Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 100 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NVnDUYk2U2mwYYPlJGF{e2G7 M4jNc|EhcA>? NGXIWIZFVVOR MkDUZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP MljZNVE6PjB2OEm=
Friend leukemic cell NGPOSnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUW1NEDPxE1? NXfjdJp7PzJiaB?= M3XmR2ROW09? NXLzSm9wUUN3ME2wMlk6KM7:TR?= MkHPNVIyODl7MUO=
K562 M1zn[mtqdmG|ZTDBd5NigQ>? M4DmNVYhcA>? MX;EUXNQ M4fjVmlvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> M3G1UFEzPDF7M{iw
HT1080 MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzVXVBoPzJiaB?= NXzB[YExTE2VTx?= M4SxNmlEPTB;Mj60JO69VQ>? MlXJNVIzPzBzN{W=
H1299 NXjQOFZFU2mwYYPlJGF{e2G7 M1u4TVIxKG2rbh?= MkLrSG1UVw>? Mk\iTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= Mn3aNVQ2OjF2MkK=
H1299 NWjUUWlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPWO|IhcA>? NITQbohFVVOR MYjJR|UxRTdwMkSg{txO NWPKZ4dzOTR3MkG0NlI>
HeLa MVzLbY5ie2ViQYPzZZk> MnrpN|AhdWmw M17ERWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHjpd5RwdmViZHXhZ4V1gWyjc3Wge4l1cCCLQ{WwJI9nKDBwMkig{txO NGX4XmQyPTZyM{m0PS=>
LOX-IMVI NInRXnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID4UpE1QCCq M2DwSWlEPTB;MT6zJO69VQ>? MXOxOVcyPTR5MB?=
NCI-H226 NEXCe2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPheo1xPDhiaB?= MYfJR|UxRTJwNjFOwG0> MV2xOVcyPTR5MB?=
RXF-631L NGPnRnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDrSG41QCCq MlXKTWM2OD1{IN88US=> Mn7GNVU4OTV2N{C=
SNB-78 M2XnOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnSxOFghcA>? MX3JR|UxRTF4IN88US=> MkHmNVU4OTV2N{C=
St-4 NXPZToxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrsV3lrPDhiaB?= NFrIWGtKSzVyPUWuNkDPxE1? M4WyPFE2PzF3NEew
ARP1 MU\GeY5kfGmxbjDBd5NigQ>? MnyyNkDPxE1? MV:2JIg> NXK2[m1xUW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v MXqxOFc{PDhyNh?=
CEM MWPLbY5ie2ViQYPzZZk> NYP2Z|ZKOSCq NVHtd242TE2VTx?= NUjQ[ZBOUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM{KM7:TR?= MXOxOlQzODB4NB?=
HCT15 NIf2bFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETBb2w1QCCq Mni4S2k2OD1yLkiyJO69VQ>? MXexOlczOzJ{Nx?=
NCI-H23 NG\6W3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LWe|Q5KGh? MXnHTVUxRTBwOUKg{txO NUewc2dKOTZ5MkOyNlc>
GM15850 M1;KRmtqdmG|ZTDBd5NigQ>? NXS0U5VHOi53IN88US=> M1noN|k3KGh? NGTJR25FVVOR NGfsfXZKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NHW3VpoyPjl{MUO2Oy=>
GM15850 M{HlZ2tqdmG|ZTDBd5NigQ>? MVGyMlUh|ryP NIPxWmc6PiCq Ml\oSG1UVw>? MnrzTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEWgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MmDkNVY6OjF|Nke=
GM15850 NIPSUYVMcW6jc3WgRZN{[Xl? NHy1Z5AzNjVizszN NEW0ZY06PiCq NXjNNng3TE2VTx?= M3nFPWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxNkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NFXJSGUyPjl{MUO2Oy=>
GM15850 MmG0T4lv[XOnIFHzd4F6 MWiyMlUh|ryP M2\LR|k3KGh? M{\HT2ROW09? NXnZWmVSUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NEHI[4QyPjl{MUO2Oy=>
GM15850 NGPLbYFMcW6jc3WgRZN{[Xl? M33sV|IvPSEQvF2= NWDmXWg1QTZiaB?= MUDEUXNQ NFPpTo5KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M{nQcVE3QTJzM{[3
GM15850 M{nwXmtqdmG|ZTDBd5NigQ>? Mo\BNk42KM7:TR?= MVW5OkBp MmHHSG1UVw>? MUnJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMU[gZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MoDpNVY6OjF|Nke=
U937 NGXP[mZHfW6ldHnvckBCe3OjeR?= MXS1JO69VQ>? NIDvSXIzPCCq NYTVTnNXTE2VTx?= NVzYOIh1S2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= MVKxO|AxPDdzOB?=
H661 Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jld|Q5KGh? NInnVodKSzVyPUGg{txO NUTwO3BrOTdzNUewNFk>
U937 MoDBSpVv[3Srb36gRZN{[Xl? M1S3VFUh|ryP NWTM[ndkOjRiaB?= M{mwTGROW09? M2HK[2lv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= MmDWNVc1PDd5NUC=
U937 MV3GeY5kfGmxbjDBd5NigQ>? NWPLOIRFOSEQvF2= NYXSfnZmOjRiaB?= NH60NpZFVVOR NU\ifpRITW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> MmH4NVc1PDd5NUC=
RAW264.7 MX\GeY5kfGmxbjDBd5NigQ>? NV\FWFlwOTBizszN NHLGPYkzPGh? MmK2e4F1\XJ? MXfJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP MU[xO|Q4PzVzOB?=
RAW264.7 NF;lO45HfW6ldHnvckBCe3OjeR?= M{O0[|ExKM7:TR?= MUGyOIg> MUj3ZZRmeg>? NFzGN5BKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKE6RIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDFwOEig{txO MV6xO|Q4PzVzOB?=
SC9 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUO0PEBp NH3IXVBKSzVyPUCuOlA3KM7:TR?= MUexO|UxPzJzOR?=
ST14A MYjGeY5kfGmxbjDBd5NigQ>? NHvFXFE2KG6P MknMO|IhcA>? MVrJcoNz\WG|ZTDpckBTTVOWL17SV2YhdVKQQTDlfJBz\XO|aX;u MX:xO|U3PTl7Mx?=
ST14A MmPxSpVv[3Srb36gRZN{[Xl? MVq1JI5O MUm3NkBp NIn1eo1KdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= NIX6c|IyPzV4NUm5Ny=>
PANC1 MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWexJO69VQ>? M2\sXmlEPTB;MD60OUDPxE1? NUezcmF4OTd3OEi3OFQ>
PANC1 MlriSpVv[3Srb36gRZN{[Xl? MXyxJO69VQ>? MVGyOEBp NXzJe2g4UW6lcnXhd4UhcW5icEKxW2FHOS:FSWCxJIdmdmViZYjwdoV{e2mxbh?= NGrRZXMyPzV6OEe0OC=>
PANC1 NUjuNIllTnWwY4Tpc44hSXO|YYm= MVKxJO69VQ>? MYCyOEBp MXvJcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= M4T0VVE4PTh6N{S0
PT45 M2fiUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjsR|V2UUN3ME20JO69VQ>? M1fXO|E4PTh6N{S0
ACHN MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVuyNUBp NY\oeHRCT0l3ME2wMlY2KM7:TR?= NUiydlZSOTd4NkK2NFY>
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SCC25 NYfJV4xMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPCSos4OiCq M3;O[2lEPTB;MT65N{DPxE1? MUeyNFE1Ozd5OB?=
SKHEP1 NYfkXXdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moj3O|IhcA>? MofhTWM2OD1|LkS2JO69VQ>? MnPCNlAyPDN5N{i=
BJ M4XSS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDzVIoyODBizszN MVm0PEBp MonqSG1UVw>? NYe2U29bT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> M4XjNFIxOTR|OESw
MUF MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ztdVExOCEQvF2= MVG0PEBp M4KxXGROW09? M2C4dGdzd3e2aDDpcohq[mm2aX;uJIF1KDBwMEWgeI8hOTByIIXN M{jxWlIxOTR|OESw
Caco-2 NEjtPJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWGxNFAh|ryP M{j2U|Q5cA>? NEDXXG1FVVOR M4rWUGlEPTB;OD6xJO69VQ>? NVjxRotnOjBzNEO4OFA>
Caco-2 M1z4O2tqdmG|ZTDBd5NigQ>? NVzEfWhLPSEQvF2= MoLaOEBp MlPPSG1UVw>? MXLJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszN NInFfVYzODF2M{i0NC=>
Caco-2 MlywT4lv[XOnIFHzd4F6 NW\wVHIyOC5|MU[gcm0hfG9iM{GuOkDPxE1? MmPtOEBp MVvEUXNQ M{\X[mV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMTD3bZRpKEmFNUCgc4YhOC5zMUmg{txO M32xdFIxOTR|OESw
Caco-2 NXnDc2R7U2mwYYPlJGF{e2G7 MYqwMlMyPiCwTTD0c{A{OS54IN88US=> MlixOEBp MWPEUXNQ M4fhUGV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMzD3bZRpKEmFNUCgc4YhOC5zNEeg{txO MlXBNlAyPDN6NEC=
Caco-2 M1PHemtqdmG|ZTDBd5NigQ>? M4WxPVYvOzJibl2geI8hPjN{IN88US=> NIHzVHo1KGh? NF;pZlhFVVOR NV;uPJBnTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO1JJdqfGhiSVO1NEBw\iBzMj62JO69VQ>? MmD6NlAyPDN6NEC=
Caco-2 NUnMTY9vU2mwYYPlJGF{e2G7 MXW2MlMzKG6PIITvJFY{OiEQvF2= MlPQOEBp M{\DPWROW09? MmXKSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2= MmjsNlAyPDN6NEC=
Caco-2 MV;LbY5ie2ViQYPzZZk> MY[wMlMyPiCwTTD0c{A{OS54IN88US=> NH\K[lg1KGh? MmjiSG1UVw>? Mn;xSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN4 NUK3NXlCOjBzNEO4OFA>
HepG2 M{fZZWtqdmG|ZTDBd5NigQ>? NF7JVZk2KM7:TR?= M3XBZ|Zp NYHkS3BCTE2VTx?= NEn2OnFKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9v MUeyNFE1Ozh2MB?=
HepG2 NH;FdYVMcW6jc3WgRZN{[Xl? NEm4[IE2KM7:TR?= Mn;BOog> NYLnbnl3TE2VTx?= MWLJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHj5dIVz[WOndInsZZRqd25? MlSwNlAyPDN6NEC=
HepG2 MYXLbY5ie2ViQYPzZZk> MkniOUDPxE1? M2L1VFZp NVjidpR1TE2VTx?= Ml\YTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= M3LlclIxOTR|OESw
HepG2 NFzsXIZMcW6jc3WgRZN{[Xl? MV61JO69VQ>? NIPjOnQ3cA>? NEjuU|VFVVOR MXTJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDIN{9JPCCqaYP0c45mKGGlZYT5cIF1cW:w Moq1NlAyPDN6NEC=
COLO205 NYfxNYNuU2mwYYPlJGF{e2G7 NWHvUpdJOTBizszN NVPUdocyOjRiaB?= NULlU3FQTE2VTx?= MnnsTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiC5aYToJGlEPTBib3[gNk4zKM7:TR?= M37MdFIxPDVzM{e4
SCC4 Mn\qT4lv[XOnIFHzd4F6 NYHuc5A6OSEQvF2= NHmyT4gzPGh? MVfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5idIXieYxqdiCjY3X0fYxifGmxbh?= NHnEZYszODR3MkKyOS=>
SCC4 NEfDNWRMcW6jc3WgRZN{[Xl? M1jhXlEh|ryP M17UTFI1cA>? M4rONGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIHHj[ZR6dGG2aX;u MWKyNFQ2OjJ{NR?=
SCC4 NHHsNVNHfW6ldHnvckBCe3OjeR?= NVLsWWI1OSEQvF2= NYDqNWt[PSCvaX6= NFjoOphC\2:waYP0JIFkfGm4aYT5JIF1KF[GUjDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiQ2nQNlQh\2WwZTDlfJBz\XO|aX;u M2DkT|IxPDV{MkK1
NB4 MWLGeY5kfGmxbjDBd5NigQ>? NH7OPVA2KM7:TR?= M3XZVFI1KGh? MYrEUXNQ MWLD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn MmHqNlA1QTF2NEC=
NB4 MlLXT4lv[XOnIFHzd4F6 NH3LOmI2KM7:TR?= MlPjNlQhcA>? MlTNSG1UVw>? M{DKe2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? MVKyNFQ6OTR2MB?=
NB4 NYLhc4YyTnWwY4Tpc44hSXO|YYm= MlX5OUDPxE1? MXmyOEBp NGH5RYJFVVOR NUPuPIVZUW6mdXP0bY9vKG:oIICyNXdCTjFxQ1nQNUBmgHC{ZYPzbY9v M1\mOVIxPDlzNESw
NB4 MoHaT4lv[XOnIFHzd4F6 NWD5TVFjPSEQvF2= NELpeG0zPCCq NHzPW5BFVVOR MULJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> M3z5NlIxPDlzNESw
NUGC3 M33h[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3zS2k2OD1{Lkm0JO69VQ>? M2fndlIxQDVyOUex
A549 NIXiVG9HfW6ldHnvckBCe3OjeR?= Mmj6OUDPxE1? M4LNZ|MhcA>? Mn;mSG1UVw>? NVLrV3h6UW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK M4fkRVIxQDV3MkC4
HUT78 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnhcoI4OiCq NWm3R5JDTE2VTx?= MYfHTVUxRTBwMzFOwG0> MYGyNFg5PDJyOB?=
U937 MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXK3NkBp NXfxZlRVTE2VTx?= NX23c5UyT0l3ME2wMlM6KM7:TR?= NWfySYdwOjB6OESyNFg>
A431 Mn:5R5l1d3SxeHnjJGF{e2G7 MYK3NkBp NInIOZBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2= M3PyRVIyODhyNkK5
A549 NXX6Wo5US3m2b4TvfIlkKEG|c3H5 MkX6O|IhcA>? M3rNWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMhd3[ncnX4dJJme3OrbnegTGRCSyC5aYToJGlEPTBib3[gNU45KM7:TR?= MoXmNlExQDB4Mkm=
CAL27 NH65Om1EgXSxdH;4bYMhSXO|YYm= MVi3NkBp MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRWwzPyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjCzMlIh|ryP NE\3dHIzOTB6ME[yPS=>
HeLa MWDDfZRwfG:6aXOgRZN{[Xl? MVe3NkBp MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuOUDPxE1? NUK1SoJNOjFyOEC2Nlk>
Sf21 M3vyRmtqdmG|ZTDBd5NigQ>? MnjPN{Bp NFTEWFdKdmirYnn0bY9vKG:oIF\sZYchfGGpZ3XkJIh2dWGwIILlZ49u[mmwYX70JGhFSUN6IHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOS5{IN88US=> MkfWNlExQDB4Mkm=
SKBR3 M3zYdmN6fG:2b4jpZ{BCe3OjeR?= NWW3U2d3PzJiaB?= MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlYh|ryP MVGyNVA5ODZ{OR?=
SKOV3 MVHDfZRwfG:6aXOgRZN{[Xl? M3K0SVczKGh? MnXXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= NHrJXWMzOTB6ME[yPS=>
COR-L23 M2XBcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G0cVExKM7:TR?= NWrUOlRXPzJiaB?= NHnnb3hFVVOR NXP2R29DT0l3ME2xMlEh|ryP Mmn2NlExQDB4NEe=
DU145 NE\lbo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnaTnJEOTBizszN MkXrO|IhcA>? NFnqb4RFVVOR MXrHTVUxRTFwMEWg{txO MUKyNVA5ODZ2Nx?=
LoVo NXjlcG9OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnXWGljOTBizszN MWG3NkBp NV7nW5luTE2VTx?= MXfHTVUxRTFwNzFOwG0> MY[yNVA5ODZ2Nx?=
MCR5-SV2 NIn0blRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVWxNEDPxE1? M{jqVVczKGh? Mni2SG1UVw>? M4TQRWdKPTB;Mj6xJO69VQ>? NGHKVIMzOTB6ME[0Oy=>
HCT116 NV6xcYw6U2mwYYPlJGF{e2G7 MUGzNEDPxE1? NHL6[VI{OCCq MWrEUXNQ MULJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w MWiyNVA5ODZ2Nx?=
HCT116 MontT4lv[XOnIFHzd4F6 NF2zXnU{OCEQvF2= NFzTUYM{OCCq NXHuOosxTE2VTx?= M1uwfmlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFNMQSCjY3X0fYxifGmxbh?= MX6yNVA5ODZ2Nx?=
U937 MVjLbY5ie2ViQYPzZZk> NFnSS2E2KM7:TR?= MXuyOEBp M4PLe2ROW09? M{LxbmlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEt7 Ml\NNlEzQTJ2OUK=
U937 NV[yWHJtU2mwYYPlJGF{e2G7 MlTuOUDPxE1? NFPDepgzPCCq NFfIUIVFVVOR NVzQeldTUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 MWeyNVI6OjR7Mh?=
U937 MorhT4lv[XOnIFHzd4F6 NXjyWJFJPSEQvF2= NHe0XoozPCCq NE\hdpVFVVOR NWW3[JVbUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHCjbj3hZ4V1gWyjdHXkJIhqe3SxbnWgTFQhdGW4ZXy= M3eyfVIyOjl{NEmy
U937 MkjTT4lv[XOnIFHzd4F6 NH62XXE2KM7:TR?= NXvMNlQ6OTVibXnu NG\VSoJFVVOR NHjy[WpKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? MYmyNVI6OjR7Mh?=
A2780 M{m0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXW5OkBp NEjtbohFVVOR MXTJR|UxRTFwNkKg{txO Ml6wNlE3OzR2M{C=
COLO205 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDKTmpwQTZiaB?= MnrSSG1UVw>? NEDJPXRKSzVyPUKuNVIh|ryP MmPkNlE3OzR2M{C=
Hep3B NHjaRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVG0PEBp MWDEUXNQ NInPSHlIUTVyPUGuNlEh|ryP NYf3UGxwOjF5MUKxOFY>
GM11272 MUTGeY5kfGmxbjDBd5NigQ>? MUOxNFAhdk1? MlruO|IhcA>? NXfRe|g1TE2VTx?= NHLiV5VT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O MXKyNVg1ODdzNh?=
CFBE41o MYnLbY5ie2ViQYPzZZk> M37sSFUh|ryP NEHxRpdFVVOR NWHXW2J3TG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP MmfpNlE6QDR7NUi=
CFBE41o MV\GeY5kfGmxbjDBd5NigQ>? MVKxJO69VQ>? M3nTXlI1KGh? MnziSG1UVw>? NYD2S2FoWmW|dH;yZZRqd25ib3[gR2ZVWiCmZXz0ZWY2ODhibYX0ZY51KHS{YX\mbYNscW6pIITvJINmdGxic4Xy[oFk\SCjczDncJlkd2[xcn3z MYqyNVk5PDl3OB?=
DU145 NELiPWFMcW6jc3WgRZN{[Xl? M3Tie|IvPSEQvF2= NGjlO|AzPCCq MoD3SG1UVw>? MlLWTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW|c3nvci=> NFy1cHczOjJ4MEG2Oi=>
DU145 NWD3cXNVU2mwYYPlJGF{e2G7 MVO1JO69VQ>? M17SPVI1KGh? M{LWWWROW09? M2nBdGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u NELpZ4YzOjJ4MEG2Oi=>
DU145 MWPLbY5ie2ViQYPzZZk> NF\TW3I2KM7:TR?= MmjJNlQhcA>? Mlm0SG1UVw>? M4\QbWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh|IHj5dIVz[WOndInsZZRqd25? NWOyWXNpOjJ{NkCxOlY>
786-0 NYnlb2RYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXK2MlIh|ryP M4faR|czKGh? M17XTWROW09? MYjHTVUxRTNwMjFOwG0> MYmyNlQ{PTZ4OR?=
A498 MmeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXmOk4zKM7:TR?= Ml;NO|IhcA>? NWflXY0yTE2VTx?= NGeyNpZIUTVyPUGuOkDPxE1? M4HzNFIzPDN3Nk[5
A549/ATCC MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVq2MlIh|ryP MnjLO|IhcA>? NGHXSYJFVVOR M4jofWdKPTB;MT62JO69VQ>? MmHINlI1OzV4Nkm=
ACHN M2DnXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVq2MlIh|ryP NXn6V4RUPzJiaB?= NWDPRoFCTE2VTx?= NX7QcYtlT0l3ME2xMlMh|ryP Ml\sNlI1OzV4Nkm=
BT549 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrmSHp{Pi5{IN88US=> MV:3NkBp Ml2ySG1UVw>? MkTES2k2OD1zLkOg{txO MVqyNlQ{PTZ4OR?=
EKVX M1\zPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjCR25RPi5{IN88US=> NEjI[po4OiCq MVjEUXNQ NWfhfnNbT0l3ME2xMlMh|ryP NGTt[IMzOjR|NU[2PS=>
HCT15 NH7pfotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrpT|Y3NjJizszN M2PRTVczKGh? NU\NcWlHTE2VTx?= NVnxbJUyT0l3ME2yMlUh|ryP NE[zW3MzOjR|NU[2PS=>
HOP92 Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfOV3FDPi5{IN88US=> NWfN[I43PzJiaB?= MVHEUXNQ M4jxNWdKPTB;NDFOwG0> MVSyNlQ{PTZ4OR?=
IGROV1 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHqfI43NjJizszN M4[2dVczKGh? MoXMSG1UVw>? NV73e4VVT0l3ME2xMlMh|ryP NXLNT3g2OjJ2M{W2Olk>
LOXIMVI MofRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2CwTVYvOiEQvF2= NYj0Z|g1PzJiaB?= MmLJSG1UVw>? NWfVd4VDT0l3ME2xJO69VQ>? NITJUFIzOjR|NU[2PS=>
M14 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnGV3lDPi5{IN88US=> MXu3NkBp NYq1XI4yTE2VTx?= NITxVlJIUTVyPUGuN{DPxE1? MmfNNlI1OzV4Nkm=
MALME-3M M2q4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv5Ok4zKM7:TR?= NGTES|k4OiCq NGjQS5FFVVOR MkfrS2k2OD1yLkOyJO69VQ>? NHr1T|gzOjR|NU[2PS=>
MCF10A MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXybIE4Pi5{IN88US=> M2XYU|Q5KGh? NEPxOJpFVVOR MoPHS2k2OD17Lk[g{txO NXzmboZvOjJ2M{W2Olk>
MDA-MB-435 NWTJRXdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\MeVYvOiEQvF2= NHTuO5I4OiCq NInDfIxFVVOR M4fVZ2dKPTB;MD61JO69VQ>? MVSyNlQ{PTZ4OR?=
MDA-MB-468 NGewd3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvmdJU3NjJizszN MXW3NkBp NYfLOVdWTE2VTx?= M2K2[mdKPTB;MD62N{DPxE1? M3TWRVIzPDN3Nk[5
MOLT4 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L5T|YvOiEQvF2= NUWwXGhYPzJiaB?= MYXEUXNQ MWjHTVUxRTBwNDFOwG0> NWDKZnN1OjJ2M{W2Olk>
NCI-ADR-RES Mnj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXxZ3I3NjJizszN MVe3NkBp MnHZSG1UVw>? NHS1NoNIUTVyPUCuNVYh|ryP MXqyNlQ{PTZ4OR?=
NCI-H23 NVjMdJRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Da[lYvOiEQvF2= MUC3NkBp NXP0[|U2TE2VTx?= M3\ES2dKPTB;MTFOwG0> NGn2XlkzOjR|NU[2PS=>
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NCI-H460 M3njZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDDOk4zKM7:TR?= Mn7MO|IhcA>? NXLRc3E3TE2VTx?= NXHBcJo4T0l3ME2wMlc6KM7:TR?= MofYNlI1OzV4Nkm=
NCI-H522 NULub2RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj4NW43NjJizszN MUW3NkBp M33ve2ROW09? M3LYWGdKPTB;MD61JO69VQ>? MVeyNlQ{PTZ4OR?=
OVCAR3 NGqxSG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;UcWduPi5{IN88US=> NWG4UZVmPzJiaB?= NWfMeINGTE2VTx?= MnrvS2k2OD1zLkOg{txO M3f1RVIzPDN3Nk[5
OVCAR4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWi2MlIh|ryP NVW1VFBkPzJiaB?= MX7EUXNQ MoPJS2k2OD12IN88US=> NXn0O4dCOjJ2M{W2Olk>
OVCAR5 NIPTUWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHoOk4zKM7:TR?= NXLvO3FuPzJiaB?= Mn\3SG1UVw>? MUfHTVUxRTBwN{mg{txO NXjafHFKOjJ2M{W2Olk>
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RXF393 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWC2MlIh|ryP MWm3NkBp Mo\pSG1UVw>? Mnn4S2k2OD1zLkOg{txO M4fx[|IzPDN3Nk[5
SF268 NFz2TpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDNS3pQPi5{IN88US=> MXS3NkBp MX7EUXNQ M{HJcmdKPTB;MT62JO69VQ>? MVyyNlQ{PTZ4OR?=
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SK-MEL-5 MmDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUO2MlIh|ryP NXzEV3lGPzJiaB?= M{LTNWROW09? MWPHTVUxRTBwNkOg{txO NYHXUopHOjJ2M{W2Olk>
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UACC257 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfuRlk3NjJizszN MVm3NkBp MmK0SG1UVw>? M{HJb2dKPTB;MD61JO69VQ>? MWWyNlQ{PTZ4OR?=
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Hep3B MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYm4WpM6PDhiaB?= M3;zUGROW09? MmPwS2k2OD1yLk[5JO69VQ>? NVLWRVU2OjJ2M{m4OlM>
BE(2)-C M3jPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknxO|IhcA>? MYDEUXNQ NVLuW4x{UUN5ME2yJO69VQ>? NE\YbGYzOjl|MkOxOi=>
Bel7402 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTiTmRWPzJiaB?= NHmwVmNFVVOR MYDHTVkxRTF5IN88US=> NGLEPI4zOzB4MUO3Oi=>
Bel7404 M2nDTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDZO|IhcA>? MXTEUXNQ M3vVU2dKQTB;MUig{txO M1:yVVI{ODZzM{e2
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A2780 CisR MnuyT4lv[XOnIFHzd4F6 NWTCWocyOThiaB?= M3;zOWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? M4\SXlI{OjV{NkCz
CAL27 sens MUfLbY5ie2ViQYPzZZk> NVTFeW1zOThiaB?= MnL2TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? NUfVWHRvOjN{NUK2NFM>
CAL27 CisR M3fFcGtqdmG|ZTDBd5NigQ>? MorWNVghcA>? M2TwO2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? MnvJNlMzPTJ4MEO=
KYSE-510 CisR MkTGT4lv[XOnIFHzd4F6 NXrnOnZYOThiaB?= M2\p[2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? MYWyN|I2OjZyMx?=
KYSE-510 sens M{n1UmtqdmG|ZTDBd5NigQ>? M2\4SlE5KGh? M2rSZ2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD63JO69VQ>? MXSyN|I2OjZyMx?=
MDA-MB-231 sens M4H3e2tqdmG|ZTDBd5NigQ>? NX7LPIh6OThiaB?= M1Hwd2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? MVmyN|I2OjZyMx?=
MDA-MB-231 CisR NEXoOotMcW6jc3WgRZN{[Xl? M3jBNFE5KGh? NUHHXWJlUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MorLNlMzPTJ4MEO=
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MDA-MB-231 M3T4cWtqdmG|ZTDBd5NigQ>? NHfLVZkyOCEQvF2= NFfJS5o{OCCvaX6= MoHySG1UVw>? NYXxXVFSUW6qaXLpeIlwdiCxZjDISGFEOmF? NHjJNpYzOzR7M{S0PS=>
MDA-MB-231 M2nFR2tqdmG|ZTDBd5NigQ>? NFfVXlAyKM7:TR?= M4T3fFI1KGh? MVTEUXNQ M4\YfWlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= NWDpfJBbOjN2OUO0OFk>
HS68 NUezVI5DS3m2b4TvfIlkKEG|c3H5 MkXNNVAh|ryP MmLTO|IhcA>? NVjUWmdxTE2VTx?= NVGwSZN1UUN3ME20MlYh|ryP M37I[FI{PTdyNUSy
MEF M3fiRmN6fG:2b4jpZ{BCe3OjeR?= M2HkdlExKM7:TR?= NVm3THZzPzJiaB?= MkjQSG1UVw>? NFj2bopKSzVyPUSuOEDPxE1? M37QV|I{PTdyNUSy
BGC823 NFHNV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzlb|NFVVOR MknyS2k2OD1|LkC5JO69VQ>? MUWyN|YxOTdyNh?=
High5 NEfTfZRMcW6jc3WgRZN{[Xl? MlKxNlQhcA>? NEDsdmxKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM3KHerdHigTWM2OCCxZjCwMlA6KM7:TR?= NV3jRWl5OjN4MEK1NlM>
High5 MnLYT4lv[XOnIFHzd4F6 MnTwNlQhcA>? MlqzTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6xNkDPxE1? NG\reFMzOzZyMkWyNy=>
High5 NXft[5hKU2mwYYPlJGF{e2G7 NWf1RpJoOjRiaB?= NHPjV3FKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= MoDuNlM3ODJ3MkO=
A549 MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzlSG1UVw>? NVrWZ4h2UUN3ME2xMlA4QSEQvF2= M{LKdlI{PjR2MkGw
HCT116 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\uUWpFVVOR M3vZPGlEPTB;MD63OVch|ryP NW[2W|BQOjN4NESyNVA>
K562 MoXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXiSHNxTE2VTx?= M3;6UmlEPTB;MD62OFUh|ryP MVSyN|Y1PDJzMB?=
GBC-SD MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUK1JO69VQ>? MYO3NkBp Mkf4SG1UVw>? NXTrcmcyUUN3ME2xOE45KM7:TR?= MXeyN|cxPzJ4MB?=
HGC27 M4PDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXO1JO69VQ>? MVW3NkBp NG\RPGZFVVOR NET0[pFKSzVyPUWuOEDPxE1? NHnTcYYzOzdyN{K2NC=>
HL60 Ml21T4lv[XOnIFHzd4F6 MoS3OUDPxE1? MkHjNlQhcA>? M{W1fGROW09? M{fibWlvcGmkaYTpc44hd2ZiSFTBRy=> MoX1NlM4ODd{NkC=
Vero MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PV[VczKGh? MYHEUXNQ NGjMbm9KSzVyPUCuPUDPxE1? MonwNlM4QDZ2NUK=
NCI60 NUPpTVc2S3m2b4TvfIlkKEG|c3H5 NEHRWWE1QCCq MofESG1UVw>? MmPES2k:OC53MzFOwG0> NX3D[pJuOjRyMUWzNlc>
SW620 NHjtempEgXSxdH;4bYMhSXO|YYm= MoPZOFghcA>? Mn;xSG1UVw>? M2eyUWdKRTBwNUSg{txO Mm[zNlQxOTV|Mke=
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KM12 MkjkR5l1d3SxeHnjJGF{e2G7 NY\Le3VpPDhiaB?= MY\EUXNQ NGLh[lBIUT1zLki4JO69VQ>? M2TqeFI1ODF3M{K3
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MDA-MB-231 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r6[|Q5KGh? NVLobWFrUUN3ME2wMlE3KM7:TR?= MlzFNlQxQTVyMU[=
MCF7 M2Xy[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe1RZo1QCCq MVnHTV0xNjR3IN88US=> NHP5eYMzPDFzOUW1OS=>
MDA-MB-435 M3PoeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvBOnNZPDhiaB?= MnnrS2k:OC56ODFOwG0> MXqyOFEyQTV3NR?=
AsPC1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPuN|Ah|ryP MoHDOFghcA>? MnqwSG1UVw>? MnTOTWM2OD1|Lk[2JO69VQ>? NXP0XnN6OjRzOEWzO|g>
Jurkat E6.1 M4D1UWtqdmG|ZTDBd5NigQ>? MVKyJIg> MVXEUXNQ NV7UdJNvUW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= MoXpNlQzPjF6NkK=
KG1 NYHVNVBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TEUFQ5KGh? MlnoTWM2OD1zLkG1JO69VQ>? M{XoWFI1PTJ3MECz
HEL NVPhTng2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUS0PEBp MVTEUXNQ NXL3cGt7UUN3ME2wMlQ6KM7:TR?= MVuyOFY6PDB3NR?=
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H460 MUfDfZRwfG:6aXOgRZN{[Xl? NV22Z21YOTJiaB?= MX\EUXNQ M2fXWWlEPTB;MD64NkDPxE1? MoLBNlQ4PjZ3NkC=
MONE1 MXrDfZRwfG:6aXOgRZN{[Xl? MnfZNVIhcA>? NXfY[GxiTE2VTx?= NUXEVoQ1UUN3ME2xMlE5KM7:TR?= MXeyOFc3PjV4MB?=
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TSGH NYHoclNkS3m2b4TvfIlkKEG|c3H5 NFHUS4IyOiCq NFvaVFVFVVOR NGHoXHRKSzVyPUKuNFkh|ryP NXfDOI5JOjR5Nk[1OlA>
HL60 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvZTZA4OiCq MkfGSG1UVw>? M1XNcGdKPTB;MD65N{DPxE1? M2K3XlI1QTByNUCw
HEK293 M{TlcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O3e|czKGh? M1vBfmROW09? MVTHTVUxRTF|IN88US=> MYCyOFkxODVyMB?=
Jurkat NGrlUItEgXSxdH;4bYMhSXO|YYm= NFe0S5UyODBizszN NGrmSoU4OiCq NUH5UmhrT0l3ME2wMlkh|ryP NELVd3QzPDlyMEe0Ny=>
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GM15850 NX[2[GhzU2mwYYPlJGF{e2G7 NUjZZXFIOi53IN88US=> MVW5OkBp NHK5UVhFVVOR M{m4W4Rw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MVyxOlkzOTN4Nx?=
GM15850 NV;OVJVmU2mwYYPlJGF{e2G7 NF;u[HkzNjVizszN M3i0VFk3KGh? MojqSG1UVw>? MoDF[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MVWxOlkzOTN4Nx?=
GM15850 MoD2T4lv[XOnIFHzd4F6 NFLYWHEzNjVizszN M4rJWlk3KGh? NE\h[npFVVOR NFjpR29ld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhQSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NVvRell4OTZ7MkGzOlc>
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HCT116 MVnLbY5ie2ViQYPzZZk> NYjHdohnOC5|IN88US=> MnnYN|AhcA>? MX3EUXNQ NX3zdXlY\G:nczDuc5QhcW6qaXLpeEBJTEGFMTDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiaHnzeI9v\SCKM1u5JIFk\XS7bHH0bY9v NIi1SnUzOTB6ME[0Oy=>
HepG2 NV\HfJZpTnWwY4Tpc44hSXO|YYm= MlK2NVAh|ryP NIe4SoozPCCq NW\CNXoyTE2VTx?= MlLi[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BpgXCncnHj[ZR6dGG2aX;uJI9nKHB3Mx?= MonXNlE2PDh3OEK=
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H9 M163Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXSy[|JqUUN3ME2yOVUvODRibl2= MlntV2FPT0WU
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NB69 MoXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDVWoJKSzVyPUSxNU44OSCwTR?= NUC0UIV5W0GQR1XS
EoL-1-cell M{Hn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\wcXdKSzVyPUS1OFI2KG6P MYHTRW5ITVJ?
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KE-37 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTh7ND62NkBvVQ>? NV\vWGltW0GQR1XS
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A427 M2LyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELXdW1KSzVyPUmyNE45PCCwTR?= MlfSV2FPT0WU
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EW-1 M{D1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfTWotKSzVyPUm0O{4zPiCwTR?= MVPTRW5ITVJ?
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EW-3 NY\5[nRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP2TWM2OD1zLkG3NlEzKM7:TR?= NUP4NJE3W0GQR1XS
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LB1047-RCC M4jhOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF23N4RKSzVyPUGuNVg{OTJizszN NXTxVVY3W0GQR1XS
VM-CUB-1 M2Xk[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfwTWM2OD1zLkG5NVA5KM7:TR?= M{D6U3NCVkeHUh?=
NB5 MoX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzHZnBmUUN3ME2xMlE6QDV4IN88US=> M{Xvd3NCVkeHUh?=
SKG-IIIa NHG5fG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDVUVFPUUN3ME2xMlI{PDZ2IN88US=> M{XaWXNCVkeHUh?=
HO-1-N-1 NHq4eHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHTW5pKSzVyPUGuNlM5OzVizszN NE\WVlZUSU6JRWK=
EFO-27 M4\RZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTFwMkWwOFMh|ryP Mn7XV2FPT0WU
MHH-NB-11 NHS3UYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\LTWM2OD1zLkK4N|I6KM7:TR?= MYXTRW5ITVJ?
SW620 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\pV5pzUUN3ME2xMlI6ODF6IN88US=> MXPTRW5ITVJ?
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VA-ES-BJ MmS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmi0TWM2OD1zLkOyOFc4KM7:TR?= MojUV2FPT0WU
HCC1419 M4HSUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT1TWM2OD1zLkO0NFI4KM7:TR?= MlPjV2FPT0WU
NCI-H69 NYrmN2dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PCTWlEPTB;MT6zOFEyOiEQvF2= M2C3XXNCVkeHUh?=
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LAMA-84 M3jYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPmTWM2OD1zLkSzPVQ2KM7:TR?= Mo\4V2FPT0WU
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BV-173 Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L1XmlEPTB;MT60O|I6OSEQvF2= MojoV2FPT0WU
NCI-H1770 M37uO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq2VWxKSzVyPUGuOFg2OzZizszN NXvORpNSW0GQR1XS
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TYK-nu M4i3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTtVphFUUN3ME2xMlQ6QDVzIN88US=> NUPEW5NwW0GQR1XS
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OVCAR-8 M4rG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL6dGJOUUN3ME2xMlU1PDd5IN88US=> MVvTRW5ITVJ?
NCI-H23 NHj6OYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTFwNUS2OFUh|ryP NHvvNIdUSU6JRWK=
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COR-L88 MoLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4W4TmlEPTB;MT61OlQzPCEQvF2= M3X4R3NCVkeHUh?=
TI-73 MoLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHPTWM2OD1zLkW5NFYh|ryP NEL0V2lUSU6JRWK=
RT-112 NWnFPYFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3FbotKSzVyPUGuOVkzQDRizszN NU[5NFY1W0GQR1XS
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HC-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDWfXpuUUN3ME2xMlU6QDZ4IN88US=> MW\TRW5ITVJ?
HT55 M3[yWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDxU4ZKSzVyPUGuOlUyOzFizszN MmTtV2FPT0WU
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MHH-ES-1 Ml;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTFwN{C0N|Uh|ryP NUDCR2twW0GQR1XS
CAL-27 M3rVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n1fWlEPTB;MT63NFYzOSEQvF2= MUHTRW5ITVJ?
COLO-800 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPCTWM2OD1zLkexNVc6KM7:TR?= NF\TTHdUSU6JRWK=
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CAMA-1 M{Htemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrlTWM2OD1zLkexPVcyKM7:TR?= MYDTRW5ITVJ?
LOXIMVI NUfqfHBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHuxUItKSzVyPUGuO|IyOSEQvF2= MoDwV2FPT0WU
NH-12 NGXGUHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\3TWM2OD1zLkeyOlkyKM7:TR?= NEXXbmhUSU6JRWK=
TCCSUP MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULjUZljUUN3ME2xMlczQDJ7IN88US=> NXLsWXU{W0GQR1XS
MDA-MB-361 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PJeGlEPTB;MT63N|E2PyEQvF2= NIrl[IhUSU6JRWK=
EW-16 NWiyfGJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvhOY1UUUN3ME2xMlc1OTB5IN88US=> Mkf6V2FPT0WU
SNU-423 M2Xy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfnTWM2OD1zLke1PFI4KM7:TR?= NW\5WIVTW0GQR1XS
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ES4 M4m2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HCN2lEPTB;MT63PFc1OSEQvF2= NFXKeoNUSU6JRWK=
PFSK-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwOECzO{DPxE1? M{DVUXNCVkeHUh?=
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JVM-3 MoX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT1TWM2OD1zLki1OFUyKM7:TR?= NVzlbJkzW0GQR1XS
OS-RC-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTQTWM2OD1zLki3NVUyKM7:TR?= M{nsOHNCVkeHUh?=
COLO-320-HSR M4TjU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofETWM2OD1zLki4NVk4KM7:TR?= Ml3rV2FPT0WU
HN M1fUWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTFwOEi3NlUh|ryP NEjCNHhUSU6JRWK=
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SCC-15 MkXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPpfWVnUUN3ME2xMlk{QDF7IN88US=> NHH6U5RUSU6JRWK=
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SW626 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInrUnVKSzVyPUGuPVQ5QTlizszN NF\QfG9USU6JRWK=
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Ramos-2G6-4C10 M3v0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1OxZWlEPTB;MT65PVQ6OyEQvF2= Mom2V2FPT0WU
A101D MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwMkCzNFMh|ryP Mn3OV2FPT0WU
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HSC-2 M4XFNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D3V2lEPTB;Mj6xNlg6QCEQvF2= NHq1b49USU6JRWK=
LCLC-97TM1 M{PLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\UTWM2OD1{LkG0OVg{KM7:TR?= M{W0SXNCVkeHUh?=
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TE-8 MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vvW2lEPTB;Mj6xOVc3PSEQvF2= NHXzdWlUSU6JRWK=
DSH1 MmT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESwcHJKSzVyPUKuNVY{QThizszN NGT4UGFUSU6JRWK=
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GCT NHnYbG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJwMUe3O{DPxE1? NFj3[4RUSU6JRWK=
SW948 M4jWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\1TWM2OD1{LkG4OFU3KM7:TR?= M4LlZ3NCVkeHUh?=
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C8166 M1HXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHPSJBDUUN3ME2yMlIyOzN2IN88US=> NYfDPYM1W0GQR1XS
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CAL-39 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnPTWM2OD1{LkKzOlI3KM7:TR?= NXnOcnh4W0GQR1XS
MDA-MB-453 NV[xfopHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTJwMkSyO|Uh|ryP NYrEbHJVW0GQR1XS
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NCI-H1666 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP4dI9KSzVyPUKuNlgyOTFizszN NWnid5NpW0GQR1XS
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5637 NEPJXZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfXV4VKSzVyPUKuN|IyOjlizszN NXnvN2NCW0GQR1XS
GB-1 M4mxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJwM{KzN|Uh|ryP MVjTRW5ITVJ?
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OAW-42 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nSbmlEPTB;Mj6zN|QyPiEQvF2= NH65[GhUSU6JRWK=
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RH-18 Mn7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHLPWtKSzVyPUKuN|UxOjJizszN NVjmVopKW0GQR1XS
NCI-H1155 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Tp[mlEPTB;Mj6zOlczPSEQvF2= M4LVXXNCVkeHUh?=
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NCI-H1437 M{fOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJwNEG4O|Mh|ryP Mmm3V2FPT0WU
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HSC-3 M3rFc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLvXXBPUUN3ME2yMlQ1PTB7IN88US=> MVTTRW5ITVJ?
GAMG M3LTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIW5T3BKSzVyPUKuOFQ2PjFizszN MVHTRW5ITVJ?
HT-1080 NXPB[oxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJwNES4OlQh|ryP NGj1[VRUSU6JRWK=
A549 MlHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvQb5FKSzVyPUKuOFQ5QTNizszN NILMOpRUSU6JRWK=
KNS-62 NGjDOW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HqSmlEPTB;Mj60OVA3OSEQvF2= NIjqeXpUSU6JRWK=
YKG-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTJwNEW0N|ch|ryP NEezXY9USU6JRWK=
LU-134-A NIPMR2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrSN5Q{UUN3ME2yMlQ4ODB6IN88US=> NYnuSZJJW0GQR1XS
FADU M2\BZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PGUWlEPTB;Mj60O|E3OiEQvF2= M3HhXHNCVkeHUh?=
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HT-3 NFzwVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\ITWM2OD1{LkS5OVM2KM7:TR?= M2jEWHNCVkeHUh?=
NCI-H2170 Mn3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJwNUC1OFkh|ryP M1z1WHNCVkeHUh?=
Mo-T Ml6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJwNUC5Nlch|ryP M1\t[3NCVkeHUh?=
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HCC38 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\ERWlEPTB;MUCuN|IzKM7:TR?= M{D5OXNCVkeHUh?=
LK-2 NXHXR2x3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFyLkSyNFgh|ryP M3fVZnNCVkeHUh?=
SF126 NYjkNpJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHoTWM2OD1zMD60O|I4KM7:TR?= NVLT[YtZW0GQR1XS
SK-MEL-1 MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPTTWM2OD1zMD63PFM5KM7:TR?= NGn6cnlUSU6JRWK=
ACN NWnVcopYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3sfmZUUUN3ME2xNE45Pjd7IN88US=> NY[zclBUW0GQR1XS
BB30-HNC NVfNVZFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\qTWM2OD1zMD64O|EyKM7:TR?= MlT5V2FPT0WU
NCI-H747 NHXrdm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTFyLki3OFYh|ryP NU\NXXV5W0GQR1XS
KYSE-150 NF3K[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlK2TWM2OD1zMT6wN|g4KM7:TR?= MYTTRW5ITVJ?
D-247MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;J[FBzUUN3ME2xNU4yODB7IN88US=> NUT4V|dwW0GQR1XS
BxPC-3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;YfmlEPTB;MUGuN|c1PyEQvF2= M2LadXNCVkeHUh?=
SK-MEL-30 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFzLkSwO|kh|ryP Mof2V2FPT0WU
CAS-1 MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnXSVJmUUN3ME2xNU41OTB7IN88US=> M1PoeHNCVkeHUh?=
no-10 NF3Cd2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXQRXNKSzVyPUGyMlEzOTdizszN NXKyZ3poW0GQR1XS
NCI-H2405 NF3sRVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LkPWlEPTB;MUKuNlA{PiEQvF2= MoLBV2FPT0WU
KGN MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTF{LkK5NFEh|ryP M2P5PXNCVkeHUh?=
BB49-HNC M4fOdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XV[WlEPTB;MUKuN|k2PiEQvF2= M2jHe3NCVkeHUh?=
NCI-H1693 M1XGbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjMfIlKSzVyPUGyMlU5OTZizszN MV7TRW5ITVJ?
RO82-W-1 M3vBfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;pd2RpUUN3ME2xN{4xPjR7IN88US=> MY\TRW5ITVJ?
CAL-85-1 NVr1VXdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\PcHdKSzVyPUGzMlQ{QTlizszN M1PTbnNCVkeHUh?=
H-EMC-SS NXPPS49jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NID1TIZKSzVyPUGzMlkyODRizszN Mn22V2FPT0WU
SW1783 M3zNTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jMTWlEPTB;MUSuNlM6OSEQvF2= Ml7RV2FPT0WU
LB771-HNC MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m2[WlEPTB;MUSuOFE6KM7:TR?= NXz6d2xrW0GQR1XS
HCC70 Mn:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV70WXRUUUN3ME2xOE41OjN|IN88US=> Mnj4V2FPT0WU
KNS-81-FD NEDZOGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjW[Xd1UUN3ME2xOE44ODR3IN88US=> MmHWV2FPT0WU
KYSE-520 NFTmXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTF2LkmyO{DPxE1? NFSxemNUSU6JRWK=
TGBC24TKB M1HVPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rPOGlEPTB;MUSuPVU{QSEQvF2= NWHCe2xxW0GQR1XS
SNB75 M{\vVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTLcpI3UUN3ME2xOU4xPzJ7IN88US=> M3\OZXNCVkeHUh?=
SW872 MknRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG3UIgyUUN3ME2xOU4zOjF6IN88US=> MYLTRW5ITVJ?
U031 NFvWfpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4H3RWlEPTB;MUWuPFAzQCEQvF2= MV3TRW5ITVJ?
ChaGo-K-1 NHiyVm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnmPXRKSzVyPUG1Mlg{PTlizszN NF23ZYdUSU6JRWK=
NCI-H441 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TvTWlEPTB;MU[uNFA{QSEQvF2= M{m4SHNCVkeHUh?=
TE-12 NITXWnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M131PGlEPTB;MU[uNVg4OyEQvF2= MoTpV2FPT0WU
NCI-H1755 MknzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTF4LkW3N{DPxE1? M2TO[HNCVkeHUh?=
KNS-42 MkPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF4Lk[1PFkh|ryP NXHkZpExW0GQR1XS
SK-PN-DW Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF5LkSyNFEh|ryP NH7TRnNUSU6JRWK=
NCI-H226 NWj0O3RiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nDbmlEPTB;MUeuPVM1PSEQvF2= M4LFXnNCVkeHUh?=
K-562 NX;acY1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTF6Lk[zNVch|ryP MkmzV2FPT0WU
A388 NF3rcXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z5O2lEPTB;MUmuNFMxOyEQvF2= M3vBNHNCVkeHUh?=
ZR-75-30 NYnsRWUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTF7LkC5Olgh|ryP MlHzV2FPT0WU
LU-135 M1Tkd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTF7LkK2N|Yh|ryP MmrPV2FPT0WU
NCI-H2029 MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTF7Lk[wNlEh|ryP M3XXZXNCVkeHUh?=
HT-1197 M4\BRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnLTWM2OD1zOT65NlI4KM7:TR?= NGexXVdUSU6JRWK=
IGR-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJyLkOxNVch|ryP NWLSbZJGW0GQR1XS
U-87-MG Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TkRmlEPTB;MkCuOlQyOyEQvF2= Ml7mV2FPT0WU
NCI-H1304 MkfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4q0Z2lEPTB;MkCuO|UxOSEQvF2= NWrkVW1TW0GQR1XS
RCC10RGB M{HRcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DSZ2lEPTB;MkGuNlgzQSEQvF2= M2\adnNCVkeHUh?=
NCI-H520 NU\xUmNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJ{Lke2NVEh|ryP MlLrV2FPT0WU
SK-LU-1 Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDGNYdKSzVyPUKzMlA4OThizszN NHSwfJNUSU6JRWK=
UACC-893 M2PlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPFd4xvUUN3ME2yN{4yODN6IN88US=> Mln4V2FPT0WU
NCI-H2347 M3K2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{C3cmlEPTB;MkOuNlY4PCEQvF2= MkjjV2FPT0WU
U-118-MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTvTWM2OD1{Mz63NlE4KM7:TR?= NGX0Wo9USU6JRWK=
NCI-H596 M4XYZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7RNpZKSzVyPUKzMlkxPTVizszN MXTTRW5ITVJ?
MZ1-PC MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHxTWM2OD1{ND62O|U6KM7:TR?= NH\2O3hUSU6JRWK=
SW1417 Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPFTWM2OD1{NT6yOFk5KM7:TR?= MlzFV2FPT0WU
NCI-H82 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PWe2lEPTB;Mk[uOFI5QCEQvF2= MkfIV2FPT0WU
COLO-678 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3rTWM2OD1{Nz60PVE6KM7:TR?= MWjTRW5ITVJ?
KURAMOCHI NF;lNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHDTWM2OD1{OD6xNlYh|ryP M{KzWXNCVkeHUh?=
NCI-H1650 M33lSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTNyLkG5NlQh|ryP NEfRelVUSU6JRWK=
HCC1954 NWmwSYd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfLZY1rUUN3ME2zNU4{PjZ4IN88US=> MYLTRW5ITVJ?
GAK MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnPUlJKSzVyPUOyMlI3OTZizszN MXHTRW5ITVJ?
YAPC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\3R2NKSzVyPUOzMlc3PDhizszN M1rGXXNCVkeHUh?=
NCI-H2228 M3HEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHiOGhKSzVyPUO0MlM3ODVizszN MkLDV2FPT0WU
VMRC-RCZ Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPm[FVKSzVyPUO2MlMxOjJizszN NX\sSXIzW0GQR1XS
NMC-G1 NIXRNmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzxTWM2OD1|Nz6wOVI6KM7:TR?= MlHnV2FPT0WU
D-336MG NHz1bXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DUWGlEPTB;NEGuPFQ1OiEQvF2= MUfTRW5ITVJ?
UACC-62 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTR{LkW1NFUh|ryP M1LtSnNCVkeHUh?=
C-33-A M1P3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fFTmlEPTB;NEWuN|I2PiEQvF2= NHG0WIRUSU6JRWK=
HCC1937 MkLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDENlk1UUN3ME20O{4yQTV6IN88US=> NUD5SHBlW0GQR1XS
HDLM-2 NY[3boJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\ZWmlEPTB;NEeuNlI5PyEQvF2= NVK2d4k1W0GQR1XS
NCI-H727 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPBZ|NmUUN3ME20O{4zPDVzIN88US=> NUH1W45qW0GQR1XS
NY MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4njNmlEPTB;NEmuN|kxQCEQvF2= NGDjfXZUSU6JRWK=
NCI-H2291 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHS1XYxKSzVyPUS5Mlg{ODFizszN MlPvV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID