Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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In DMSO USD 191 In stock
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Cited by 99 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MXrLbY5ie2ViQYPzZZk> NFPYO5EyKGh? M3;CVmROW09? Mk\FZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP M4TPfVEyQTZyNEi5
Friend leukemic cell MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfLN5A5PTBizszN M1e1SlczKGh? M3f5NWROW09? M4mwW2lEPTB;MD65PUDPxE1? MVyxNlExQTlzMx?=
K562 NUKyVmRbU2mwYYPlJGF{e2G7 MVi2JIg> MojWSG1UVw>? MUTJcohq[mm2aX;uJI9nKGi3bXHuJIhqe3SxbnWg[IVi[2W2eXzhd4UhMG2reIT1doUhd2ZiSFTBR|Eh[W6mIFjERWMzMSC5aYToJGlEPTBib3[gNE4xOSEQvF2= M3TWe|EzPDF7M{iw
HT1080 M3riU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvuO|IhcA>? NHnaSIpFVVOR MVfJR|UxRTJwNDFOwG0> NVOzdndlOTJ{N{CxO|U>
H1299 MorRT4lv[XOnIFHzd4F6 MXSyNEBucW5? MYrEUXNQ M2rX[GlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJTEGFIHXufplu\SC5aYToJGlEPTBib3[gNE4yQTRizszN M4[wZlE1PTJzNEKy
H1299 M{Hu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDoU5Q4OiCq MnrrSG1UVw>? MXLJR|UxRTdwMkSg{txO MnHuNVQ2OjF2MkK=
HeLa MlXJT4lv[XOnIFHzd4F6 NVrXeY5zOzBibXnu MkXVTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaHnzeI9v\SCmZXHj[ZR6dGG|ZTD3bZRpKEmFNUCgc4YhOC5{ODFOwG0> NEPCeGIyPTZyM{m0PS=>
LOX-IMVI M2Pwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX[0PEBp M4PoO2lEPTB;MT6zJO69VQ>? NXnBbpJtOTV5MUW0O|A>
NCI-H226 Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfiOFghcA>? MXPJR|UxRTJwNjFOwG0> NHTrUYwyPTdzNUS3NC=>
RXF-631L M4Xx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\O[lQ5KGh? NI\TOZZKSzVyPUKg{txO NVKxW5lrOTV5MUW0O|A>
SNB-78 M1nFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm1cXo1QCCq NYfyW2NoUUN3ME2xOkDPxE1? M2jaPFE2PzF3NEew
St-4 NHXYcHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlOxOFghcA>? NYK2bXB2UUN3ME21MlIh|ryP MmH3NVU4OTV2N{C=
ARP1 Ml3JSpVv[3Srb36gRZN{[Xl? MX:yJO69VQ>? MojEOkBp NX;pPYhjUW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v MmnMNVQ4OzR6ME[=
CEM M1TWXGtqdmG|ZTDBd5NigQ>? M1S3ZlEhcA>? MWrEUXNQ NEDsdoNKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Mh|ryP MXexOlQzODB4NB?=
HCT15 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\mSY41QCCq Ml;1S2k2OD1yLkiyJO69VQ>? MX[xOlczOzJ{Nx?=
NCI-H23 NI[2cWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3XSG01QCCq MnH0S2k2OD1yLkmyJO69VQ>? MlLxNVY4OjN{Mke=
GM15850 MVPLbY5ie2ViQYPzZZk> MkHXNk42KM7:TR?= MnvxPVYhcA>? MlvwSG1UVw>? NIfiWWJKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MXGxOlkzOTN4Nx?=
GM15850 NYD3[lRyU2mwYYPlJGF{e2G7 NX6ydZhWOi53IN88US=> NFzHTVc6PiCq NYXJXJJ[TE2VTx?= NXrDO2pPUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M{LRbFE3QTJzM{[3
GM15850 Ml7CT4lv[XOnIFHzd4F6 MnrLNk42KM7:TR?= NXjvd25kQTZiaB?= NW\QdlZUTE2VTx?= NUf6ZZFYUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MnvYNVY6OjF|Nke=
GM15850 M{HB[WtqdmG|ZTDBd5NigQ>? Mn\sNk42KM7:TR?= MnHKPVYhcA>? MmnMSG1UVw>? NXTLXXAyUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MUexOlkzOTN4Nx?=
GM15850 MWnLbY5ie2ViQYPzZZk> MUWyMlUh|ryP MUG5OkBp NWrrVnRMTE2VTx?= NYnlO244UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MWWxOlkzOTN4Nx?=
GM15850 MYrLbY5ie2ViQYPzZZk> NWLFZWpPOi53IN88US=> M2rRdlk3KGh? MWDEUXNQ NX:0[|F3UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M4rFVlE3QTJzM{[3
U937 MlKxSpVv[3Srb36gRZN{[Xl? NHj2Umo2KM7:TR?= M{XIXVI1KGh? MWDEUXNQ NYrpcW9iS2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= M3rhUVE4ODB2N{G4
H661 NF3vU5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP6OFghcA>? NEPFTnhKSzVyPUGg{txO NGeyO|cyPzF3N{CwPS=>
U937 NHnnU21HfW6ldHnvckBCe3OjeR?= NGDPR5g2KM7:TR?= M2fWU|I1KGh? M2XsOmROW09? NFS3em9KdmO{ZXHz[UBqdiCqaYP0c45mKEh|IHHj[ZR6dGG2aX;u M1u5NVE4PDR5N{Ww
U937 MoXmSpVv[3Srb36gRZN{[Xl? MW[xJO69VQ>? NY\TVWlYOjRiaB?= MnPkSG1UVw>? MULF[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= MW[xO|Q1Pzd3MB?=
RAW264.7 M3HGT2Z2dmO2aX;uJGF{e2G7 NHTEOY0yOCEQvF2= MWCyOIg> NYXUSJA3f2G2ZYK= NXTx[nRCUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCWTl\hcJBp[SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjd4IN88US=> MXSxO|Q4PzVzOB?=
RAW264.7 NXzIcZRyTnWwY4Tpc44hSXO|YYm= NYfQTm5xOTBizszN M{HXblI1cA>? M2nnPZdifGW{ M2rJNWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> NXjOTpJTOTd2N{e1NVg>
SC9 M3;xc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mor2OFghcA>? NXzBcYlJUUN3ME2wMlYxPiEQvF2= NIX4[I0yPzVyN{KxPS=>
ST14A NYH1T5l6TnWwY4Tpc44hSXO|YYm= MW[1JI5O Ml35O|IhcA>? NYfjNWtYUW6lcnXhd4UhcW5iUlXTWE9PWlOIIH3SUmEh\XiycnXzd4lwdg>? M3WwVFE4PTZ3OUmz
ST14A MV\GeY5kfGmxbjDBd5NigQ>? Mlr6OUBvVQ>? MWi3NkBp NGTlTmJKdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= MnG2NVc2PjV7OUO=
PANC1 NV\SZ3VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj1WoRGOSEQvF2= MnXITWM2OD1yLkS1JO69VQ>? NUD1WIJbOTd3OEi3OFQ>
PANC1 MoPlSpVv[3Srb36gRZN{[Xl? NEPzVJgyKM7:TR?= MWGyOEBp NY\aUohkUW6lcnXhd4UhcW5icEKxW2FHOS:FSWCxJIdmdmViZYjwdoV{e2mxbh?= NEXYbHQyPzV6OEe0OC=>
PANC1 NXTGT2FETnWwY4Tpc44hSXO|YYm= NIXS[GoyKM7:TR?= M{\DVlI1KGh? M2jmbWlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u MnH2NVc2QDh5NES=
PT45 NY\QXXhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3BVGZbUUN3ME20JO69VQ>? NUOxVlNmOTd3OEi3OFQ>
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SCC25 MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\6O|IhcA>? NUntcYEzUUN3ME2xMlk{KM7:TR?= NUS2UXBNOjBzNEO3O|g>
SKHEP1 NGPXWmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7k[pU4OiCq MonWTWM2OD1|LkS2JO69VQ>? NX;1PJVIOjBzNEO3O|g>
BJ MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3S1WlExOCEQvF2= NWXDdIw{PDhiaB?= MmXSSG1UVw>? M3TmUmdzd3e2aDDpcohq[mm2aX;uJIF1KDBwMEWgeI8hOTByIIXN NGPoSo8zODF2M{i0NC=>
MUF NX\6PHVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L4V|ExOCEQvF2= M3zkeFQ5KGh? NELZfXdFVVOR NVvWZXNvT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> M2PVVFIxOTR|OESw
Caco-2 NHLCZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY[xNFAh|ryP NHPkT3A1QGh? NICyXGFFVVOR MnnMTWM2OD16LkGg{txO NHTKR3czODF2M{i0NC=>
Caco-2 NVLHbZhFU2mwYYPlJGF{e2G7 M1n1NlUh|ryP MVK0JIg> NXvPVGlNTE2VTx?= NUjocIhzUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBi[2W2eXzheIlwdiCLQ{WwJI9nKDBwMEO3JO69VQ>? MXeyNFE1Ozh2MB?=
Caco-2 M1\2SGtqdmG|ZTDBd5NigQ>? MX2wMlMyPiCwTTD0c{A{OS54IN88US=> NELo[I41KGh? NH7mRZZFVVOR Ml;1SZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUNzIIfpeIghUUN3MDDv[kAxNjFzOTFOwG0> M4fzdVIxOTR|OESw
Caco-2 MojrT4lv[XOnIFHzd4F6 M2HoVlAvOzF4IH7NJJRwKDNzLk[g{txO NILrUJo1KGh? M4HLfmROW09? NH\PNWtGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Oge4l1cCCLQ{WwJI9nKDBwMUS3JO69VQ>? M4TBOFIxOTR|OESw
Caco-2 Ml\3T4lv[XOnIFHzd4F6 NETJXXc3NjN{IH7NJJRwKDZ|MjFOwG0> MYG0JIg> NEHYeYVFVVOR NVnGOZIyTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO1JJdqfGhiSVO1NEBw\iBzMj62JO69VQ>? NWjwfWtHOjBzNEO4OFA>
Caco-2 M37vS2tqdmG|ZTDBd5NigQ>? NI\5cGU3NjN{IH7NJJRwKDZ|MjFOwG0> M4fVU|QhcA>? NVTLS5BQTE2VTx?= MneySZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2= NGDRU44zODF2M{i0NC=>
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HepG2 MVvLbY5ie2ViQYPzZZk> M3r1OlUh|ryP NGDQW3U3cA>? NYjqOnpYTE2VTx?= NXi1d|VRUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBi[2W2eXzheIlwdg>? MX:yNFE1Ozh2MB?=
HepG2 NXP1NW1VU2mwYYPlJGF{e2G7 M4XGVVUh|ryP MX[2bC=> NHnrOnpFVVOR Ml7aTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDofZBmemGlZYT5cIF1cW:w Ml\UNlAyPDN6NEC=
HepG2 M2\M[2tqdmG|ZTDBd5NigQ>? NX7idY9ZPSEQvF2= NVnBfZBwPmh? NYDSXms2TE2VTx?= M1K1bWlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= MoThNlAyPDN6NEC=
HepG2 MW\LbY5ie2ViQYPzZZk> MoXLOUDPxE1? M{n1W|Zp NGDrdppFVVOR M2TE[Glv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= NFLEV4YzODF2M{i0NC=>
COLO205 MmPsT4lv[XOnIFHzd4F6 M2HvTVExKM7:TR?= NWq3U45lOjRiaB?= MYXEUXNQ M3jSOmlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25id3n0bEBKSzVyIH;mJFIvOiEQvF2= M3;Id|IxPDVzM{e4
SCC4 MWHLbY5ie2ViQYPzZZk> MXGxJO69VQ>? MWKyOIg> M2THUWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjD0eYJ2dGmwIHHj[ZR6dGG2aX;u NGHJWJIzODR3MkKyOS=>
SCC4 NYixSmZNU2mwYYPlJGF{e2G7 NH;6U3QyKM7:TR?= MnH6NlRp M1[4ZWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIHHj[ZR6dGG2aX;u M1PWb|IxPDV{MkK1
SCC4 NF7nNHZHfW6ldHnvckBCe3OjeR?= M4DCXlEh|ryP M2nGbFUhdWmw NVHmOY5MSWexbnnzeEBi[3Srdnn0fUBifCCYRGKgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIFPZVFI1KGenbnWg[ZhxemW|c3nvci=> M2X1[FIxPDV{MkK1
NB4 MVLGeY5kfGmxbjDBd5NigQ>? NE\QN3M2KM7:TR?= NYrDUoh{OjRiaB?= MV\EUXNQ M3nTOmNmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHHjZ5VufWyjdHnvckBifCCycnWtS|EheGijc3W= NVq5bZJrOjB2OUG0OFA>
NB4 NGLZT5pMcW6jc3WgRZN{[Xl? MoO0OUDPxE1? M{LlT|I1KGh? NVSxOpNXTE2VTx?= M3r1NGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? MX[yNFQ6OTR2MB?=
NB4 NF;BcGxHfW6ldHnvckBCe3OjeR?= MojUOUDPxE1? Ml7sNlQhcA>? NXP1PVNqTE2VTx?= MWrJcoR2[3Srb36gc4YheDJzV1HGNU9EUVBzIHX4dJJme3Orb36= NGnBUIQzODR7MUS0NC=>
NB4 NXi3WZJiU2mwYYPlJGF{e2G7 NGTNXII2KM7:TR?= M1rSNVI1KGh? NVzNOYp1TE2VTx?= NGjtOlVKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdg>? NV63[XhbOjB2OUG0OFA>
NUGC3 NX\vb2dKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjHTVUxRTJwOUSg{txO MYqyNFg2ODl5MR?=
A549 M1rqW2Z2dmO2aX;uJGF{e2G7 NYfsTpBUPSEQvF2= NEXUPWo{KGh? NUK4S5lTTE2VTx?= NXPiUGhDUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK MmHqNlA5PTV{MEi=
HUT78 NIXXdGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D3UVczKGh? NFnBNmRFVVOR MX\HTVUxRTBwMzFOwG0> M3[2ZlIxQDh2MkC4
U937 NIXvOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS3W2c4OiCq M2XXXWROW09? MnTKS2k2OD1yLkO5JO69VQ>? MonLNlA5QDR{MEi=
A431 MWXDfZRwfG:6aXOgRZN{[Xl? M2nhdlczKGh? M3W4eWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gOE4zKM7:TR?= NELnZ4czOTB6ME[yPS=>
A549 MnPGR5l1d3SxeHnjJGF{e2G7 NWm4PGJLPzJiaB?= Mn\tR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlgh|ryP NIjHU4EzOTB6ME[yPS=>
CAL27 NV;w[WRQS3m2b4TvfIlkKEG|c3H5 NIq1Z3A4OiCq MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRWwzPyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjCzMlIh|ryP NEfHZ3QzOTB6ME[yPS=>
HeLa M1rFcWN6fG:2b4jpZ{BCe3OjeR?= MVe3NkBp NUGwOVNwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjVizszN NYixcoFoOjFyOEC2Nlk>
Sf21 NHW5cGpMcW6jc3WgRZN{[Xl? NV\zO3J4OyCq M4PE[mlvcGmkaYTpc44hd2ZiRnzh[{B1[WepZXSgbJVu[W5icnXjc41jcW6jboSgTGRCSzhiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyNjJizszN M{LYT|IyODhyNkK5
SKBR3 NVK1S3NpS3m2b4TvfIlkKEG|c3H5 NYLWNlhIPzJiaB?= NVHDPZZ6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uEUkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi54IN88US=> NFHSeGIzOTB6ME[yPS=>
SKOV3 M1TL[WN6fG:2b4jpZ{BCe3OjeR?= M2LQZlczKGh? MnK0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= MYmyNVA5ODZ{OR?=
COR-L23 MmHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVyxNEDPxE1? Mn3rO|IhcA>? NV73eoN{TE2VTx?= NXv0N2pxT0l3ME2xMlEh|ryP M2HQXVIyODhyNkS3
DU145 NGHUUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYGzUFhEOTBizszN MUK3NkBp MmrnSG1UVw>? NGLCPVNIUTVyPUGuNFUh|ryP M3LrTlIyODhyNkS3
LoVo M3;GTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYCxNEDPxE1? NX\HZmZxPzJiaB?= MkDhSG1UVw>? M1HGVWdKPTB;MT63JO69VQ>? MXqyNVA5ODZ2Nx?=
MCR5-SV2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoKwNVAh|ryP Mlq4O|IhcA>? MofBSG1UVw>? MVrHTVUxRTJwMTFOwG0> NW\zVWtqOjFyOEC2OFc>
HCT116 MXTLbY5ie2ViQYPzZZk> MVWzNEDPxE1? NVXBXG1{OzBiaB?= MVfEUXNQ M1L1PWlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= MnXGNlExQDB4NEe=
HCT116 MmTrT4lv[XOnIFHzd4F6 MYGzNEDPxE1? NF7wXmU{OCCq NWfxfpZYTE2VTx?= NHT6VINKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= NWjPenRMOjFyOEC2OFc>
U937 Ml7WT4lv[XOnIFHzd4F6 MoDYOUDPxE1? MkmyNlQhcA>? MXLEUXNQ M1;hcWlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEt7 M1jC[lIyOjl{NEmy
U937 MnK4T4lv[XOnIFHzd4F6 NE\4dHI2KM7:TR?= MWOyOEBp NFuzV2pFVVOR M2G1VmlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEtzOB?= MYKyNVI6OjR7Mh?=
U937 NYP5NoJQU2mwYYPlJGF{e2G7 MoXHOUDPxE1? M33Tc|I1KGh? NVjZZ|J4TE2VTx?= MYfJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gdIFvNWGlZYT5cIF1\WRiaHnzeI9v\SCKNDDs[ZZmdA>? Mo\YNlEzQTJ2OUK=
U937 NEHWRpVMcW6jc3WgRZN{[Xl? MXi1JO69VQ>? M{Hx[FE2KG2rbh?= MUjEUXNQ NHnScY5KdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? NIKweIEzOTJ7MkS5Ni=>
A2780 MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWW5OkBp NUnBcJJMTE2VTx?= NWPNdlRQUUN3ME2xMlYzKM7:TR?= NWjnbFFSOjF4M{S0N|A>
COLO205 M1HtRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXK5OkBp M4HRVGROW09? M3\4W2lEPTB;Mj6xNkDPxE1? Mo\tNlE3OzR2M{C=
Hep3B MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnOOIdmPDhiaB?= NVnOSpllTE2VTx?= M4jKXmdKPTB;MT6yNUDPxE1? NGD2bWUzOTdzMkG0Oi=>
GM11272 M4nOVWZ2dmO2aX;uJGF{e2G7 NXryS|c1OTByIH7N MmnZO|IhcA>? M3nOSGROW09? NH;TU5pT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O NVjuRVk{OjF6NEC3NVY>
CFBE41o MX;LbY5ie2ViQYPzZZk> MlPsOUDPxE1? MljwSG1UVw>? MlT2SI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO M1LzcVIyQTh2OUW4
CFBE41o NEjXdXhHfW6ldHnvckBCe3OjeR?= MnjvNUDPxE1? MUmyOEBp NIfoPVhFVVOR MlfwVoV{fG:{YYTpc44hd2ZiQ1\UVkBl\Wy2YV[1NFghdXW2YX70JJRz[W[oaXPrbY5oKHSxIHPlcIwhe3W{ZnHj[UBieyCpbInjc4Zwem2| MVSyNVk5PDl3OB?=
DU145 NH\ydGpMcW6jc3WgRZN{[Xl? M2jZUlIvPSEQvF2= MmnlNlQhcA>? M3HjfmROW09? NX7zW3A5UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? NEXzWVEzOjJ4MEG2Oi=>
DU145 M2K0c2tqdmG|ZTDBd5NigQ>? M2LhZlUh|ryP Ml;5NlQhcA>? MnjuSG1UVw>? NWDmR3lMUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSESgZYNmfHmuYYTpc44> MmftNlIzPjBzNk[=
DU145 MmDhT4lv[XOnIFHzd4F6 Mn;2OUDPxE1? MnvONlQhcA>? M3P5NGROW09? NXnITItFUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSEOgbJlx\XKjY3X0fYxifGmxbh?= MkLXNlIzPjBzNk[=
786-0 NYn4R2FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL0Ok4zKM7:TR?= M4HWPFczKGh? MoPmSG1UVw>? MknwS2k2OD1|LkKg{txO MWiyNlQ{PTZ4OR?=
A498 NUnTN41GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3nRVlXPi5{IN88US=> NV\k[2NZPzJiaB?= MX;EUXNQ M1;UfGdKPTB;MT62JO69VQ>? MX[yNlQ{PTZ4OR?=
A549/ATCC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vaZVYvOiEQvF2= NWTxR3Y6PzJiaB?= NYTSWG12TE2VTx?= NWrRdZNJT0l3ME2xMlYh|ryP NEHsbmwzOjR|NU[2PS=>
ACHN MkXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjTPFBDPi5{IN88US=> NHfQVJE4OiCq M2DER2ROW09? NHzkT3FIUTVyPUGuN{DPxE1? MYGyNlQ{PTZ4OR?=
BT549 NY\2XmNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYq2MlIh|ryP NGLHOpA4OiCq MXHEUXNQ MVfHTVUxRTFwMzFOwG0> MnLPNlI1OzV4Nkm=
EKVX M1;6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nUT|YvOiEQvF2= MVK3NkBp Mn7kSG1UVw>? NW\YTYZ4T0l3ME2xMlMh|ryP NIPRR2QzOjR|NU[2PS=>
HCT15 NGPEVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;4VFYvOiEQvF2= NY\WRWhqPzJiaB?= NELofJRFVVOR MXvHTVUxRTJwNTFOwG0> M2Tj[lIzPDN3Nk[5
HOP92 NEPw[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULiPZlQPi5{IN88US=> NIH6cYc4OiCq NYPPT|hWTE2VTx?= MoDoS2k2OD12IN88US=> MmPoNlI1OzV4Nkm=
IGROV1 NF25dIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYO2MlIh|ryP MkW1O|IhcA>? M3y0PWROW09? NUfseY45T0l3ME2xMlMh|ryP Ml[1NlI1OzV4Nkm=
LOXIMVI MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\QOk4zKM7:TR?= MoHDO|IhcA>? M2TYVWROW09? M3:1RWdKPTB;MTFOwG0> NX\XO4VHOjJ2M{W2Olk>
M14 NGTBTm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HTV|YvOiEQvF2= MV[3NkBp NFLyTWtFVVOR MYXHTVUxRTFwMzFOwG0> MY[yNlQ{PTZ4OR?=
MALME-3M MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUixWpo1Pi5{IN88US=> M1PGRlczKGh? M17scWROW09? MXPHTVUxRTBwM{Kg{txO NH;TRpczOjR|NU[2PS=>
MCF10A MorzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVu2MlIh|ryP MXK0PEBp MYLEUXNQ NXvLeVVGT0l3ME25MlYh|ryP MYiyNlQ{PTZ4OR?=
MDA-MB-435 M{jFbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYi2MlIh|ryP NGG2VWc4OiCq NGriPHpFVVOR MXzHTVUxRTBwNTFOwG0> Mn6yNlI1OzV4Nkm=
MDA-MB-468 M1rYc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXm2MlIh|ryP MoXRO|IhcA>? MlLZSG1UVw>? MYnHTVUxRTBwNkOg{txO NULLcI52OjJ2M{W2Olk>
MOLT4 NHXwXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\HR|YvOiEQvF2= NX;acJI4PzJiaB?= MWTEUXNQ NHHhWYVIUTVyPUCuOEDPxE1? M3faVlIzPDN3Nk[5
NCI-ADR-RES NUjzRnRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3lZ5djPi5{IN88US=> NVfkWnpqPzJiaB?= MkTvSG1UVw>? MW\HTVUxRTBwMU[g{txO MVqyNlQ{PTZ4OR?=
NCI-H23 MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWq2MlIh|ryP MmTGO|IhcA>? M3:zbGROW09? Mk\xS2k2OD1zIN88US=> NFf5PIgzOjR|NU[2PS=>
NCI-H322M MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zNNFYvOiEQvF2= M2n0SFczKGh? MV7EUXNQ NEmwR4NIUTVyPUCuO|kh|ryP MW[yNlQ{PTZ4OR?=
NCI-H460 M{jYb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVu2MlIh|ryP NFTxWlg4OiCq NGfud2xFVVOR NFTFV5hIUTVyPUCuO|kh|ryP M2HnfFIzPDN3Nk[5
NCI-H522 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\lfFYvOiEQvF2= MnzOO|IhcA>? M4j1VWROW09? M2nRbGdKPTB;MD61JO69VQ>? MoTvNlI1OzV4Nkm=
OVCAR3 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nkU|YvOiEQvF2= NHvTd2Q4OiCq NH32[lVFVVOR NHjhXlNIUTVyPUGuN{DPxE1? NUe3XHBROjJ2M{W2Olk>
OVCAR4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVS2MlIh|ryP M2jYe|czKGh? Moi3SG1UVw>? M33x[mdKPTB;NDFOwG0> MYiyNlQ{PTZ4OR?=
OVCAR5 MorzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXm2MlIh|ryP MUe3NkBp MmfOSG1UVw>? NYXPVmhMT0l3ME2wMlc6KM7:TR?= MV6yNlQ{PTZ4OR?=
OVCAR8 MnTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX6bnhXPi5{IN88US=> MVW3NkBp NUjFXIJPTE2VTx?= NIq0N2lIUTVyPUCuOUDPxE1? MXiyNlQ{PTZ4OR?=
RXF393 MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLHdXVsPi5{IN88US=> MXq3NkBp NELGe5VFVVOR MX;HTVUxRTFwMzFOwG0> NEXBPZQzOjR|NU[2PS=>
SF268 MnfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLHWmI3NjJizszN MVm3NkBp MlHBSG1UVw>? NYHHXYNQT0l3ME2xMlYh|ryP Ml\SNlI1OzV4Nkm=
SF295 M2fLOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXwTndrPi5{IN88US=> M4XqO|czKGh? MWjEUXNQ Ml7YS2k2OD1zLk[g{txO NXmxSIVROjJ2M{W2Olk>
SF539 NXfJSpp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3H0OFYvOiEQvF2= MW[3NkBp NXrXeWdvTE2VTx?= NVy2VFFuT0l3ME2yJO69VQ>? M2DFTVIzPDN3Nk[5
SK-MEL-2 M1zCfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfWfY9NPi5{IN88US=> Ml\4O|IhcA>? M1\FcGROW09? NH\1SFlIUTVyPUGuN{DPxE1? M1KxZlIzPDN3Nk[5
SK-MEL-28 NVnSfHNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzoOk4zKM7:TR?= NHjEbVk4OiCq NEix[HlFVVOR MX;HTVUxRTFizszN MWmyNlQ{PTZ4OR?=
SK-MEL-5 M2HLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TtV|YvOiEQvF2= NV;xcINHPzJiaB?= NH\T[oNFVVOR NVfzRmtYT0l3ME2wMlY{KM7:TR?= M{X3fVIzPDN3Nk[5
SKOV3 M2TlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHqbWk3NjJizszN NXrXcGVsPzJiaB?= M3Lpe2ROW09? MYnHTVUxRTFizszN MoLsNlI1OzV4Nkm=
SN12C MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3X1d|YvOiEQvF2= M4X6blczKGh? NHPjVVdFVVOR NX\4bHJMT0l3ME2yJO69VQ>? MWOyNlQ{PTZ4OR?=
SNB19 NWDMXnNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV22MlIh|ryP MlzKO|IhcA>? Mmj1SG1UVw>? NGS2WlRIUTVyPUCuOlMh|ryP MVKyNlQ{PTZ4OR?=
SNB75 NYDVTlg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;IcVYvOiEQvF2= NIjvU5M4OiCq MnPOSG1UVw>? MnXxS2k2OD1yLke5JO69VQ>? NXj2bodsOjJ2M{W2Olk>
SR MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVW2MlIh|ryP MmrGO|IhcA>? NYK4e21{TE2VTx?= MUTHTVUxRTBwNDFOwG0> NX\yVWsxOjJ2M{W2Olk>
T47D MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWi2MlIh|ryP MmnwO|IhcA>? Mo\RSG1UVw>? MV\HTVUxRTBwNTFOwG0> NGPHPY8zOjR|NU[2PS=>
TK10 NG\1V3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIP4fXE3NjJizszN Mk\SO|IhcA>? NGXyO2RFVVOR MVrHTVUxRTBwNkOg{txO MWKyNlQ{PTZ4OR?=
UACC257 NG\4V2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nHbFYvOiEQvF2= NHHvSIw4OiCq NV3HUYplTE2VTx?= NIL1eFZIUTVyPUCuOUDPxE1? M1XVTVIzPDN3Nk[5
UACC62 M4nMRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLKUY1SPi5{IN88US=> NWPOXHV6PzJiaB?= MnTRSG1UVw>? M{LIemdKPTB;MD60JO69VQ>? MnTHNlI1OzV4Nkm=
UO31 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGP4WIg3NjJizszN NVPaT4pGPzJiaB?= M4XvUGROW09? NGnUVFRIUTVyPUCuOUDPxE1? M3j4RVIzPDN3Nk[5
Hep3B M3T2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\tOFghcA>? MojQSG1UVw>? NIP3VVVIUTVyPUCuOlkh|ryP M4P4V|IzPDN7OE[z
BE(2)-C NYfrO4FWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknyO|IhcA>? NGTQW5FFVVOR NEO3U2JKSzdyPUKg{txO M2r3b|IzQTN{M{G2
Bel7402 NEDiUVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUC3[oxSPzJiaB?= NXPCUoZuTE2VTx?= MVrHTVkxRTF5IN88US=> NVTkPVJJOjNyNkGzO|Y>
Bel7404 M4nHXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3EbIs4OiCq MlfhSG1UVw>? M1jsPWdKQTB;MUig{txO MWiyN|A3OTN5Nh?=
BGC823 M3jjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\Hb2U4OiCq MnHPSG1UVw>? MYHHTVkxRTdwNTFOwG0> M4HXUlI{ODZzM{e2
MGC803 Mn7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T2WFczKGh? NHPSXZpFVVOR M4jHWmdKQTB;MUCuPEDPxE1? MmO3NlMxPjF|N{[=
SGC7901 NEPpOWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXmO|IhcA>? NXzLUZhsTE2VTx?= MlTxS2k6OD17LkSg{txO MVeyN|A3OTN5Nh?=
SKHEP1 MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVi3NkBp MVPEUXNQ MW\HTVkxRTF5IN88US=> MlTJNlMxPjF|N{[=
SMMC7721 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TSelczKGh? MmDJSG1UVw>? M37XeWdKQTB;MkCg{txO MXmyN|A3OTN5Nh?=
NUGC3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUexNEDPxE1? NHL0bpBIUT1{Lkm0JO69VQ>? NGjVTJczOzF4M{OzNi=>
A2780 CisR MmLpT4lv[XOnIFHzd4F6 MVKxPEBp M{f3WGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? MknqNlMzPTJ4MEO=
CAL27 sens NYLqbpQxU2mwYYPlJGF{e2G7 MWmxPEBp M33GeGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? MXqyN|I2OjZyMx?=
CAL27 CisR Mnn0T4lv[XOnIFHzd4F6 MYKxPEBp M3O1TGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M3nFTlI{OjV{NkCz
KYSE-510 CisR M2L0UWtqdmG|ZTDBd5NigQ>? NGnzO3AyQCCq M1v1NWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? MXyyN|I2OjZyMx?=
KYSE-510 sens MUPLbY5ie2ViQYPzZZk> MYqxPEBp NF31RZlKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? MWGyN|I2OjZyMx?=
MDA-MB-231 sens MnSwT4lv[XOnIFHzd4F6 MkTBNVghcA>? MmX6TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? MVWyN|I2OjZyMx?=
MDA-MB-231 CisR MXPLbY5ie2ViQYPzZZk> MUGxPEBp MlLuTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NYrDPW0{OjN{NUK2NFM>
ES2 M3LKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rLUVQ5KGh? NXG1OlBWTE2VTx?= MkLTTWM2OD1zMj63JO69VQ>? MWSyN|Q6OzR2OR?=
MDA-MB-231 NYrUfHlzU2mwYYPlJGF{e2G7 NUfh[oFHOTBizszN NXHte4oxOzBibXnu NUPUdYFGTE2VTx?= M1LYbWlvcGmkaYTpc44hd2ZiSFTBR|Ji NESzbWkzOzR7M{S0PS=>
MDA-MB-231 M1HOSmtqdmG|ZTDBd5NigQ>? MV6xJO69VQ>? MnLmNlQhcA>? M4\ndGROW09? MXjJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw NHXxUFUzOzR7M{S0PS=>
HS68 NWrVWWFbS3m2b4TvfIlkKEG|c3H5 NVXpWZdKOTBizszN NVrZUFQ3PzJiaB?= NFjISGFFVVOR M1TyZ2lEPTB;ND62JO69VQ>? NWTtTpVFOjN3N{C1OFI>
MEF NHLyOm9EgXSxdH;4bYMhSXO|YYm= NYHKVmJKOTBizszN MWK3NkBp MofFSG1UVw>? NELHSWhKSzVyPUSuOEDPxE1? MnXiNlM2PzB3NEK=
BGC823 M1v0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnEUXNQ MVPHTVUxRTNwMEmg{txO NYD4U3NOOjN4MEG3NFY>
High5 M{HaOmtqdmG|ZTDBd5NigQ>? NXLDN|VlOjRiaB?= MlzjTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDOkB4cXSqIFnDOVAhd2ZiMD6wPUDPxE1? NH7ieGUzOzZyMkWyNy=>
High5 NW\5e484U2mwYYPlJGF{e2G7 M3\lUVI1KGh? MXLJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? NXTRRmdYOjN4MEK1NlM>
High5 MUnLbY5ie2ViQYPzZZk> M3P1PVI1KGh? NGXiOW1KdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= NFvVT2YzOzZyMkWyNy=>
A549 NULnOFZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\RbGROW09? Ml2wTWM2OD1zLkC3PUDPxE1? MVGyN|Y1PDJzMB?=
HCT116 MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrFVmhFVVOR M3Ht[GlEPTB;MD63OVch|ryP Ml\XNlM3PDR{MUC=
K562 NULsWXVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonCSG1UVw>? MXrJR|UxRTBwNkS1JO69VQ>? NEnNd2czOzZ2NEKxNC=>
GBC-SD MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvnOWlSPSEQvF2= MnzyO|IhcA>? MlnlSG1UVw>? MnzwTWM2OD1zND64JO69VQ>? MmnkNlM4ODd{NkC=
HGC27 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nHTlUh|ryP NWDRWVA3PzJiaB?= M{H0dmROW09? MVTJR|UxRTVwNDFOwG0> MlGwNlM4ODd{NkC=
HL60 NFfDTWNMcW6jc3WgRZN{[Xl? NHLpXYI2KM7:TR?= Mmm3NlQhcA>? MUTEUXNQ M3m1RmlvcGmkaYTpc44hd2ZiSFTBRy=> M{jqe|I{PzB5Mk[w
Vero M1jHVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInHcGU4OiCq M1T4W2ROW09? MVTJR|UxRTBwOTFOwG0> NGLJZoUzOzd6NkS1Ni=>
NCI60 MWjDfZRwfG:6aXOgRZN{[Xl? M2HscFQ5KGh? NXnsRWZNTE2VTx?= NYnHSFdKT0l;MD61N{DPxE1? NETV[lMzPDBzNUOyOy=>
SW620 NIjuc|ZEgXSxdH;4bYMhSXO|YYm= NYLrXYljPDhiaB?= NYX5XpNsTE2VTx?= MUHHTV0xNjV2IN88US=> M4n0[FI1ODF3M{K3
U251 NIO2[4ZEgXSxdH;4bYMhSXO|YYm= NF;MXVQ1QCCq MXHEUXNQ MmrIS2k:OS53MzFOwG0> NWr5[IhXOjRyMUWzNlc>
KM12 MWnDfZRwfG:6aXOgRZN{[Xl? MXi0PEBp MXnEUXNQ MYnHTV0yNjh6IN88US=> NIHQPHEzPDBzNUOyOy=>
Hs578T MVzDfZRwfG:6aXOgRZN{[Xl? NYHO[pl6PDhiaB?= NETvb4VFVVOR NUjhVoJmT0l;ND64N{DPxE1? NUHhT29MOjRyMUWzNlc>
MDA-MB-231 M3\TW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYq0PEBp Ml\0TWM2OD1yLkG2JO69VQ>? NEjEU2ozPDB7NUCxOi=>
MCF7 M3LO[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFixNXU1QCCq M3TqfWdKRTBwNEWg{txO MnTYNlQyOTl3NUW=
MDA-MB-435 M1nxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LGOVQ5KGh? NV;1NI1vT0l;MD64PEDPxE1? NVS2enRFOjRzMUm1OVU>
AsPC1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGzSHM{OCEQvF2= NIHhVYM1QCCq Mn;aSG1UVw>? M17SfWlEPTB;Mz62OkDPxE1? NHq5bpUzPDF6NUO3PC=>
Jurkat E6.1 MlzVT4lv[XOnIFHzd4F6 MVmyJIg> MWfEUXNQ MWPJcohq[mm2aX;uJI9nKEiGQVO0JJdqfGhiSVO1NEBw\iByLkC0JO69VQ>? MYOyOFI3OTh4Mh?=
KG1 MnfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmSwOFghcA>? NGfQNWpKSzVyPUGuNVUh|ryP MX[yOFUzPTByMx?=
HEL MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXyO3R7PDhiaB?= NF3ZXHVFVVOR NH\zeIZKSzVyPUCuOFkh|ryP M3HsXlI1Pjl2MEW1
HSC3 M1;MOGN6fG:2b4jpZ{BCe3OjeR?= M1j5b|EzKGh? NFK3bYdFVVOR M4TmVmlEPTB;MD63NUDPxE1? M4rlT|I1PzZ4NU[w
HT-29 M3L3cWN6fG:2b4jpZ{BCe3OjeR?= NIf2e2syOiCq MXzEUXNQ M1rLPWlEPTB;MD63NkDPxE1? Mmm2NlQ4PjZ3NkC=
KB NVvTcoRCS3m2b4TvfIlkKEG|c3H5 MWGxNkBp NFTpTZlFVVOR NXfrVVBtUUN3ME2wMlc2KM7:TR?= MUiyOFc3PjV4MB?=
H460 MXPDfZRwfG:6aXOgRZN{[Xl? MoXmNVIhcA>? MmnjSG1UVw>? MofRTWM2OD1yLkiyJO69VQ>? NF3h[oozPDd4NkW2NC=>
MONE1 MoPMR5l1d3SxeHnjJGF{e2G7 NXqwPJFXOTJiaB?= M2i2ZmROW09? NIDV[mFKSzVyPUGuNVgh|ryP NI\G[2MzPDd4NkW2NC=>
MKN45 MUDDfZRwfG:6aXOgRZN{[Xl? M37acFEzKGh? M2TicmROW09? MX7JR|UxRTFwMkWg{txO NVftNXJqOjR5Nk[1OlA>
TSGH NGq2ZohEgXSxdH;4bYMhSXO|YYm= MVixNkBp MYTEUXNQ M{HM[GlEPTB;Mj6wPUDPxE1? MUKyOFc3PjV4MB?=
HL60 NYnXc4dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUK3NkBp NV3EUFl4TE2VTx?= M3fWdmdKPTB;MD65N{DPxE1? M1LCWlI1QTByNUCw
HEK293 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nWZVczKGh? MofOSG1UVw>? M{K1OWdKPTB;MUOg{txO NYSyXZBpOjR7MEC1NFA>
Jurkat NVruN4FnS3m2b4TvfIlkKEG|c3H5 NUDsb2lCOTByIN88US=> NYrmPG1FPzJiaB?= MoHLS2k2OD1yLkmg{txO NVuz[FBuOjR7MEC3OFM>
GM15850 NVLZZm9kU2mwYYPlJGF{e2G7 NXK3e5VCOi53IN88US=> NVfqTo04QTZiaB?= MoPFSG1UVw>? NIrXU3Jld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhOTRiYXPleJlt[XSrb36gc4YhTliQIHflcoU> NGjFZoYyPjl{MUO2Oy=>
GM15850 NUjvOJh6U2mwYYPlJGF{e2G7 NFL5dlQzNjVizszN NEDjW5U6PiCq MWHEUXNQ NVLoO|c4\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDViYXPleJlt[XSrb36gc4YhTliQIHflcoU> MV6xOlkzOTN4Nx?=
GM15850 NVWzRWY6U2mwYYPlJGF{e2G7 NI\2[IMzNjVizszN M33KWFk3KGh? M13YU2ROW09? NF3lfoFld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhOTJiYXPleJlt[XSrb36gc4YhTliQIHflcoU> MV[xOlkzOTN4Nx?=
GM15850 NF;LS3RMcW6jc3WgRZN{[Xl? Mn;QNk42KM7:TR?= MlfJPVYhcA>? MUDEUXNQ Ml7u[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MlXWNVY6OjF|Nke=
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VM-CUB-1 NUPwR|JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1ruOmlEPTB;MT6xPVExQCEQvF2= NGXDOmhUSU6JRWK=
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SKG-IIIa MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFwMkO0OlQh|ryP MWjTRW5ITVJ?
HO-1-N-1 M1XufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTFwMkO4N|Uh|ryP NWrmUJdEW0GQR1XS
EFO-27 M{LYUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfiTWM2OD1zLkK1NFQ{KM7:TR?= M3vVd3NCVkeHUh?=
MHH-NB-11 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjvSJRKSzVyPUGuNlg{OjlizszN MWrTRW5ITVJ?
SW620 M{PWRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\pUmxMUUN3ME2xMlI6ODF6IN88US=> MorzV2FPT0WU
MOLT-16 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TZ[2lEPTB;MT6yPVc6PyEQvF2= MXLTRW5ITVJ?
NTERA-S-cl-D1 NHrpboJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\qTWM2OD1zLkOxO|YyKM7:TR?= NIP2[IhUSU6JRWK=
VA-ES-BJ MkjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nSV2lEPTB;MT6zNlQ4PyEQvF2= Mlv3V2FPT0WU
HCC1419 NUe3V2duT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[3fI5OUUN3ME2xMlM1ODJ5IN88US=> MnLwV2FPT0WU
NCI-H69 MmnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4OxWmlEPTB;MT6zOFEyOiEQvF2= M{LqUnNCVkeHUh?=
DEL MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFwM{WxOlIh|ryP NFm5Z|JUSU6JRWK=
LXF-289 M2rudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfxPIxKSzVyPUGuN|UzPCEQvF2= Ml3WV2FPT0WU
EW-11 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7LTWM2OD1zLkO2NFI3KM7:TR?= NV7SfFdKW0GQR1XS
KP-4 M3HPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFwM{ewPFUh|ryP NGOzOnlUSU6JRWK=
NOS-1 MkXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHETWM2OD1zLkSxNVk1KM7:TR?= NWPFcWFYW0GQR1XS
SK-NEP-1 NWX3TnJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmmwTWM2OD1zLkSxOlk{KM7:TR?= NXnzSItzW0GQR1XS
LAMA-84 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFwNEO5OFUh|ryP MmDsV2FPT0WU
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HuO9 M3vpeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT1TWM2OD1zLkS1N|YzKM7:TR?= MXnTRW5ITVJ?
COLO-684 M1jXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHCTWM2OD1zLkS2NVE5KM7:TR?= MUDTRW5ITVJ?
EW-24 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1z6bmlEPTB;MT60OlU{OSEQvF2= M2PSO3NCVkeHUh?=
BV-173 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T4emlEPTB;MT60O|I6OSEQvF2= NFrjN|ZUSU6JRWK=
NCI-H1770 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETyOFZKSzVyPUGuOFg2OzZizszN NUjmR29XW0GQR1XS
HuP-T4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TEWGlEPTB;MT60PVMh|ryP M37Lb3NCVkeHUh?=
TYK-nu M1TaXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy0O41vUUN3ME2xMlQ6QDVzIN88US=> M4LNe3NCVkeHUh?=
YH-13 M1njZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTHXVd[UUN3ME2xMlQ6QDl2IN88US=> MoKxV2FPT0WU
H4 NHz0T2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTFwNUC5NVIh|ryP NIPueXBUSU6JRWK=
OVCAR-8 NUfvOlJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfTTWM2OD1zLkW0OFc4KM7:TR?= MkLRV2FPT0WU
NCI-H23 NEj3PZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\mTWlEPTB;MT61OFY1PSEQvF2= MYXTRW5ITVJ?
ES7 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv6TWM2OD1zLkW0O|c{KM7:TR?= NWrmc4sxW0GQR1XS
COR-L88 M2LaVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTFwNU[0NlQh|ryP MljjV2FPT0WU
TI-73 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvhbJdqUUN3ME2xMlU6ODZizszN MUTTRW5ITVJ?
RT-112 MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXy1T4dJUUN3ME2xMlU6Ojh2IN88US=> NGLoOmVUSU6JRWK=
HuO-3N1 NHrDTWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTFwNUmzPFUh|ryP MmfNV2FPT0WU
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IA-LM NX70XGM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYGxNWtrUUN3ME2xMlY6Ojd6IN88US=> MlK3V2FPT0WU
EM-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4i3WmlEPTB;MT63NFAyPCEQvF2= M1TyV3NCVkeHUh?=
MHH-ES-1 M2HLVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzkTY9jUUN3ME2xMlcxPDN3IN88US=> MlvSV2FPT0WU
CAL-27 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXWUldKSzVyPUGuO|A3OjFizszN NIrCPW1USU6JRWK=
COLO-800 M4rV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvLTWM2OD1zLkexNVc6KM7:TR?= MkPMV2FPT0WU
HCE-T NFvjRo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfhVoF3UUN3ME2xMlcyPSEQvF2= NI\tZmFUSU6JRWK=
CAMA-1 NYj6V5RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELSRnJKSzVyPUGuO|E6PzFizszN M4fYSXNCVkeHUh?=
LOXIMVI MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrPNJpQUUN3ME2xMlczOTFizszN MW\TRW5ITVJ?
NH-12 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmniTWM2OD1zLkeyOlkyKM7:TR?= M{\uVXNCVkeHUh?=
TCCSUP MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFwN{K4Nlkh|ryP Mn33V2FPT0WU
MDA-MB-361 NVThNVg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfZfYxKSzVyPUGuO|MyPTdizszN M4rGfHNCVkeHUh?=
EW-16 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjCOm9qUUN3ME2xMlc1OTB5IN88US=> M4LaUnNCVkeHUh?=
SNU-423 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC2[pdyUUN3ME2xMlc2QDJ5IN88US=> M4LGSXNCVkeHUh?=
Daoy NV7Qcmp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPoTWM2OD1zLke2N|E6KM7:TR?= NVq2[49JW0GQR1XS
ES4 MmjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PXVmlEPTB;MT63PFc1OSEQvF2= M4\KcHNCVkeHUh?=
PFSK-1 M3vsOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTwblBUUUN3ME2xMlgxOzdizszN M{XyTnNCVkeHUh?=
ES3 NHPOenZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i5fmlEPTB;MT64NlY5OSEQvF2= MVrTRW5ITVJ?
ONS-76 M4Tkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwOEK4PVch|ryP M1XW[HNCVkeHUh?=
JVM-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwOEW0OVEh|ryP MWXTRW5ITVJ?
OS-RC-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnxTWM2OD1zLki3NVUyKM7:TR?= NGTzSlNUSU6JRWK=
COLO-320-HSR MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr0TWM2OD1zLki4NVk4KM7:TR?= NHTsSlVUSU6JRWK=
HN MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTDTWM2OD1zLki4O|I2KM7:TR?= NGj2[nVUSU6JRWK=
HT NXPuOHlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTFwOEi5OFch|ryP MV7TRW5ITVJ?
LoVo M1noSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPKbY9KSzVyPUGuPFk5OSEQvF2= MULTRW5ITVJ?
CGTH-W-1 NWjWbHRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkf3TWM2OD1zLki5PVQ3KM7:TR?= NGjYfXJUSU6JRWK=
NB6 M1Hi[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTFwOUGyPVgh|ryP MljLV2FPT0WU
EW-22 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTFwOUK4PFch|ryP MXzTRW5ITVJ?
ES6 Moe4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTFwOUO2N|Eh|ryP NWK4OW13W0GQR1XS
SCC-15 MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzvdnFZUUN3ME2xMlk{QDF7IN88US=> M{j3b3NCVkeHUh?=
HL-60 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3mcWFtUUN3ME2xMlk{QTB{IN88US=> NGPoR49USU6JRWK=
human HOP-92 M3HlOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn0TWM2OD1zLkm0NFY2KM7:TR?= M{CzeHNCVkeHUh?=
SW626 NHHy[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DLSWlEPTB;MT65OFg6QSEQvF2= MoPrV2FPT0WU
HEC-1 M{DDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTQSpQ4UUN3ME2xMlk2OzZizszN Mo\EV2FPT0WU
LB2241-RCC NFH3VIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFwOUiyN|Eh|ryP NXL2eXkzW0GQR1XS
Ramos-2G6-4C10 NHrXTnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnVRllKSzVyPUGuPVk1QTNizszN M3izUXNCVkeHUh?=
A101D M3frSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nTNGlEPTB;Mj6yNFMxOyEQvF2= NI\4OIdUSU6JRWK=
NCI-H446 M2HLS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJwMES1PVkh|ryP MW\TRW5ITVJ?
SBC-5 NWLFcW9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L4cWlEPTB;Mj6wOlE1PyEQvF2= NUL0WXRDW0GQR1XS
HOS M1PXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH1[XNiUUN3ME2yMlA4PjV|IN88US=> MWTTRW5ITVJ?
K5 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJwMEe4NVEh|ryP NEfybFZUSU6JRWK=
HLE NHOzeJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnRR4ZKSzVyPUKuNFg2OjlizszN NYXTbG9vW0GQR1XS
HSC-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP0cnNKSzVyPUKuNVI5QThizszN MnO5V2FPT0WU
LCLC-97TM1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrwTWM2OD1{LkG0OVg{KM7:TR?= MomzV2FPT0WU
DMS-273 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJwMUS4N|ch|ryP MnHFV2FPT0WU
TE-8 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjlTlBKSzVyPUKuNVU4PjVizszN NGDLcpJUSU6JRWK=
DSH1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJwMU[zPVgh|ryP MWrTRW5ITVJ?
CAL-51 NFXseoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XOZWlEPTB;Mj6xOlY6QSEQvF2= M4T1OnNCVkeHUh?=
IST-SL1 MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\nfWpKSzVyPUKuNVY5PDRizszN MmDHV2FPT0WU
GCT NH\jVYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DjcWlEPTB;Mj6xO|c4KM7:TR?= NWnFfI1WW0GQR1XS
SW948 NIr4cZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPuNo9VUUN3ME2yMlE5PDV4IN88US=> NWfKR|k1W0GQR1XS
NOMO-1 M{jQfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJwMUmzNVch|ryP MUfTRW5ITVJ?
C8166 NX\zSVFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTJwMkGzN|Qh|ryP MlPHV2FPT0WU
OC-314 MmLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrIfVBxUUN3ME2yMlI{OjV7IN88US=> NUHIPZZUW0GQR1XS
CAL-39 MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7tflUxUUN3ME2yMlI{PjJ4IN88US=> MlWxV2FPT0WU
MDA-MB-453 NVPDWJlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1S2TmlEPTB;Mj6yOFI4PSEQvF2= NXrSc4JQW0GQR1XS
A673 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LiS2lEPTB;Mj6yOVg3OiEQvF2= NF7UZpZUSU6JRWK=
HTC-C3 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TJNWlEPTB;Mj6yOlg2KM7:TR?= MYfTRW5ITVJ?
NCI-H1666 Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJwMkixNVEh|ryP MVzTRW5ITVJ?
PSN1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJwMki5NVMh|ryP M1K5S3NCVkeHUh?=
GI-1 Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJwM{C1OFMh|ryP MljjV2FPT0WU
HuH-7 MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TJXGlEPTB;Mj6zNFY{PyEQvF2= NWDWNJdNW0GQR1XS
JAR MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe4PHc4UUN3ME2yMlMyQTh5IN88US=> MoPXV2FPT0WU
5637 M1vQcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJwM{KxNlkh|ryP NGPOeWlUSU6JRWK=
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KP-N-YS M1LFc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHOTWM2OD1{LkOyOlE2KM7:TR?= NFnNOJRUSU6JRWK=
OAW-42 NWfUcWhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\ETWM2OD1{LkOzOFE3KM7:TR?= NYT0Zot2W0GQR1XS
8-MG-BA MlrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmm4TWM2OD1{LkOzPVA3KM7:TR?= MlLXV2FPT0WU
RH-18 NV\QSHFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC3fYJKSzVyPUKuN|UxOjJizszN NHqyOWpUSU6JRWK=
NCI-H1155 NGD2eYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfGXIRKSzVyPUKuN|Y4OjVizszN NWfDc5Y4W0GQR1XS
NB17 NUHOVGNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\NOFJKSzVyPUKuN|gzPDNizszN MknFV2FPT0WU
NCI-H1437 Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTnTWM2OD1{LkSxPFc{KM7:TR?= MkKyV2FPT0WU
SN12C NHPlb25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfRTWM2OD1{LkSzNlE1KM7:TR?= Ml30V2FPT0WU
HSC-3 NFvtcFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{D0U2lEPTB;Mj60OFUxQSEQvF2= MnK2V2FPT0WU
GAMG NH3q[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHDUHhKSzVyPUKuOFQ2PjFizszN MnfFV2FPT0WU
HT-1080 M1r1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJwNES4OlQh|ryP NYLQfVg5W0GQR1XS
A549 M4\jemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFqzTJZKSzVyPUKuOFQ5QTNizszN NUG5N2ZtW0GQR1XS
KNS-62 NEPE[WFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HzcmlEPTB;Mj60OVA3OSEQvF2= MlPRV2FPT0WU
YKG-1 NUSwUXg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7rTWM2OD1{LkS1OFM4KM7:TR?= NGLidJhUSU6JRWK=
LU-134-A MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDwPIhKSzVyPUKuOFcxODhizszN M3;KU3NCVkeHUh?=
FADU MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jvfmlEPTB;Mj60O|E3OiEQvF2= MojiV2FPT0WU
TGBC11TKB NWHOTZFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nH[WlEPTB;Mj60O|E4PyEQvF2= NVrsdVNoW0GQR1XS
HT-3 M3L2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGCxPWFKSzVyPUKuOFk2OzVizszN M37C[nNCVkeHUh?=
NCI-H2170 NYH3eHh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO3RXlTUUN3ME2yMlUxPTR7IN88US=> M4XUcnNCVkeHUh?=
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CCRF-CEM NFn4Z5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjJTWM2OD1{LkWzNFQ{KM7:TR?= NXizU24xW0GQR1XS
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NCI-H292 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJwOE[1PVYh|ryP MkXYV2FPT0WU
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T-24 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlL3TWM2OD1|LkG1NFch|ryP NGj3SnhUSU6JRWK=
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GR-ST NG\QSXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLTTWM2OD1|LkKyNVM6KM7:TR?= MVLTRW5ITVJ?
LB2518-MEL NXPp[G5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnNWGZQUUN3ME2zMlIzOzl6IN88US=> MmCzV2FPT0WU
T47D MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3NNmN6UUN3ME2zMlI{PjJ5IN88US=> M4Htc3NCVkeHUh?=
NCI-H1651 NFvlTGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTNwMkS2OFQh|ryP NWizfHZNW0GQR1XS
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HT-29 M4Pw[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm2OnhPUUN3ME2zMlI3PjF2IN88US=> MmWwV2FPT0WU
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NCI-H1563 NV7KT5U{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDiU2hKSzVyPUOuN|MxOThizszN M{LaRXNCVkeHUh?=
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L-428 MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rpWGlEPTB;Mz60NFA1PSEQvF2= NF7iNFFUSU6JRWK=
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SW1116 Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3y[nhoUUN3ME2zMlQ3OjZ7IN88US=> NV3ZVWNFW0GQR1XS
DMS-114 NYfKWIRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPwfoxZUUN3ME2zMlQ4ODZ4IN88US=> NHfac|JUSU6JRWK=
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COLO-829 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[1emR3UUN3ME2zMlUxODd|IN88US=> NX:w[3R7W0GQR1XS
J82 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnETWM2OD1|LkWwOVch|ryP NIXkSGxUSU6JRWK=
EW-13 NF32b25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTaS2xKSzVyPUOuOVI2OSEQvF2= MnPBV2FPT0WU
RXF393 NGLCU4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj3WmxvUUN3ME2zMlU{Ojl2IN88US=> NFzrVGdUSU6JRWK=
CAL-62 M4XqV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPDVpBKSzVyPUOuOVQ2OTRizszN NEDrfZRUSU6JRWK=
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BT-474 M1HDV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fL[mlEPTB;Mz62N|MyKM7:TR?= M4HvZ3NCVkeHUh?=
KYSE-180 NXXzSokzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;HPWlEPTB;Mz62N|M4OiEQvF2= M{LS[nNCVkeHUh?=
NCI-H650 MnrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfvdlZuUUN3ME2zMlY1Ojh5IN88US=> Mn[4V2FPT0WU
Detroit562 M{jKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljTTWM2OD1|Lk[1NFIzKM7:TR?= MonkV2FPT0WU
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KYSE-450 NHflcIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7NVW94UUN3ME2zMlY5PTh{IN88US=> M2jG[HNCVkeHUh?=
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MEL-JUSO MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTZTWM2OD1|Lki5NVU{KM7:TR?= MUnTRW5ITVJ?
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OVCAR-4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXmPZFNUUN3ME2zMlkzQDh7IN88US=> NV;oZ41UW0GQR1XS
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COR-L105 M1v0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\2eWlEPTB;ND6xN|A2OSEQvF2= NVPZN286W0GQR1XS
CAL-12T NVfEU3FnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTRwMUOxNFMh|ryP NEXTNnJUSU6JRWK=
SCH M{fNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjCTWM2OD12LkG1O|Q{KM7:TR?= M2XvZ3NCVkeHUh?=
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KP-N-YN MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jRS2lEPTB;ND6yNFkzPyEQvF2= NWDI[2xMW0GQR1XS
T98G NHPoe|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTRwMkKxOVch|ryP MXnTRW5ITVJ?
CAL-54 M37COmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHVcJEyUUN3ME20MlIzOzhzIN88US=> M3;CRnNCVkeHUh?=
CAL-33 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLFTWM2OD12LkKzNFY1KM7:TR?= MXXTRW5ITVJ?
SNU-C2B NXq3SWdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\mR3FKSzVyPUSuNlQ4PjlizszN NF3oXY5USU6JRWK=
NUGC-3 M2XXZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvUTWM2OD12LkK1OVA2KM7:TR?= MYjTRW5ITVJ?
DOK M4m4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjsdpJKSzVyPUSuNlY2QTNizszN NUDWd2Z7W0GQR1XS
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KYSE-70 NFPqdJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rkSmlEPTB;ND6yPVM1KM7:TR?= Mn3lV2FPT0WU
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EPLC-272H MmS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLFVYpKSzVyPUSuN|g6PSEQvF2= M1Li[3NCVkeHUh?=
CAL-120 NELsU4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTRwM{i5PVIh|ryP MUPTRW5ITVJ?
LS-513 Mnr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTRwNEKxPVgh|ryP NHvxboRUSU6JRWK=
CAPAN-1 MorqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O4UGlEPTB;ND60NlM5OiEQvF2= Mn;MV2FPT0WU
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GMS-10 MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7CTWM2OD12LkSyPFE6KM7:TR?= M1n4XXNCVkeHUh?=
NCI-N87 NFzwfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PTNGlEPTB;ND61NFg3QCEQvF2= NH\3PZdUSU6JRWK=
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NCI-H1395 M{S2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTFyLkG3PEDPxE1? NVrCWW04W0GQR1XS
NCI-H2052 Ml3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4O0N2lEPTB;MUCuNVg5OiEQvF2= NF;penFUSU6JRWK=
A375 NVHnVJRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTFyLkK0OVIh|ryP MmizV2FPT0WU
HCC38 NXLVUlh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHhc4NKSzVyPUGwMlMzOiEQvF2= MkTQV2FPT0WU
LK-2 M3fQe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLjUYk4UUN3ME2xNE41OjB6IN88US=> NGW1ZnFUSU6JRWK=
SF126 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTzTWM2OD1zMD60O|I4KM7:TR?= M2O1THNCVkeHUh?=
SK-MEL-1 NFPJW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTFyLke4N|gh|ryP MWHTRW5ITVJ?
ACN M4XTOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFyLki2O|kh|ryP M4rEUnNCVkeHUh?=
BB30-HNC NIj4WVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;ESZIzUUN3ME2xNE45PzFzIN88US=> MkLRV2FPT0WU
NCI-H747 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mle3TWM2OD1zMD64O|Q3KM7:TR?= MnjXV2FPT0WU
KYSE-150 NIXUb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTFzLkCzPFch|ryP MnnWV2FPT0WU
D-247MG NWruXYpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nzVWlEPTB;MUGuNVAxQSEQvF2= NYq2Z2IzW0GQR1XS
BxPC-3 NFToXZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW4TWM2OD1zMT6zO|Q4KM7:TR?= MmLWV2FPT0WU
SK-MEL-30 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTFzLkSwO|kh|ryP NFHQeIJUSU6JRWK=
CAS-1 NV\CcpFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\oTWM2OD1zMT60NVA6KM7:TR?= M3vpSXNCVkeHUh?=
no-10 Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPXTWM2OD1zMj6xNlE4KM7:TR?= M2nYN3NCVkeHUh?=
NCI-H2405 NETVW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfuTWM2OD1zMj6yNFM3KM7:TR?= NHr0eWNUSU6JRWK=
KGN NHzjfZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorRTWM2OD1zMj6yPVAyKM7:TR?= MknXV2FPT0WU
BB49-HNC NUTzfnoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTF{LkO5OVYh|ryP MnK3V2FPT0WU
NCI-H1693 MkfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nTbmlEPTB;MUKuOVgyPiEQvF2= MWrTRW5ITVJ?
RO82-W-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnRVmlKSzVyPUGzMlA3PDlizszN MnzWV2FPT0WU
CAL-85-1 NXzXRYpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HlTmlEPTB;MUOuOFM6QSEQvF2= MXnTRW5ITVJ?
H-EMC-SS NV\icHI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jEVGlEPTB;MUOuPVExPCEQvF2= Mmn4V2FPT0WU
SW1783 NXP6S4pOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWW4XlZQUUN3ME2xOE4zOzlzIN88US=> MnvzV2FPT0WU
LB771-HNC Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLiTWM2OD1zND60NVkh|ryP NWDRXWRlW0GQR1XS
HCC70 NWTjW2NCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF2LkSyN|Mh|ryP M3r5V3NCVkeHUh?=
KNS-81-FD NFX2UXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;rbIJWUUN3ME2xOE44ODR3IN88US=> MXPTRW5ITVJ?
KYSE-520 M{LuNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfoTWM2OD1zND65Nlch|ryP MVnTRW5ITVJ?
TGBC24TKB NUK4VGNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1S5ZWlEPTB;MUSuPVU{QSEQvF2= NYHYOJB{W0GQR1XS
SNB75 NEnyS2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHSR3c2UUN3ME2xOU4xPzJ7IN88US=> M{PZ[XNCVkeHUh?=
SW872 NHfSRZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDocYJrUUN3ME2xOU4zOjF6IN88US=> M4mye3NCVkeHUh?=
U031 NX24NmtIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2f3ZWlEPTB;MUWuPFAzQCEQvF2= NI\tToVUSU6JRWK=
ChaGo-K-1 Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWroU5lEUUN3ME2xOU45OzV7IN88US=> MVzTRW5ITVJ?
NCI-H441 NEfTSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrYZmdRUUN3ME2xOk4xODN7IN88US=> MYfTRW5ITVJ?
TE-12 NVXVVoFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPUOFJoUUN3ME2xOk4yQDd|IN88US=> M2XRU3NCVkeHUh?=
NCI-H1755 NYTnSINuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXDUmdKSzVyPUG2MlU4OyEQvF2= MoPBV2FPT0WU
KNS-42 Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrpZXFKSzVyPUG2MlY2QDlizszN MY\TRW5ITVJ?
SK-PN-DW Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfmTWM2OD1zNz60NlAyKM7:TR?= MnP4V2FPT0WU
NCI-H226 NFr4[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlztTWM2OD1zNz65N|Q2KM7:TR?= M{LxRnNCVkeHUh?=
K-562 M1fCcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzuOJRiUUN3ME2xPE43OzF5IN88US=> MkjwV2FPT0WU
A388 M165Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\GcmlEPTB;MUmuNFMxOyEQvF2= Moj5V2FPT0WU
ZR-75-30 NEjDe41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq4WmRKSzVyPUG5MlA6PjhizszN M4LlUXNCVkeHUh?=
LU-135 NIDxfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvYSZdKSzVyPUG5MlI3OzZizszN MlXXV2FPT0WU
NCI-H2029 MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH4U3VKSzVyPUG5MlYxOjFizszN M1HGS3NCVkeHUh?=
HT-1197 NXTObpd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHXTWM2OD1zOT65NlI4KM7:TR?= MmG4V2FPT0WU
IGR-1 NVT1ZVB{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInaTHNKSzVyPUKwMlMyOTdizszN MlXXV2FPT0WU
U-87-MG NInIS|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJyLk[0NVMh|ryP Ml\hV2FPT0WU
NCI-H1304 NGLCeXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4POPWlEPTB;MkCuO|UxOSEQvF2= M3HkUXNCVkeHUh?=
RCC10RGB Mnj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojKTWM2OD1{MT6yPFI6KM7:TR?= M1L0d3NCVkeHUh?=
NCI-H520 M{HyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzUSFdKSzVyPUKyMlc3OTFizszN NXTiTnNIW0GQR1XS
SK-LU-1 NFHVcVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfPe3lKSzVyPUKzMlA4OThizszN NFTicnlUSU6JRWK=
UACC-893 M1XCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\sPWlEPTB;MkOuNVA{QCEQvF2= M{XhZnNCVkeHUh?=
NCI-H2347 NYnWUYVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ry[2lEPTB;MkOuNlY4PCEQvF2= NFnJXmtUSU6JRWK=
U-118-MG NGi4dmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\jTWM2OD1{Mz63NlE4KM7:TR?= NGfJcYlUSU6JRWK=
NCI-H596 NHHaXYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoezTWM2OD1{Mz65NFU2KM7:TR?= MnLDV2FPT0WU
MZ1-PC NEHFVGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW1VWtKSzVyPUK0MlY4PTlizszN MVHTRW5ITVJ?
SW1417 MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnOWItWUUN3ME2yOU4zPDl6IN88US=> NXfZfmRnW0GQR1XS
NCI-H82 NYnkPZJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJ4LkSyPFgh|ryP M2\PVnNCVkeHUh?=
COLO-678 NYjqc41iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPuUVhKSzVyPUK3MlQ6OTlizszN Mmm4V2FPT0WU
KURAMOCHI MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLLTWM2OD1{OD6xNlYh|ryP NF7ReIFUSU6JRWK=
NCI-H1650 NVjudWZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnOWY1KSzVyPUOwMlE6OjRizszN M{LqOXNCVkeHUh?=
HCC1954 NYLJcXM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnuwTWM2OD1|MT6zOlY3KM7:TR?= M{nwenNCVkeHUh?=
GAK MkXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH3TWM2OD1|Mj6yOlE3KM7:TR?= MlfGV2FPT0WU
YAPC M{HnWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzzTWM2OD1|Mz63OlQ5KM7:TR?= NHvHRm9USU6JRWK=
NCI-H2228 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2G2[mlEPTB;M{SuN|YxPSEQvF2= NHX5bVdUSU6JRWK=
VMRC-RCZ M37idWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTN4LkOwNlIh|ryP MXvTRW5ITVJ?
NMC-G1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorkTWM2OD1|Nz6wOVI6KM7:TR?= NWfUcoppW0GQR1XS
D-336MG M2C2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTRzLki0OFIh|ryP MnTTV2FPT0WU
UACC-62 NH\DcWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PBeWlEPTB;NEKuOVUxPSEQvF2= NFHMO41USU6JRWK=
C-33-A MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTR3LkOyOVYh|ryP M3fhfnNCVkeHUh?=
HCC1937 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\RZ2lEPTB;NEeuNVk2QCEQvF2= NFTyRmNUSU6JRWK=
HDLM-2 NV33OndCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXrTWM2OD12Nz6yNlg4KM7:TR?= MYLTRW5ITVJ?
NCI-H727 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TEfGlEPTB;NEeuNlQ2OSEQvF2= MWTTRW5ITVJ?
NY MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTR7LkO5NFgh|ryP NXTpNG9EW0GQR1XS
NCI-H2291 NH:4dFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT4fmpKSzVyPUS5Mlg{ODFizszN MWTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 53 mg/mL (200.52 mM)
Ethanol 3 mg/mL (11.35 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 5mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID