Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 100 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MXzLbY5ie2ViQYPzZZk> M{\odVEhcA>? MkfjSG1UVw>? MVLhcpRqNUiGQVOxJIFkfGm4aYT5JJdqfGhiSVO1NEBw\iByLkGxNkDPxE1? NEHuUWEyOTl4MES4PS=>
Friend leukemic cell Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvVOVAh|ryP NUKzWI1DPzJiaB?= NY\RWmVYTE2VTx?= MX;JR|UxRTBwOUmg{txO MYixNlExQTlzMx?=
K562 MYXLbY5ie2ViQYPzZZk> MV22JIg> Mnr5SG1UVw>? M3\pW2lvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> NYjk[pJGOTJ2MUmzPFA>
HT1080 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XKb|czKGh? NUfTeG14TE2VTx?= NV2zNZhLUUN3ME2yMlQh|ryP NX;vPFBLOTJ{N{CxO|U>
H1299 MYrLbY5ie2ViQYPzZZk> MkXSNlAhdWmw NVLx[VBTTE2VTx?= Mo\KTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= MmXyNVQ2OjF2MkK=
H1299 M4fVSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWK3NkBp NIrhXnlFVVOR Ml:5TWM2OD15LkK0JO69VQ>? Mn\ONVQ2OjF2MkK=
HeLa Ml\YT4lv[XOnIFHzd4F6 NXr6cmRXOzBibXnu NEHv[VJKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDobZN1d26nIHTlZYNmfHmuYYPlJJdqfGhiSVO1NEBw\iByLkK4JO69VQ>? Mk\nNVU3ODN7NEm=
LOX-IMVI NGPhWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe2cXJPPDhiaB?= MV;JR|UxRTFwMzFOwG0> MYexOVcyPTR5MB?=
NCI-H226 NHSzSFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nQ[FQ5KGh? NY\2U21jUUN3ME2yMlYh|ryP MnXBNVU4OTV2N{C=
RXF-631L MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXe0PEBp NInn[YdKSzVyPUKg{txO M2TYZ|E2PzF3NEew
SNB-78 M3;kXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;ZV|Q5KGh? NFPySJdKSzVyPUG2JO69VQ>? NVro[5hiOTV5MUW0O|A>
St-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m0[VQ5KGh? NGnBTIdKSzVyPUWuNkDPxE1? NXWxNlFKOTV5MUW0O|A>
ARP1 MYLGeY5kfGmxbjDBd5NigQ>? MYWyJO69VQ>? NUe0XpcyPiCq MXfJcoR2[3Srb36gc4YhWDJzV1HGNUBo\W6nIHX4dJJme3Orb36= NFm0WmwyPDd|NEiwOi=>
CEM MnTuT4lv[XOnIFHzd4F6 MWexJIg> MYfEUXNQ M4Ph[mlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? NUXKOXlJOTZ2MkCwOlQ>
HCT15 Ml;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W0N|Q5KGh? NITB[YlIUTVyPUCuPFIh|ryP M2DMT|E3PzJ|MkK3
NCI-H23 NX7nVIdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjkT2c1QCCq MmO4S2k2OD1yLkmyJO69VQ>? NGDiUGUyPjd{M{KyOy=>
GM15850 MljLT4lv[XOnIFHzd4F6 NV3YbJlpOi53IN88US=> M12zblk3KGh? MkTrSG1UVw>? MkLxTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEG0JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NFj6UVIyPjl{MUO2Oy=>
GM15850 NUfqbVhVU2mwYYPlJGF{e2G7 MXKyMlUh|ryP NUXLfmNLQTZiaB?= M1u2NGROW09? NULFeVlFUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NIq5eHAyPjl{MUO2Oy=>
GM15850 MV\LbY5ie2ViQYPzZZk> NH;neXAzNjVizszN Mmi5PVYhcA>? NIqxN4RFVVOR MVLJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMUKgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M{PhVVE3QTJzM{[3
GM15850 M3rWdGtqdmG|ZTDBd5NigQ>? NYTDU2NFOi53IN88US=> MUW5OkBp NFH6XnZFVVOR NGraemtKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NH75SmMyPjl{MUO2Oy=>
GM15850 MWXLbY5ie2ViQYPzZZk> M1jReVIvPSEQvF2= MlXLPVYhcA>? M2XKcGROW09? MUDJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViODDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? Mnm1NVY6OjF|Nke=
GM15850 M1:xV2tqdmG|ZTDBd5NigQ>? M1fLWVIvPSEQvF2= M4foU|k3KGh? MWnEUXNQ MWfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMU[gZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M2HjNFE3QTJzM{[3
U937 NF\iNYVHfW6ldHnvckBCe3OjeR?= MoG5OUDPxE1? MoDXNlQhcA>? M{PL[GROW09? M3L5XWNmdGxiY4njcIUh[XK{ZYP0JIJ6KGGlY4XteYxifGmxbjDheEBUN0d{L12gdIhie2V? M1jOU|E4ODB2N{G4
H661 Moq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\BNHk1QCCq NXzhPIFbUUN3ME2xJO69VQ>? MoSwNVcyPTdyMEm=
U937 M2C3V2Z2dmO2aX;uJGF{e2G7 M4j3VlUh|ryP NYfBc3VXOjRiaB?= NUfVSVdUTE2VTx?= NUfLSnAzUW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> M3PyblE4PDR5N{Ww
U937 MlL2SpVv[3Srb36gRZN{[Xl? M4PJNlEh|ryP NWXKSllmOjRiaB?= Mn:xSG1UVw>? MmnxSYZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= MnmzNVc1PDd5NUC=
RAW264.7 MoThSpVv[3Srb36gRZN{[Xl? NHnQ[oEyOCEQvF2= MUOyOIg> NHTvWVR4[XSnch?= NGn1Xm5KdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN NXPqVXY3OTd2N{e1NVg>
RAW264.7 NHP2UGVHfW6ldHnvckBCe3OjeR?= Ml;0NVAh|ryP MYiyOIg> NX[0cXhJf2G2ZYK= M3LofWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> NIWwVI8yPzR5N{WxPC=>
SC9 Ml3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYexN|M{PDhiaB?= MWHJR|UxRTBwNkC2JO69VQ>? Mn7mNVc2ODd{MUm=
ST14A M2[3W2Z2dmO2aX;uJGF{e2G7 NXXkenN2PSCwTR?= NIrFV3k4OiCq M3riUmlv[3KnYYPlJIlvKFKHU2SvUnJUTiCvUl7BJIV5eHKnc4Ppc44> MWCxO|U3PTl7Mx?=
ST14A NGPUVWlHfW6ldHnvckBCe3OjeR?= MmfyOUBvVQ>? NYnFVlY{PzJiaB?= MmDITY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? NUfU[XhnOTd3NkW5PVM>
PANC1 NGHsNoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nh[|Eh|ryP NXXxcJJ1UUN3ME2wMlQ2KM7:TR?= NGi0TYQyPzV6OEe0OC=>
PANC1 MmS5SpVv[3Srb36gRZN{[Xl? NGKycoYyKM7:TR?= MmLjNlQhcA>? Mo\xTY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? MnLmNVc2QDh5NES=
PANC1 NYXJWYt3TnWwY4Tpc44hSXO|YYm= NI\M[|kyKM7:TR?= NEnsbGkzPCCq M{fwOmlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u M2Dp[|E4PTh6N{S0
PT45 NW[yWJRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfHSZVNUUN3ME20JO69VQ>? MnLVNVc2QDh5NES=
ACHN M{\OTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWWyNUBp NYTFbXRNT0l3ME2wMlY2KM7:TR?= M3[5VlE4PjZ{NkC2
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NCI-H358 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHmwT284OiCq NGDtdpBKSzVyPUKuOUDPxE1? NVPMS3p7OjBzNEO3O|g>
SCC15 NUO2NoF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XFUFczKGh? M13VcGlEPTB;Mj60PUDPxE1? NYTob2xPOjBzNEO3O|g>
SCC25 NIXmfIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEL5WmM4OiCq MXXJR|UxRTFwOUOg{txO MmTWNlAyPDN5N{i=
SKHEP1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3ZO|IhcA>? NXvQ[4JQUUN3ME2zMlQ3KM7:TR?= M{\3cFIxOTR|N{e4
BJ Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYixNFAh|ryP MXK0PEBp MXrEUXNQ MnTtS5Jwf3SqIHnubIljcXSrb36gZZQhOC5yNTD0c{AyODBidV2= NYfMR3B[OjBzNEO4OFA>
MUF NXy5OGVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX[xNFAh|ryP M4TUblQ5KGh? MVXEUXNQ NHnhdoZIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> M1;ZNVIxOTR|OESw
Caco-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vHU|ExOCEQvF2= NYnCSo9IPDiq NUC0NXZNTE2VTx?= MmTOTWM2OD16LkGg{txO MY[yNFE1Ozh2MB?=
Caco-2 MVTLbY5ie2ViQYPzZZk> M4rt[VUh|ryP Mlr2OEBp MoTTSG1UVw>? NXj3ZYROUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBi[2W2eXzheIlwdiCLQ{WwJI9nKDBwMEO3JO69VQ>? MVuyNFE1Ozh2MB?=
Caco-2 MUXLbY5ie2ViQYPzZZk> M{fDZlAvOzF4IH7NJJRwKDNzLk[g{txO MnPROEBp MUXEUXNQ M{fPUWV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMTD3bZRpKEmFNUCgc4YhOC5zMUmg{txO NYSze|hpOjBzNEO4OFA>
Caco-2 M1fXOmtqdmG|ZTDBd5NigQ>? MY[wMlMyPiCwTTD0c{A{OS54IN88US=> M1[w[VQhcA>? NVLIO5k6TE2VTx?= MmT2SZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN|IIfpeIghUUN3MDDv[kAxNjF2NzFOwG0> Mk\pNlAyPDN6NEC=
Caco-2 Mn7JT4lv[XOnIFHzd4F6 NUT4cJM{Pi5|MjDuUUB1dyB4M{Kg{txO M3HhelQhcA>? M4jMNWROW09? NH\POFRGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Wge4l1cCCLQ{WwJI9nKDF{Lk[g{txO NV;WTZpqOjBzNEO4OFA>
Caco-2 NFfQRlRMcW6jc3WgRZN{[Xl? M37UUlYvOzJibl2geI8hPjN{IN88US=> M{XLOlQhcA>? NVmxW4JmTE2VTx?= MnnYSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2= M{i3NFIxOTR|OESw
Caco-2 NELXO2RMcW6jc3WgRZN{[Xl? M1W3N|AvOzF4IH7NJJRwKDNzLk[g{txO MUO0JIg> MWfEUXNQ NFK2coRGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{[= NW\wTW9FOjBzNEO4OFA>
HepG2 M13ybGtqdmG|ZTDBd5NigQ>? NH\QZYk2KM7:TR?= M1fuS|Zp MnvCSG1UVw>? M3HHW2lv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgZYNmfHmuYYTpc44> NFLSU3czODF2M{i0NC=>
HepG2 NFz2T29McW6jc3WgRZN{[Xl? M1XLW|Uh|ryP Mn\5Oog> MU\EUXNQ NWPacFRvUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBpgXCncnHj[ZR6dGG2aX;u NFWxUWYzODF2M{i0NC=>
HepG2 MYPLbY5ie2ViQYPzZZk> NHrhXnA2KM7:TR?= MYC2bC=> MWPEUXNQ MoO5TY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= MmS1NlAyPDN6NEC=
HepG2 MoDpT4lv[XOnIFHzd4F6 MWW1JO69VQ>? NVLvT2liPmh? Ml\hSG1UVw>? NHe1N41KdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBJOy:KNDDobZN1d26nIHHj[ZR6dGG2aX;u MoXrNlAyPDN6NEC=
COLO205 M2O1WmtqdmG|ZTDBd5NigQ>? NVHJcYpxOTBizszN MX[yOEBp MlHwSG1UVw>? MV7Jcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizJIFk\XS7bHH0bY9vKHerdHigTWM2OCCxZjCyMlIh|ryP MmnJNlA1PTF|N{i=
SCC4 NH;oR|RMcW6jc3WgRZN{[Xl? NWLMRoZmOSEQvF2= MofhNlRp NXThXpkzUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44> NXLpUmh7OjB2NUKyNlU>
SCC4 MW\LbY5ie2ViQYPzZZk> MmPENUDPxE1? MkPCNlRp NGGz[mFKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDhZ4V1gWyjdHnvci=> M3P1NVIxPDV{MkK1
SCC4 NYDsT5R[TnWwY4Tpc44hSXO|YYm= NEHyPWEyKM7:TR?= MlHTOUBucW5? Mn[5RYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= MnXENlA1PTJ{MkW=
NB4 NWLWOW9ITnWwY4Tpc44hSXO|YYm= M{XkOlUh|ryP NXeyZ|cyOjRiaB?= Mn\CSG1UVw>? MVHD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn MnfqNlA1QTF2NEC=
NB4 NHjydoJMcW6jc3WgRZN{[Xl? MXe1JO69VQ>? NIWxOnkzPCCq M1HVV2ROW09? M4LxU2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? NWfHNXNoOjB2OUG0OFA>
NB4 MoDTSpVv[3Srb36gRZN{[Xl? Mn70OUDPxE1? MV[yOEBp MonJSG1UVw>? NYq3N4lxUW6mdXP0bY9vKG:oIICyNXdCTjFxQ1nQNUBmgHC{ZYPzbY9v Mlr6NlA1QTF2NEC=
NB4 M{jIW2tqdmG|ZTDBd5NigQ>? NUCweFNJPSEQvF2= NXjvPYhtOjRiaB?= MkHBSG1UVw>? MUjJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> NGXhd2wzODR7MUS0NC=>
NUGC3 Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C1dmdKPTB;Mj65OEDPxE1? NYfVOJFGOjB6NUC5O|E>
A549 Mn;nSpVv[3Srb36gRZN{[Xl? NVTWenREPSEQvF2= MnjmN{Bp NYjyWolmTE2VTx?= M2H1R2lv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCOQ{PJTS=> NELyeWwzODh3NUKwPC=>
HUT78 NV;BOHdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX6zOGh3PzJiaB?= MljISG1UVw>? M2H5d2dKPTB;MD6zJO69VQ>? M4W5RVIxQDh2MkC4
U937 M{SzVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\5RVczKGh? M4nxNGROW09? MUXHTVUxRTBwM{mg{txO Mo[2NlA5QDR{MEi=
A431 NV3nTmt4S3m2b4TvfIlkKEG|c3H5 MUW3NkBp NE\wTmhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2= NV\RWGpMOjFyOEC2Nlk>
A549 MXXDfZRwfG:6aXOgRZN{[Xl? M4DC[VczKGh? NUGzcGtwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjhizszN MkjCNlExQDB4Mkm=
CAL27 NEWycJVEgXSxdH;4bYMhSXO|YYm= NVzHc3JwPzJiaB?= MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRWwzPyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjCzMlIh|ryP NYf2VpJ3OjFyOEC2Nlk>
HeLa M3XrOmN6fG:2b4jpZ{BCe3OjeR?= M4LCVlczKGh? NXTBXXVlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjVizszN MYKyNVA5ODZ{OR?=
Sf21 NF;QeoRMcW6jc3WgRZN{[Xl? MX:zJIg> NX\ZXXpmUW6qaXLpeIlwdiCxZjDGcIFoKHSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBJTEGFODDlfJBz\XO|ZXSge4l1cCCLQ{WwJI9nKDFwMjFOwG0> NUPXSGdCOjFyOEC2Nlk>
SKBR3 MnP0R5l1d3SxeHnjJGF{e2G7 NXTDdppqPzJiaB?= MmLKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= MoT0NlExQDB4Mkm=
SKOV3 MofyR5l1d3SxeHnjJGF{e2G7 M171b|czKGh? NVTnRXpWS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi5{IN88US=> M2n2elIyODhyNkK5
COR-L23 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTmS21uOTBizszN MoX4O|IhcA>? NIq1Oo1FVVOR NUOxNIo1T0l3ME2xMlEh|ryP NVLoPJU4OjFyOEC2OFc>
DU145 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVexNEDPxE1? NIiwRpE4OiCq NULLOGZuTE2VTx?= MkXIS2k2OD1zLkC1JO69VQ>? M4nB[|IyODhyNkS3
LoVo MmrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojsNVAh|ryP MUm3NkBp M2LGWWROW09? NXW5clM6T0l3ME2xMlch|ryP NV72OpU4OjFyOEC2OFc>
MCR5-SV2 NGLkVFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXGxNEDPxE1? M2LEblczKGh? NX:yPIlWTE2VTx?= MUTHTVUxRTJwMTFOwG0> MYiyNVA5ODZ2Nx?=
HCT116 M2nRXmtqdmG|ZTDBd5NigQ>? M376NlMxKM7:TR?= M1;id|MxKGh? MV7EUXNQ NX[w[nZbUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4Yh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> MYKyNVA5ODZ2Nx?=
HCT116 MYrLbY5ie2ViQYPzZZk> MXqzNEDPxE1? NX7XeIxQOzBiaB?= MYrEUXNQ MknTTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN2s6KGGlZYT5cIF1cW:w NIPZN|QzOTB6ME[0Oy=>
U937 MYTLbY5ie2ViQYPzZZk> NF3hPVA2KM7:TR?= NVy0OmZROjRiaB?= NGLFZYJFVVOR M1LIT2lvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEt7 MVeyNVI6OjR7Mh?=
U937 NVLrN3pJU2mwYYPlJGF{e2G7 MVe1JO69VQ>? MYKyOEBp NX\MS2JJTE2VTx?= NVuxXWh7UW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 NWi3S|RGOjF{OUK0PVI>
U937 Mlq5T4lv[XOnIFHzd4F6 NXjwS4E5PSEQvF2= M3HnTVI1KGh? NIPrXGJFVVOR MnfKTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? MUCyNVI6OjR7Mh?=
U937 NGXTOnFMcW6jc3WgRZN{[Xl? NVH2SolyPSEQvF2= NFHwZZQyPSCvaX6= M{Sw[2ROW09? NILnUHlKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? MoTZNlEzQTJ2OUK=
A2780 NXvuOYdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3sW|VjQTZiaB?= NWq1cXl7TE2VTx?= MlvyTWM2OD1zLk[yJO69VQ>? Ml\mNlE3OzR2M{C=
COLO205 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDmcodrQTZiaB?= NVHNUFNtTE2VTx?= MmrDTWM2OD1{LkGyJO69VQ>? NYLrW4VoOjF4M{S0N|A>
Hep3B NXHs[FJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHT6eHk1QCCq NECxdXhFVVOR MmXvS2k2OD1zLkKxJO69VQ>? MYKyNVcyOjF2Nh?=
GM11272 MofZSpVv[3Srb36gRZN{[Xl? NVvzXYF1OTByIH7N MVe3NkBp NGHWTmRFVVOR MojTVoVi[3SrdnH0bY9vKG:oIF3lR5AzKG23dHHueEBmgHC{ZYPzbY9vKGG2IEGwJJRwKDFyMDDuUS=> M4G0bFIyQDRyN{G2
CFBE41o NXPkdndiU2mwYYPlJGF{e2G7 NFKz[|g2KM7:TR?= Mn:ySG1UVw>? M3HvV2Rwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? NGrySYgzOTl6NEm1PC=>
CFBE41o MVPGeY5kfGmxbjDBd5NigQ>? M{jwcVEh|ryP NV33O3dnOjRiaB?= M1\6ZWROW09? M3PaPHJme3SxcnH0bY9vKG:oIFPGWHIh\GWudHHGOVA5KG23dHHueEB1emGoZnnjb4lv\yC2bzDj[YxtKHO3cn\hZ4Uh[XNiZ3z5Z49nd3Kvcx?= MojVNlE6QDR7NUi=
DU145 NELlUXBMcW6jc3WgRZN{[Xl? MlTsNk42KM7:TR?= NVTYVmZxOjRiaB?= M3viZmROW09? MmPrTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW|c3nvci=> M17qTlIzOjZyMU[2
DU145 NH2zUIhMcW6jc3WgRZN{[Xl? MoPQOUDPxE1? M3TtNlI1KGh? M1\YSmROW09? MorOTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36= NUDUNIJlOjJ{NkCxOlY>
DU145 MnLlT4lv[XOnIFHzd4F6 NVXKXHBsPSEQvF2= MX2yOEBp NVfhSVBUTE2VTx?= NVnVNZJUUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSEOgbJlx\XKjY3X0fYxifGmxbh?= MWmyNlI3ODF4Nh?=
786-0 NF[2PFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HuS|YvOiEQvF2= M4LqclczKGh? NGfmTZdFVVOR M3L1SWdKPTB;Mz6yJO69VQ>? NWfTR2pyOjJ2M{W2Olk>
A498 MnzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;xdlUyPi5{IN88US=> M2PZWFczKGh? M4jRT2ROW09? MYPHTVUxRTFwNjFOwG0> NX3VSYR{OjJ2M{W2Olk>
A549/ATCC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\YOk4zKM7:TR?= MnzjO|IhcA>? MYPEUXNQ M1rleWdKPTB;MT62JO69VQ>? NHO3OpQzOjR|NU[2PS=>
ACHN Mn\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWO2MlIh|ryP MYK3NkBp NH7DWotFVVOR MX7HTVUxRTFwMzFOwG0> MUiyNlQ{PTZ4OR?=
BT549 M{DxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m3b|YvOiEQvF2= MYi3NkBp NIPkUYJFVVOR MWDHTVUxRTFwMzFOwG0> MY[yNlQ{PTZ4OR?=
EKVX MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jhb|YvOiEQvF2= NVT6Tmh1PzJiaB?= NV;NeHoyTE2VTx?= NXHRPHlHT0l3ME2xMlMh|ryP M37ObVIzPDN3Nk[5
HCT15 MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjmZ3k3NjJizszN NFjweXY4OiCq MUTEUXNQ MmXJS2k2OD1{LkWg{txO MkfiNlI1OzV4Nkm=
HOP92 NHzBTYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\ZdVQ3NjJizszN NXy4NIt1PzJiaB?= NVfofGJ{TE2VTx?= NGDx[HFIUTVyPUSg{txO NFz1UlkzOjR|NU[2PS=>
IGROV1 M1PWemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPjZ2s3NjJizszN NEjsb4I4OiCq MoLySG1UVw>? MlTlS2k2OD1zLkOg{txO NGfrUngzOjR|NU[2PS=>
LOXIMVI NFXoVGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\3XpY3NjJizszN NWD3N3FoPzJiaB?= M13kTWROW09? M2qxTWdKPTB;MTFOwG0> MmX1NlI1OzV4Nkm=
M14 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUn1NW1LPi5{IN88US=> M{W2c|czKGh? NFiwWY1FVVOR MnjFS2k2OD1zLkOg{txO NUS5XFdLOjJ2M{W2Olk>
MALME-3M Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\GXVYvOiEQvF2= M{fOcVczKGh? M2HjN2ROW09? MWnHTVUxRTBwM{Kg{txO NYPje5liOjJ2M{W2Olk>
MCF10A NX7UU4FrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWK2MlIh|ryP MoXTOFghcA>? NHT5NodFVVOR NX6yTHhuT0l3ME25MlYh|ryP NHLPU3IzOjR|NU[2PS=>
MDA-MB-435 MkDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jPOFYvOiEQvF2= MX:3NkBp MXLEUXNQ MXTHTVUxRTBwNTFOwG0> MUeyNlQ{PTZ4OR?=
MDA-MB-468 NHnUU5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzQPWNuPi5{IN88US=> NFPE[II4OiCq Mmi0SG1UVw>? MnnXS2k2OD1yLk[zJO69VQ>? MoLXNlI1OzV4Nkm=
MOLT4 NELiXVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\aPJU3NjJizszN NWfJZm5RPzJiaB?= M4m2TGROW09? NYXzWGlrT0l3ME2wMlQh|ryP MVuyNlQ{PTZ4OR?=
NCI-ADR-RES M1LCZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\EOk4zKM7:TR?= MknSO|IhcA>? M3\VUWROW09? M2fkTWdKPTB;MD6xOkDPxE1? NVPkT5lvOjJ2M{W2Olk>
NCI-H23 M4HTV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX22MlIh|ryP M3vHRVczKGh? NVHXRWF2TE2VTx?= M1PD[GdKPTB;MTFOwG0> MYOyNlQ{PTZ4OR?=
NCI-H322M MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVO2MlIh|ryP NFjDSGM4OiCq NH[4N5JFVVOR MmfKS2k2OD1yLke5JO69VQ>? NWi4bGZJOjJ2M{W2Olk>
NCI-H460 M2PlZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTLXYEzPi5{IN88US=> NUP0[21tPzJiaB?= NFjt[pRFVVOR MVnHTVUxRTBwN{mg{txO NWLLeXFlOjJ2M{W2Olk>
NCI-H522 M4K0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu0Ok4zKM7:TR?= MXS3NkBp MWDEUXNQ M{fNb2dKPTB;MD61JO69VQ>? NX25WXdMOjJ2M{W2Olk>
OVCAR3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W0OlYvOiEQvF2= NXHVV5RlPzJiaB?= Mmm3SG1UVw>? MYHHTVUxRTFwMzFOwG0> NUnNUWdSOjJ2M{W2Olk>
OVCAR4 NI\Hdm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVu2MlIh|ryP NU\2NpN4PzJiaB?= M1r5bWROW09? MoTES2k2OD12IN88US=> NHHiU44zOjR|NU[2PS=>
OVCAR5 M3v2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLvZ3BGPi5{IN88US=> NIDuN284OiCq NUX3[5JjTE2VTx?= NYW4VJA4T0l3ME2wMlc6KM7:TR?= NXHoN4lSOjJ2M{W2Olk>
OVCAR8 NFG2[lZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7MUIZqPi5{IN88US=> M3jFdFczKGh? M1rjbWROW09? Mnu5S2k2OD1yLkWg{txO MoTjNlI1OzV4Nkm=
RXF393 NI[0VlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;OT|YvOiEQvF2= M{mxUlczKGh? MVjEUXNQ NF:zOWJIUTVyPUGuN{DPxE1? M{LVUFIzPDN3Nk[5
SF268 NGrNXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLzOk4zKM7:TR?= MoO4O|IhcA>? MU\EUXNQ NV[4ZoZmT0l3ME2xMlYh|ryP M1jwZlIzPDN3Nk[5
SF295 NFW1ZYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[wSFYvOiEQvF2= NVK5fnYxPzJiaB?= M1\G[2ROW09? M3myV2dKPTB;MT62JO69VQ>? M2LRdFIzPDN3Nk[5
SF539 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzPTJNnPi5{IN88US=> NX\4OmRIPzJiaB?= M2fo[2ROW09? M3nCcGdKPTB;MjFOwG0> MkfxNlI1OzV4Nkm=
SK-MEL-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUO4dnpLPi5{IN88US=> M2W4OlczKGh? M1vMdWROW09? NIL1TXlIUTVyPUGuN{DPxE1? NFLURZgzOjR|NU[2PS=>
SK-MEL-28 NIe0OYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTKcZJuPi5{IN88US=> NGPPbWo4OiCq NV;Ce3ZETE2VTx?= MXLHTVUxRTFizszN NWfEV3N1OjJ2M{W2Olk>
SK-MEL-5 MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjWOk4zKM7:TR?= NWLxPVZZPzJiaB?= M37GWmROW09? MoLwS2k2OD1yLk[zJO69VQ>? NGKySYozOjR|NU[2PS=>
SKOV3 M{PRSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rBO|YvOiEQvF2= MlW2O|IhcA>? MoHWSG1UVw>? M2LBeWdKPTB;MTFOwG0> M3XVRVIzPDN3Nk[5
SN12C NWHEZWtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvsfHA3NjJizszN MkDGO|IhcA>? M3T3UGROW09? NWLCSXcxT0l3ME2yJO69VQ>? NIT5fXYzOjR|NU[2PS=>
SNB19 NVLaOGNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWm2MlIh|ryP M1z4bVczKGh? NELnRnBFVVOR Mmm3S2k2OD1yLk[zJO69VQ>? NF7TOXYzOjR|NU[2PS=>
SNB75 NVLyUpYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:2MlIh|ryP M3PEcVczKGh? MXrEUXNQ NHTLNmxIUTVyPUCuO|kh|ryP NVj4bWlXOjJ2M{W2Olk>
SR Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzVRWl7Pi5{IN88US=> NHjHZYY4OiCq NXqz[4tVTE2VTx?= MorYS2k2OD1yLkSg{txO NGrFNmUzOjR|NU[2PS=>
T47D MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEm0PXI3NjJizszN M1\BfFczKGh? M3Luc2ROW09? MVTHTVUxRTBwNTFOwG0> NYX4O|NzOjJ2M{W2Olk>
TK10 MnrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;QfVlTPi5{IN88US=> MYm3NkBp MWfEUXNQ MX7HTVUxRTBwNkOg{txO M3O1NlIzPDN3Nk[5
UACC257 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTmcZM2Pi5{IN88US=> M360fVczKGh? NX7z[ZY5TE2VTx?= NWnOUIN5T0l3ME2wMlUh|ryP MXuyNlQ{PTZ4OR?=
UACC62 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUi2MlIh|ryP NWP0[XZNPzJiaB?= M1vTZmROW09? NGTtV5NIUTVyPUCuOEDPxE1? M1XjPFIzPDN3Nk[5
UO31 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYf2PHViPi5{IN88US=> M3;KSFczKGh? NVHuNW5YTE2VTx?= NXfX[5RrT0l3ME2wMlUh|ryP Mn7vNlI1OzV4Nkm=
Hep3B MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLiOFghcA>? Ml7VSG1UVw>? M4ezW2dKPTB;MD62PUDPxE1? MmH2NlI1Ozl6NkO=
BE(2)-C NVfWU5d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWC3NkBp M1XZfGROW09? NUfwd4Z4UUN5ME2yJO69VQ>? M1LXfVIzQTN{M{G2
Bel7402 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PKcFczKGh? Ml3HSG1UVw>? NU[zNoJRT0l7ME2xO{DPxE1? MmnoNlMxPjF|N{[=
Bel7404 NU\kZYtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPDO|IhcA>? Mn7PSG1UVw>? NYSySZNET0l7ME2xPEDPxE1? MnPQNlMxPjF|N{[=
BGC823 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjtPGRWPzJiaB?= MUHEUXNQ NGX4[lRIUTlyPUeuOUDPxE1? MnPTNlMxPjF|N{[=
MGC803 MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLkSJhuPzJiaB?= M4r2c2ROW09? NYLSfVM5T0l7ME2xNE45KM7:TR?= NGTXcXMzOzB4MUO3Oi=>
SGC7901 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33jbFczKGh? M1n3S2ROW09? NETsZ41IUTlyPUmuOEDPxE1? MXuyN|A3OTN5Nh?=
SKHEP1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfjO|IhcA>? MV3EUXNQ NUSzNnh4T0l7ME2xO{DPxE1? Mn7ONlMxPjF|N{[=
SMMC7721 NVHwdFRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlL5O|IhcA>? M1HsUmROW09? NYLleo52T0l7ME2yNEDPxE1? NF61cG8zOzB4MUO3Oi=>
NUGC3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVKxNEDPxE1? MljSS2k:Oi57NDFOwG0> MoXHNlMyPjN|M{K=
A2780 CisR M1nhSGtqdmG|ZTDBd5NigQ>? NX30XlM2OThiaB?= MnHLTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkS0JO69VQ>? M{fqPVI{OjV{NkCz
CAL27 sens MWHLbY5ie2ViQYPzZZk> MXmxPEBp MkXpTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? M1;Lc|I{OjV{NkCz
CAL27 CisR MWTLbY5ie2ViQYPzZZk> NYnyXGZwOThiaB?= MVzJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO MkT3NlMzPTJ4MEO=
KYSE-510 CisR M2KzTGtqdmG|ZTDBd5NigQ>? NU\xcJJsOThiaB?= M1L3[2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? M3XZblI{OjV{NkCz
KYSE-510 sens M3i2R2tqdmG|ZTDBd5NigQ>? MmLZNVghcA>? MV3Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNzFOwG0> NH;HPWUzOzJ3Mk[wNy=>
MDA-MB-231 sens MXjLbY5ie2ViQYPzZZk> MmX2NVghcA>? M{TOTWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M{\BdFI{OjV{NkCz
MDA-MB-231 CisR MXPLbY5ie2ViQYPzZZk> MXixPEBp NH73U2RKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP Mmi2NlMzPTJ4MEO=
ES2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTqOFghcA>? MUPEUXNQ NXvufWdMUUN3ME2xNk44KM7:TR?= MV:yN|Q6OzR2OR?=
MDA-MB-231 NWC1OnNCU2mwYYPlJGF{e2G7 NXnZfIlzOTBizszN M1;SXFMxKG2rbh?= M3PBcWROW09? NIjKWFdKdmirYnn0bY9vKG:oIFjERWMz[Q>? NXn2PHFiOjN2OUO0OFk>
MDA-MB-231 NHjNc41McW6jc3WgRZN{[Xl? NFjrNYwyKM7:TR?= NEjTRZUzPCCq NHX3NFVFVVOR M1;3RWlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= NH7UT3QzOzR7M{S0PS=>
HS68 MYLDfZRwfG:6aXOgRZN{[Xl? NXzSZol{OTBizszN M3iyNVczKGh? MWLEUXNQ Ml6wTWM2OD12Lk[g{txO MoP5NlM2PzB3NEK=
MEF MWPDfZRwfG:6aXOgRZN{[Xl? NXPueXk5OTBizszN MlO1O|IhcA>? MUfEUXNQ NHixRXlKSzVyPUSuOEDPxE1? NFfUVZozOzV5MEW0Ni=>
BGC823 NYX0WGNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDEUXNQ MWPHTVUxRTNwMEmg{txO NUGzTYpjOjN4MEG3NFY>
High5 M3;EeGtqdmG|ZTDBd5NigQ>? MXOyOEBp MX\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>? NVq4d3drOjN4MEK1NlM>
High5 MXfLbY5ie2ViQYPzZZk> MlTCNlQhcA>? NVKwdHMzUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4yOiEQvF2= Mk[yNlM3ODJ3MkO=
High5 Mm\6T4lv[XOnIFHzd4F6 NWPweJlzOjRiaB?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? NUTaOVRROjN4MEK1NlM>
A549 NI\BOJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XNOGROW09? NYPSNnFRUUN3ME2xMlA4QSEQvF2= NXPVR2VDOjN4NESyNVA>
HCT116 NWf0OHJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXTeocxTE2VTx?= M2HWWmlEPTB;MD63OVch|ryP NYXHVoV6OjN4NESyNVA>
K562 Mn;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXwNmRZTE2VTx?= NECyOYpKSzVyPUCuOlQ2KM7:TR?= M2nDZVI{PjR2MkGw
GBC-SD NVrRcIJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPB[nY2PSEQvF2= NUPEb3o1PzJiaB?= M2jwTmROW09? M{DYU2lEPTB;MUSuPEDPxE1? MnXjNlM4ODd{NkC=
HGC27 NWXDVmNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nOelUh|ryP MYS3NkBp M3HWdGROW09? Ml7vTWM2OD13LkSg{txO MkPmNlM4ODd{NkC=
HL60 MnLyT4lv[XOnIFHzd4F6 M4\wPFUh|ryP MXeyOEBp NVHI[3pyTE2VTx?= Ml7kTY5pcWKrdHnvckBw\iCKRFHD Moi3NlM4ODd{NkC=
Vero MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfpV4M2PzJiaB?= NGDqdI9FVVOR M3TadmlEPTB;MD65JO69VQ>? M3HuSlI{Pzh4NEWy
NCI60 M{PzWWN6fG:2b4jpZ{BCe3OjeR?= MXm0PEBp MorFSG1UVw>? Ml\oS2k:OC53MzFOwG0> NGrldIQzPDBzNUOyOy=>
SW620 M{Hw[2N6fG:2b4jpZ{BCe3OjeR?= MV60PEBp NWLqN3doTE2VTx?= MVnHTV0xNjV2IN88US=> M{XBTVI1ODF3M{K3
U251 M{[3R2N6fG:2b4jpZ{BCe3OjeR?= M4XYS|Q5KGh? MknISG1UVw>? NFvOV5dIUT1zLkWzJO69VQ>? NXv4[pdxOjRyMUWzNlc>
KM12 Mn\pR5l1d3SxeHnjJGF{e2G7 NF\VXWY1QCCq NVLXPFlHTE2VTx?= MnXCS2k:OS56ODFOwG0> NULzVoNIOjRyMUWzNlc>
Hs578T MlzOR5l1d3SxeHnjJGF{e2G7 M3vm[VQ5KGh? NYrPNJJ5TE2VTx?= NVLHOZdOT0l;ND64N{DPxE1? NX7CdZNDOjRyMUWzNlc>
MDA-MB-231 MoDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:0RVQ5KGh? MWjJR|UxRTBwMU[g{txO NVPKc41lOjRyOUWwNVY>
MCF7 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TxfFQ5KGh? MVTHTV0xNjR3IN88US=> Ml23NlQyOTl3NUW=
MDA-MB-435 NFjyTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[2N|k1QCCq NH;2SFNIUT1yLki4JO69VQ>? M2HpflI1OTF7NUW1
AsPC1 NF[zS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVKzNEDPxE1? NGnBcpE1QCCq NI\nT4pFVVOR NYLZRWpyUUN3ME2zMlY3KM7:TR?= NITxRmwzPDF6NUO3PC=>
Jurkat E6.1 MorQT4lv[XOnIFHzd4F6 NX7yXJpUOiCq MnfNSG1UVw>? MknmTY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1? MmjsNlQzPjF6NkK=
KG1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEC1UGU1QCCq NFe2[5FKSzVyPUGuNVUh|ryP M{Ww[lI1PTJ3MECz
HEL NETUb|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX60PEBp NVj5NGhwTE2VTx?= MVnJR|UxRTBwNEmg{txO NF\MNpYzPDZ7NEC1OS=>
HSC3 MnzBR5l1d3SxeHnjJGF{e2G7 NVqxZXgxOTJiaB?= NWi5WJJUTE2VTx?= NX;0Vm5bUUN3ME2wMlcyKM7:TR?= MYWyOFc3PjV4MB?=
HT-29 NEXuVlhEgXSxdH;4bYMhSXO|YYm= NXXSb3BtOTJiaB?= MlX4SG1UVw>? MVzJR|UxRTBwN{Kg{txO MVuyOFc3PjV4MB?=
KB NFvT[nBEgXSxdH;4bYMhSXO|YYm= M4HB[VEzKGh? Mo\zSG1UVw>? MW\JR|UxRTBwN{Wg{txO MkXPNlQ4PjZ3NkC=
H460 NYPQPFFvS3m2b4TvfIlkKEG|c3H5 NFvWOFUyOiCq NFnjTmtFVVOR MV;JR|UxRTBwOEKg{txO NGXSSIMzPDd4NkW2NC=>
MONE1 NIPKVJpEgXSxdH;4bYMhSXO|YYm= NX\zWVBYOTJiaB?= NYm2Uo17TE2VTx?= Moj6TWM2OD1zLkG4JO69VQ>? NIHjfpMzPDd4NkW2NC=>
MKN45 MWnDfZRwfG:6aXOgRZN{[Xl? MUGxNkBp NWLiTnR[TE2VTx?= M{Tud2lEPTB;MT6yOUDPxE1? Ml30NlQ4PjZ3NkC=
TSGH Ml\pR5l1d3SxeHnjJGF{e2G7 NILz[ngyOiCq MUPEUXNQ NEm2fGJKSzVyPUKuNFkh|ryP NGj0TW0zPDd4NkW2NC=>
HL60 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVG3NkBp M3fjd2ROW09? M{DmRmdKPTB;MD65N{DPxE1? NVX5bHJwOjR7MEC1NFA>
HEK293 M{HvT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fZe|czKGh? MX;EUXNQ MknHS2k2OD1zMzFOwG0> MoL5NlQ6ODB3MEC=
Jurkat M2rJOWN6fG:2b4jpZ{BCe3OjeR?= NXLqT3p3OTByIN88US=> MojzO|IhcA>? MVXHTVUxRTBwOTFOwG0> NEHQ[G8zPDlyMEe0Ny=>
GM15850 NGmwcZlMcW6jc3WgRZN{[Xl? M{TSZVIvPSEQvF2= NUf4d3pXQTZiaB?= Mm\USG1UVw>? NF3DNHBld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhOTRiYXPleJlt[XSrb36gc4YhTliQIHflcoU> MVWxOlkzOTN4Nx?=
GM15850 NIPHfGxMcW6jc3WgRZN{[Xl? M2fxZVIvPSEQvF2= MmjkPVYhcA>? MkH6SG1UVw>? M4q1TYRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MnLENVY6OjF|Nke=
GM15850 NFnBXJNMcW6jc3WgRZN{[Xl? MkjXNk42KM7:TR?= NIHYZZE6PiCq MmrESG1UVw>? NGWwZnRld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhOTJiYXPleJlt[XSrb36gc4YhTliQIHflcoU> Mn2zNVY6OjF|Nke=
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GM15850 NHz3RZNMcW6jc3WgRZN{[Xl? NYfYfXVoOi53IN88US=> MmniPVYhcA>? MUXEUXNQ Mn\q[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NEjNW5EyPjl{MUO2Oy=>
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LB1047-RCC M3v3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvVTWM2OD1zLkG4N|EzKM7:TR?= MVHTRW5ITVJ?
VM-CUB-1 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;0bXduUUN3ME2xMlE6OTB6IN88US=> Moi1V2FPT0WU
NB5 NVnNWGppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX5TWM2OD1zLkG5PFU3KM7:TR?= MVjTRW5ITVJ?
SKG-IIIa MojJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm4TWM2OD1zLkKzOFY1KM7:TR?= M1v5TXNCVkeHUh?=
HO-1-N-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m1S2lEPTB;MT6yN|g{PSEQvF2= NYC1UIxSW0GQR1XS
EFO-27 NI\ocFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M361WGlEPTB;MT6yOVA1OyEQvF2= Mm[3V2FPT0WU
MHH-NB-11 Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPWWYxMUUN3ME2xMlI5OzJ7IN88US=> MkjBV2FPT0WU
SW620 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfuTWVKSzVyPUGuNlkxOThizszN MnfUV2FPT0WU
MOLT-16 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17wNWlEPTB;MT6yPVc6PyEQvF2= M{j5RnNCVkeHUh?=
NTERA-S-cl-D1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTFwM{G3OlEh|ryP NEDHVZFUSU6JRWK=
VA-ES-BJ NVvIR2lXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLZTWM2OD1zLkOyOFc4KM7:TR?= NWS0cG5CW0GQR1XS
HCC1419 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjMcZBQUUN3ME2xMlM1ODJ5IN88US=> M2Hie3NCVkeHUh?=
NCI-H69 M3mzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjtWpVIUUN3ME2xMlM1OTF{IN88US=> NGq4T2tUSU6JRWK=
DEL NEPDSGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv1T4dKSzVyPUGuN|UyPjJizszN NGXYbnhUSU6JRWK=
LXF-289 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwM{WyOEDPxE1? NWrJXnh2W0GQR1XS
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NOS-1 M4rlV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXGcVNyUUN3ME2xMlQyOTl2IN88US=> M1PqZnNCVkeHUh?=
SK-NEP-1 NGTEfGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3xd4R4UUN3ME2xMlQyPjl|IN88US=> M4n6fHNCVkeHUh?=
LAMA-84 M2TpbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml6xTWM2OD1zLkSzPVQ2KM7:TR?= MlHhV2FPT0WU
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HuO9 NVLqbGh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnKyTWM2OD1zLkS1N|YzKM7:TR?= NGHUZXRUSU6JRWK=
COLO-684 Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrwN3N4UUN3ME2xMlQ3OTF6IN88US=> M3vMOXNCVkeHUh?=
EW-24 NFXXdo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[yRWlEPTB;MT60OlU{OSEQvF2= M17UO3NCVkeHUh?=
BV-173 NH3vTVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:xTWM2OD1zLkS3NlkyKM7:TR?= MX;TRW5ITVJ?
NCI-H1770 NXr3PHVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e5O2lEPTB;MT60PFU{PiEQvF2= NVW2RVJ[W0GQR1XS
HuP-T4 Mn\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z1WmlEPTB;MT60PVMh|ryP MoPSV2FPT0WU
TYK-nu M2PpUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfCNndVUUN3ME2xMlQ6QDVzIN88US=> M4XTcXNCVkeHUh?=
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OVCAR-8 M4rSTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnzTWM2OD1zLkW0OFc4KM7:TR?= MXrTRW5ITVJ?
NCI-H23 MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTFwNUS2OFUh|ryP MlHvV2FPT0WU
ES7 NIDadlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULtWpZ7UUN3ME2xMlU1Pzd|IN88US=> NWX0e|lYW0GQR1XS
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TI-73 NGPWcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17kXWlEPTB;MT61PVA3KM7:TR?= NFizNm5USU6JRWK=
RT-112 Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDMUoV4UUN3ME2xMlU6Ojh2IN88US=> M3zQPXNCVkeHUh?=
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HT55 NUWxNGtFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTFwNkWxN|Eh|ryP NUjKTIZrW0GQR1XS
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MHH-ES-1 M2fwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;PTWM2OD1zLkewOFM2KM7:TR?= NXm3O|QxW0GQR1XS
CAL-27 NWLGcGFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjnOoxKSzVyPUGuO|A3OjFizszN NIO3XI9USU6JRWK=
COLO-800 NFfTcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX6xeXpoUUN3ME2xMlcyOTd7IN88US=> NGPDb|JUSU6JRWK=
HCE-T MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rhS2lEPTB;MT63NVUh|ryP MUHTRW5ITVJ?
CAMA-1 MoXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP5WJZvUUN3ME2xMlcyQTdzIN88US=> M33xU3NCVkeHUh?=
LOXIMVI NW\oR41ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXsSFFKSzVyPUGuO|IyOSEQvF2= MoLSV2FPT0WU
NH-12 M{Tmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTGXHFKSzVyPUGuO|I3QTFizszN NGLWO5hUSU6JRWK=
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MDA-MB-361 M3vnSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFwN{OxOVch|ryP Ml7OV2FPT0WU
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Daoy NH62fIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPPd2lKSzVyPUGuO|Y{OTlizszN MYXTRW5ITVJ?
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PFSK-1 NF7u[oRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP3VHBKSzVyPUGuPFA{PyEQvF2= M3TsOHNCVkeHUh?=
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ONS-76 NYnlWYVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFwOEK4PVch|ryP M4HKU3NCVkeHUh?=
JVM-3 NV\YR2c1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwOEW0OVEh|ryP NYnsfY5uW0GQR1XS
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COLO-320-HSR NFTXWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTFwOEixPVch|ryP MonGV2FPT0WU
HN NGHscGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLP[IRKSzVyPUGuPFg4OjVizszN NVG3WWhsW0GQR1XS
HT MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS5OVJDUUN3ME2xMlg5QTR5IN88US=> MXXTRW5ITVJ?
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EW-22 NIr3ZVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\EcVV[UUN3ME2xMlkzQDh5IN88US=> NXu0N3E{W0GQR1XS
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human HOP-92 MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTFwOUSwOlUh|ryP NF\Me3dUSU6JRWK=
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LB2241-RCC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjGdJh4UUN3ME2xMlk5OjNzIN88US=> NIe4VFlUSU6JRWK=
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A101D MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJwMkCzNFMh|ryP MX3TRW5ITVJ?
NCI-H446 M2Lu[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXXTWM2OD1{LkC0OVk6KM7:TR?= M3LrcXNCVkeHUh?=
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HOS NVfQWYRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYi1RoxoUUN3ME2yMlA4PjV|IN88US=> NWmzeHVSW0GQR1XS
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LCLC-97TM1 M17VTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPTTWM2OD1{LkG0OVg{KM7:TR?= NUP6dXFiW0GQR1XS
DMS-273 NFjaepBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3NTWM2OD1{LkG0PFM4KM7:TR?= MV3TRW5ITVJ?
TE-8 MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;qTWM2OD1{LkG1O|Y2KM7:TR?= MVPTRW5ITVJ?
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SW948 M3XF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTJwMUi0OVYh|ryP MYTTRW5ITVJ?
NOMO-1 M1nWe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLBRYVKSzVyPUKuNVk{OTdizszN M3Tkb3NCVkeHUh?=
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CAL-39 M{CyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJwMkO2NlYh|ryP M1\QXnNCVkeHUh?=
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HTC-C3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJwMk[4OUDPxE1? MYXTRW5ITVJ?
NCI-H1666 MmDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnLTWM2OD1{LkK4NVEyKM7:TR?= NX7kSYtiW0GQR1XS
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GI-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJwM{C1OFMh|ryP MX7TRW5ITVJ?
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8-MG-BA MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHMXZFsUUN3ME2yMlM{QTB4IN88US=> M{L4b3NCVkeHUh?=
RH-18 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\2VGlEPTB;Mj6zOVAzOiEQvF2= NEHyVmhUSU6JRWK=
NCI-H1155 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjwO2dFUUN3ME2yMlM3PzJ3IN88US=> M3vPZnNCVkeHUh?=
NB17 NGHSSotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJwM{iyOFMh|ryP MnPhV2FPT0WU
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HSC-3 NF7XUWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJwNES1NFkh|ryP MnvCV2FPT0WU
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HT-1080 NY\qV|R7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJwNES4OlQh|ryP NVvyUI4yW0GQR1XS
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KNS-62 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;zUWlEPTB;Mj60OVA3OSEQvF2= MX3TRW5ITVJ?
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LU-134-A NWfLcFJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrObYF6UUN3ME2yMlQ4ODB6IN88US=> MUTTRW5ITVJ?
FADU NWTtS446T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LIZmlEPTB;Mj60O|E3OiEQvF2= NXL1WHV{W0GQR1XS
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GT3TKB M{PRdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrsfYhJUUN3ME2zMlEyOjh|IN88US=> MXTTRW5ITVJ?
TK10 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe5UWN3UUN3ME2zMlE{PzJ2IN88US=> MlPQV2FPT0WU
T-24 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXq[JlKSzVyPUOuNVUxPyEQvF2= MVrTRW5ITVJ?
A498 NH;5dppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfHW3c6UUN3ME2zMlIxQDdzIN88US=> NUPyZ|ZQW0GQR1XS
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HT-29 M1zlO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrodXRzUUN3ME2zMlI3PjF2IN88US=> MmHSV2FPT0WU
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RKO NXHJ[HB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPiZ4hyUUN3ME2zMlMxPzV5IN88US=> M3zJSnNCVkeHUh?=
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DJM-1 MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLaN21oUUN3ME2zMlM4Pjd2IN88US=> MXvTRW5ITVJ?
L-428 M{\ZZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojSTWM2OD1|LkSwNFQ2KM7:TR?= MXfTRW5ITVJ?
NCI-H2122 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X3bWlEPTB;Mz60NVMyOiEQvF2= MUHTRW5ITVJ?
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639-V Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3TSWxKSzVyPUOuOFYxPTdizszN NVTneVVLW0GQR1XS
SW1116 M4ezOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu0UGQ5UUN3ME2zMlQ3OjZ7IN88US=> MYTTRW5ITVJ?
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COLO-829 NHnkUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjTSVRXUUN3ME2zMlUxODd|IN88US=> NI[4UlJUSU6JRWK=
J82 MlnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DCS2lEPTB;Mz61NFU4KM7:TR?= NUPYc3JYW0GQR1XS
EW-13 MnvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[1TWM2OD1|LkWyOVEh|ryP NYTa[mNzW0GQR1XS
RXF393 M{HEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml25TWM2OD1|LkWzNlk1KM7:TR?= MkW1V2FPT0WU
CAL-62 NF;HcHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHmTWM2OD1|LkW0OVE1KM7:TR?= NGroOmhUSU6JRWK=
OCUB-M NVLhSIN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXjTWM2OD1|LkW0OlY2KM7:TR?= MVvTRW5ITVJ?
BT-474 NUXDdYZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTNwNkOzNUDPxE1? MnLuV2FPT0WU
KYSE-180 NWixbWtDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn0Z|FWUUN3ME2zMlY{Ozd{IN88US=> NH;tdJJUSU6JRWK=
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Detroit562 M4DUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTNwNkWwNlIh|ryP M3LpU3NCVkeHUh?=
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KYSE-450 MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfidWdSUUN3ME2zMlY5PTh{IN88US=> Mn;BV2FPT0WU
KYSE-510 NWLqcWltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlyyTWM2OD1|LkeyNVgyKM7:TR?= NEfIeXlUSU6JRWK=
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RPMI-7951 NXfjeFNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDjOppiUUN3ME2zMlc1PzJ|IN88US=> MnL4V2FPT0WU
Becker MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfXTWM2OD1|Lke1NFEzKM7:TR?= M2PKe3NCVkeHUh?=
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MEL-JUSO MmDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrlRZdvUUN3ME2zMlg6OTV|IN88US=> NVfwTnpRW0GQR1XS
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OVCAR-4 NGn1PVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjSTWM2OD1|LkmyPFg6KM7:TR?= M{j5Z3NCVkeHUh?=
ETK-1 Mm\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jK[2lEPTB;Mz65OFY{PSEQvF2= Mk\jV2FPT0WU
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CAL-12T M3ThW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XUSGlEPTB;ND6xN|ExOyEQvF2= NX7FXmFxW0GQR1XS
SCH MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjUPFlyUUN3ME20MlE2PzR|IN88US=> M2XM[nNCVkeHUh?=
CW-2 NVGyTmtlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTRwMUmwNFEh|ryP M3r4XXNCVkeHUh?=
HCC1806 NIPxXmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\hbZFlUUN3ME20MlIxOzF{IN88US=> M1fIcXNCVkeHUh?=
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CAL-54 NF\YdYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrCVmx1UUN3ME20MlIzOzhzIN88US=> MnXUV2FPT0WU
CAL-33 M1vkUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWiyZoxNUUN3ME20MlI{ODZ2IN88US=> NWrBdJJyW0GQR1XS
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NUGC-3 NWHBbW0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTW[|V{UUN3ME20MlI2PTB3IN88US=> MYXTRW5ITVJ?
DOK Mon6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTRwMk[1PVMh|ryP MVPTRW5ITVJ?
MMAC-SF NV;PeXBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWraN2toUUN3ME20MlI3QDV7IN88US=> MXLTRW5ITVJ?
KYSE-70 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrGe2VKSzVyPUSuNlk{PCEQvF2= NGGzdWxUSU6JRWK=
A204 MnqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTRwM{W4NFMh|ryP NFTHXoxUSU6JRWK=
SCC-25 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTRwM{W4NVkh|ryP NYfiNY15W0GQR1XS
EPLC-272H M{[xW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTRwM{i5OUDPxE1? M4jPZnNCVkeHUh?=
CAL-120 M3LaVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3wTo9uUUN3ME20MlM5QTl{IN88US=> NITNSI1USU6JRWK=
LS-513 MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTRwNEKxPVgh|ryP MnvsV2FPT0WU
CAPAN-1 NHHMOphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvsVZNPUUN3ME20MlQzOzh{IN88US=> NH;XWXFUSU6JRWK=
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SK-MEL-28 NIi2cGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M121NmlEPTB;MUCuNFE6OyEQvF2= NUPrN3dqW0GQR1XS
NCI-H2452 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFyLkG2JO69VQ>? NWi1fZFWW0GQR1XS
NCI-H1395 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzGS4lKSzVyPUGwMlE4QCEQvF2= MVHTRW5ITVJ?
NCI-H2052 NID3OZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\ZTWM2OD1zMD6xPFgzKM7:TR?= Ml\SV2FPT0WU
A375 NFHVcFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3WTWM2OD1zMD6yOFUzKM7:TR?= MmXJV2FPT0WU
HCC38 M4DEdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFSyfG9KSzVyPUGwMlMzOiEQvF2= M1vmR3NCVkeHUh?=
LK-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnjbFFKSzVyPUGwMlQzODhizszN MYTTRW5ITVJ?
SF126 NGHQbZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXBe2VKSzVyPUGwMlQ4OjdizszN NXT6dYJuW0GQR1XS
SK-MEL-1 M3\1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XkZmlEPTB;MUCuO|g{QCEQvF2= M4fMWnNCVkeHUh?=
ACN M{C2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Tmb2lEPTB;MUCuPFY4QSEQvF2= MoLVV2FPT0WU
BB30-HNC NYfKbFJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7tWVFKSzVyPUGwMlg4OTFizszN MkL3V2FPT0WU
NCI-H747 NHrldZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi1ZXVoUUN3ME2xNE45PzR4IN88US=> NHfpT3JUSU6JRWK=
KYSE-150 M1HST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHMTWM2OD1zMT6wN|g4KM7:TR?= M1PwdnNCVkeHUh?=
D-247MG MkLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzKdZJKSzVyPUGxMlExODlizszN NWrNO45qW0GQR1XS
BxPC-3 NEXrSYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Lh[GlEPTB;MUGuN|c1PyEQvF2= MVnTRW5ITVJ?
SK-MEL-30 NVfkOlZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nJSWlEPTB;MUGuOFA4QSEQvF2= NWX5PJR5W0GQR1XS
CAS-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFzLkSxNFkh|ryP NX23dYJ3W0GQR1XS
no-10 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlraTWM2OD1zMj6xNlE4KM7:TR?= NWjZTHRNW0GQR1XS
NCI-H2405 NFX2enhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLaR5NsUUN3ME2xNk4zODN4IN88US=> MUDTRW5ITVJ?
KGN MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXrPGhnUUN3ME2xNk4zQTBzIN88US=> MkK2V2FPT0WU
BB49-HNC MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTF{LkO5OVYh|ryP MoLOV2FPT0WU
NCI-H1693 NYf0bWlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV20SI9oUUN3ME2xNk42QDF4IN88US=> NIWwV2RUSU6JRWK=
RO82-W-1 NEfISHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULKNZNzUUN3ME2xN{4xPjR7IN88US=> MlnwV2FPT0WU
CAL-85-1 NV63WW9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTF|LkSzPVkh|ryP MYDTRW5ITVJ?
H-EMC-SS NF3VdHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjDbXdIUUN3ME2xN{46OTB2IN88US=> M4HhS3NCVkeHUh?=
SW1783 NWLjdItYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVX5[HNPUUN3ME2xOE4zOzlzIN88US=> M3rJN3NCVkeHUh?=
LB771-HNC MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;UTWM2OD1zND60NVkh|ryP NF63bZlUSU6JRWK=
HCC70 NEXS[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHSwUG5KSzVyPUG0MlQzOzNizszN NEDiU4ZUSU6JRWK=
KNS-81-FD NU[yZZQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LCTmlEPTB;MUSuO|A1PSEQvF2= M2nLN3NCVkeHUh?=
KYSE-520 M4r3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTF2LkmyO{DPxE1? MoW5V2FPT0WU
TGBC24TKB NV;0WYhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2D6UWlEPTB;MUSuPVU{QSEQvF2= M17wfXNCVkeHUh?=
SNB75 M1:5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmKwTWM2OD1zNT6wO|I6KM7:TR?= MkT5V2FPT0WU
SW872 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfoXZoyUUN3ME2xOU4zOjF6IN88US=> NFvwb|BUSU6JRWK=
U031 NIfHS|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LtSmlEPTB;MUWuPFAzQCEQvF2= M1vPVnNCVkeHUh?=
ChaGo-K-1 M{jwTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFm0flZKSzVyPUG1Mlg{PTlizszN NWG2NlVlW0GQR1XS
NCI-H441 NFjqVmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT6TWM2OD1zNj6wNFM6KM7:TR?= NYnkcph{W0GQR1XS
TE-12 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfGcHRKSzVyPUG2MlE5PzNizszN MYXTRW5ITVJ?
NCI-H1755 NY\rT2xqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTBTWM2OD1zNj61O|Mh|ryP MlPoV2FPT0WU
KNS-42 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HlWmlEPTB;MU[uOlU5QSEQvF2= M1j5b3NCVkeHUh?=
SK-PN-DW NYjSOHF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTF5LkSyNFEh|ryP MXLTRW5ITVJ?
NCI-H226 MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFex[YFKSzVyPUG3Mlk{PDVizszN NVj4NFA5W0GQR1XS
K-562 MmXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF6Lk[zNVch|ryP MXjTRW5ITVJ?
A388 M{e1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jWR2lEPTB;MUmuNFMxOyEQvF2= NGTPUnlUSU6JRWK=
ZR-75-30 NXn3bFR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonuTWM2OD1zOT6wPVY5KM7:TR?= NUH1XmF2W0GQR1XS
LU-135 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrHb|JXUUN3ME2xPU4zPjN4IN88US=> MoLPV2FPT0WU
NCI-H2029 NIjYZmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF7Lk[wNlEh|ryP M3z0UnNCVkeHUh?=
HT-1197 MoH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLX[lVKSzVyPUG5MlkzOjdizszN MYPTRW5ITVJ?
IGR-1 NVjoSWZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTJyLkOxNVch|ryP NFLTNmtUSU6JRWK=
U-87-MG MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX4RXkyUUN3ME2yNE43PDF|IN88US=> MoruV2FPT0WU
NCI-H1304 NHnHblZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVSxTIJuUUN3ME2yNE44PTBzIN88US=> NHzqNplUSU6JRWK=
RCC10RGB MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDQTmp7UUN3ME2yNU4zQDJ7IN88US=> MYLTRW5ITVJ?
NCI-H520 NYPERlgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTJ{Lke2NVEh|ryP NUXkeG9PW0GQR1XS
SK-LU-1 MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TVWWlEPTB;MkOuNFcyQCEQvF2= M1PVbnNCVkeHUh?=
UACC-893 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7tTWM2OD1{Mz6xNFM5KM7:TR?= MW\TRW5ITVJ?
NCI-H2347 NFjKbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJ|LkK2O|Qh|ryP NGLjXWRUSU6JRWK=
U-118-MG MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJ|LkeyNVch|ryP M2W4XXNCVkeHUh?=
NCI-H596 M2jQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[xVWlEPTB;MkOuPVA2PSEQvF2= Mo\YV2FPT0WU
MZ1-PC MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fnO2lEPTB;MkSuOlc2QSEQvF2= NV7j[IplW0GQR1XS
SW1417 M{m5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ3LkK0PVgh|ryP MVnTRW5ITVJ?
NCI-H82 M2j0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vwNWlEPTB;Mk[uOFI5QCEQvF2= MomwV2FPT0WU
COLO-678 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX4OJluUUN3ME2yO{41QTF7IN88US=> M2PMZnNCVkeHUh?=
KURAMOCHI MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{foc2lEPTB;MkiuNVI3KM7:TR?= NHHURVBUSU6JRWK=
NCI-H1650 Ml;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jVNWlEPTB;M{CuNVkzPCEQvF2= NGDnbFRUSU6JRWK=
HCC1954 NUnuRWxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP1UnIxUUN3ME2zNU4{PjZ4IN88US=> NVuxcFZUW0GQR1XS
GAK NYm3OnBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnr5TWM2OD1|Mj6yOlE3KM7:TR?= NHHtbI5USU6JRWK=
YAPC M1iySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jnUWlEPTB;M{OuO|Y1QCEQvF2= MW\TRW5ITVJ?
NCI-H2228 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPnTWM2OD1|ND6zOlA2KM7:TR?= NE\OdZZUSU6JRWK=
VMRC-RCZ NGLIUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDuVHh2UUN3ME2zOk4{ODJ{IN88US=> MXjTRW5ITVJ?
NMC-G1 M2DWN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTN5LkC1Nlkh|ryP MULTRW5ITVJ?
D-336MG M4XGU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTRzLki0OFIh|ryP M33UUHNCVkeHUh?=
UACC-62 MnzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;MTWM2OD12Mj61OVA2KM7:TR?= NVnH[|kxW0GQR1XS
C-33-A NITPXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn24TWM2OD12NT6zNlU3KM7:TR?= MVjTRW5ITVJ?
HCC1937 NV;ISpFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrnfoFKSzVyPUS3MlE6PThizszN MnjwV2FPT0WU
HDLM-2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTR5LkKyPFch|ryP MmOyV2FPT0WU
NCI-H727 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DuRmlEPTB;NEeuNlQ2OSEQvF2= Mm[zV2FPT0WU
NY NVPaZ3p5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\oTWM2OD12OT6zPVA5KM7:TR?= NYHRSo5yW0GQR1XS
NCI-H2291 MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXkUVdsUUN3ME20PU45OzBzIN88US=> NXjkOWtQW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+ddH2O
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID