW09?M2Phd2lEPTB;Mz62OkDPxE1?NYiwepFGOjRzOEWzO|g>
Jurkat E6.1NVLq[5Y5U2mwYYPlJGF{e2G7MXKyJIg>Ml;mSG1UVw>?MkHWTY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1?M{HlOlI1OjZzOE[y
KG1NVHVXIJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M17Gc|Q5KGh?M{X1TmlEPTB;MT6xOUDPxE1?M2Lnd|I1PTJ3MECz
HELMV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVe0PEBpNUfheGxnTE2VTx?=M3nnXGlEPTB;MD60PUDPxE1?NUWxVowyOjR4OUSwOVU>
HSC3MWrDfZRwfG:6aXOgRZN{[Xl?Mn;WNVIhcA>?M3\5cGROW09?NEXZVGxKSzVyPUCuO|Eh|ryPMYWyOFc3PjV4MB?=
HT-29MmriR5l1d3SxeHnjJGF{e2G7NHjicWUyOiCqMYnEUXNQM1OwUWlEPTB;MD63NkDPxE1?MXOyOFc3PjV4MB?=
KBNHmzR4pEgXSxdH;4bYMhSXO|YYm=M3TzPFEzKGh?NGDJSIRFVVORNV;ISlVTUUN3ME2wMlc2KM7:TR?=M2Ph[FI1PzZ4NU[w
H460Mm\vR5l1d3SxeHnjJGF{e2G7M{HrWlEzKGh?M2HMUGROW09?NWjienNDUUN3ME2wMlgzKM7:TR?=NV7DO2UyOjR5Nk[1OlA>
MONE1NXO0dnJJS3m2b4TvfIlkKEG|c3H5NUi4PGZiOTJiaB?=NVHtPJRHTE2VTx?=NEXLfIhKSzVyPUGuNVgh|ryPNY\GUldbOjR5Nk[1OlA>
MKN45M{PadGN6fG:2b4jpZ{BCe3OjeR?=NX\zUHNWOTJiaB?=M4npeWROW09?M4rzdmlEPTB;MT6yOUDPxE1?M1;DOlI1PzZ4NU[w
TSGHMXHDfZRwfG:6aXOgRZN{[Xl?MVKxNkBpMUHEUXNQNFm0U2dKSzVyPUKuNFkh|ryPNEfs[4szPDd4NkW2NC=>
HL60NGjVfFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnXFO|IhcA>?MUHEUXNQNW\1b5hxT0l3ME2wMlk{KM7:TR?=NUCzbYZQOjR7MEC1NFA>
HEK293NED0VoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH\ufnc4OiCqM{WzTGROW09?M3PoNGdKPTB;MUOg{txONIn3eZIzPDlyMEWwNC=>
JurkatMXjDfZRwfG:6aXOgRZN{[Xl?MXGxNFAh|ryPMkG4O|IhcA>?NWjjfVRuT0l3ME2wMlkh|ryPNH3aeXUzPDlyMEe0Ny=>
GM15850MonmT4lv[XOnIFHzd4F6M4HETFIvPSEQvF2=NGLU[ms6PiCqMlz4SG1UVw>?NHS4cJJld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhOTRiYXPleJlt[XSrb36gc4YhTliQIHflcoU>NX:1[oUzOTZ7MkGzOlc>
GM15850MV\LbY5ie2ViQYPzZZk>MYCyMlUh|ryPMUO5OkBpMljiSG1UVw>?MnjN[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW=MoXnNVY6OjF|Nke=
GM15850MXLLbY5ie2ViQYPzZZk>M3jsNFIvPSEQvF2=M4rkT|k3KGh?MWLEUXNQMom1[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7lMXGxOlkzOTN4Nx?=
GM15850M3TPSmtqdmG|ZTDBd5NigQ>?M2DMWlIvPSEQvF2=NHvW[XA6PiCqNILVfFBFVVORMXjkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?=MnziNVY6OjF|Nke=
GM15850NYHZRnp[U2mwYYPlJGF{e2G7MlftNk42KM7:TR?=NEe5SIs6PiCqMlLxSG1UVw>?NES0Z3Bld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhQCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=>Mm\xNVY6OjF|Nke=
GM15850MkWxT4lv[XOnIFHzd4F6M3vWT|IvPSEQvF2=MUG5OkBpMkTxSG1UVw>?MlzG[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7lMYixOlkzOTN4Nx?=
GM15850Mk\ISpVv[3Srb36gRZN{[Xl?NFK2ZWo2KM7:TR?=M3fjc|EzKGh?MVvEUXNQMoTqbIF{KG6xIHXm[oVkfCCxbjDGXG4hdVKQQTDlfJBz\XO|aX;uMVyxOlkzOTN4Nx?=
U937M2DzWGtqdmG|ZTDBd5NigQ>?M3PG[lUh|ryPNGrzSIMzPCCqMVrEUXNQMl;DbIF{KG6xIHXm[oVkfCCxbjDhcJBp[SC2dXL1cIlvKGGlZYT5cIF1cW:wNF2wRlUyPzR2N{e1NC=>
U937NIeybGdMcW6jc3WgRZN{[Xl?NIfHeFcyKM7:TR?=NEL4OnIzPCCqM1SxTWROW09?M4TDWohieyCwbzDl[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?=MXixO|Q1Pzd3MB?=
PANC1NIr5OVJHfW6ldHnvckBCe3OjeR?=MVWxJO69VQ>?Mn7ZNlQhcA>?Mlnm[I9meyCwb4SgbY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36=NXXrfZRVOTd3OEi3OFQ>
PANC1MnewSpVv[3Srb36gRZN{[Xl?M3nLfVEh|ryPMmeyOFghKGh?Mn7D[I9meyCwb4SgbY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36=MXWxO|U5QDd2NB?=
Caco-2NFjoNlBHfW6ldHnvckBCe3OjeR?=M3m5clUh|ryPMmTpNlQhcA>?NVjmUWdyTE2VTx?=M1[0Z4Rw\XNibn;0JIlv\HWlZTDQNlFYSUZzIHflcoUh\XiycnXzd4lwdg>?NFjsN4szODF2M{i0NC=>
SCC4MXvGeY5kfGmxbjDBd5NigQ>?NGrFfm4yKM7:TR?=NIfKTIgyOCCvaX6=NGXFSY9FVVORMoOzbIF{KG6xIHHnc45qe3RiYXP0bZZqfHliYYSgWmRTKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBEYVB{NDDn[Y5mKGW6cILld5Nqd25?NV7rUIttOjB2NUKyNlU>
A549MmT5SpVv[3Srb36gRZN{[Xl?MXq1JO69VQ>?NVTOeod[OyCqMlKxSG1UVw>?NHj3XHVld2W|IH7veEBqdmS3Y3WgZZV1d3CqYXf5JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lKMl\UNlA5PTV{MEi=
HCT116NV35XJFrU2mwYYPlJGF{e2G7M1nJcFAvOyEQvF2=M1Tx[FMxKGh?MmL6SG1UVw>?NYjR[JNx\G:nczDuc5QhcW6qaXLpeEBJTEGFMTDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiaHnzeI9v\SCKM1u5JIFk\XS7bHH0bY9vNGnuO5EzOTB6ME[0Oy=>
HepG2Mo\qSpVv[3Srb36gRZN{[Xl?MlrvNVAh|ryPNInr[GIzPCCqM1jqdmROW09?NHjCd|Jld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KGi7cHXyZYNmfHmuYYTpc44hd2ZicEWzM{P1[|IyPTR6NUiy
GM11272MXzGeY5kfGmxbjDBd5NigQ>?NXnteJpHOC5zIN88US=>NEjYWG84OiCqNULITHpPTE2VTx?=NVvUXWZ1\G:nczDuc5QhemWjY4TpeoF1\SCPZVPwNkBufXSjboSg[ZhxemW|c3nvci=>MXSyNVg1ODdzNh?=
MDA-MB-231M1eycWtqdmG|ZTDBd5NigQ>?NG\TNo4yOCEQvF2=NUPMSYdxPSCvaX6=M{jXdWROW09?NEHYTmpld2W|IH7veEBqdmirYnn0JGhFSUN{YR?=NX7YcWFROjN2OUO0OFk>
MDA-MB-231NFn4V4RMcW6jc3WgRZN{[Xl?NEXKfnkyKM7:TR?=NVnoUVd6OjRiaB?=MlzHSG1UVw>?NVjjR3hn\G:nczDuc5QhcW6qaXLpeEBJTEGFNjDhd5Nme3OnZDDhd{Bi[2W2eXzheIlwdiCuZY\lcJMhd2ZidIXieYxqdg>?NEG3OYozOzR7M{S0PS=>
K562MVnLbY5ie2ViQYPzZZk>MoDw[I9meyCwb4SgbY5pcWKrdDDISGFENEnab48zOzV7MUGxNS=>
JurkatNWT1bIZuS3m2b4TvfIlkKEG|c3H5M3fT[lIxKM7:TR?=NXvnO3R3PzJiaB?=MlzKSG1UVw>?M{LOPY5wKGO7dH;0c5hq[2m2eTDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvci=>MXGyOFMxPDN2OB?=
HCT116NF\WRVhCeG:ydH;zbZMhSXO|YYm=M4\tNVMh|ryPNGO5dYIzPCCqM1zHRmROW09?MoKz[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCyNUOgdJJwfGWrbjDs[ZZmdA>?M3;hNFI1PzZ4NU[w
KASUMI-1M3KwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYXJR|UxRTl7LkG3JI5OMoHlV2FPT0WU
KARPAS-45NEfkdYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnPPTWM2OD1zN{OuPFkhdk1?MVrTRW5ITVJ?
BHT-101NXfRUGFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFTkT3JKSzVyPUK0OE4yQCCwTR?=NH;2bldUSU6JRWK=
H9MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkHpTWM2OD1{NUWuNFQhdk1?MVHTRW5ITVJ?
PA-1MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoLETWM2OD1{OE[uNlYhdk1?MVrTRW5ITVJ?
NEC8NXnqcnduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYTrSWNMUUN3ME2yPFkvOzhibl2=M{LBNnNCVkeHUh?=
MHH-PREB-1M1PMe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkTGTWM2OD1{OUSuOVMhdk1?NHGyOoNUSU6JRWK=
NB7M4PyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYDJR|UxRTN2NT63OEBvVQ>?MWDTRW5ITVJ?
A3-KAWM4TXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV3JR|UxRTRyMD61PUBvVQ>?NUizNIRyW0GQR1XS
NB69MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWG3dmZKUUN3ME20NVEvPzFibl2=NGq2U2dUSU6JRWK=
EoL-1-cellNHm4SlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVnJR|UxRTR3NEK1JI5OMli0V2FPT0WU
CHP-212M2nXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWW2PIs5UUN3ME20OVcvPTNibl2=M1HyNnNCVkeHUh?=
C2BBe1NVT1RXM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV3JR|UxRTR5Mj6xPUBvVQ>?NIDOXYRUSU6JRWK=
697MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlrVTWM2OD12N{OuOFEhdk1?NWjMbFQ6W0GQR1XS
BCPAPNHv5cGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mk[2TWM2OD13MEGuOFIhdk1?MmXnV2FPT0WU
L-363MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Ml;jTWM2OD13MEOuNUBvVQ>?M4XnU3NCVkeHUh?=
ES8MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTV{Mz61N{BvVQ>?NXPOSXE2W0GQR1XS
BE-13NEjvSXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnT5TWM2OD13Mk[uPVYhdk1?NULaWXpSW0GQR1XS
CTB-1NHjwV3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mk\RTWM2OD13M{euPVIhdk1?NUftVGdUW0GQR1XS
HD-MY-ZMYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2H0fWlEPTB;NUO4MlE{KG6PNIOxOJZUSU6JRWK=
NKM-1NEnRZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4HQfWlEPTB;NUS0MlI4KG6PNX:4SIpPW0GQR1XS
NCI-H720Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXPJR|UxRTV4MD6xPEBvVQ>?NGPJUpVUSU6JRWK=
KY821MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYnJR|UxRTV4Mz6yOUBvVQ>?MmDyV2FPT0WU
OVCAR-5MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYnJR|UxRTV5Nj6xNUBvVQ>?MnHnV2FPT0WU
CTV-1MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlzrTWM2OD13OEGuOVYhdk1?M{nXPXNCVkeHUh?=
P12-ICHIKAWANID1W4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXLJR|UxRTV7Nj61NUBvVQ>?NEDQPYVUSU6JRWK=
DBM4KxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHXp[GtKSzVyPUW5PE42PyCwTR?=Mn\DV2FPT0WU
CHL-1NFrBZnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2XwWWlEPTB;NkSyMlA5KG6PM2\6TnNCVkeHUh?=
A4-FukM4HXbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUHJR|UxRTZ2ND65NUBvVQ>?M3PWVHNCVkeHUh?=
MV-4-11Mmm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mnf4TWM2OD14NUmuNUBvVQ>?MnrNV2FPT0WU
RPMI-8226MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoG5TWM2OD14N{iuNVghdk1?MlHxV2FPT0WU
NB14MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{H0SWlEPTB;Nkm2Mlk2KG6PNH[3[lNUSU6JRWK=
DOHH-2NYDTXnMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3rEZWlEPTB;N{C2MlY5KG6PMX3TRW5ITVJ?
D-423MGNGnEc2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVjtcYU{UUN3ME23NFYvQDlibl2=M33HNnNCVkeHUh?=
D-283MEDMmfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2DRZ2lEPTB;N{G0MlE1KG6PM2\5O3NCVkeHUh?=
ES1NWTqU4llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYnJR|UxRTd{ND60JI5ONYTvUpJZW0GQR1XS
GOTOM4DncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml3rTWM2OD15MkmuNVIhdk1?NHza[GNUSU6JRWK=
NCI-H209MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGPWcIFKSzVyPUeyPU46KG6PMVrTRW5ITVJ?
MOLT-13Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmXwTWM2OD15M{iuPVghdk1?MUPTRW5ITVJ?
ATN-1NVPYSo0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4jzeWlEPTB;N{SwMlI5KG6PNFf2PFlUSU6JRWK=
DU-4475M2izU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVrJR|UxRTd3MT65NUBvVQ>?Ml7tV2FPT0WU
NB10MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWTJR|UxRTd3MT65NkBvVQ>?NEXLVGJUSU6JRWK=
KG-1MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVfJR|UxRTd5NT60OUBvVQ>?NUTLO4hrW0GQR1XS
MOLT-4MmHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmGyTWM2OD15OEeuOFYhdk1?NXL2TplxW0GQR1XS
TE-1M1\id2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3\Xd2lEPTB;N{mxMlEhdk1?MkfHV2FPT0WU
SBC-1NWnmXIZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV7DT2dHUUN3ME23PVMvQDRibl2=NESyNWpUSU6JRWK=
HELNU\nXXJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUHJR|UxRThyNj6wPEBvVQ>?NITiV5pUSU6JRWK=
SK-MEL-2NI\5b49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1m3WGlEPTB;OEC5MlQ1KG6PNHXMS45USU6JRWK=
KU812M1fVNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NImxOIhKSzVyPUixN{4yKG6PMWnTRW5ITVJ?
RPMI-8866NXK3R2ZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1z4d2lEPTB;OEGzMlY4KG6PMWnTRW5ITVJ?
ALL-POM4PpUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUfJR|UxRThzND62OkBvVQ>?NX:1cZVGW0GQR1XS
LU-139MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXX2c|g1UUN3ME24NlIvQDZibl2=NEG0ZlFUSU6JRWK=
RS4-11MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXLJR|UxRTh|Mj60OUBvVQ>?NWH0WGdQW0GQR1XS
EW-18MmLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFHkfFNKSzVyPUizNk46PiCwTR?=MW\TRW5ITVJ?
P30-OHKMmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoLITWM2OD16M{WuO{BvVQ>?M3rGOnNCVkeHUh?=
D-566MGMUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{XwTmlEPTB;OEO4MlYzKG6PNFjZ[2RUSU6JRWK=
HSC-4NUOxWGFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV\JR|UxRTh2Nj61NUBvVQ>?NX;IU|lCW0GQR1XS
QIMR-WILNWe2XphLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGHSNopKSzVyPUi2Nk4xOyCwTR?=M{PrVHNCVkeHUh?=
SW954MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MonyTWM2OD16NkOuNVYhdk1?NF7RVZpUSU6JRWK=
HGC-27MmDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGDtNlZKSzVyPUi3Nk4{PCCwTR?=MkDvV2FPT0WU
HHNF7oXY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXPkPXJzUUN3ME24PVQvOTJibl2=NXPjTodkW0GQR1XS
KE-37NGDFVIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHG2OZlKSzVyPUi5OE43OiCwTR?=NVHYWXl{W0GQR1XS
SK-N-DZMomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnjiTWM2OD17MECuOFMhdk1?MlfkV2FPT0WU
J-RT3-T3-5NHf3eJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVHuWFF7UUN3ME25NVAvPDlibl2=NH\MdGpUSU6JRWK=
A427Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWq4VFRrUUN3ME25NlAvQDRibl2=NYXFbmR2W0GQR1XS
ECC10MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2f1eGlEPTB;OUS1Mlg4KG6PM1ezN3NCVkeHUh?=
EW-1NH\GeJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEnsVlRKSzVyPUm0O{4zPiCwTR?=NV;UVWhUW0GQR1XS
MIA-PaCa-2M3X3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoflTWM2OD17NEmuNVIhdk1?NYLGZ|N3W0GQR1XS
HCC2218MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIPJ[GNKSzVyPUm1PE41QCCwTR?=MorZV2FPT0WU
HAL-01NGjNfmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2rGbGlEPTB;OU[4MlA1KG6PNY\uNHFQW0GQR1XS
RDMWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{HY[mlEPTB;OUe0MlQ2KG6PM2XseXNCVkeHUh?=
SK-N-ASNEjkT|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkPWTWM2OD17OEiuNUBvVQ>?MV;TRW5ITVJ?
ML-2NUCwXmRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkjrTWM2OD1zLkCwOFA4KM7:TR?=MXPTRW5ITVJ?
MEL-HOMoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYfCOZN2UUN3ME2xMlAxPTh{IN88US=>MnnEV2FPT0WU
MS-1MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWDJR|UxRTFwMEC2NVch|ryPMXLTRW5ITVJ?
NCI-SNU-1NVLqTWsxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIjZfGRKSzVyPUGuNFI{OzFizszNMXLTRW5ITVJ?
8505CMXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYLJR|UxRTFwMEKzN|Eh|ryPM3vXdXNCVkeHUh?=
MN-60Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYDJR|UxRTFwMEK2PEDPxE1?NYHoPFNiW0GQR1XS
SASMVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX\JR|UxRTFwMESwPFEh|ryPNELuSHlUSU6JRWK=
EFM-19NYfnOmU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoTrTWM2OD1zLkC0PFc6KM7:TR?=NYHEdGNYW0GQR1XS
Ca9-22NYKzflJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFK1flRKSzVyPUGuNFUyODdizszNNIjTXXpUSU6JRWK=
NBsusSRNGHtWWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmLUTWM2OD1zLkC1NVY3KM7:TR?=NEfLWlJUSU6JRWK=
NB13NWPBcmtLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlXpTWM2OD1zLkC1OVAyKM7:TR?=NWDEcG1oW0GQR1XS
SF295M3PpNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NInLW21KSzVyPUGuNFY3OjRizszNNYDT[GJTW0GQR1XS
U-2-OSNFLpTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnLoTWM2OD1zLkC3PVEyKM7:TR?=MlTTV2FPT0WU
NCI-H526M3rDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlLwTWM2OD1zLkC4NlkyKM7:TR?=NFTKUolUSU6JRWK=
KMOE-2Mlf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXP3SYcxUUN3ME2xMlA6PDJ{IN88US=>NWjBTZlmW0GQR1XS
RCM-1NGfMVmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYXJR|UxRTFwMUKxNFIh|ryPNHPreYRUSU6JRWK=
MC116MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX\CS4duUUN3ME2xMlE{PjJzIN88US=>MUnTRW5ITVJ?
NCI-H1092NYCxWWV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVXkdWF7UUN3ME2xMlE2PDB4IN88US=>MVLTRW5ITVJ?
EW-3NVGwOZU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYOwV2RuUUN3ME2xMlE4OjF{IN88US=>MXnTRW5ITVJ?
HCT-116MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{CwemlEPTB;MT6xO|c2KM7:TR?=M4jWOXNCVkeHUh?=
MC-IXCMmCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHn2UlBKSzVyPUGuNVc5QDFizszNM1jqenNCVkeHUh?=
LB1047-RCCM3zFSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX\sVYw6UUN3ME2xMlE5OzF{IN88US=>NH3IdJBUSU6JRWK=
VM-CUB-1MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4m1[mlEPTB;MT6xPVExQCEQvF2=MV\TRW5ITVJ?
NB5NXjLTXB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnrSTWM2OD1zLkG5PFU3KM7:TR?=MlvqV2FPT0WU
SKG-IIIaMXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWnre|V{UUN3ME2xMlI{PDZ2IN88US=>M4nsNXNCVkeHUh?=
HO-1-N-1M17jUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHfvbXZKSzVyPUGuNlM5OzVizszNMYHTRW5ITVJ?
EFO-27NHfFcmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHnaOWZKSzVyPUGuNlUxPDNizszNMY\TRW5ITVJ?
MHH-NB-11NE[wXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NY\OVFk{UUN3ME2xMlI5OzJ7IN88US=>M{i5bnNCVkeHUh?=
SW620NH;UTJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUPJR|UxRTFwMkmwNVgh|ryPM4TFbnNCVkeHUh?=
MOLT-16NUL1XHY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4DVTWlEPTB;MT6yPVc6PyEQvF2=Ml7SV2FPT0WU
NTERA-S-cl-D1NGHJWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEKycHFKSzVyPUGuN|E4PjFizszNNHXZfJRUSU6JRWK=
VA-ES-BJM363S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoPTTWM2OD1zLkOyOFc4KM7:TR?=MYrTRW5ITVJ?
HCC1419MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXK0VIt{UUN3ME2xMlM1ODJ5IN88US=>M{LhZnNCVkeHUh?=
NCI-H69M1z1S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXi5NJRtUUN3ME2xMlM1OTF{IN88US=>NIrKOIhUSU6JRWK=
DELMl64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoDBTWM2OD1zLkO1NVYzKM7:TR?=MYXTRW5ITVJ?
LXF-289NITPVVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXzJR|UxRTFwM{WyOEDPxE1?NXHCcFBZW0GQR1XS
EW-11MkD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUnJR|UxRTFwM{[wNlYh|ryPNVHy[4liW0GQR1XS
KP-4NF3Sb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NY[yVoxRUUN3ME2xMlM4ODh3IN88US=>NX;qbVJ{W0GQR1XS
NOS-1NFzVOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXXJR|UxRTFwNEGxPVQh|ryPM2LzSXNCVkeHUh?=
SK-NEP-1M{\WNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{LQeWlEPTB;MT60NVY6OyEQvF2=NXHsNmV[W0GQR1XS
LAMA-84NVrKOIVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmnPTWM2OD1zLkSzPVQ2KM7:TR?=NEixOIdUSU6JRWK=
ES5M33aZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MU\JR|UxRTFwNESzJO69VQ>?NHPnSlNUSU6JRWK=
HuO9Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUDjS4lYUUN3ME2xMlQ2OzZ{IN88US=>M3S4VXNCVkeHUh?=
COLO-684NXfLflVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NELUOmtKSzVyPUGuOFYyOThizszNMXTTRW5ITVJ?
EW-24NEnDZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkjqTWM2OD1zLkS2OVMyKM7:TR?=MXrTRW5ITVJ?
BV-173MmfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mmq5TWM2OD1zLkS3NlkyKM7:TR?=NYH4XYtDW0GQR1XS
NCI-H1770NH\lV|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXLOfFRnUUN3ME2xMlQ5PTN4IN88US=>NGrBSpNUSU6JRWK=
HuP-T4NGO5XGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVPJR|UxRTFwNEmzJO69VQ>?MYHTRW5ITVJ?
TYK-nuMnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{nlTmlEPTB;MT60PVg2OSEQvF2=M{PQVHNCVkeHUh?=
YH-13NU\DcXBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVjJR|UxRTFwNEm4PVQh|ryPMV\TRW5ITVJ?
H4NF\rTnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnHpTWM2OD1zLkWwPVEzKM7:TR?=NYTvbnh6W0GQR1XS
OVCAR-8NVnyRXE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWLJR|UxRTFwNUS0O|ch|ryPMUfTRW5ITVJ?
NCI-H23Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MU\JR|UxRTFwNUS2OFUh|ryPMVnTRW5ITVJ?
ES7NViyR4hLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFG2ZVVKSzVyPUGuOVQ4PzNizszNNVXjeHJiW0GQR1XS
COR-L88M4f2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGDpUZlKSzVyPUGuOVY1OjRizszNMkiwV2FPT0WU
TI-73MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWLJR|UxRTFwNUmwOkDPxE1?MXrTRW5ITVJ?
RT-112NGnvfpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXrMVXdYUUN3ME2xMlU6Ojh2IN88US=>NYXxO|BvW0GQR1XS
HuO-3N1MlzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1jjR2lEPTB;MT61PVM5PSEQvF2=M4HwUHNCVkeHUh?=
HC-1NGj3U|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmHCTWM2OD1zLkW5PFY3KM7:TR?=MW\TRW5ITVJ?
HT55NYK2U4ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWe3UZV{UUN3ME2xMlY2OTNzIN88US=>M2XLUXNCVkeHUh?=
IA-LMNITEVZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFTBcFdKSzVyPUGuOlkzPzhizszNMUHTRW5ITVJ?
EM-2NV:0VXRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUjMOXdrUUN3ME2xMlcxODF2IN88US=>NU\mbpl2W0GQR1XS
MHH-ES-1M{jlOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M162R2lEPTB;MT63NFQ{PSEQvF2=NEK1[nNUSU6JRWK=
CAL-27MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVzJR|UxRTFwN{C2NlEh|ryPNF6xVmhUSU6JRWK=
COLO-800NVjEc|dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2HacmlEPTB;MT63NVE4QSEQvF2=M{WyRXNCVkeHUh?=
HCE-TMn\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NID0VlJKSzVyPUGuO|E2KM7:TR?=NXfDcJR{W0GQR1XS
CAMA-1MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYfJR|UxRTFwN{G5O|Eh|ryPNI\FRZVUSU6JRWK=
LOXIMVIMm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUXJR|UxRTFwN{KxNUDPxE1?NXrLUpp5W0GQR1XS
NH-12NUHm[5h6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFzp[|ZKSzVyPUGuO|I3QTFizszNMUHTRW5ITVJ?
TCCSUPMmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mly1TWM2OD1zLkeyPFI6KM7:TR?=MUXTRW5ITVJ?
MDA-MB-361M33xZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVjkW3duUUN3ME2xMlc{OTV5IN88US=>M1;vfXNCVkeHUh?=
EW-16NIK0flJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUXTNZZMUUN3ME2xMlc1OTB5IN88US=>M{\LUnNCVkeHUh?=
SNU-423MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWPJR|UxRTFwN{W4Nlch|ryPNUDmZpNEW0GQR1XS
DaoyNF7ZPXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYfJR|UxRTFwN{[zNVkh|ryPMY\TRW5ITVJ?
ES4MoTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXXZR5prUUN3ME2xMlc5PzRzIN88US=>MnLYV2FPT0WU
PFSK-1NXzWUJJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWDJR|UxRTFwOECzO{DPxE1?M1XIRXNCVkeHUh?=
ES3M3PicGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUnKOHhtUUN3ME2xMlgzPjhzIN88US=>MlLwV2FPT0WU
ONS-76NFTkWndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml7oTWM2OD1zLkiyPFk4KM7:TR?=MULTRW5ITVJ?
JVM-3MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mmf1TWM2OD1zLki1OFUyKM7:TR?=NV3IUJhiW0GQR1XS
OS-RC-2MkWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MY\JR|UxRTFwOEexOVEh|ryPNIj4e4VUSU6JRWK=
COLO-320-HSRNFG5XlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M33tUWlEPTB;MT64PFE6PyEQvF2=MnHDV2FPT0WU
HNMXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NY\teVBuUUN3ME2xMlg5PzJ3IN88US=>MY\TRW5ITVJ?
HTNGfEdoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlX2TWM2OD1zLki4PVQ4KM7:TR?=MX3TRW5ITVJ?
LoVoM1;mWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlzrTWM2OD1zLki5PFEh|ryPMkK4V2FPT0WU
CGTH-W-1MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFm5PW9KSzVyPUGuPFk6PDZizszNNE[4NFdUSU6JRWK=
NB6NFLMOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnraTWM2OD1zLkmxNlk5KM7:TR?=NV3ObIROW0GQR1XS
EW-22NYTkS|VRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1HwS2lEPTB;MT65Nlg5PyEQvF2=NVHnZnJTW0GQR1XS
ES6M1W2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml7zTWM2OD1zLkmzOlMyKM7:TR?=NHzIVGVUSU6JRWK=
SCC-15MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHXnW|NKSzVyPUGuPVM5OTlizszNNXXaeFk1W0GQR1XS
HL-60MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MW\JR|UxRTFwOUO5NFIh|ryPMk\kV2FPT0WU
human HOP-92MmXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVv4UlY1UUN3ME2xMlk1ODZ3IN88US=>NIPIOmlUSU6JRWK=
SW626NELjTopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX7JR|UxRTFwOUS4PVkh|ryPMVzTRW5ITVJ?
HEC-1M4LycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoDJTWM2OD1zLkm1N|Yh|ryPNIPQUlRUSU6JRWK=
LB2241-RCCMWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Moe0TWM2OD1zLkm4NlMyKM7:TR?=NETJSotUSU6JRWK=
Ramos-2G6-4C10MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnjzTWM2OD1zLkm5OFk{KM7:TR?=M{nhT3NCVkeHUh?=
A101DMX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV3yZplFUUN3ME2yMlIxOzB|IN88US=>NIfKWHNUSU6JRWK=
NCI-H446M3fvTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX7JR|UxRTJwMES1PVkh|ryPNX7JV45FW0GQR1XS
SBC-5MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWPjZ29oUUN3ME2yMlA3OTR5IN88US=>MYXTRW5ITVJ?
HOSNHvQNGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHHHb4NKSzVyPUKuNFc3PTNizszNNUTzWWdLW0GQR1XS
K5MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1\hNWlEPTB;Mj6wO|gyOSEQvF2=NFrqfYdUSU6JRWK=
HLENHvmNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYHJR|UxRTJwMEi1Nlkh|ryPMn62V2FPT0WU
HSC-2Mlq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVzYR3ZVUUN3ME2yMlEzQDl6IN88US=>NXfJTXdRW0GQR1XS
LCLC-97TM1M2e2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXLhWYZjUUN3ME2yMlE1PTh|IN88US=>NYGyfGNiW0GQR1XS
DMS-273NIj3UZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn3lTWM2OD1{LkG0PFM4KM7:TR?=MXzTRW5ITVJ?
TE-8NXS4UXlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3\Fc2lEPTB;Mj6xOVc3PSEQvF2=MlPJV2FPT0WU
DSH1MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUnZTW55UUN3ME2yMlE3Ozl6IN88US=>MkjlV2FPT0WU
CAL-51MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHXlTo9KSzVyPUKuNVY3QTlizszNMUHTRW5ITVJ?
IST-SL1NHXLe3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MY\JR|UxRTJwMU[4OFQh|ryPNVz1V3JpW0GQR1XS
GCTNHnOcWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHTPRXVKSzVyPUKuNVc4PyEQvF2=M4\Hc3NCVkeHUh?=
SW948NGTRc4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3PlZmlEPTB;Mj6xPFQ2PiEQvF2=NHvZd5RUSU6JRWK=
NOMO-1MlvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYXJR|UxRTJwMUmzNVch|ryPM4q0ZnNCVkeHUh?=
C8166NXv6OWtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYO5SFdPUUN3ME2yMlIyOzN2IN88US=>NV;RR5NmW0GQR1XS
OC-314MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NU[5TG5PUUN3ME2yMlI{OjV7IN88US=>MVLTRW5ITVJ?
CAL-39MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEnXUJRKSzVyPUKuNlM3OjZizszNMUjTRW5ITVJ?
MDA-MB-453Ml7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGG2bJBKSzVyPUKuNlQzPzVizszNM4W1bnNCVkeHUh?=
A673NWfnOWFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mlj0TWM2OD1{LkK1PFYzKM7:TR?=NV\TWHVjW0GQR1XS
HTC-C3M2\CeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUDJR|UxRTJwMk[4OUDPxE1?NGi1ZmdUSU6JRWK=
NCI-H1666NHe5bphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIXxUHRKSzVyPUKuNlgyOTFizszNMYnTRW5ITVJ?
PSN1NHnwVm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4HTTmlEPTB;Mj6yPFkyOyEQvF2=MkfHV2FPT0WU
GI-1MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWfJR|UxRTJwM{C1OFMh|ryPMVXTRW5ITVJ?
HuH-7MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MW\JR|UxRTJwM{C2N|ch|ryPMVzTRW5ITVJ?
JARNYm5cnQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHywNFRKSzVyPUKuN|E6QDdizszNNILje2lUSU6JRWK=
5637M{ewS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF;2eGFKSzVyPUKuN|IyOjlizszNNX;3RpRDW0GQR1XS
GB-1MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYnvNVNXUUN3ME2yMlMzOzN3IN88US=>Ml7MV2FPT0WU
KP-N-YSNU\0UYRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1LpTmlEPTB;Mj6zNlYyPSEQvF2=M3P6d3NCVkeHUh?=
OAW-42NWCzVVVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGj3S|JKSzVyPUKuN|M1OTZizszNM37YcnNCVkeHUh?=
8-MG-BAMoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFe4bVFKSzVyPUKuN|M6ODZizszNMX;TRW5ITVJ?
RH-18NFjFPIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NI\qV3hKSzVyPUKuN|UxOjJizszNM4TEenNCVkeHUh?=
NCI-H1155NY\Qc4hlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4\xe2lEPTB;Mj6zOlczPSEQvF2=MV;TRW5ITVJ?
NB17Mkf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3zlbmlEPTB;Mj6zPFI1OyEQvF2=MYnTRW5ITVJ?
NCI-H1437NFX0PHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGjtWYxKSzVyPUKuOFE5PzNizszNMmrnV2FPT0WU
SN12CMkjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWjJR|UxRTJwNEOyNVQh|ryPM3nwOnNCVkeHUh?=
HSC-3NYO0OldrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHmyS2dKSzVyPUKuOFQ2ODlizszNNHPRW4lUSU6JRWK=
GAMGMV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M37X[mlEPTB;Mj60OFU3OSEQvF2=NEnZRVdUSU6JRWK=
HT-1080MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmPRTWM2OD1{LkS0PFY1KM7:TR?=MmH4V2FPT0WU
A549MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoixTWM2OD1{LkS0PFk{KM7:TR?=M2HleHNCVkeHUh?=
KNS-62NGi2S29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGTyXZRKSzVyPUKuOFUxPjFizszNNVTXOJJkW0GQR1XS
YKG-1MmLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEX0UJVKSzVyPUKuOFU1OzdizszNNHfuXIpUSU6JRWK=
LU-134-ANWXhTWp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mm\qTWM2OD1{LkS3NFA5KM7:TR?=M4HGOHNCVkeHUh?=
FADUNFf3UIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mo\ETWM2OD1{LkS3NVYzKM7:TR?=NF[zdHVUSU6JRWK=
TGBC11TKBNGLvU|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{DxbGlEPTB;Mj60O|E4PyEQvF2=NHLnbWxUSU6JRWK=
HT-3Mlj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVHJR|UxRTJwNEm1N|Uh|ryPMWjTRW5ITVJ?
NCI-H2170MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mlm1TWM2OD1{LkWwOVQ6KM7:TR?=NVHnZ2JpW0GQR1XS
Mo-TNITEXJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXjJR|UxRTJwNUC5Nlch|ryPNWHH[pRJW0GQR1XS
CCRF-CEMMnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{\jUGlEPTB;Mj61N|A1OyEQvF2=NXvVOWZ3W0GQR1XS
KU-19-19MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGXsfXFKSzVyPUKuOVM2OTNizszNMVrTRW5ITVJ?
NCI-H1048MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXXJR|UxRTJwNUWwNlUh|ryPNIjmVXlUSU6JRWK=
KOSC-2NHrze25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYrJR|UxRTJwNU[wO|Yh|ryPMmi1V2FPT0WU
A431NXXpTm5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWLJR|UxRTJwNU[zN|Uh|ryPM2eyV3NCVkeHUh?=
COR-L23MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXrSUGh[UUN3ME2yMlU5PTZ4IN88US=>M3XESHNCVkeHUh?=
MKN28NY\3bGtpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYXJR|UxRTJwNUmwN|ch|ryPMnLUV2FPT0WU
22RV1NYDVfFgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXPJR|UxRTJwNUmyO|Qh|ryPMXjTRW5ITVJ?
ABC-1MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV\JR|UxRTJwNkC0OkDPxE1?MW\TRW5ITVJ?
NCI-H2126MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmXnTWM2OD1{Lk[wPVg1KM7:TR?=NV\ocnRJW0GQR1XS
DoTc2-4510M4\VU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHLDWFdKSzVyPUKuOlIyQDVizszNMlGyV2FPT0WU
SCC-4NWfQ[2hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MW\JR|UxRTJwNkOwNVIh|ryPM3rHenNCVkeHUh?=
NCI-H661NH\wZ5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXXsXlFVUUN3ME2yMlY1ODh3IN88US=>MnTWV2FPT0WU
RPMI-2650Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoXKTWM2OD1{Lk[0NVQ{KM7:TR?=NVLETXZbW0GQR1XS
NCI-H510ANEPxd5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUXIXlZIUUN3ME2yMlY1PDJ4IN88US=>MYfTRW5ITVJ?
BPH-1MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MofMTWM2OD1{Lk[1PFUh|ryPMmqxV2FPT0WU
M14NXfwXWxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MojjTWM2OD1{Lk[2PVk{KM7:TR?=NHr2NpNUSU6JRWK=
G-402M3fQTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWHJR|UxRTJwN{C0OVEh|ryPMkHGV2FPT0WU
AsPC-1MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYTTXGNZUUN3ME2yMlcyOTdizszNMonqV2FPT0WU
NB12M1:2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYW2PGM1UUN3ME2yMlcyPzFizszNMX7TRW5ITVJ?
SK-HEP-1NG\Ld3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVjJR|UxRTJwN{SzPVEh|ryPMWTTRW5ITVJ?
U-266NYfQUJppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1S3bGlEPTB;Mj63O|EzOSEQvF2=NIO2c3BUSU6JRWK=
AM-38NUO2UXpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVnJR|UxRTJwN{ezOVUh|ryPNYnMWHN3W0GQR1XS
PC-14MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFT1SXRKSzVyPUKuPFA2OSEQvF2=M3PZSnNCVkeHUh?=
EGI-1NHH5fIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmjOTWM2OD1{LkixO|Q{KM7:TR?=M{jFNnNCVkeHUh?=
LS-411NMWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWPJR|UxRTJwOEKzN{DPxE1?NGXZdGNUSU6JRWK=
BFTC-905M3j2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4PxeGlEPTB;Mj64OVUzOyEQvF2=M37vZ3NCVkeHUh?=
CaR-1M{TBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MljCTWM2OD1{Lki2JO69VQ>?MXnTRW5ITVJ?
NCI-H292NIj0OlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3q0RWlEPTB;Mj64OlU6PiEQvF2=MljiV2FPT0WU
8305CMkX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlvwTWM2OD1{Lki2OlQ2KM7:TR?=NVjmN5RZW0GQR1XS
SNU-449MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV7FN5JkUUN3ME2yMlg6OTh{IN88US=>NULqeXg1W0GQR1XS
LCLC-103HNVH1V5B1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUHpd3llUUN3ME2yMlkxPDN6IN88US=>MX3TRW5ITVJ?
SW1573M2jCT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUPJR|UxRTJwOU[wPFIh|ryPNHH2[ZVUSU6JRWK=
MLMAMWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVPJS2lMUUN3ME2yMlk3PzF5IN88US=>MUjTRW5ITVJ?
NCI-H1355NWHXXYt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn\nTWM2OD1|LkCwO|k3KM7:TR?=Mn3GV2FPT0WU
RMG-IMYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1jIUWlEPTB;Mz6wNlU6OiEQvF2=MkCwV2FPT0WU
BB65-RCCNI\0UnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFXreY5KSzVyPUOuNFM{OTRizszNNXz0[JJzW0GQR1XS
PC-3NV;yR45vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF:wN2JKSzVyPUOuNFM5PzRizszNNEPMdWhUSU6JRWK=
SF268NYPIeWRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGLrOGlKSzVyPUOuNFQ2OjNizszNNEG1bZFUSU6JRWK=
NCI-H810MoW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkjzTWM2OD1|LkC0PFI{KM7:TR?=NHfhcHJUSU6JRWK=
MEG-01M4LPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mke2TWM2OD1|LkC2NVY1KM7:TR?=MlzJV2FPT0WU
SW13NX7vXpV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIe0ZZRKSzVyPUOuNFc5PDdizszNM1vwcHNCVkeHUh?=
RH-1Ml64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlrkTWM2OD1|LkGwNlc5KM7:TR?=MkXLV2FPT0WU
GT3TKBM4LvdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX;JR|UxRTNwMUGyPFMh|ryPNHTxO4RUSU6JRWK=
TK10NGHqOWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1PsU2lEPTB;Mz6xN|czPCEQvF2=NVHXXHVpW0GQR1XS
T-24MlnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3zGR2lEPTB;Mz6xOVA4KM7:TR?=MXrTRW5ITVJ?
A498MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1vIRWlEPTB;Mz6yNFg4OSEQvF2=MorvV2FPT0WU
GR-STMVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIHSXZVKSzVyPUOuNlIyOzlizszNNGTnSlRUSU6JRWK=
LB2518-MELMnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYPJR|UxRTNwMkKzPVgh|ryPMk\iV2FPT0WU
T47DM1\tdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYXVc29YUUN3ME2zMlI{PjJ5IN88US=>MYrTRW5ITVJ?
NCI-H1651NF\YVmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGPhbJlKSzVyPUOuNlQ3PDRizszNNHfKSYxUSU6JRWK=
EC-GI-10NUmwOmk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHvJVJVKSzVyPUOuNlYyPTNizszNMnHRV2FPT0WU
HT-29MlrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MonjTWM2OD1|LkK2OlE1KM7:TR?=M3\jdXNCVkeHUh?=
GI-ME-NM{[0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXHJR|UxRTNwMkm1NVEh|ryPNH:wW2hUSU6JRWK=
SW756NX;pZY42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYrJR|UxRTNwMkm2Nlkh|ryPNVTW[ldNW0GQR1XS
RKONWnlUFNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2HEXGlEPTB;Mz6zNFc2PyEQvF2=NGjmWXhUSU6JRWK=
NCI-H1563NIHNXmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXjJR|UxRTNwM{OwNVgh|ryPNH3MT4tUSU6JRWK=
DJM-1MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlG2TWM2OD1|LkO3Olc1KM7:TR?=MXXTRW5ITVJ?
L-428M3\FbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUHJR|UxRTNwNECwOFUh|ryPM{Hrc3NCVkeHUh?=
NCI-H2122MkLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUS3b4Z2UUN3ME2zMlQyOzF{IN88US=>M{TUOXNCVkeHUh?=
Ca-SkiMYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MoLaTWM2OD1|LkS1OFMh|ryPM130b3NCVkeHUh?=
639-VNH\E[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MknwTWM2OD1|LkS2NFU4KM7:TR?=MnHxV2FPT0WU
SW1116NH3X[HVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXrJR|UxRTNwNE[yOlkh|ryPNH;P[HRUSU6JRWK=
DMS-114MmrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX3GVWJYUUN3ME2zMlQ4ODZ4IN88US=>M{jkOHNCVkeHUh?=
MZ2-MELNGfLdotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIPEXWNKSzVyPUOuOFc3QDFizszNM1y4V3NCVkeHUh?=
COLO-829NXG1[FVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M13PRWlEPTB;Mz61NFA4OyEQvF2=M1fiXnNCVkeHUh?=
J82MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGmwXopKSzVyPUOuOVA2PyEQvF2=NImyVIdUSU6JRWK=
EW-13M3X3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVvDfHROUUN3ME2zMlUzPTFizszNMmHsV2FPT0WU
RXF393NHH4coZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUnJR|UxRTNwNUOyPVQh|ryPMn;LV2FPT0WU
CAL-62M3zVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1LXOGlEPTB;Mz61OFUyPCEQvF2=M1zBVXNCVkeHUh?=
OCUB-MNYPBU3BRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoHPTWM2OD1|LkW0OlY2KM7:TR?=NH7p[YpUSU6JRWK=
BT-474MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH3DWGhKSzVyPUOuOlM{OSEQvF2=NXzwZ3M5W0GQR1XS
KYSE-180MlnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlzITWM2OD1|Lk[zN|czKM7:TR?=MV\TRW5ITVJ?
NCI-H650NXLZ[oFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NY\Wb5JwUUN3ME2zMlY1Ojh5IN88US=>M3vvSHNCVkeHUh?=
Detroit562NFvGNWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2rRS2lEPTB;Mz62OVAzOiEQvF2=NYLXfVZwW0GQR1XS
SW48NE\zXXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1\w[2lEPTB;Mz62OVY2PyEQvF2=NHTUeotUSU6JRWK=
KYSE-450M3fZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEGyU2lKSzVyPUOuOlg2QDJizszNNUTXSoZXW0GQR1XS
KYSE-510M3O3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn62TWM2OD1|LkeyNVgyKM7:TR?=Ml\ZV2FPT0WU
GP5dM{Lk[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWHJR|UxRTNwN{K5OUDPxE1?MmftV2FPT0WU
RPMI-7951MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml3qTWM2OD1|Lke0O|I{KM7:TR?=MUXTRW5ITVJ?
BeckerNFfVOZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV\HTJNwUUN3ME2zMlc2ODF{IN88US=>NGjBSWZUSU6JRWK=
WM-115NV60dXd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIf4fo1KSzVyPUOuO|gyQTVizszNMnn2V2FPT0WU
G-401MlzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUPJR|UxRTNwN{mwPFUh|ryPNULsXZd4W0GQR1XS
PANC-08-13MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2nuPGlEPTB;Mz63PVYxOiEQvF2=MnSwV2FPT0WU
SW982NX:xfmt5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVq5b|E6UUN3ME2zMlgxPTVzIN88US=>M4XtbHNCVkeHUh?=
D-263MGNGO3cXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkS0TWM2OD1|LkiyNFUyKM7:TR?=MlP4V2FPT0WU
KM-H2Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUTJR|UxRTNwOEK2NlQh|ryPNUfxOmpDW0GQR1XS
SK-MEL-3NHHxWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkjnTWM2OD1|LkiyPFQyKM7:TR?=M1TSe3NCVkeHUh?=
NCI-H1581Moj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnXWTWM2OD1|Lki0OFg5KM7:TR?=NHnaNlJUSU6JRWK=
LS-123MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRTNwOEe5NFkh|ryPM{\QfXNCVkeHUh?=
CAKI-1MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1m2TWlEPTB;Mz64PVA2OiEQvF2=M1jVbXNCVkeHUh?=
MEL-JUSONVPZZ4hPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1jqXWlEPTB;Mz64PVE2OyEQvF2=NXW3[mp2W0GQR1XS
HCE-4MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MonjTWM2OD1|LkmxOlY{KM7:TR?=M2jwVHNCVkeHUh?=
TE-10MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYCwSY1FUUN3ME2zMlkzODFizszNNEjrUI1USU6JRWK=
OVCAR-4M{HaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYDJR|UxRTNwOUK4PFkh|ryPNFfPSItUSU6JRWK=
ETK-1MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NULD[ld5UUN3ME2zMlk1PjN3IN88US=>MnqyV2FPT0WU
A2780M2P3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmGyTWM2OD12LkC1PVY3KM7:TR?=NUK3[41jW0GQR1XS
LU-65NU\leIZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGrC[mtKSzVyPUSuNFc3OzNizszNMXjTRW5ITVJ?
BHYMVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{\GOGlEPTB;ND6xNlQ6PSEQvF2=NITXWIhUSU6JRWK=
COR-L105NW\0d4pTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVPJR|UxRTRwMUOwOVEh|ryPNX7QeIV7W0GQR1XS
CAL-12TM2TSOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmfzTWM2OD12LkGzNVA{KM7:TR?=NF;6cYJUSU6JRWK=
SCHNH;IO5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MojzTWM2OD12LkG1O|Q{KM7:TR?=M2C1[3NCVkeHUh?=
CW-2M3:3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml33TWM2OD12LkG5NFAyKM7:TR?=Mn;FV2FPT0WU
HCC1806M33yb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYPJR|UxRTRwMkCzNVIh|ryPNIn5OXBUSU6JRWK=
KP-N-YNM2jzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4DwNmlEPTB;ND6yNFkzPyEQvF2=MljXV2FPT0WU
T98GM2fjfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1rFZWlEPTB;ND6yNlE2PyEQvF2=NULzdVB6W0GQR1XS
CAL-54MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnHvTWM2OD12LkKyN|gyKM7:TR?=MkLJV2FPT0WU
CAL-33NGP5VVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXmzcZFwUUN3ME20MlI{ODZ2IN88US=>M3fIcHNCVkeHUh?=
SNU-C2BNH36elZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFfmZW9KSzVyPUSuNlQ4PjlizszNNX7kSG1OW0GQR1XS
NUGC-3MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXPJR|UxRTRwMkW1NFUh|ryPMYXTRW5ITVJ?
DOKMXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX\JR|UxRTRwMk[1PVMh|ryPMXHTRW5ITVJ?
MMAC-SFMnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVTJR|UxRTRwMk[4OVkh|ryPNUDBU3BYW0GQR1XS
KYSE-70NUXxRXIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoD6TWM2OD12LkK5N|Qh|ryPNXLtOIRuW0GQR1XS
A204M1jFS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXvJR|UxRTRwM{W4NFMh|ryPM4PqeHNCVkeHUh?=
SCC-25M2OwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkS2TWM2OD12LkO1PFE6KM7:TR?=NUjoXXRtW0GQR1XS
EPLC-272HM4XQeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXvJR|UxRTRwM{i5OUDPxE1?MljtV2FPT0WU
CAL-120NGXGcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVTJR|UxRTRwM{i5PVIh|ryPMVXTRW5ITVJ?
LS-513MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1PuTWlEPTB;ND60NlE6QCEQvF2=M2PyTnNCVkeHUh?=
CAPAN-1M3zzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEC5fVhKSzVyPUSuOFI{QDJizszNM3i4WnNCVkeHUh?=
ESS-1M4fT[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{nrTGlEPTB;ND60NlczPCEQvF2=MUXTRW5ITVJ?
GMS-10MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1nNXmlEPTB;ND60NlgyQSEQvF2=NEXNN3NUSU6JRWK=
NCI-N87NV\qdoc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmfxTWM2OD12LkWwPFY5KM7:TR?=NWHyT4R5W0GQR1XS
HMV-IINGLhNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVH5WGEyUUN3ME20MlUyPzNizszNMXfTRW5ITVJ?
COLO-741MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NICzVZJKSzVyPUSuOVU6QTRizszNNH3tOWFUSU6JRWK=
MKN45M3TVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4nreWlEPTB;ND61O|c{OiEQvF2=NXLaWVBTW0GQR1XS
OAW-28NWHVU|Z5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoL2TWM2OD12LkW4N|k5KM7:TR?=M3jhXnNCVkeHUh?=
OCI-AML2NWPOUYxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{TuPWlEPTB;ND62OVI{QCEQvF2=MXrTRW5ITVJ?
MDA-MB-231M4HkSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M16xc2lEPTB;ND63NFI1OyEQvF2=M1qxR3NCVkeHUh?=
NCI-H1648MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXzJR|UxRTRwN{KyO|Mh|ryPMl\SV2FPT0WU
NCI-H1792MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIO0UVdKSzVyPUSuO|YyODdizszNMn\tV2FPT0WU
GCIYNHjwUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFXQZ4NKSzVyPUSuO|c1OjRizszNMl;nV2FPT0WU
Hs-578-TNWfwbXExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWTJR|UxRTRwN{e2OVUh|ryPNIrleIpUSU6JRWK=
SW962Moe4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4rxdGlEPTB;ND63PFAyOSEQvF2=NVLhOnc1W0GQR1XS
NCI-H630MlzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEW5NYVKSzVyPUSuO|gxQDFizszNNFjYSFdUSU6JRWK=
786-0M1\uN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NU\kSoY3UUN3ME20Mlc5Pzd|IN88US=>MYrTRW5ITVJ?
FTC-133NFK4SHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYTFNG9nUUN3ME20Mlc6OjZ|IN88US=>NXj1PWREW0GQR1XS
BT-20MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXLJR|UxRTRwN{m0Nlkh|ryPMXvTRW5ITVJ?
MewoMnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFzjXIlKSzVyPUSuPFE4PDdizszNM1T3[XNCVkeHUh?=
SW780MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHTHWWdKSzVyPUSuPFU4PjZizszNMlviV2FPT0WU
OE33M4nCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYjROpVNUUN3ME20Mlg4PzF|IN88US=>NGjGV3JUSU6JRWK=
HCC1569NXnNS2ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NU\GdXRJUUN3ME20Mlg5PDV6IN88US=>NX[2WlJvW0GQR1XS
TE-6MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUPJR|UxRTRwOUO5O|ch|ryPM3:xVnNCVkeHUh?=
SK-N-FIM1njeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIn1[Y1KSzVyPUSuPVQ1OjFizszNMYLTRW5ITVJ?
PANC-03-27Mk\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHzaXpFKSzVyPUSuPVk6PjJizszNNXfLXooxW0GQR1XS
MCF7M{LVRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2fyWGlEPTB;NT6wNFc{QCEQvF2=NYfIN4ltW0GQR1XS
UACC-257NFf5bY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHrm[JlKSzVyPUWuNFI5PDVizszNMXLTRW5ITVJ?
SW1088M1;NRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX7GPWxwUUN3ME21MlAzQTR2IN88US=>MkjFV2FPT0WU
A704NUCwXG1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlHYTWM2OD13LkCzNFYh|ryPMlPiV2FPT0WU
A2058NGDyW2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlLtTWM2OD13LkC1PVA5KM7:TR?=NILW[lRUSU6JRWK=
Calu-3M3nRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn[1TWM2OD13LkC2OFUzKM7:TR?=NXHocGhDW0GQR1XS
RERF-LC-MSMYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnLFTWM2OD13LkC2PVA{KM7:TR?=NILzc29USU6JRWK=
AU565MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2DqUWlEPTB;NT6wPVcxOiEQvF2=NXfsOVBsW0GQR1XS
DMS-79NFzRWFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXK0NWt5UUN3ME21MlE{QDh|IN88US=>Mo\aV2FPT0WU
DK-MGNEG4eGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoTNTWM2OD13LkG4OFM5KM7:TR?=Ml3rV2FPT0WU
HuCCT1MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX\CRpFzUUN3ME21MlI{QDV4IN88US=>MWDTRW5ITVJ?
HT-144MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkfETWM2OD13LkK0PVg4KM7:TR?=MUnTRW5ITVJ?
M059JNIjvZ2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHfyR3BKSzVyPUWuNlU4PiEQvF2=M{jmb3NCVkeHUh?=
COLO-792MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVXJR|UxRTVwMk[zOVYh|ryPMnfDV2FPT0WU
SF539MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MofjTWM2OD13LkK2OlMzKM7:TR?=MWfTRW5ITVJ?
SK-UT-1NILNSGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX\JR|UxRTVwMke3OVEh|ryPNEDGfmdUSU6JRWK=
NCI-H1703MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHj4PFVKSzVyPUWuN|U5OjZizszNNXHEPW95W0GQR1XS
SW837Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGK1OJVKSzVyPUWuN|c5PzhizszNMlfDV2FPT0WU
U251MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXLUc3Q6UUN3ME21MlM6ODl4IN88US=>MnrRV2FPT0WU
SW1710M2P6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlzZTWM2OD13LkSxOVU1KM7:TR?=M3GzSXNCVkeHUh?=
NCI-H1299M4LjR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWXnUpJ1UUN3ME21MlQ3OzN3IN88US=>M17WfHNCVkeHUh?=
RVH-421MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHTud4hKSzVyPUWuOFk6ODhizszNM1TSSnNCVkeHUh?=
UM-UC-3M33ReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2izcGlEPTB;NT62NlY2OSEQvF2=MmHnV2FPT0WU
MDA-MB-175-VIINES2SWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIPibXNKSzVyPUWuOlQxPDFizszNMorYV2FPT0WU
KYSE-270MknwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV7JR|UxRTVwNk[wN|Eh|ryPMUjTRW5ITVJ?
COLO-668NV\uNYZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NUjtZ|E3UUN3ME21MlcyOzJizszNM1\WZnNCVkeHUh?=
LN-405MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MonjTWM2OD13LkezNFg2KM7:TR?=MmH4V2FPT0WU
HT-1376M2\1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2jSfmlEPTB;NT63PFA2OiEQvF2=MlnNV2FPT0WU
769-PM1uzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVrJR|UxRTVwOE[3NVgh|ryPNX6yPYp{W0GQR1XS
HuP-T3NIi0OVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFvpfppKSzVyPUWuPFg3PzdizszNNVPufplSW0GQR1XS
MDA-MB-415MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYmzNXlwUUN3ME21MlkzOTN7IN88US=>MX7TRW5ITVJ?
MKN7NXnSU|Z5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVPJR|UxRTVwOUi4JO69VQ>?NGHmT4RUSU6JRWK=
KS-1NHzNSo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFe1S|hKSzVyPUWuPVg5OzZizszNM2jweHNCVkeHUh?=
647-VNULuT4ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGnZWHJKSzVyPUWuPVkyPDhizszNM2HuUXNCVkeHUh?=
COLO-679M4TacWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYjJR|UxRTZwMECyOVUh|ryPMnTXV2FPT0WU
AN3-CAM{fQV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXfmdGtLUUN3ME22MlA{PDRzIN88US=>NWXvOoNSW0GQR1XS
C32MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWDJR|UxRTZwMUOwN|Qh|ryPMmPIV2FPT0WU
KM12MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3i0R2lEPTB;Nj6yOFA6QSEQvF2=NHrFd3pUSU6JRWK=
KINGS-1MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1flbWlEPTB;Nj6yOlE2OiEQvF2=NVjFW3RFW0GQR1XS
KYSE-410MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFPXOnJKSzVyPU[uN|A3PDVizszNM1exbnNCVkeHUh?=
HPAF-IINFXyOYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIHvSJRKSzVyPU[uN|U1QCEQvF2=NGXJWG1USU6JRWK=
LAN-6MmexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFjZbnBKSzVyPU[uOFk3OzFizszNNWDaXIt2W0GQR1XS
LU-99AMWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXLWO4NtUUN3ME22MlU2QTh7IN88US=>M1G2cnNCVkeHUh?=
SJSA-1M2rJXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXHJR|UxRTZwNU[zOFch|ryPMX;TRW5ITVJ?
MSTO-211HNVzId2VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVzIOWJvUUN3ME22MlczOjN|IN88US=>NU\WUpNKW0GQR1XS
SW900NGnzR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M17IbGlEPTB;Nj63OlIzOSEQvF2=NFLHdY9USU6JRWK=
LNCaP-Clone-FGCNV7meHN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4XhOGlEPTB;Nj64NFQxOyEQvF2=M3fVd3NCVkeHUh?=
OMC-1M2rVPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NELyfmZKSzVyPU[uPFU1ODJizszNNXK4PG96W0GQR1XS
IST-MEL1NEf2VHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXXNdodHUUN3ME22Mlg6PjZ7IN88US=>M1PoO3NCVkeHUh?=
TE-9MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUXJR|UxRTZwOEm4OFch|ryPMlnJV2FPT0WU
NCI-H2030MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M37Od2lEPTB;Nj65NVIzPiEQvF2=MVTTRW5ITVJ?
BFTC-909NILGfVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWLJR|UxRTdwMEC2OFEh|ryPNYXaRmRJW0GQR1XS
NCI-SNU-5M{HleGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGT2fppKSzVyPUeuNFIyPTlizszNNEXwN2VUSU6JRWK=
TE-5NXf5dmxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVvJb2xDUUN3ME23MlAzQDhzIN88US=>NFO3RlFUSU6JRWK=
SK-MES-1MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVfORlRQUUN3ME23MlA2PDJ5IN88US=>NXK1TFM5W0GQR1XS
SHP-77NFfkeotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVrJR|UxRTdwMUO5OVIh|ryPMWPTRW5ITVJ?
NCI-H1623MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFfRUIJKSzVyPUeuNVQxPzJizszNNH\qSlZUSU6JRWK=
TE-11MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1f5UGlEPTB;Nz6xOVE5PCEQvF2=NIm4b|hUSU6JRWK=
EKVXMn7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3LEZ2lEPTB;Nz6xPVI3PyEQvF2=MlT1V2FPT0WU
OVCAR-3NX\ZV|hMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEe2WXdKSzVyPUeuNlEyOzNizszNM3nl[XNCVkeHUh?=
C3AMn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkXRTWM2OD15LkO0OVIh|ryPM3rkU3NCVkeHUh?=
CFPAC-1NUfU[FY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWC4RmpHUUN3ME23MlM3OjJ{IN88US=>NX7TcHJSW0GQR1XS
MG-63M{LqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NI\3XHlKSzVyPUeuOFE5PDlizszNNFfufVNUSU6JRWK=
KYSE-140NHjQVnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3fsXWlEPTB;Nz60OFA3OSEQvF2=M2jqO3NCVkeHUh?=
MPP-89MoPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MW\JR|UxRTdwNUm3Nlkh|ryPMUPTRW5ITVJ?
COLO-824MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEnod2lKSzVyPUeuO|I5PjNizszNMnHRV2FPT0WU
SiHaNGLiUGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIHBO3JKSzVyPUeuPFM4ODdizszNNUP5fVE3W0GQR1XS
SNU-387NWHHVmNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NG[w[JlKSzVyPUeuPFU{PDdizszNM1\2Z3NCVkeHUh?=
A172MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX3JR|UxRTdwOE[xO|Ih|ryPM2f0b3NCVkeHUh?=
COLO-680NMnLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2PVWmlEPTB;Nz65NVc{KM7:TR?=MWLTRW5ITVJ?
HCC1395NXfmS3ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mo\5TWM2OD16LkC1OFUzKM7:TR?=M3v0WXNCVkeHUh?=
NCI-H28M4O5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4Xvc2lEPTB;OD6wOVk3OyEQvF2=M1TzOnNCVkeHUh?=
LC-2-adM2\JcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoX1TWM2OD16LkKxPVM4KM7:TR?=NV;ubJRmW0GQR1XS
S-117M2HDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVvJR|UxRThwMkWzOVMh|ryPMXfTRW5ITVJ?
NCI-H1838MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml;lTWM2OD16LkK1O|gyKM7:TR?=MnHuV2FPT0WU
PANC-10-05MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVrp[GNRUUN3ME24MlM4ODR5IN88US=>NX\IcWwzW0GQR1XS
KALS-1M{XCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{PsPGlEPTB;OD61NFkzQCEQvF2=M1riOHNCVkeHUh?=
LS-1034MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHPib4RKSzVyPUiuOVc1OzdizszNMoPoV2FPT0WU
TGBC1TKBNGjVeWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4HZeGlEPTB;OD63N|U{PSEQvF2=MlnSV2FPT0WU
OE19NGSy[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3jo[GlEPTB;OD63OlI3OiEQvF2=NFjybFlUSU6JRWK=
D-502MGMlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MojtTWM2OD16Lke2PVk1KM7:TR?=M4Pz[3NCVkeHUh?=
JEG-3MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHv1PZpKSzVyPUiuO|g3OThizszNMVXTRW5ITVJ?
DBTRG-05MGMkjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVW4UG5HUUN3ME24Mlg4PTZ3IN88US=>Mn\IV2FPT0WU
ME-180M2LpZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEPWXnBKSzVyPUmuNFY4OjVizszNMXrTRW5ITVJ?
NCI-H1573NGL1OIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3fFdWlEPTB;OT6xNFU{OiEQvF2=MmHWV2FPT0WU
HCC2998MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmjSTWM2OD17LkGzOlgyKM7:TR?=MYPTRW5ITVJ?
ACHNMWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUHJR|UxRTlwMkS5O|Uh|ryPNYT6S5N2W0GQR1XS
D-392MGMWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mk[xTWM2OD17LkK1O|E2KM7:TR?=Ml[xV2FPT0WU
no-11MmG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX25So5jUUN3ME25MlI3ODJ6IN88US=>MVjTRW5ITVJ?
KLENY\kN|g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXnrO3lbUUN3ME25MlMzOjN{IN88US=>MYPTRW5ITVJ?
Calu-6Ml3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnOwTWM2OD17LkO3OVI5KM7:TR?=MnvIV2FPT0WU
LB831-BLCNFPoPIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlztTWM2OD17LkS1NVcyKM7:TR?=NEj4RlVUSU6JRWK=
SW684NXnETnRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEjlfYlKSzVyPUmuOFYyOTZizszNMkDOV2FPT0WU
SH-4MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{PNdmlEPTB;OT60PVM3PCEQvF2=MnS1V2FPT0WU
IST-MES1MlrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3\JTWlEPTB;OT61NVY1PCEQvF2=MWjTRW5ITVJ?
Saos-2MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF[0SllKSzVyPUmuOVIyQTVizszNNXrSc2FXW0GQR1XS
NCI-H2087NILiNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHf1[llKSzVyPUmuOlc{PTJizszNMUfTRW5ITVJ?
SCC-9NYLoWIxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NILxdXJKSzVyPUmuO|E5OTZizszNNF2wUpNUSU6JRWK=
MFE-280NHv0TodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoLYTWM2OD17LkeyO|g2KM7:TR?=MlW3V2FPT0WU
BENMluxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4jifmlEPTB;OT64NlE2QSEQvF2=MlXqV2FPT0WU
CP50-MEL-BM1mzWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYDJR|UxRTlwOUK0N|Ih|ryPNGX5eWFUSU6JRWK=
SK-MEL-28NXW5e4RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFPMfm9KSzVyPUGwMlAyQTNizszNMXzTRW5ITVJ?
NCI-H2452NUTWWld3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHuxbWVKSzVyPUGwMlE3KM7:TR?=NVXmNnhLW0GQR1XS
NCI-H1395NXr5UHZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MojhTWM2OD1zMD6xO|gh|ryPNWLlfGY3W0GQR1XS
NCI-H2052M4fB[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYLJR|UxRTFyLkG4PFIh|ryPMUXTRW5ITVJ?
A375NUK0NW05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NX\Cb29tUUN3ME2xNE4zPDV{IN88US=>Mo\RV2FPT0WU
HCC38MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1WxUWlEPTB;MUCuN|IzKM7:TR?=MnPuV2FPT0WU
LK-2M4LuOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVzJR|UxRTFyLkSyNFgh|ryPM4nVU3NCVkeHUh?=
SF126NHSw[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX;3UXd2UUN3ME2xNE41PzJ5IN88US=>NV;vdHI1W0GQR1XS
SK-MEL-1M2nnNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXy1e5htUUN3ME2xNE44QDN6IN88US=>M2n1dXNCVkeHUh?=
ACNNVjCZ3pxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV7JR|UxRTFyLki2O|kh|ryPMmj2V2FPT0WU
BB30-HNCNInvbZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUfReXd{UUN3ME2xNE45PzFzIN88US=>MWHTRW5ITVJ?
NCI-H747MmrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUHQNph2UUN3ME2xNE45PzR4IN88US=>M3XZWnNCVkeHUh?=
KYSE-150NEfRWnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV3DWFc5UUN3ME2xNU4xOzh5IN88US=>NWexOHNoW0GQR1XS
D-247MGMXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmnKTWM2OD1zMT6xNFA6KM7:TR?=M1ziVHNCVkeHUh?=
BxPC-3NVLzOGhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVrxR3MzUUN3ME2xNU4{PzR5IN88US=>NGK1SGpUSU6JRWK=
SK-MEL-30NELSXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkX4TWM2OD1zMT60NFc6KM7:TR?=NEfMPIVUSU6JRWK=
CAS-1NH7SWo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGn5OFlKSzVyPUGxMlQyODlizszNNFHheVZUSU6JRWK=
no-10MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVHkWpYxUUN3ME2xNk4yOjF5IN88US=>NHXwOVVUSU6JRWK=
NCI-H2405MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnrCTWM2OD1zMj6yNFM3KM7:TR?=NEDSbXhUSU6JRWK=
KGNNE\1UY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEjWdWtKSzVyPUGyMlI6ODFizszNMkTIV2FPT0WU
BB49-HNCM{izcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGTENmtKSzVyPUGyMlM6PTZizszNMXHTRW5ITVJ?
NCI-H1693NFWx[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnHBTWM2OD1zMj61PFE3KM7:TR?=M{PyNXNCVkeHUh?=
RO82-W-1Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXTJeWMyUUN3ME2xN{4xPjR7IN88US=>MVnTRW5ITVJ?
CAL-85-1NEDhVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{\kfWlEPTB;MUOuOFM6QSEQvF2=M4\V[HNCVkeHUh?=
H-EMC-SSNXzOdI9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUTJR|UxRTF|LkmxNFQh|ryPNUHESId4W0GQR1XS
SW1783NF:yOW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUH2bHJlUUN3ME2xOE4zOzlzIN88US=>NIHYOm9USU6JRWK=
LB771-HNCMkmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{j0[WlEPTB;MUSuOFE6KM7:TR?=MoDEV2FPT0WU
HCC70NYTsfoZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn\oTWM2OD1zND60NlM{KM7:TR?=NVvtdZg{W0GQR1XS
KNS-81-FDNXK4NFVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXfiVIx6UUN3ME2xOE44ODR3IN88US=>MYHTRW5ITVJ?
KYSE-520NFe2cohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2rOPGlEPTB;MUSuPVI4KM7:TR?=M2HGVXNCVkeHUh?=
TGBC24TKBM3TKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4jmO2lEPTB;MUSuPVU{QSEQvF2=NF60RmRUSU6JRWK=
SNB75MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn3KTWM2OD1zNT6wO|I6KM7:TR?=MU\TRW5ITVJ?
SW872MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVjiepJKUUN3ME2xOU4zOjF6IN88US=>MWXTRW5ITVJ?
U031MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFLy[HhKSzVyPUG1MlgxOjhizszNNFXhboxUSU6JRWK=
ChaGo-K-1M4X1O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmrVTWM2OD1zNT64N|U6KM7:TR?=NGTKc3RUSU6JRWK=
NCI-H441M17wTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3rWO2lEPTB;MU[uNFA{QSEQvF2=MUDTRW5ITVJ?
TE-12MmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHm4RmtKSzVyPUG2MlE5PzNizszNNEXqeppUSU6JRWK=
NCI-H1755MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3GybGlEPTB;MU[uOVc{KM7:TR?=MX7TRW5ITVJ?
KNS-42MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXnJR|UxRTF4Lk[1PFkh|ryPM4TCdXNCVkeHUh?=
SK-PN-DWMXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4fVdWlEPTB;MUeuOFIxOSEQvF2=MoTPV2FPT0WU
NCI-H226NUTY[4hNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUHJR|UxRTF5LkmzOFUh|ryPNGfFdYhUSU6JRWK=
K-562NVfuOFI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXnXfXh6UUN3ME2xPE43OzF5IN88US=>Mn7QV2FPT0WU
A388NWn2cYhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYn6PW5yUUN3ME2xPU4xOzB|IN88US=>MlvPV2FPT0WU
ZR-75-30NI\BV4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVHJR|UxRTF7LkC5Olgh|ryPMXnTRW5ITVJ?
LU-135NHjWXXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnnITWM2OD1zOT6yOlM3KM7:TR?=MVfTRW5ITVJ?
NCI-H2029MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWP3PYRtUUN3ME2xPU43ODJzIN88US=>MYPTRW5ITVJ?
HT-1197MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVXQRVVPUUN3ME2xPU46OjJ5IN88US=>NG\XNIlUSU6JRWK=
IGR-1NVvOcld3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnLhTWM2OD1{MD6zNVE4KM7:TR?=M3\UUHNCVkeHUh?=
U-87-MGM{jmSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NITVZWdKSzVyPUKwMlY1OTNizszNM{XqfnNCVkeHUh?=
NCI-H1304M{G1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIfjfHdKSzVyPUKwMlc2ODFizszNM4TGVnNCVkeHUh?=
RCC10RGBM1\td2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NITnbotKSzVyPUKxMlI5OjlizszNNXrpR4xmW0GQR1XS
NCI-H520M2HsVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYjTOI9QUUN3ME2yNk44PjFzIN88US=>NIrtN4hUSU6JRWK=
SK-LU-1NFqyUmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXHx[HRtUUN3ME2yN{4xPzF6IN88US=>M{HpNHNCVkeHUh?=
UACC-893NVnG[JdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYTLT2pYUUN3ME2yN{4yODN6IN88US=>M{DqS3NCVkeHUh?=
NCI-H2347M17rUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{PxT2lEPTB;MkOuNlY4PCEQvF2=MWTTRW5ITVJ?
U-118-MGNFTY[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4Wwd2lEPTB;MkOuO|IyPyEQvF2=M{PxO3NCVkeHUh?=
NCI-H596M4mwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXXJR|UxRTJ|LkmwOVUh|ryPM1PsTnNCVkeHUh?=
MZ1-PCM2TyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFrCfJBKSzVyPUK0MlY4PTlizszNM4XCenNCVkeHUh?=
SW1417MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmjsTWM2OD1{NT6yOFk5KM7:TR?=MYXTRW5ITVJ?
NCI-H82M4\Nbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3[3TmlEPTB;Mk[uOFI5QCEQvF2=NF:4S5VUSU6JRWK=
COLO-678NHzVT3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3X0[GlEPTB;MkeuOFkyQSEQvF2=NGi4RpNUSU6JRWK=
KURAMOCHIMnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVK2SFR[UUN3ME2yPE4yOjZizszNNWT5bVh{W0GQR1XS
NCI-H1650MmnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFrucZBKSzVyPUOwMlE6OjRizszNNYPERoxOW0GQR1XS
HCC1954NUXtR4pbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHTOVpdKSzVyPUOxMlM3PjZizszNMV7TRW5ITVJ?
GAKMYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1HoWGlEPTB;M{KuNlYyPiEQvF2=NFOwW4xUSU6JRWK=
YAPCM3y3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX;JR|UxRTN|Lke2OFgh|ryPNELC[3dUSU6JRWK=
NCI-H2228MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlnPTWM2OD1|ND6zOlA2KM7:TR?=NXTtdI5[W0GQR1XS
VMRC-RCZNWPmTGNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmL0TWM2OD1|Nj6zNFIzKM7:TR?=MnS1V2FPT0WU
NMC-G1M1XZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXzJR|UxRTN5LkC1Nlkh|ryPMmTsV2FPT0WU
D-336MGM16wWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3nVTmlEPTB;NEGuPFQ1OiEQvF2=NVXn[nJbW0GQR1XS
UACC-62NFz1d|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlvMTWM2OD12Mj61OVA2KM7:TR?=NYC4bpNxW0GQR1XS
C-33-AMl;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlTITWM2OD12NT6zNlU3KM7:TR?=MoLZV2FPT0WU
HCC1937NHrpeVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnuwTWM2OD12Nz6xPVU5KM7:TR?=NF70cHBUSU6JRWK=
HDLM-2NILSdY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEHMVpJKSzVyPUS3MlIzQDdizszNMoDwV2FPT0WU
NCI-H727MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFLmN2hKSzVyPUS3MlI1PTFizszNM3vVWXNCVkeHUh?=
NYM4XpfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mk\sTWM2OD12OT6zPVA5KM7:TR?=M3nqdHNCVkeHUh?=
NCI-H2291M1vhN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{LtNWlEPTB;NEmuPFMxOSEQvF2=NFrVTYVUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]
Features

Protocol(Only for Reference)

Kinase Assay:

[1]

Immunoprecipitation-HDAC assays The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.

Cell Assay:

[2]

Cell lines LNCaP, PC-3, and TSU-Pr1
Concentrations Dissolved in DMSO, final concentrations ~7.5 μM
Incubation Time 1, 2, 3 and 4 days
Method

Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.

Animal Study:

[2]

Animal Models Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
Formulation Dissolved in DMSO
Dosages ~100 mg/kg/day
Administration Injection i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Richon VM, et al. Proc Natl Acad Sci U S A, 1998, 95(6), 3003-3007.

[2] Butler LM, et al. Cancer Res, 2000, 60(18), 5165-5170.

view more

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02707900 Not yet recruiting HIV-1 Infection Cynthia L Gay, MD|National Institute of Allergy and Infec  ...more Cynthia L Gay, MD|National Institute of Allergy and Infectious Diseases (NIAID)|University of North Carolina, Chapel Hill March 2016 Phase 1
NCT02638090 Recruiting Lung Cancer|Non-small Cell Lung Cancer H. Lee Moffitt Cancer Center and Research Institute|Merck  ...more H. Lee Moffitt Cancer Center and Research Institute|Merck Sharp & Dohme Corp. February 2016 Phase 1|Phase 2
NCT02619253 Recruiting Renal Cell Carcinoma|Urinary Bladder Neoplasms Roberto Pili|Indiana University January 2016 Phase 1|Phase 2

view more

Chemical Information

Download Vorinostat (SAHA, MK0683) SDF
Molecular Weight (MW) 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 53 mg/mL (200.52 mM)
Ethanol 3 mg/mL (11.35 mM)
Water <1 mg/mL (<1 mM)
In vivo 2% DMSO+30% PEG 300+ddH2O 5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name N1-​hydroxy-​N8-​phenyl-octanediamide

Frequently Asked Questions

  • Question 1
    What’s the recommendation about reconstitution of the compound for in vivo animal study?

    Answer: We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related HDAC Products

  • LMK-235

    LMK-235 is a selective inhibitor of HDAC4 and HDAC5 with IC50 of 11.9 nM and 4.2 nM, respectively.

  • CAY10603

    CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs.

  • 4SC-202

    4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.

  • Panobinostat (LBH589)

    Panobinostat (LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Phase 3.

  • Entinostat (MS-275)

    Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Phase 3.

  • Trichostatin A (TSA)

    Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM in cell-free assays.

  • Romidepsin (FK228, Depsipeptide)

    Romidepsin (FK228, depsipeptide) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively.

    Features:More effective than other classical HDAC inhibitors such as TSA, TPX, and butyrate.

  • RGFP966

    RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.

  • Tubastatin A

    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).

  • Mocetinostat (MGCD0103)

    Mocetinostat (MGCD0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Phase 2.

Recently Viewed Items

Tags: buy Vorinostat (SAHA, MK0683) | Vorinostat (SAHA, MK0683) ic50 | Vorinostat (SAHA, MK0683) price | Vorinostat (SAHA, MK0683) cost | Vorinostat (SAHA, MK0683) solubility dmso | Vorinostat (SAHA, MK0683) purchase | Vorinostat (SAHA, MK0683) manufacturer | Vorinostat (SAHA, MK0683) research buy | Vorinostat (SAHA, MK0683) order | Vorinostat (SAHA, MK0683) mouse | Vorinostat (SAHA, MK0683) chemical structure | Vorinostat (SAHA, MK0683) mw | Vorinostat (SAHA, MK0683) molecular weight | Vorinostat (SAHA, MK0683) datasheet | Vorinostat (SAHA, MK0683) supplier | Vorinostat (SAHA, MK0683) in vitro | Vorinostat (SAHA, MK0683) cell line | Vorinostat (SAHA, MK0683) concentration | Vorinostat (SAHA, MK0683) nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us