Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 100 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M4e0PWtqdmG|ZTDBd5NigQ>? NWjve3FCOSCq NWL1PVdvTE2VTx?= Mmq2ZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP M3;4ZVEyQTZyNEi5
Friend leukemic cell MorXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DPcVUxKM7:TR?= M3n4XVczKGh? MWfEUXNQ M17xPGlEPTB;MD65PUDPxE1? MmrINVIyODl7MUO=
K562 M121ZmtqdmG|ZTDBd5NigQ>? MmTLOkBp MmW1SG1UVw>? M2i1cGlvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> M2nNWFEzPDF7M{iw
HT1080 M2Dxbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDDO|IhcA>? M3P5d2ROW09? MnnUTWM2OD1{LkSg{txO MWCxNlI4ODF5NR?=
H1299 M{X5TmtqdmG|ZTDBd5NigQ>? Ml\0NlAhdWmw MUjEUXNQ NF\DZppKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> M1XHdlE1PTJzNEKy
H1299 M3XxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PUOFczKGh? NFTIO4hFVVOR Mm\zTWM2OD15LkK0JO69VQ>? NGrC[4cyPDV{MUSyNi=>
HeLa M2jlNWtqdmG|ZTDBd5NigQ>? MV[zNEBucW5? Mn7tTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaHnzeI9v\SCmZXHj[ZR6dGG|ZTD3bZRpKEmFNUCgc4YhOC5{ODFOwG0> NYDxUlFYOTV4MEO5OFk>
LOX-IMVI MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWW0PEBp MnPkTWM2OD1zLkOg{txO NIexdlYyPTdzNUS3NC=>
NCI-H226 NGLk[ohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDEOFghcA>? MoG2TWM2OD1{Lk[g{txO NVuxZXMzOTV5MUW0O|A>
RXF-631L NH\3OGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jL[lQ5KGh? NH;qcGtKSzVyPUKg{txO M2DWfVE2PzF3NEew
SNB-78 M4L5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXGXZc1QCCq MVzJR|UxRTF4IN88US=> NFzIWFAyPTdzNUS3NC=>
St-4 NGjlc4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGOwTHA1QCCq MYLJR|UxRTVwMjFOwG0> NWW2N4I5OTV5MUW0O|A>
ARP1 MmHaSpVv[3Srb36gRZN{[Xl? NFziXIEzKM7:TR?= NEHLcZo3KGh? M{DncGlv\HWldHnvckBw\iCSMkHXRWYyKGenbnWg[ZhxemW|c3nvci=> NFrBT5QyPDd|NEiwOi=>
CEM MV7LbY5ie2ViQYPzZZk> NFu0fG0yKGh? MYrEUXNQ NXjTS4hjUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM{KM7:TR?= Mk[5NVY1OjByNkS=
HCT15 NFjOWZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PXSVQ5KGh? MlSwS2k2OD1yLkiyJO69VQ>? MlqzNVY4OjN{Mke=
NCI-H23 NWnueWI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jadVQ5KGh? NHvYPWpIUTVyPUCuPVIh|ryP M3KwWlE3PzJ|MkK3
GM15850 NFjqbndMcW6jc3WgRZN{[Xl? NEHnRogzNjVizszN NW[2Z4d[QTZiaB?= MYHEUXNQ NGC4VVZKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NILiSFcyPjl{MUO2Oy=>
GM15850 NEPvOGVMcW6jc3WgRZN{[Xl? M3G0[FIvPSEQvF2= Ml;0PVYhcA>? NH6wc29FVVOR NXmwWXd7UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M4rnPFE3QTJzM{[3
GM15850 M{nMcmtqdmG|ZTDBd5NigQ>? M3PKOFIvPSEQvF2= M3TFU|k3KGh? MXvEUXNQ NHrofYxKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MkfLNVY6OjF|Nke=
GM15850 MmPKT4lv[XOnIFHzd4F6 NG[3XngzNjVizszN NWrvNYt[QTZiaB?= NFHudIVFVVOR MULJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViOTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? NIDrToYyPjl{MUO2Oy=>
GM15850 MlvPT4lv[XOnIFHzd4F6 NIr4eIozNjVizszN MkfCPVYhcA>? M{Pwc2ROW09? M171U2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M37OcFE3QTJzM{[3
GM15850 M1TTS2tqdmG|ZTDBd5NigQ>? MWWyMlUh|ryP MlvVPVYhcA>? MmjiSG1UVw>? NIPMZnlKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVYh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NGHSOYwyPjl{MUO2Oy=>
U937 NWSwNXZ4TnWwY4Tpc44hSXO|YYm= NIHmdoo2KM7:TR?= NGHlVW0zPCCq MXPEUXNQ M{TkN2NmdGxiY4njcIUh[XK{ZYP0JIJ6KGGlY4XteYxifGmxbjDheEBUN0d{L12gdIhie2V? NXXNNGV4OTdyMES3NVg>
H661 NWrvcZJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF71Z5I1QCCq M3LqWmlEPTB;MTFOwG0> M4PqSFE4OTV5MEC5
U937 NV7nWYNNTnWwY4Tpc44hSXO|YYm= M1;T[lUh|ryP Ml;wNlQhcA>? NVrTe3d5TE2VTx?= MX3JcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w MYCxO|Q1Pzd3MB?=
U937 MoHaSpVv[3Srb36gRZN{[Xl? M3;YeFEh|ryP M3jzblI1KGh? NXHTOZlUTE2VTx?= NYrhWJJpTW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> NIPITHAyPzR2N{e1NC=>
RAW264.7 NWPOS3BTTnWwY4Tpc44hSXO|YYm= M3fhPVExKM7:TR?= MXiyOIg> NV\VWXBvf2G2ZYK= NGnkXYZKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN NYnaTXBPOTd2N{e1NVg>
RAW264.7 Moj0SpVv[3Srb36gRZN{[Xl? NX\hcm9KOTBizszN M3HVclI1cA>? M4XnZpdifGW{ NVuzNXZKUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJJdqfGhiSVO1NEBw\iBzLki4JO69VQ>? M{e0T|E4PDd5NUG4
SC9 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3CSFB7PDhiaB?= MX3JR|UxRTBwNkC2JO69VQ>? M17nclE4PTB5MkG5
ST14A NGfpXI1HfW6ldHnvckBCe3OjeR?= NY\oco1XPSCwTR?= M3TJ[lczKGh? M1PvSGlv[3KnYYPlJIlvKFKHU2SvUnJUTiCvUl7BJIV5eHKnc4Ppc44> NFnZPG0yPzV4NUm5Ny=>
ST14A MmHISpVv[3Srb36gRZN{[Xl? MlqwOUBvVQ>? M4\nV|czKGh? MYHJcoNz\WG|ZTDpckBGOkZzIH3SUmEh\XiycnXzd4lwdg>? MlLMNVc2PjV7OUO=
PANC1 M2m1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUGxJO69VQ>? MXXJR|UxRTBwNEWg{txO MknkNVc2QDh5NES=
PANC1 NHj3cVVHfW6ldHnvckBCe3OjeR?= M{jTdFEh|ryP MYGyOEBp M1vD[Glv[3KnYYPlJIlvKHB{MWfBSlEwS0mSMTDn[Y5mKGW6cILld5Nqd25? MmK2NVc2QDh5NES=
PANC1 NYLCb2VWTnWwY4Tpc44hSXO|YYm= NV\SOI9TOSEQvF2= MlzsNlQhcA>? NE\W[25KdmO{ZXHz[UBqdiCyMkfrbZAyKGenbnWg[ZhxemW|c3nvci=> NVHpUnQxOTd3OEi3OFQ>
PT45 NXzQSpExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTRizszN MkTLNVc2QDh5NES=
ACHN MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfKNlEhcA>? NH7RWmVIUTVyPUCuOlUh|ryP NEnNOVgyPzZ4Mk[wOi=>
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DMS114 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37Ed|Q5KGh? NG\Pbo9IUTVyPUKuPUDPxE1? M1z3VFE6PDF7MkC1
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SKHEP1 NHLVUGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO3NkBp NUT1UZVFUUN3ME2zMlQ3KM7:TR?= MUOyNFE1Ozd5OB?=
BJ MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\pW5pyOTByIN88US=> M{HE[VQ5KGh? NWTpS|RXTE2VTx?= M3G5NWdzd3e2aDDpcohq[mm2aX;uJIF1KDBwMEWgeI8hOTByIIXN NF;idlUzODF2M{i0NC=>
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Caco-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nKdlExOCEQvF2= MmHjOFhp Mn\CSG1UVw>? NFjMVG1KSzVyPUiuNUDPxE1? Mo\xNlAyPDN6NEC=
Caco-2 NInye4FMcW6jc3WgRZN{[Xl? MVK1JO69VQ>? M3u3S|QhcA>? M2LrRmROW09? NF7QUndKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9vKEmFNUCgc4YhOC5yM{eg{txO NUnsc4d6OjBzNEO4OFA>
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Caco-2 MX3LbY5ie2ViQYPzZZk> NGXsd5o3NjN{IH7NJJRwKDZ|MjFOwG0> MUS0JIg> MljjSG1UVw>? M4rpbWV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNTD3bZRpKEmFNUCgc4YhOTJwNjFOwG0> NYDSUVd7OjBzNEO4OFA>
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HepG2 MnLoT4lv[XOnIFHzd4F6 Ml\POUDPxE1? MUe2bC=> MYfEUXNQ NVvBdIV1UW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBpgXCncnHj[ZR6dGG2aX;u MWGyNFE1Ozh2MB?=
HepG2 M1yxSGtqdmG|ZTDBd5NigQ>? MXO1JO69VQ>? Mlz3Oog> MlHTSG1UVw>? MkTHTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= MXWyNFE1Ozh2MB?=
HepG2 NYm1U3pSU2mwYYPlJGF{e2G7 NEnEeoI2KM7:TR?= NGLkdoE3cA>? M4nFcGROW09? Mo\DTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgTFMwUDRiaHnzeI9v\SCjY3X0fYxifGmxbh?= NWLtSnp3OjBzNEO4OFA>
COLO205 M1fHZmtqdmG|ZTDBd5NigQ>? M3S5UVExKM7:TR?= Mkn6NlQhcA>? M3jHW2ROW09? MWjJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizJIFk\XS7bHH0bY9vKHerdHigTWM2OCCxZjCyMlIh|ryP MmnpNlA1PTF|N{i=
SCC4 Mn\RT4lv[XOnIFHzd4F6 Mn\BNUDPxE1? NHHIUnAzPGh? NWDkO|FyUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44> MnjjNlA1PTJ{MkW=
SCC4 NUn0emNYU2mwYYPlJGF{e2G7 M4rnS|Eh|ryP Ml3UNlRp MYHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCjY3X0fYxifGmxbh?= MUCyNFQ2OjJ{NR?=
SCC4 MYHGeY5kfGmxbjDBd5NigQ>? M3\OZVEh|ryP MmSwOUBucW5? MlXoRYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= M4TETVIxPDV{MkK1
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NB4 NEnJc|ZMcW6jc3WgRZN{[Xl? MYi1JO69VQ>? M1\1blI1KGh? MWLEUXNQ NHTvSGdKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNmfHmuYYTlJJR2[nWuaX6gcIV3\Wx? MXKyNFQ6OTR2MB?=
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NB4 MnfhT4lv[XOnIFHzd4F6 M3;YNFUh|ryP M{DZZ|I1KGh? MlfqSG1UVw>? M{D3fWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIFk\XS7bHH0bY9v NI\s[Y0zODR7MUS0NC=>
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A549 NEWydIhHfW6ldHnvckBCe3OjeR?= NGfFO|I2KM7:TR?= MYOzJIg> M3LuUWROW09? MWfJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hVEN|SVm= NX7aXZhmOjB6NUWyNFg>
HUT78 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVe4UIZ5PzJiaB?= NX;RZ2V5TE2VTx?= NE\3ZnZIUTVyPUCuN{DPxE1? MlXsNlA5QDR{MEi=
U937 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HrTlczKGh? NV\6U3cyTE2VTx?= MXXHTVUxRTBwM{mg{txO NWL5V457OjB6OESyNFg>
A431 MVPDfZRwfG:6aXOgRZN{[Xl? M4HRUlczKGh? M2X2OmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gOE4zKM7:TR?= M3vMfFIyODhyNkK5
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CAL27 MXLDfZRwfG:6aXOgRZN{[Xl? M4m1Z|czKGh? NGPHUZZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA{NjJizszN NWLYOmxVOjFyOEC2Nlk>
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Sf21 MWnLbY5ie2ViQYPzZZk> NVX5S21mOyCq M1W1WmlvcGmkaYTpc44hd2ZiRnzh[{B1[WepZXSgbJVu[W5icnXjc41jcW6jboSgTGRCSzhiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyNjJizszN M3H6OFIyODhyNkK5
SKBR3 M1;5[2N6fG:2b4jpZ{BCe3OjeR?= MXW3NkBp M{W5OGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvPiEQvF2= MoW4NlExQDB4Mkm=
SKOV3 M2rMXWN6fG:2b4jpZ{BCe3OjeR?= MoHRO|IhcA>? NI[zToxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjJizszN NGjMc4gzOTB6ME[yPS=>
COR-L23 NFzTSVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPMNVAh|ryP Mnu0O|IhcA>? MVfEUXNQ MVnHTVUxRTFwMTFOwG0> M{\RflIyODhyNkS3
DU145 NHzZUVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDQSmMyOCEQvF2= MUO3NkBp MYXEUXNQ MljoS2k2OD1zLkC1JO69VQ>? M{TrdlIyODhyNkS3
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HCT116 NVHXeXUyU2mwYYPlJGF{e2G7 MXKzNEDPxE1? NIDOOIc{OCCq M2DFWGROW09? MXPJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w MmO0NlExQDB4NEe=
HCT116 Mny1T4lv[XOnIFHzd4F6 MnK5N|Ah|ryP MUWzNEBp MYjEUXNQ M4nGVmlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFNMQSCjY3X0fYxifGmxbh?= NHnuNnIzOTB6ME[0Oy=>
U937 MYnLbY5ie2ViQYPzZZk> MX21JO69VQ>? M1u2SVI1KGh? MXjEUXNQ MV\Jcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMQQ>? NWD3R4p7OjF{OUK0PVI>
U937 MoXST4lv[XOnIFHzd4F6 M3;5dFUh|ryP NWHXT4pHOjRiaB?= MXfEUXNQ M2jSe2lvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEtzOB?= M4P6blIyOjl{NEmy
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A2780 M4rxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTlWmViQTZiaB?= NYexOm1GTE2VTx?= M1raVGlEPTB;MT62NkDPxE1? M3\MWlIyPjN2NEOw
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GM11272 M2LrPWZ2dmO2aX;uJGF{e2G7 MXGxNFAhdk1? NV;lUJhPPzJiaB?= NH3kd4FFVVOR NGjTTZZT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O MVeyNVg1ODdzNh?=
CFBE41o NE\SNldMcW6jc3WgRZN{[Xl? M3zvdVUh|ryP MVnEUXNQ MlvwSI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO NXXaSHczOjF7OES5OVg>
CFBE41o NWfTfpVoTnWwY4Tpc44hSXO|YYm= M1LoWFEh|ryP Mn\zNlQhcA>? M1\mTWROW09? NGT1e2pT\XO2b4LheIlwdiCxZjDDSnRTKGSnbIThSlUxQCCvdYThcpQhfHKjZn\pZ4tqdmdidH:gZ4VtdCC|dYLmZYNmKGG|IHfsfYNw\m:{bYO= M2rJPFIyQTh2OUW4
DU145 Mmj3T4lv[XOnIFHzd4F6 MkfJNk42KM7:TR?= NGKze20zPCCq M{HOS2ROW09? MUnJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhfXC{ZXf1cIF1cW:wIH;mJJAzOXejZkGgdJJwfGWrbjDlfJBz\XO|aX;u M3\UN|IzOjZyMU[2
DU145 NYDuOI5NU2mwYYPlJGF{e2G7 M1jWTFUh|ryP MljSNlQhcA>? MUHEUXNQ MYHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJPCCjY3X0fYxifGmxbh?= NVW0W4pzOjJ{NkCxOlY>
DU145 M1jqXmtqdmG|ZTDBd5NigQ>? MmDVOUDPxE1? NFHjTFgzPCCq NVXmNYN2TE2VTx?= NEXrZ4hKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaHnzeI9v\SCKMzDofZBmemGlZYT5cIF1cW:w NWeyfplIOjJ{NkCxOlY>
786-0 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fSVVYvOiEQvF2= MYO3NkBp NXLyRWFiTE2VTx?= M1mweWdKPTB;Mz6yJO69VQ>? MV6yNlQ{PTZ4OR?=
A498 NH\SSnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M16xT|YvOiEQvF2= M3\xS|czKGh? MVvEUXNQ M4Tw[WdKPTB;MT62JO69VQ>? MWGyNlQ{PTZ4OR?=
A549/ATCC MkDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfFOmNPPi5{IN88US=> MUO3NkBp NEHL[ZNFVVOR NX2zdGxnT0l3ME2xMlYh|ryP NF7BV3gzOjR|NU[2PS=>
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HCT15 MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1n0c|YvOiEQvF2= NFP3SlA4OiCq M{TiVGROW09? M3TkZWdKPTB;Mj61JO69VQ>? MUGyNlQ{PTZ4OR?=
HOP92 NV7lOFdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7wVWxRPi5{IN88US=> NXzLc3VZPzJiaB?= NH25cHFFVVOR MoD6S2k2OD12IN88US=> M3fFV|IzPDN3Nk[5
IGROV1 MmDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlK0Ok4zKM7:TR?= NHjTUpY4OiCq Mn23SG1UVw>? MVnHTVUxRTFwMzFOwG0> M{G0NFIzPDN3Nk[5
LOXIMVI MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPKcpU3NjJizszN MWq3NkBp MofHSG1UVw>? NFTsZ3FIUTVyPUGg{txO M{HKPVIzPDN3Nk[5
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MALME-3M MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfE[HZWPi5{IN88US=> M3[2WFczKGh? M4i4[mROW09? NIXEUVlIUTVyPUCuN|Ih|ryP MnL3NlI1OzV4Nkm=
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NCI-ADR-RES MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHlO2hTPi5{IN88US=> MX63NkBp NXLsU2g1TE2VTx?= NYLLfIV3T0l3ME2wMlE3KM7:TR?= NVLIe|RLOjJ2M{W2Olk>
NCI-H23 M{T1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV:2MlIh|ryP NVi3WVBXPzJiaB?= NFzYUFZFVVOR MV3HTVUxRTFizszN NIDMe2MzOjR|NU[2PS=>
NCI-H322M NGDMemNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLr[nM3NjJizszN NY\yfpVjPzJiaB?= Mo\DSG1UVw>? NXjyS4JYT0l3ME2wMlc6KM7:TR?= NWG2PVZoOjJ2M{W2Olk>
NCI-H460 MlfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXO2MlIh|ryP MkPiO|IhcA>? NWHDWo1RTE2VTx?= M3\0TmdKPTB;MD63PUDPxE1? Mly1NlI1OzV4Nkm=
NCI-H522 MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHIOIZPPi5{IN88US=> MorOO|IhcA>? M{fWOmROW09? MVLHTVUxRTBwNTFOwG0> MWmyNlQ{PTZ4OR?=
OVCAR3 MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXvOk4zKM7:TR?= MWm3NkBp NYnrU49LTE2VTx?= MorpS2k2OD1zLkOg{txO MV6yNlQ{PTZ4OR?=
OVCAR4 MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPHPVBsPi5{IN88US=> NGnWWoM4OiCq M1vwWWROW09? M4rKWmdKPTB;NDFOwG0> NVPFbYVjOjJ2M{W2Olk>
OVCAR5 NYiwOVlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWizbIZMPi5{IN88US=> M4ntRlczKGh? M1vG[2ROW09? M3XpS2dKPTB;MD63PUDPxE1? NIizd4kzOjR|NU[2PS=>
OVCAR8 NUTZc4VvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjUOZU3NjJizszN Ml3XO|IhcA>? NFXSd5BFVVOR NEfOWmdIUTVyPUCuOUDPxE1? Ml7ZNlI1OzV4Nkm=
RXF393 NYrKWWVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHkVnM3NjJizszN NX;ndYF6PzJiaB?= NX[3bGRHTE2VTx?= M{\USWdKPTB;MT6zJO69VQ>? NUL2eYRuOjJ2M{W2Olk>
SF268 MmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPHbnI3Pi5{IN88US=> Ml70O|IhcA>? M2rUb2ROW09? MojpS2k2OD1zLk[g{txO MXSyNlQ{PTZ4OR?=
SF295 NEXrSphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fINFYvOiEQvF2= M4jke|czKGh? MVnEUXNQ MVTHTVUxRTFwNjFOwG0> Mn\XNlI1OzV4Nkm=
SF539 NGixPY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO2MlIh|ryP MkP2O|IhcA>? MXvEUXNQ MkT0S2k2OD1{IN88US=> NXTObVJnOjJ2M{W2Olk>
SK-MEL-2 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn3XXg3NjJizszN MlzJO|IhcA>? NVnWWYlHTE2VTx?= NIXLU2NIUTVyPUGuN{DPxE1? MlrwNlI1OzV4Nkm=
SK-MEL-28 NYDYU4dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PWXFYvOiEQvF2= NFK3T484OiCq NXjTSFc6TE2VTx?= NV:3cHRmT0l3ME2xJO69VQ>? MYKyNlQ{PTZ4OR?=
SK-MEL-5 NFHSSItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoflOk4zKM7:TR?= MVi3NkBp M1LDZmROW09? MnSzS2k2OD1yLk[zJO69VQ>? MWqyNlQ{PTZ4OR?=
SKOV3 MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jxdlYvOiEQvF2= MUO3NkBp M{PxdGROW09? MYXHTVUxRTFizszN NUTYZ4xUOjJ2M{W2Olk>
SN12C M1jyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr4UZY3NjJizszN NWT6OXJTPzJiaB?= NWnTVVg1TE2VTx?= MVLHTVUxRTJizszN M1[xU|IzPDN3Nk[5
SNB19 NWXVNlJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXUOk4zKM7:TR?= MkfrO|IhcA>? M1jnO2ROW09? NEn5XWJIUTVyPUCuOlMh|ryP MmfLNlI1OzV4Nkm=
SNB75 M3TaXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vNfFYvOiEQvF2= NUfKXmZCPzJiaB?= MUjEUXNQ MVfHTVUxRTBwN{mg{txO MYCyNlQ{PTZ4OR?=
SR Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLFOk4zKM7:TR?= MUG3NkBp NYnZTndyTE2VTx?= NIO3WHJIUTVyPUCuOEDPxE1? MW[yNlQ{PTZ4OR?=
T47D NVS2RYxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorPOk4zKM7:TR?= NGewNGY4OiCq NUPSdJU5TE2VTx?= MUXHTVUxRTBwNTFOwG0> M2TFclIzPDN3Nk[5
TK10 NUHGfFlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPGNm03Pi5{IN88US=> MUi3NkBp NITPdmJFVVOR Mn;vS2k2OD1yLk[zJO69VQ>? NUX4eG1YOjJ2M{W2Olk>
UACC257 NVPheHFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli5Ok4zKM7:TR?= M4LCbVczKGh? MoPjSG1UVw>? NFr5R25IUTVyPUCuOUDPxE1? NVvKZ5FkOjJ2M{W2Olk>
UACC62 NEXQNZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fVRVYvOiEQvF2= MmnqO|IhcA>? M2TKPGROW09? NXH4XngxT0l3ME2wMlQh|ryP M{jpTFIzPDN3Nk[5
UO31 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYG2MlIh|ryP MUW3NkBp M1\kUmROW09? MYTHTVUxRTBwNTFOwG0> MXyyNlQ{PTZ4OR?=
Hep3B M2TZbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH62N4Q1QCCq NX7DNldRTE2VTx?= MofmS2k2OD1yLk[5JO69VQ>? NF\yS|czOjR|OUi2Ny=>
BE(2)-C NUnOb3VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvjTFdPPzJiaB?= NGfQR4tFVVOR NGTZPVJKSzdyPUKg{txO MnGzNlI6OzJ|MU[=
Bel7402 M{HtfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnZT2JwPzJiaB?= MWHEUXNQ NETQOY1IUTlyPUG3JO69VQ>? NWjpPWpPOjNyNkGzO|Y>
Bel7404 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTDUZZxPzJiaB?= MknKSG1UVw>? MVfHTVkxRTF6IN88US=> NY[1T29wOjNyNkGzO|Y>
BGC823 M1nzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPrZXI2PzJiaB?= M373bmROW09? MY\HTVkxRTdwNTFOwG0> NV24OoZiOjNyNkGzO|Y>
MGC803 NF2ybllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj2Zms4OiCq NYjvO|JrTE2VTx?= NFG3c45IUTlyPUGwMlgh|ryP MkT1NlMxPjF|N{[=
SGC7901 NUHCbYU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTpO|IhcA>? Mn3sSG1UVw>? MmS5S2k6OD17LkSg{txO M{GyUlI{ODZzM{e2
SKHEP1 NHf6XHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPkcGs4OiCq NWDDRoNjTE2VTx?= NIDEWHpIUTlyPUG3JO69VQ>? NHTZZVMzOzB4MUO3Oi=>
SMMC7721 NGHIZWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TmflczKGh? NGHz[ZhFVVOR NGrLbHNIUTlyPUKwJO69VQ>? MXWyN|A3OTN5Nh?=
NUGC3 Mn;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVyxNEDPxE1? MoDDS2k:Oi57NDFOwG0> MXyyN|E3OzN|Mh?=
A2780 CisR NWfxSGpQU2mwYYPlJGF{e2G7 MXSxPEBp MmfuTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkS0JO69VQ>? MkK2NlMzPTJ4MEO=
CAL27 sens NYX1VHVKU2mwYYPlJGF{e2G7 NXj0NVB1OThiaB?= NWLEfVRVUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= NFHhOVAzOzJ3Mk[wNy=>
CAL27 CisR MUPLbY5ie2ViQYPzZZk> NI\sVFAyQCCq NY\4S3NPUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MljQNlMzPTJ4MEO=
KYSE-510 CisR MV\LbY5ie2ViQYPzZZk> NGTmU24yQCCq MY\Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNUmg{txO NXW3VHFzOjN{NUK2NFM>
KYSE-510 sens MVTLbY5ie2ViQYPzZZk> Mn6xNVghcA>? MmG3TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO NWj0WnU4OjN{NUK2NFM>
MDA-MB-231 sens MVrLbY5ie2ViQYPzZZk> NWHwZ5gzOThiaB?= M3e4OWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NHfOc4QzOzJ3Mk[wNy=>
MDA-MB-231 CisR MmXNT4lv[XOnIFHzd4F6 MoHuNVghcA>? NUDFb5o4UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MnG2NlMzPTJ4MEO=
ES2 NH3Wd3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVq0PEBp NH7XemdFVVOR NEi5cGRKSzVyPUGyMlch|ryP MlXrNlM1QTN2NEm=
MDA-MB-231 NVvnTYFyU2mwYYPlJGF{e2G7 MnXWNVAh|ryP MlWzN|AhdWmw M4XKc2ROW09? NXLk[FhYUW6qaXLpeIlwdiCxZjDISGFEOmF? NICyXlAzOzR7M{S0PS=>
MDA-MB-231 NYTBfI51U2mwYYPlJGF{e2G7 NVTyU49yOSEQvF2= NGnLdmkzPCCq MXLEUXNQ NXnVUGExUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> NXi4N5ZKOjN2OUO0OFk>
HS68 MmL1R5l1d3SxeHnjJGF{e2G7 NIWxcVgyOCEQvF2= NF3Pdnk4OiCq NEXBcZhFVVOR NFfSN2tKSzVyPUSuOkDPxE1? NX[2UnZbOjN3N{C1OFI>
MEF Mor2R5l1d3SxeHnjJGF{e2G7 NUXvZmJqOTBizszN MmXmO|IhcA>? NIK5NFJFVVOR NIjzVo5KSzVyPUSuOEDPxE1? MV[yN|U4ODV2Mh?=
BGC823 NWfweIM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjYd2k4TE2VTx?= NXjHeFVZT0l3ME2zMlA6KM7:TR?= MYSyN|YxOTdyNh?=
High5 NF:2VIlMcW6jc3WgRZN{[Xl? Mki3NlQhcA>? NGPzPI9KdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM3KHerdHigTWM2OCCxZjCwMlA6KM7:TR?= MnvxNlM3ODJ3MkO=
High5 M3voemtqdmG|ZTDBd5NigQ>? MXSyOEBp NFfPUGJKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlEzKM7:TR?= NHnB[3kzOzZyMkWyNy=>
High5 M3jYc2tqdmG|ZTDBd5NigQ>? Mn;kNlQhcA>? M1HhSmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Mhf2m2aDDJR|UxKG:oIECuNVch|ryP MXKyN|YxOjV{Mx?=
A549 M{D5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PjZWROW09? MWHJR|UxRTFwMEe5JO69VQ>? M3fJeFI{PjR2MkGw
HCT116 NV\0ZY1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrEUXNQ NIDENIxKSzVyPUCuO|U4KM7:TR?= NFrJT5YzOzZ2NEKxNC=>
K562 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjEUXNQ MlvnTWM2OD1yLk[0OUDPxE1? MlvENlM3PDR{MUC=
GBC-SD MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWGzdIJ6PSEQvF2= M33oe|czKGh? MWnEUXNQ MlvVTWM2OD1zND64JO69VQ>? NGq3WGQzOzdyN{K2NC=>
HGC27 MmPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqxOUDPxE1? M{TS[|czKGh? M4jBSWROW09? NXnSfG1tUUN3ME21MlQh|ryP M2rRTVI{PzB5Mk[w
HL60 Mm\RT4lv[XOnIFHzd4F6 NWfmNWJXPSEQvF2= MV:yOEBp NUC3OWJkTE2VTx?= MnzzTY5pcWKrdHnvckBw\iCKRFHD MmjmNlM4ODd{NkC=
Vero MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUi3NkBp NULxeYJTTE2VTx?= NHvHd2pKSzVyPUCuPUDPxE1? NUPjb3Q2OjN5OE[0OVI>
NCI60 Mnz1R5l1d3SxeHnjJGF{e2G7 MWC0PEBp Mnf1SG1UVw>? MYLHTV0xNjV|IN88US=> NGnGRm0zPDBzNUOyOy=>
SW620 NWf3fZFHS3m2b4TvfIlkKEG|c3H5 MoP1OFghcA>? M{X0ZWROW09? NGCzNXlIUT1yLkW0JO69VQ>? M2\UdVI1ODF3M{K3
U251 NX3G[IVjS3m2b4TvfIlkKEG|c3H5 NWTX[nJXPDhiaB?= MoLlSG1UVw>? MnzOS2k:OS53MzFOwG0> M4XDVFI1ODF3M{K3
KM12 M1y5bWN6fG:2b4jpZ{BCe3OjeR?= M4q3dlQ5KGh? MlPsSG1UVw>? NV3oWGhbT0l;MT64PEDPxE1? M3XBR|I1ODF3M{K3
Hs578T MlfsR5l1d3SxeHnjJGF{e2G7 MXy0PEBp MXvEUXNQ NFK1RXdIUT12LkizJO69VQ>? NW\GS2x6OjRyMUWzNlc>
MDA-MB-231 MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXqRoQ1QCCq MkPlTWM2OD1yLkG2JO69VQ>? MX:yOFA6PTBzNh?=
MCF7 NGjkNG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXROFghcA>? NIHleVFIUT1yLkS1JO69VQ>? M3;3fVI1OTF7NUW1
MDA-MB-435 NVfZWmtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Lw[FQ5KGh? MVHHTV0xNjh6IN88US=> MUeyOFEyQTV3NR?=
AsPC1 NFvKNVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDz[XU{OCEQvF2= NHXi[JA1QCCq M4X6e2ROW09? NVvudWl3UUN3ME2zMlY3KM7:TR?= Ml\WNlQyQDV|N{i=
Jurkat E6.1 NVGxZZZWU2mwYYPlJGF{e2G7 NX3oR|NHOiCq NFPBTphFVVOR M3T2b2lvcGmkaYTpc44hd2ZiSFTBR|Qhf2m2aDDJR|UxKG:oIECuNFQh|ryP Mln5NlQzPjF6NkK=
KG1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYm0PEBp NUDne3NOUUN3ME2xMlE2KM7:TR?= NYDMWpRNOjR3MkWwNFM>
HEL NUL2SXU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzROFghcA>? NGLGUGRFVVOR MmDBTWM2OD1yLkS5JO69VQ>? Mmr1NlQ3QTRyNUW=
HSC3 M2LwXmN6fG:2b4jpZ{BCe3OjeR?= MlPsNVIhcA>? NYXkXoJLTE2VTx?= MkDNTWM2OD1yLkexJO69VQ>? NV7jWpBWOjR5Nk[1OlA>
HT-29 NYLoZ2x[S3m2b4TvfIlkKEG|c3H5 MoPINVIhcA>? Ml\jSG1UVw>? NIrybXJKSzVyPUCuO|Ih|ryP MYWyOFc3PjV4MB?=
KB NEjoepJEgXSxdH;4bYMhSXO|YYm= NXK3OmtZOTJiaB?= NYn6TG4xTE2VTx?= MkjHTWM2OD1yLke1JO69VQ>? MWmyOFc3PjV4MB?=
H460 M4\5d2N6fG:2b4jpZ{BCe3OjeR?= MkK3NVIhcA>? MmOxSG1UVw>? MkfkTWM2OD1yLkiyJO69VQ>? M2eybFI1PzZ4NU[w
MONE1 M3;h[mN6fG:2b4jpZ{BCe3OjeR?= MnnkNVIhcA>? NGfLOVlFVVOR MV\JR|UxRTFwMUig{txO NXjzbI9oOjR5Nk[1OlA>
MKN45 MWHDfZRwfG:6aXOgRZN{[Xl? MlvUNVIhcA>? NX3uUFRSTE2VTx?= NV;KOGE{UUN3ME2xMlI2KM7:TR?= M4i0R|I1PzZ4NU[w
TSGH NUj5doZRS3m2b4TvfIlkKEG|c3H5 NGPqSFAyOiCq MXvEUXNQ NEDwZlNKSzVyPUKuNFkh|ryP M13ROFI1PzZ4NU[w
HL60 NIfERmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrLWXJJPzJiaB?= M{PLU2ROW09? Ml;RS2k2OD1yLkmzJO69VQ>? NYPYUJo2OjR7MEC1NFA>
HEK293 NWH2S4hFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7G[YZvPzJiaB?= Mn33SG1UVw>? MkLFS2k2OD1zMzFOwG0> MkDGNlQ6ODB3MEC=
Jurkat NIHVclZEgXSxdH;4bYMhSXO|YYm= NYq0TFNLOTByIN88US=> NEXmdWs4OiCq Moq5S2k2OD1yLkmg{txO MmLXNlQ6ODB5NEO=
GM15850 MVzLbY5ie2ViQYPzZZk> NYjUSZF2Oi53IN88US=> NEi2bpg6PiCq Mn\hSG1UVw>? NWrBZmtb\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDNibInzbY5mKDF2IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m M1XnPFE3QTJzM{[3
GM15850 M4TWTmtqdmG|ZTDBd5NigQ>? MWmyMlUh|ryP NGTtXlc6PiCq M1zJUGROW09? NXP5UWxt\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDViYXPleJlt[XSrb36gc4YhTliQIHflcoU> MkO5NVY6OjF|Nke=
GM15850 NUXBdlNFU2mwYYPlJGF{e2G7 NG\lT4EzNjVizszN NEXyWo06PiCq NUixOJJxTE2VTx?= MkSx[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MlfWNVY6OjF|Nke=
GM15850 M{fF[2tqdmG|ZTDBd5NigQ>? NHPnSoMzNjVizszN NFHhTWc6PiCq NFLsNIpFVVOR NGC2eGJld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhQSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NGnqVXQyPjl{MUO2Oy=>
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NCI-H661 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYH5UlFrUUN3ME2yMlY1ODh3IN88US=> MVnTRW5ITVJ?
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EGI-1 M1HUT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\HbZd6UUN3ME2yMlgyPzR|IN88US=> MVzTRW5ITVJ?
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EC-GI-10 NVG5R2p1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm0SFU6UUN3ME2zMlI3OTV|IN88US=> NIrwcZJUSU6JRWK=
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SW1116 NHvUXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTNwNE[yOlkh|ryP Mmi5V2FPT0WU
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EW-13 NIfJdo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq5TWM2OD1|LkWyOVEh|ryP MWjTRW5ITVJ?
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CAL-62 NHrZWG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfBTWM2OD1|LkW0OVE1KM7:TR?= M4mxfnNCVkeHUh?=
OCUB-M MoP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTNwNUS2OlUh|ryP MVXTRW5ITVJ?
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NCI-H1581 M3vCUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTNwOES0PFgh|ryP NITLNXBUSU6JRWK=
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TE-10 M3SzeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnWwTWM2OD1|LkmyNFEh|ryP NHS4SVZUSU6JRWK=
OVCAR-4 NYfES4hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4i3XmlEPTB;Mz65Nlg5QSEQvF2= MVHTRW5ITVJ?
ETK-1 M{fIVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P5S2lEPTB;Mz65OFY{PSEQvF2= M1TOOHNCVkeHUh?=
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COR-L105 M4DTemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLWTWM2OD12LkGzNFUyKM7:TR?= MXfTRW5ITVJ?
CAL-12T M32zfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17C[mlEPTB;ND6xN|ExOyEQvF2= NELOd3BUSU6JRWK=
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CAL-54 NUjLUYszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r2NmlEPTB;ND6yNlM5OSEQvF2= NFrzeZBUSU6JRWK=
CAL-33 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWG3RnUyUUN3ME20MlI{ODZ2IN88US=> M2TqUHNCVkeHUh?=
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KYSE-70 Mn3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTRwMkmzOEDPxE1? NGnsPXhUSU6JRWK=
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CAL-120 M3\4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTVe4tKSzVyPUSuN|g6QTJizszN M1WyeHNCVkeHUh?=
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GMS-10 M{fnRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmC5TWM2OD12LkSyPFE6KM7:TR?= M3\EOnNCVkeHUh?=
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NCI-H2452 M2jRR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\Tb|VXUUN3ME2xNE4yPiEQvF2= NH3ocZdUSU6JRWK=
NCI-H1395 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i2XmlEPTB;MUCuNVc5KM7:TR?= NYLxVHk3W0GQR1XS
NCI-H2052 NYDnZ|JIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTFyLkG4PFIh|ryP M4jPZnNCVkeHUh?=
A375 NXT4[nNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFyLkK0OVIh|ryP NH2ybo1USU6JRWK=
HCC38 M2LIUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzLTWM2OD1zMD6zNlIh|ryP MV\TRW5ITVJ?
LK-2 NVrOVpJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFyLkSyNFgh|ryP NHS2UFNUSU6JRWK=
SF126 NIn2WmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTFyLkS3Nlch|ryP Ml76V2FPT0WU
SK-MEL-1 M4Hkd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFyLke4N|gh|ryP MUjTRW5ITVJ?
ACN NX\lS4E{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1njNGlEPTB;MUCuPFY4QSEQvF2= NI\MVpBUSU6JRWK=
BB30-HNC M4Hi[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXVTWM2OD1zMD64O|EyKM7:TR?= NUeyOJh2W0GQR1XS
NCI-H747 Moj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfDPXVKSzVyPUGwMlg4PDZizszN NULze4NKW0GQR1XS
KYSE-150 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M331VmlEPTB;MUGuNFM5PyEQvF2= MkDpV2FPT0WU
D-247MG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjId2hKSzVyPUGxMlExODlizszN NWXtS4dIW0GQR1XS
BxPC-3 M{SwWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLyeHRKSzVyPUGxMlM4PDdizszN NG\O[|lUSU6JRWK=
SK-MEL-30 NIHiVFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH6SoE2UUN3ME2xNU41ODd7IN88US=> MmL5V2FPT0WU
CAS-1 MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTFzLkSxNFkh|ryP MWDTRW5ITVJ?
no-10 NUHrVGo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M132d2lEPTB;MUKuNVIyPyEQvF2= NV7MXZVuW0GQR1XS
NCI-H2405 NI\3W|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rGO2lEPTB;MUKuNlA{PiEQvF2= NFjyNmFUSU6JRWK=
KGN MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;ZRWlEPTB;MUKuNlkxOSEQvF2= NYfFN4RZW0GQR1XS
BB49-HNC M2jPdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TqXWlEPTB;MUKuN|k2PiEQvF2= Ml;tV2FPT0WU
NCI-H1693 M1vEWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz2TWM2OD1zMj61PFE3KM7:TR?= MX;TRW5ITVJ?
RO82-W-1 NWDrfW9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;BTWM2OD1zMz6wOlQ6KM7:TR?= MlOyV2FPT0WU
CAL-85-1 NVHIUWNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zlfmlEPTB;MUOuOFM6QSEQvF2= NGPyVGtUSU6JRWK=
H-EMC-SS NVfLVppbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLkSnlKSzVyPUGzMlkyODRizszN MY\TRW5ITVJ?
SW1783 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLRTWM2OD1zND6yN|kyKM7:TR?= M{HUNnNCVkeHUh?=
LB771-HNC NIrsNIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XScmlEPTB;MUSuOFE6KM7:TR?= NHPYZmhUSU6JRWK=
HCC70 MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vETWlEPTB;MUSuOFI{OyEQvF2= NGLKOo9USU6JRWK=
KNS-81-FD MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjmZWxKSzVyPUG0MlcxPDVizszN MmLlV2FPT0WU
KYSE-520 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTF2LkmyO{DPxE1? NXXFcmd6W0GQR1XS
TGBC24TKB NF;VbIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zMbGlEPTB;MUSuPVU{QSEQvF2= M2r1Z3NCVkeHUh?=
SNB75 NXTZNGh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3v6TWlEPTB;MUWuNFczQSEQvF2= M1rTdXNCVkeHUh?=
SW872 NE\SRmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e1U2lEPTB;MUWuNlIyQCEQvF2= MV3TRW5ITVJ?
U031 MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrMZ5kyUUN3ME2xOU45ODJ6IN88US=> NV6wZ5psW0GQR1XS
ChaGo-K-1 MoXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG0VnlTUUN3ME2xOU45OzV7IN88US=> MofpV2FPT0WU
NCI-H441 NGDTbIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\XeHIzUUN3ME2xOk4xODN7IN88US=> Mn3pV2FPT0WU
TE-12 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPvTWM2OD1zNj6xPFc{KM7:TR?= NVnVPXVJW0GQR1XS
NCI-H1755 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorUTWM2OD1zNj61O|Mh|ryP NFn3fnlUSU6JRWK=
KNS-42 MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\BcFRNUUN3ME2xOk43PTh7IN88US=> M1;uOXNCVkeHUh?=
SK-PN-DW NHjsNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnCWZpxUUN3ME2xO{41OjBzIN88US=> M37UcXNCVkeHUh?=
NCI-H226 NXK2R4xOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHhTWM2OD1zNz65N|Q2KM7:TR?= M2fiPHNCVkeHUh?=
K-562 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzhOldKSzVyPUG4MlY{OTdizszN NHH6U21USU6JRWK=
A388 NVTsVJhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DRcGlEPTB;MUmuNFMxOyEQvF2= NVHaO5VpW0GQR1XS
ZR-75-30 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjKTWM2OD1zOT6wPVY5KM7:TR?= M3HBcHNCVkeHUh?=
LU-135 NWHNSZhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fvc2lEPTB;MUmuNlY{PiEQvF2= NYnX[og3W0GQR1XS
NCI-H2029 M1HmWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTib49KSzVyPUG5MlYxOjFizszN M1HONnNCVkeHUh?=
HT-1197 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF7LkmyNlch|ryP NIfSRZdUSU6JRWK=
IGR-1 Ml\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW5SW5DUUN3ME2yNE4{OTF5IN88US=> Mk\uV2FPT0WU
U-87-MG MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJyLk[0NVMh|ryP MXXTRW5ITVJ?
NCI-H1304 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne3TWM2OD1{MD63OVAyKM7:TR?= MXzTRW5ITVJ?
RCC10RGB NUH2fJJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[yWpN2UUN3ME2yNU4zQDJ7IN88US=> NH;UNlhUSU6JRWK=
NCI-H520 NF;OVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\0TWM2OD1{Mj63OlEyKM7:TR?= NHm5b3RUSU6JRWK=
SK-LU-1 NV74UpFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;TRpB1UUN3ME2yN{4xPzF6IN88US=> NFXabGNUSU6JRWK=
UACC-893 NX[2Tm15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJ|LkGwN|gh|ryP NXHJe|M4W0GQR1XS
NCI-H2347 M1f4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfOZlVKSzVyPUKzMlI3PzRizszN MVLTRW5ITVJ?
U-118-MG M{[2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PVb2lEPTB;MkOuO|IyPyEQvF2= NH3oVXhUSU6JRWK=
NCI-H596 NWfEcYY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;3b2lEPTB;MkOuPVA2PSEQvF2= NHX1TZlUSU6JRWK=
MZ1-PC Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVy2XGtbUUN3ME2yOE43PzV7IN88US=> MWDTRW5ITVJ?
SW1417 NH;5SJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfxWGpKSzVyPUK1MlI1QThizszN M{jQVHNCVkeHUh?=
NCI-H82 NXzQUoQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJ4LkSyPFgh|ryP NFe2NpFUSU6JRWK=
COLO-678 NVTPV2VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnCOoxKSzVyPUK3MlQ6OTlizszN NV7IXZZPW0GQR1XS
KURAMOCHI NH62UY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrOTWM2OD1{OD6xNlYh|ryP NXnZN3hkW0GQR1XS
NCI-H1650 M2\IfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGW5cHFKSzVyPUOwMlE6OjRizszN NUTKSmpJW0GQR1XS
HCC1954 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnjOIs2UUN3ME2zNU4{PjZ4IN88US=> NX3FVGlqW0GQR1XS
GAK M3T0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPtSJNKSzVyPUOyMlI3OTZizszN M2f3bHNCVkeHUh?=
YAPC MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\0[ldKSzVyPUOzMlc3PDhizszN NF:x[oxUSU6JRWK=
NCI-H2228 MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jxbWlEPTB;M{SuN|YxPSEQvF2= MYHTRW5ITVJ?
VMRC-RCZ M4DCTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LFd2lEPTB;M{[uN|AzOiEQvF2= MV7TRW5ITVJ?
NMC-G1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTN5LkC1Nlkh|ryP M{LFOnNCVkeHUh?=
D-336MG MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTRzLki0OFIh|ryP M1G2V3NCVkeHUh?=
UACC-62 M3rEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHYboJKSzVyPUSyMlU2ODVizszN MmK1V2FPT0WU
C-33-A NXHQOpF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTR3LkOyOVYh|ryP NWPu[otiW0GQR1XS
HCC1937 NHTQepFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETXcXpKSzVyPUS3MlE6PThizszN M4jKTHNCVkeHUh?=
HDLM-2 M2POO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXBTWM2OD12Nz6yNlg4KM7:TR?= MYPTRW5ITVJ?
NCI-H727 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTwWWdnUUN3ME20O{4zPDVzIN88US=> NGXzUJhUSU6JRWK=
NY NVHtcVZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jJcWlEPTB;NEmuN|kxQCEQvF2= MWnTRW5ITVJ?
NCI-H2291 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrr[3pKSzVyPUS5Mlg{ODFizszN NUHtSmw1W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID