Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 100 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M1rOcWtqdmG|ZTDBd5NigQ>? MYGxJIg> NYSycZFjTE2VTx?= NYHOUXVC[W62aT3ISGFEOSCjY4Tpeol1gSC5aYToJGlEPTBib3[gNE4yOTJizszN NEXsd24yOTl4MES4PS=>
Friend leukemic cell NWfBZ49YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fXclUxKM7:TR?= M4\HN|czKGh? Mn;xSG1UVw>? NF;5PI1KSzVyPUCuPVkh|ryP NXjHfHhXOTJzMEm5NVM>
K562 M3vKTWtqdmG|ZTDBd5NigQ>? NGDTVGI3KGh? M1\nSGROW09? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJIhqe3SxbnWg[IVi[2W2eXzhd4UhMG2reIT1doUhd2ZiSFTBR|Eh[W6mIFjERWMzMSC5aYToJGlEPTBib3[gNE4xOSEQvF2= M3HHfFEzPDF7M{iw
HT1080 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHYTWg6PzJiaB?= MYTEUXNQ NVewSoZ4UUN3ME2yMlQh|ryP MUKxNlI4ODF5NR?=
H1299 MUPLbY5ie2ViQYPzZZk> NFvGRmwzOCCvaX6= MmLtSG1UVw>? NHvxcHRKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> Mn7mNVQ2OjF2MkK=
H1299 NH\2fYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PoSVczKGh? NUjLNWpsTE2VTx?= NXPVfXBlUUN3ME23MlI1KM7:TR?= M3ziSlE1PTJzNEKy
HeLa NXj6Oo14U2mwYYPlJGF{e2G7 NHLBXYw{OCCvaX6= NGfrOZhKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDobZN1d26nIHTlZYNmfHmuYYPlJJdqfGhiSVO1NEBw\iByLkK4JO69VQ>? MYWxOVYxOzl2OR?=
LOX-IMVI M1fpdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1OyO|Q5KGh? NGj2dWJKSzVyPUGuN{DPxE1? NYT2cGM2OTV5MUW0O|A>
NCI-H226 NYXr[HU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmG2OFghcA>? NFLES2hKSzVyPUKuOkDPxE1? MknVNVU4OTV2N{C=
RXF-631L NILqTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXe0PEBp NFXJdGhKSzVyPUKg{txO NH3OToEyPTdzNUS3NC=>
SNB-78 NYTnTXJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LpcVQ5KGh? MmXRTWM2OD1zNjFOwG0> NX\TZXpXOTV5MUW0O|A>
St-4 M3u4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G2XlQ5KGh? MXvJR|UxRTVwMjFOwG0> NXPaOYlqOTV5MUW0O|A>
ARP1 M4ToU2Z2dmO2aX;uJGF{e2G7 M{HteVIh|ryP M{\zdFYhcA>? NXPve2ZXUW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NUXJZlNxOTR5M{S4NFY>
CEM MXfLbY5ie2ViQYPzZZk> MnPONUBp M4O0eGROW09? M{jGdmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? NHjX[2cyPjR{MEC2OC=>
HCT15 NYLrcpl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;ISnA1QCCq M1HUTmdKPTB;MD64NkDPxE1? NEjVflUyPjd{M{KyOy=>
NCI-H23 MljPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7afos1QCCq NGjTUZdIUTVyPUCuPVIh|ryP M{G3Z|E3PzJ|MkK3
GM15850 MXvLbY5ie2ViQYPzZZk> NYjWVYRTOi53IN88US=> M13JOVk3KGh? MVnEUXNQ NVT0elU1UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NX\acVllOTZ7MkGzOlc>
GM15850 NFexRpZMcW6jc3WgRZN{[Xl? NHLibFIzNjVizszN MYK5OkBp MVnEUXNQ NFfnd2FKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NEnSRZUyPjl{MUO2Oy=>
GM15850 MVvLbY5ie2ViQYPzZZk> NGjJb|YzNjVizszN NIrhcZc6PiCq MVXEUXNQ Mn;ETY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NWTHfWo4OTZ7MkGzOlc>
GM15850 NH\Z[VFMcW6jc3WgRZN{[Xl? NW\uVY5{Oi53IN88US=> M3XhfVk3KGh? Mn\TSG1UVw>? NV\aSlNqUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MWqxOlkzOTN4Nx?=
GM15850 NF;C[ZFMcW6jc3WgRZN{[Xl? NFfDTGkzNjVizszN MkjFPVYhcA>? NEHHWndFVVOR MUDJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViODDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? NFPSXIoyPjl{MUO2Oy=>
GM15850 M3q3d2tqdmG|ZTDBd5NigQ>? MnHINk42KM7:TR?= MWi5OkBp MkGzSG1UVw>? Mo\ZTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEG2JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n Ml:2NVY6OjF|Nke=
U937 MnO0SpVv[3Srb36gRZN{[Xl? MmrGOUDPxE1? MoHUNlQhcA>? MoLYSG1UVw>? NFnkeHlE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn MV:xO|AxPDdzOB?=
H661 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7iOFghcA>? NY\mcGt5UUN3ME2xJO69VQ>? MV6xO|E2PzByOR?=
U937 NELxfllHfW6ldHnvckBCe3OjeR?= M1vrb|Uh|ryP M{jwUVI1KGh? MmnzSG1UVw>? NGTLZlRKdmO{ZXHz[UBqdiCqaYP0c45mKEh|IHHj[ZR6dGG2aX;u Mn\1NVc1PDd5NUC=
U937 NGXPdFlHfW6ldHnvckBCe3OjeR?= Ml:wNUDPxE1? MUSyOEBp Mn;USG1UVw>? NYDiS4ZMTW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> MY[xO|Q1Pzd3MB?=
RAW264.7 NXnTWpB[TnWwY4Tpc44hSXO|YYm= NU\ISVVuOTBizszN MmDyNlRp NHS3e4x4[XSnch?= MV7Jcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP NVXNeY1zOTd2N{e1NVg>
RAW264.7 NEH5SoZHfW6ldHnvckBCe3OjeR?= NIfybWoyOCEQvF2= MkHJNlRp MUP3ZZRmeg>? M2nzRWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> MmXVNVc1Pzd3MUi=
SC9 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP4OFghcA>? NFnLXWFKSzVyPUCuOlA3KM7:TR?= NYXhSpgxOTd3MEeyNVk>
ST14A NXK4VHJ4TnWwY4Tpc44hSXO|YYm= NF;GSnc2KG6P NYjKOW0zPzJiaB?= MVTJcoNz\WG|ZTDpckBTTVOWL17SV2YhdVKQQTDlfJBz\XO|aX;u NFHWVWEyPzV4NUm5Ny=>
ST14A MVjGeY5kfGmxbjDBd5NigQ>? NHrX[Wc2KG6P M2\uWFczKGh? NEjx[4pKdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= MUOxO|U3PTl7Mx?=
PANC1 NXzKNYRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD2ZooyOSEQvF2= NGLwdmtKSzVyPUCuOFUh|ryP NGL3SpUyPzV6OEe0OC=>
PANC1 NWTYU|h7TnWwY4Tpc44hSXO|YYm= NWDabXcyOSEQvF2= NV21ZnNTOjRiaB?= NEHsXZFKdmO{ZXHz[UBqdiCyMkHXRWYyN0OLUEGg[4Vv\SCneIDy[ZN{cW:w NXPTWW5nOTd3OEi3OFQ>
PANC1 M4DVT2Z2dmO2aX;uJGF{e2G7 MnnaNUDPxE1? NVz1[ZpbOjRiaB?= M4LhbWlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u M3zoNlE4PTh6N{S0
PT45 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O5dWlEPTB;NDFOwG0> NIn0Z2IyPzV6OEe0OC=>
ACHN MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfxSZpZOjFiaB?= MX\HTVUxRTBwNkWg{txO NXHVXZFSOTd4NkK2NFY>
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SKHEP1 M2nT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnFV|I4OiCq NVnlN3BpUUN3ME2zMlQ3KM7:TR?= M{TGW|IxOTR|N{e4
BJ MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1H2UVExOCEQvF2= M2\WWlQ5KGh? M3vQc2ROW09? NHnDeJFIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> NEL4XpgzODF2M{i0NC=>
MUF Ml\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX0XpcyODBizszN M4DUOFQ5KGh? NHT6WWRFVVOR MlXRS5Jwf3SqIHnubIljcXSrb36gZZQhOC5yNTD0c{AyODBidV2= M1THOFIxOTR|OESw
Caco-2 M4DCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPJWZpbOTByIN88US=> NXHYZmR5PDiq MnPWSG1UVw>? MX3JR|UxRThwMTFOwG0> MnXONlAyPDN6NEC=
Caco-2 MW\LbY5ie2ViQYPzZZk> M1H4NVUh|ryP M2nUOlQhcA>? NH3FV3ZFVVOR MYfJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszN Mmn4NlAyPDN6NEC=
Caco-2 Mlv6T4lv[XOnIFHzd4F6 M3rodFAvOzF4IH7NJJRwKDNzLk[g{txO M{nQe|QhcA>? NXLNb3BpTE2VTx?= MX3FfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzFid3n0bEBKSzVyIH;mJFAvOTF7IN88US=> NUfyc2VXOjBzNEO4OFA>
Caco-2 NGXDPWRMcW6jc3WgRZN{[Xl? NIHSclIxNjNzNjDuUUB1dyB|MT62JO69VQ>? M4X6Z|QhcA>? MYDEUXNQ NIjqW29GgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Oge4l1cCCLQ{WwJI9nKDBwMUS3JO69VQ>? M4XzPFIxOTR|OESw
Caco-2 NHLuT5FMcW6jc3WgRZN{[Xl? NYfMZ4hbPi5|MjDuUUB1dyB4M{Kg{txO MnfYOEBp NYLWOnAzTE2VTx?= NXnlNWc{TXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO1JJdqfGhiSVO1NEBw\iBzMj62JO69VQ>? MYeyNFE1Ozh2MB?=
Caco-2 MUnLbY5ie2ViQYPzZZk> MV[2MlMzKG6PIITvJFY{OiEQvF2= M3PZOFQhcA>? M2i1SWROW09? NYHJenE{TXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO3JJdqfGhiSVO1NEBw\iB2MTFOwG0> NUHWOoU2OjBzNEO4OFA>
Caco-2 MoS4T4lv[XOnIFHzd4F6 M4rheVAvOzF4IH7NJJRwKDNzLk[g{txO MnjtOEBp NHq4bHRFVVOR M2q5XWV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNh?= Moj6NlAyPDN6NEC=
HepG2 NV;MOWlnU2mwYYPlJGF{e2G7 MVy1JO69VQ>? MkHOOog> NF3nd3NFVVOR MVvJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;u NGrUT20zODF2M{i0NC=>
HepG2 MoPOT4lv[XOnIFHzd4F6 NYPZVFZsPSEQvF2= MVK2bC=> MkCxSG1UVw>? Mlu0TY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDofZBmemGlZYT5cIF1cW:w NYW3eYJ6OjBzNEO4OFA>
HepG2 NVHXXHhxU2mwYYPlJGF{e2G7 NGrxfYg2KM7:TR?= NEDMeYQ3cA>? NXG3[WZpTE2VTx?= NW[wNo5NUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> NYPSVZh5OjBzNEO4OFA>
HepG2 NInLPXVMcW6jc3WgRZN{[Xl? NWnPUZZGPSEQvF2= M{nNdlZp M2rRR2ROW09? M3izTWlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= NWXYSZhKOjBzNEO4OFA>
COLO205 NHLhTGZMcW6jc3WgRZN{[Xl? M{DaOFExKM7:TR?= NFzZZXQzPCCq M3:3RmROW09? MWXJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizJIFk\XS7bHH0bY9vKHerdHigTWM2OCCxZjCyMlIh|ryP NF\4WnQzODR3MUO3PC=>
SCC4 M4X1c2tqdmG|ZTDBd5NigQ>? Ml7oNUDPxE1? M3TLV|I1cA>? MV7Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5idIXieYxqdiCjY3X0fYxifGmxbh?= NXvPXIdXOjB2NUKyNlU>
SCC4 MUXLbY5ie2ViQYPzZZk> NWXDcGY2OSEQvF2= MVOyOIg> MonUTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViYXPleJlt[XSrb36= MV:yNFQ2OjJ{NR?=
SCC4 NV33dlI5TnWwY4Tpc44hSXO|YYm= M3fi[VEh|ryP NFrXRnk2KG2rbh?= NHzPU4xC\2:waYP0JIFkfGm4aYT5JIF1KF[GUjDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiQ2nQNlQh\2WwZTDlfJBz\XO|aX;u Ml7SNlA1PTJ{MkW=
NB4 NWHOXY9OTnWwY4Tpc44hSXO|YYm= M2nacVUh|ryP MUGyOEBp Ml;QSG1UVw>? NVm4OWJ6S2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNkfW23bHH0bY9vKGG2IIDy[U1IOSCyaHHz[S=> MWOyNFQ6OTR2MB?=
NB4 NV[5cJp5U2mwYYPlJGF{e2G7 NGTpVmk2KM7:TR?= MYGyOEBp NHTUVFhFVVOR MoP4TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHHj[ZR6dGG2ZTD0eYJ2dGmwIHzleoVt MkPqNlA1QTF2NEC=
NB4 NHrINmZHfW6ldHnvckBCe3OjeR?= NGK5WFI2KM7:TR?= M1P1eFI1KGh? NEDsdHNFVVOR M1\JZWlv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> MVSyNFQ6OTR2MB?=
NB4 MUfLbY5ie2ViQYPzZZk> M3vKRVUh|ryP MlnLNlQhcA>? NUH6dFNTTE2VTx?= MWHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> MWCyNFQ6OTR2MB?=
NUGC3 NFjOXZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTDR2c4T0l3ME2yMlk1KM7:TR?= MoCzNlA5PTB7N{G=
A549 NXHtbHMzTnWwY4Tpc44hSXO|YYm= M1rhS|Uh|ryP MXKzJIg> MkfzSG1UVw>? NUXETFB{UW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK Mm\YNlA5PTV{MEi=
HUT78 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nBOVczKGh? MoPhSG1UVw>? NVn2RoNrT0l3ME2wMlMh|ryP MUOyNFg5PDJyOB?=
U937 MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{i3elczKGh? NYfJdm1{TE2VTx?= MlvnS2k2OD1yLkO5JO69VQ>? M4TWclIxQDh2MkC4
A431 Mm\JR5l1d3SxeHnjJGF{e2G7 M3H3PFczKGh? NEPxWmdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2= NInTT28zOTB6ME[yPS=>
A549 M2Lid2N6fG:2b4jpZ{BCe3OjeR?= M2Swe|czKGh? M4\FOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMhd3[ncnX4dJJme3OrbnegTGRCSyC5aYToJGlEPTBib3[gNU45KM7:TR?= NXOxW4hoOjFyOEC2Nlk>
CAL27 NH\JZ3hEgXSxdH;4bYMhSXO|YYm= MVi3NkBp NHPNUY1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA{NjJizszN NYLmUJk4OjFyOEC2Nlk>
HeLa NV;RSVc2S3m2b4TvfIlkKEG|c3H5 M3;sVlczKGh? M{C1fWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMhd3[ncnX4dJJme3OrbnegTGRCSyC5aYToJGlEPTBib3[gNU42KM7:TR?= NVz3U|YzOjFyOEC2Nlk>
Sf21 NF3RfIdMcW6jc3WgRZN{[Xl? NInQe3k{KGh? M4jvemlvcGmkaYTpc44hd2ZiRnzh[{B1[WepZXSgbJVu[W5icnXjc41jcW6jboSgTGRCSzhiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyNjJizszN MV:yNVA5ODZ{OR?=
SKBR3 M3T0fWN6fG:2b4jpZ{BCe3OjeR?= M1j5U|czKGh? M4HQUmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvPiEQvF2= NWXZ[|JiOjFyOEC2Nlk>
SKOV3 MmjWR5l1d3SxeHnjJGF{e2G7 MojRO|IhcA>? MkXqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= MnL5NlExQDB4Mkm=
COR-L23 MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVixNEDPxE1? MWm3NkBp MYfEUXNQ MY\HTVUxRTFwMTFOwG0> M3XXc|IyODhyNkS3
DU145 M1S4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH0NVAh|ryP MX[3NkBp MojvSG1UVw>? MnG3S2k2OD1zLkC1JO69VQ>? MoXONlExQDB4NEe=
LoVo NXrhNHZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn30NVAh|ryP MVO3NkBp NWD1d2JRTE2VTx?= M1TqNGdKPTB;MT63JO69VQ>? NWLvbnhROjFyOEC2OFc>
MCR5-SV2 MmXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVqxNEDPxE1? MYe3NkBp MUjEUXNQ NYC1b3VlT0l3ME2yMlEh|ryP Mo\INlExQDB4NEe=
HCT116 M{DqdWtqdmG|ZTDBd5NigQ>? MnTHN|Ah|ryP MYizNEBp MlvJSG1UVw>? MnjrTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= MUKyNVA5ODZ2Nx?=
HCT116 MnO5T4lv[XOnIFHzd4F6 M4PUWVMxKM7:TR?= M4H5eFMxKGh? NEfOPZNFVVOR NFPrZmVKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= M2D2SFIyODhyNkS3
U937 MnjMT4lv[XOnIFHzd4F6 MYC1JO69VQ>? M4fsS|I1KGh? MX3EUXNQ NEDoTYVKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNOR?= MkTiNlEzQTJ2OUK=
U937 NEHHXVZMcW6jc3WgRZN{[Xl? MlW4OUDPxE1? NE\iRlUzPCCq NWi2fG45TE2VTx?= NUPR[mxmUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 M3nIZ|IyOjl{NEmy
U937 MlHYT4lv[XOnIFHzd4F6 NIXycpg2KM7:TR?= NYftPHV5OjRiaB?= M3zPZ2ROW09? M4W4emlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBx[W5vYXPleJlt[XSnZDDobZN1d26nIFi0JIxmfmWu MljrNlEzQTJ2OUK=
U937 NEGydVRMcW6jc3WgRZN{[Xl? MUS1JO69VQ>? NITqZYcyPSCvaX6= NHH2N49FVVOR NYe0bG1NUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? MWiyNVI6OjR7Mh?=
A2780 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYq5OkBp MXzEUXNQ NFXKT4tKSzVyPUGuOlIh|ryP NGPhdXEzOTZ|NESzNC=>
COLO205 MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPkc4hDQTZiaB?= MVXEUXNQ NFnOS3NKSzVyPUKuNVIh|ryP M4HCSlIyPjN2NEOw
Hep3B MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml32OFghcA>? NH64SZFFVVOR NH\6ZYpIUTVyPUGuNlEh|ryP NYiyeHR[OjF5MUKxOFY>
GM11272 MofWSpVv[3Srb36gRZN{[Xl? MkKwNVAxKG6P M1L1RVczKGh? M3TmZWROW09? NGPnW3pT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O MWeyNVg1ODdzNh?=
CFBE41o NILsXHdMcW6jc3WgRZN{[Xl? NWrycnB4PSEQvF2= MU\EUXNQ Mlm0SI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO MXeyNVk5PDl3OB?=
CFBE41o MnPNSpVv[3Srb36gRZN{[Xl? MXqxJO69VQ>? MY[yOEBp M3rXO2ROW09? NULORnFGWmW|dH;yZZRqd25ib3[gR2ZVWiCmZXz0ZWY2ODhibYX0ZY51KHS{YX\mbYNscW6pIITvJINmdGxic4Xy[oFk\SCjczDncJlkd2[xcn3z MYCyNVk5PDl3OB?=
DU145 Mo\FT4lv[XOnIFHzd4F6 M{XTclIvPSEQvF2= NU\CXIk6OjRiaB?= Mn3qSG1UVw>? MVHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhfXC{ZXf1cIF1cW:wIH;mJJAzOXejZkGgdJJwfGWrbjDlfJBz\XO|aX;u NYLNWHhFOjJ{NkCxOlY>
DU145 NF\NfY1McW6jc3WgRZN{[Xl? MXi1JO69VQ>? MoG5NlQhcA>? NYHxRW5mTE2VTx?= MXjJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJPCCjY3X0fYxifGmxbh?= MV6yNlI3ODF4Nh?=
DU145 MnvMT4lv[XOnIFHzd4F6 MVq1JO69VQ>? MWGyOEBp NUPycGpzTE2VTx?= MV3Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9v M4XQblIzOjZyMU[2
786-0 M4fRNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LndFYvOiEQvF2= M1rMclczKGh? MofHSG1UVw>? NWTh[mtVT0l3ME2zMlIh|ryP NGTmdpkzOjR|NU[2PS=>
A498 NV7ieIR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf6UYg3NjJizszN NU\UNpFmPzJiaB?= MmTLSG1UVw>? NF\wT4dIUTVyPUGuOkDPxE1? NFrwdG8zOjR|NU[2PS=>
A549/ATCC NULNWGtVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:2MlIh|ryP M3rISlczKGh? MVPEUXNQ MY\HTVUxRTFwNjFOwG0> MmfGNlI1OzV4Nkm=
ACHN NF;JXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nwdFYvOiEQvF2= NWDjNYdSPzJiaB?= Mn\kSG1UVw>? MUTHTVUxRTFwMzFOwG0> NG\jSnYzOjR|NU[2PS=>
BT549 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXK2MlIh|ryP M3vtSlczKGh? M2nUNGROW09? NFfGb4NIUTVyPUGuN{DPxE1? NHmwSpYzOjR|NU[2PS=>
EKVX NIrWcppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPZ[Is3NjJizszN M37JR|czKGh? M1rIdmROW09? MmjjS2k2OD1zLkOg{txO MkfSNlI1OzV4Nkm=
HCT15 M1jEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1T4ZlYvOiEQvF2= M3zjeVczKGh? M1iy[GROW09? NVPGdFM4T0l3ME2yMlUh|ryP NUTCN|JZOjJ2M{W2Olk>
HOP92 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vONlYvOiEQvF2= MVq3NkBp MWfEUXNQ NY\2O4ZST0l3ME20JO69VQ>? MXqyNlQ{PTZ4OR?=
IGROV1 M3vLS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGW2NpE3NjJizszN M2\yXFczKGh? MnnNSG1UVw>? MXHHTVUxRTFwMzFOwG0> Ml7zNlI1OzV4Nkm=
LOXIMVI MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULveVkzPi5{IN88US=> M1jPXlczKGh? NXXsZZI2TE2VTx?= MVzHTVUxRTFizszN M17aVlIzPDN3Nk[5
M14 M4rEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\UfVhQPi5{IN88US=> MoLVO|IhcA>? M3vsemROW09? NFfhT2RIUTVyPUGuN{DPxE1? NInTZ3MzOjR|NU[2PS=>
MALME-3M NFnYboxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYG2MlIh|ryP MUG3NkBp NV25PIg4TE2VTx?= M4L5N2dKPTB;MD6zNkDPxE1? NGjQeFgzOjR|NU[2PS=>
MCF10A M3rWVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS3eppnPi5{IN88US=> MXm0PEBp NFLpbo1FVVOR NH7qcm1IUTVyPUmuOkDPxE1? NIHXb4IzOjR|NU[2PS=>
MDA-MB-435 M1jOfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;4Ok4zKM7:TR?= MUi3NkBp MlXGSG1UVw>? NVTiZm85T0l3ME2wMlUh|ryP MYiyNlQ{PTZ4OR?=
MDA-MB-468 NIrPd4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vRe|YvOiEQvF2= NES4ZYQ4OiCq NIPPd|NFVVOR MoS2S2k2OD1yLk[zJO69VQ>? MYSyNlQ{PTZ4OR?=
MOLT4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTvOk4zKM7:TR?= MnXxO|IhcA>? NUDGfoZYTE2VTx?= NF;4RmVIUTVyPUCuOEDPxE1? NG\FcmIzOjR|NU[2PS=>
NCI-ADR-RES MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV22MlIh|ryP NEDDcos4OiCq NX74cGM3TE2VTx?= M1PDfGdKPTB;MD6xOkDPxE1? M4LSdlIzPDN3Nk[5
NCI-H23 Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHNS2s3NjJizszN M2S1Z|czKGh? NFfxfZBFVVOR NH;VNXZIUTVyPUGg{txO MlznNlI1OzV4Nkm=
NCI-H322M NEPMUGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPNOk4zKM7:TR?= M3;TZ|czKGh? NYHqR3djTE2VTx?= MXjHTVUxRTBwN{mg{txO Mlz2NlI1OzV4Nkm=
NCI-H460 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vwOlYvOiEQvF2= NETZOIY4OiCq M4HWVmROW09? NITabVBIUTVyPUCuO|kh|ryP M2L1TlIzPDN3Nk[5
NCI-H522 NXGzV3ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmGwOk4zKM7:TR?= MnLKO|IhcA>? MmDKSG1UVw>? NXPEN3kzT0l3ME2wMlUh|ryP NILZbW0zOjR|NU[2PS=>
OVCAR3 MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWO0UItXPi5{IN88US=> Mo\iO|IhcA>? NFmwfHpFVVOR NISxeFNIUTVyPUGuN{DPxE1? NVXNZ40xOjJ2M{W2Olk>
OVCAR4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\QPXU3NjJizszN MXi3NkBp MnzLSG1UVw>? NVPIW25JT0l3ME20JO69VQ>? MXOyNlQ{PTZ4OR?=
OVCAR5 NHjuO5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fENFYvOiEQvF2= MVy3NkBp Mk\TSG1UVw>? MkPCS2k2OD1yLke5JO69VQ>? NVXLSYhpOjJ2M{W2Olk>
OVCAR8 M1HwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUi5[4hEPi5{IN88US=> NWLUVoFLPzJiaB?= NXfrdXRbTE2VTx?= MYfHTVUxRTBwNTFOwG0> NHjUfHYzOjR|NU[2PS=>
RXF393 MoKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[0RXhUPi5{IN88US=> NXnBcnFLPzJiaB?= NGLVfpRFVVOR NGfqXGRIUTVyPUGuN{DPxE1? MnrHNlI1OzV4Nkm=
SF268 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\PXlYvOiEQvF2= NXrNeGp[PzJiaB?= MkPnSG1UVw>? MXXHTVUxRTFwNjFOwG0> NV3HUml2OjJ2M{W2Olk>
SF295 MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDOOk4zKM7:TR?= MVu3NkBp M3rPcWROW09? MUjHTVUxRTFwNjFOwG0> M4i1ZVIzPDN3Nk[5
SF539 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3uSm5wPi5{IN88US=> MmLYO|IhcA>? Ml36SG1UVw>? M4TtOGdKPTB;MjFOwG0> M1zCWlIzPDN3Nk[5
SK-MEL-2 NH3wbpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[4fYk3NjJizszN NU[0e2F1PzJiaB?= Mk\TSG1UVw>? MUDHTVUxRTFwMzFOwG0> MmH0NlI1OzV4Nkm=
SK-MEL-28 NYDoNFlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjQZ203NjJizszN NYnuflhQPzJiaB?= NEPjR41FVVOR MkH6S2k2OD1zIN88US=> M{[4eVIzPDN3Nk[5
SK-MEL-5 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXO2MlIh|ryP M2rWWlczKGh? M{\JNGROW09? Mli1S2k2OD1yLk[zJO69VQ>? MWiyNlQ{PTZ4OR?=
SKOV3 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq4Ok4zKM7:TR?= MkS4O|IhcA>? M3\CT2ROW09? M1[yc2dKPTB;MTFOwG0> NFy2N3QzOjR|NU[2PS=>
SN12C M1fW[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX:2MlIh|ryP NEi4ZoM4OiCq MluySG1UVw>? NWTHZW17T0l3ME2yJO69VQ>? Ml;nNlI1OzV4Nkm=
SNB19 NXjiPVBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLBOk4zKM7:TR?= MWG3NkBp M4rSUGROW09? MnrwS2k2OD1yLk[zJO69VQ>? M2\he|IzPDN3Nk[5
SNB75 NUTWSmRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33GNFYvOiEQvF2= MXe3NkBp NYezeZBvTE2VTx?= NHTvXY9IUTVyPUCuO|kh|ryP MXWyNlQ{PTZ4OR?=
SR MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPrVIQ3NjJizszN NVnUWlRkPzJiaB?= MmOzSG1UVw>? MX;HTVUxRTBwNDFOwG0> NFzsPJkzOjR|NU[2PS=>
T47D NH;KcmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjqeZE3NjJizszN NEXqNmk4OiCq MoW2SG1UVw>? M17lSWdKPTB;MD61JO69VQ>? NF32R2IzOjR|NU[2PS=>
TK10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDwTopHPi5{IN88US=> NVvPUoYxPzJiaB?= MorJSG1UVw>? M2DU[2dKPTB;MD62N{DPxE1? MmnHNlI1OzV4Nkm=
UACC257 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPvT|I3NjJizszN NEjNfXk4OiCq NFXhUplFVVOR NVLTeol1T0l3ME2wMlUh|ryP M1\mW|IzPDN3Nk[5
UACC62 NHXYcplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfzOk4zKM7:TR?= M1vBR|czKGh? MVvEUXNQ M335OmdKPTB;MD60JO69VQ>? MYOyNlQ{PTZ4OR?=
UO31 MmL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfDOJZEPi5{IN88US=> NVn0R3hkPzJiaB?= NIGzSopFVVOR Ml7hS2k2OD1yLkWg{txO NGHBd4EzOjR|NU[2PS=>
Hep3B MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PvPVQ5KGh? M4D2b2ROW09? NUHLZ|JwT0l3ME2wMlY6KM7:TR?= MUCyNlQ{QTh4Mx?=
BE(2)-C NYi0PIF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\scZRGPzJiaB?= M4i3fGROW09? NYT5OGtVUUN5ME2yJO69VQ>? NGjsdmgzOjl|MkOxOi=>
Bel7402 NV\wfZB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\peXVnPzJiaB?= MWLEUXNQ MVnHTVkxRTF5IN88US=> MXKyN|A3OTN5Nh?=
Bel7404 M1G1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknaO|IhcA>? NX\BWFc4TE2VTx?= NXroeVRET0l7ME2xPEDPxE1? NETCc|YzOzB4MUO3Oi=>
BGC823 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rlSVczKGh? NI\W[o9FVVOR MYfHTVkxRTdwNTFOwG0> NYqxXXBjOjNyNkGzO|Y>
MGC803 NWrmbmxPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLJO|IhcA>? M37nfWROW09? M4DWbGdKQTB;MUCuPEDPxE1? NHXpWJkzOzB4MUO3Oi=>
SGC7901 NHLLRWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj4VWo4OiCq NFXBN3BFVVOR NETEN4lIUTlyPUmuOEDPxE1? M3jOeVI{ODZzM{e2
SKHEP1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7vO|IhcA>? NYrsU3F5TE2VTx?= NYHwc4N5T0l7ME2xO{DPxE1? M4nhclI{ODZzM{e2
SMMC7721 MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLnO|IhcA>? M{HFcmROW09? NWXEU2pVT0l7ME2yNEDPxE1? NHXEb4UzOzB4MUO3Oi=>
NUGC3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYexNEDPxE1? NYPH[VJNT0l;Mj65OEDPxE1? NH3TRpUzOzF4M{OzNi=>
A2780 CisR NHK4fohMcW6jc3WgRZN{[Xl? MmCzNVghcA>? M4[wcWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? M3L5SlI{OjV{NkCz
CAL27 sens Mk\jT4lv[XOnIFHzd4F6 M1PpPFE5KGh? M3q4NmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? NGPvcFAzOzJ3Mk[wNy=>
CAL27 CisR MknQT4lv[XOnIFHzd4F6 MVexPEBp MXTJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO MXeyN|I2OjZyMx?=
KYSE-510 CisR MnnUT4lv[XOnIFHzd4F6 NXP6e5JHOThiaB?= NYLXXGtlUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= MkHLNlMzPTJ4MEO=
KYSE-510 sens Mlz0T4lv[XOnIFHzd4F6 M4ny[FE5KGh? MXvJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNzFOwG0> M{PuNVI{OjV{NkCz
MDA-MB-231 sens MVrLbY5ie2ViQYPzZZk> M2rkTlE5KGh? MVzJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO MVGyN|I2OjZyMx?=
MDA-MB-231 CisR M3TJNmtqdmG|ZTDBd5NigQ>? M1PXUFE5KGh? M2Hn[2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? MXqyN|I2OjZyMx?=
ES2 Ml3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLKZ5U1QCCq MWPEUXNQ MlPKTWM2OD1zMj63JO69VQ>? MXeyN|Q6OzR2OR?=
MDA-MB-231 MmLYT4lv[XOnIFHzd4F6 MWOxNEDPxE1? M3HzPFMxKG2rbh?= Mne5SG1UVw>? M2P4dGlvcGmkaYTpc44hd2ZiSFTBR|Ji NEjXcnMzOzR7M{S0PS=>
MDA-MB-231 NFTiSJZMcW6jc3WgRZN{[Xl? MX2xJO69VQ>? NU\SRZpmOjRiaB?= MnPCSG1UVw>? M4jKe2lvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= MlvLNlM1QTN2NEm=
HS68 NXjCfXlXS3m2b4TvfIlkKEG|c3H5 M1m1N|ExKM7:TR?= M3rnSFczKGh? M{jmcWROW09? M1\3fmlEPTB;ND62JO69VQ>? MlvVNlM2PzB3NEK=
MEF MXrDfZRwfG:6aXOgRZN{[Xl? Mk\4NVAh|ryP MlS4O|IhcA>? MXjEUXNQ NXz3U45DUUN3ME20MlQh|ryP NEe0WG0zOzV5MEW0Ni=>
BGC823 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTEUXNQ MkHwS2k2OD1|LkC5JO69VQ>? MoToNlM3ODF5ME[=
High5 NIXTZYpMcW6jc3WgRZN{[Xl? M4HyWVI1KGh? M3zzPWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Yhf2m2aDDJR|UxKG:oIECuNFkh|ryP NYL2N5p5OjN4MEK1NlM>
High5 MXzLbY5ie2ViQYPzZZk> M3j0dFI1KGh? NX3QXGw6UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4yOiEQvF2= NFG3O4szOzZyMkWyNy=>
High5 MYDLbY5ie2ViQYPzZZk> MoLmNlQhcA>? MVXJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? MUKyN|YxOjV{Mx?=
A549 NV\HeXRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXDSG1UVw>? Mn23TWM2OD1zLkC3PUDPxE1? NEnTXJkzOzZ2NEKxNC=>
HCT116 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1iyXmROW09? M1r5SWlEPTB;MD63OVch|ryP M1S1RlI{PjR2MkGw
K562 MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLjNlJFVVOR Mlz1TWM2OD1yLk[0OUDPxE1? MorKNlM3PDR{MUC=
GBC-SD NG\5PYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV21JO69VQ>? M13XOVczKGh? M3vQXmROW09? NUSweIRpUUN3ME2xOE45KM7:TR?= NEDKSo8zOzdyN{K2NC=>
HGC27 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDHb482KM7:TR?= M4HxWlczKGh? NITGSnVFVVOR MmjpTWM2OD13LkSg{txO MlftNlM4ODd{NkC=
HL60 NILYVWRMcW6jc3WgRZN{[Xl? MnLVOUDPxE1? NFr2dJozPCCq MXXEUXNQ M1PmXWlvcGmkaYTpc44hd2ZiSFTBRy=> MnryNlM4ODd{NkC=
Vero NEDUdHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETIcFM4OiCq M1z3d2ROW09? MoTvTWM2OD1yLkmg{txO NUPwU|FwOjN5OE[0OVI>
NCI60 NWq2[oZDS3m2b4TvfIlkKEG|c3H5 NGi1e5M1QCCq M{DEcmROW09? M3S4T2dKRTBwNUOg{txO NWftUmtOOjRyMUWzNlc>
SW620 M3W3cGN6fG:2b4jpZ{BCe3OjeR?= MlHZOFghcA>? NV\GT3NWTE2VTx?= MlHHS2k:OC53NDFOwG0> M{[y[FI1ODF3M{K3
U251 MoPCR5l1d3SxeHnjJGF{e2G7 M4D6ZVQ5KGh? MoHCSG1UVw>? MmnhS2k:OS53MzFOwG0> M1LXblI1ODF3M{K3
KM12 MkPWR5l1d3SxeHnjJGF{e2G7 MVG0PEBp MYXEUXNQ NXfpZ4RUT0l;MT64PEDPxE1? M1j0RlI1ODF3M{K3
Hs578T NYm5XJY3S3m2b4TvfIlkKEG|c3H5 NF3nU3c1QCCq MkX1SG1UVw>? NYrUcHk2T0l;ND64N{DPxE1? MUmyOFAyPTN{Nx?=
MDA-MB-231 MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf6R3U1QCCq MknaTWM2OD1yLkG2JO69VQ>? NHX1XFIzPDB7NUCxOi=>
MCF7 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjy[Wc4PDhiaB?= NV3NNYNQT0l;MD60OUDPxE1? NUHuco42OjRzMUm1OVU>
MDA-MB-435 NWrm[|FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X0PFQ5KGh? NXS5WJAyT0l;MD64PEDPxE1? MUiyOFEyQTV3NR?=
AsPC1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUezNEDPxE1? Mor0OFghcA>? MWDEUXNQ M2jj[WlEPTB;Mz62OkDPxE1? MoLmNlQyQDV|N{i=
Jurkat E6.1 Mn3QT4lv[XOnIFHzd4F6 NV7rcJQyOiCq MY\EUXNQ NWj2R203UW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= NYLkc5M1OjR{NkG4OlI>
KG1 NVXsTmFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7UWYU1QCCq M3\1SGlEPTB;MT6xOUDPxE1? NX;jUGRQOjR3MkWwNFM>
HEL MoLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofLOFghcA>? M{fsTmROW09? MUfJR|UxRTBwNEmg{txO MXyyOFY6PDB3NR?=
HSC3 MWHDfZRwfG:6aXOgRZN{[Xl? MlzCNVIhcA>? NHHVV5pFVVOR NVrCclRkUUN3ME2wMlcyKM7:TR?= NXTDTJI5OjR5Nk[1OlA>
HT-29 NG\3d5hEgXSxdH;4bYMhSXO|YYm= NELY[VAyOiCq NXLoT|dWTE2VTx?= NWrnSnY4UUN3ME2wMlczKM7:TR?= MXuyOFc3PjV4MB?=
KB M1;sXGN6fG:2b4jpZ{BCe3OjeR?= NX;Ve2l1OTJiaB?= NUPPPWJqTE2VTx?= NVPEU5lWUUN3ME2wMlc2KM7:TR?= M{LzPVI1PzZ4NU[w
H460 M13QeWN6fG:2b4jpZ{BCe3OjeR?= MlH5NVIhcA>? NY\mSpVnTE2VTx?= NVzWZXZJUUN3ME2wMlgzKM7:TR?= Ml;UNlQ4PjZ3NkC=
MONE1 NGjJV|NEgXSxdH;4bYMhSXO|YYm= MkLVNVIhcA>? NITBb5lFVVOR MVzJR|UxRTFwMUig{txO NXXEb3RjOjR5Nk[1OlA>
MKN45 Mn7wR5l1d3SxeHnjJGF{e2G7 M4nOPFEzKGh? M2Hxe2ROW09? NWrieVNZUUN3ME2xMlI2KM7:TR?= MYOyOFc3PjV4MB?=
TSGH MVfDfZRwfG:6aXOgRZN{[Xl? M1nNS|EzKGh? M3rvS2ROW09? NV:4UIdyUUN3ME2yMlA6KM7:TR?= MWmyOFc3PjV4MB?=
HL60 Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrMTGE4OiCq M1L1WmROW09? NWnTZXRLT0l3ME2wMlk{KM7:TR?= Mme0NlQ6ODB3MEC=
HEK293 NILJSVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUe3NkBp NYnhdo1qTE2VTx?= NG\2VlBIUTVyPUGzJO69VQ>? NWfzWGxlOjR7MEC1NFA>
Jurkat NFPE[5dEgXSxdH;4bYMhSXO|YYm= NWXkbZdTOTByIN88US=> M2HKb|czKGh? NX:zO3AxT0l3ME2wMlkh|ryP M3PGdlI1QTByN{Sz
GM15850 MX7LbY5ie2ViQYPzZZk> MVuyMlUh|ryP MnX1PVYhcA>? MX;EUXNQ M1TG[IRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UAyPCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MV2xOlkzOTN4Nx?=
GM15850 NEjudJhMcW6jc3WgRZN{[Xl? NHLPNJYzNjVizszN MXK5OkBp MnH5SG1UVw>? NFrhSlVld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhPSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MVOxOlkzOTN4Nx?=
GM15850 M3fGdmtqdmG|ZTDBd5NigQ>? MWWyMlUh|ryP MYC5OkBp MmPXSG1UVw>? NUXWbpJU\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF{IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m M4nE[lE3QTJzM{[3
GM15850 Ml\pT4lv[XOnIFHzd4F6 M4jF[|IvPSEQvF2= M1fnPVk3KGh? NEnD[5NFVVOR M3HvfYRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UA6KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NIjVRYcyPjl{MUO2Oy=>
GM15850 NHnSPY5McW6jc3WgRZN{[Xl? MXmyMlUh|ryP NXnDWlQ4QTZiaB?= M3nTVGROW09? M2m2[YRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA5KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M{TtdVE3QTJzM{[3
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NCI-H1666 NGjjVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJwMkixNVEh|ryP MWPTRW5ITVJ?
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JAR Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG1VYp4UUN3ME2yMlMyQTh5IN88US=> Ml\jV2FPT0WU
5637 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13HdmlEPTB;Mj6zNlEzQSEQvF2= NX3nSFlCW0GQR1XS
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KP-N-YS M134N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHKTWM2OD1{LkOyOlE2KM7:TR?= NHe1e5lUSU6JRWK=
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8-MG-BA MmG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjOSpN5UUN3ME2yMlM{QTB4IN88US=> NFfINVNUSU6JRWK=
RH-18 NVHydWJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJwM{WwNlIh|ryP MmTuV2FPT0WU
NCI-H1155 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTISYpsUUN3ME2yMlM3PzJ3IN88US=> NFnpTYtUSU6JRWK=
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HSC-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3XVmVtUUN3ME2yMlQ1PTB7IN88US=> M13UXnNCVkeHUh?=
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LU-134-A NH;4dXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[3TWM2OD1{LkS3NFA5KM7:TR?= NYL3cVVSW0GQR1XS
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NCI-H2170 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\xVnRxUUN3ME2yMlUxPTR7IN88US=> MlXmV2FPT0WU
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A375 MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;0d2lEPTB;MUCuNlQ2OiEQvF2= NV;hW3BwW0GQR1XS
HCC38 NIfXXmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PO[mlEPTB;MUCuN|IzKM7:TR?= M3nzRnNCVkeHUh?=
LK-2 NUP4UoV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TzW2lEPTB;MUCuOFIxQCEQvF2= M4TDN3NCVkeHUh?=
SF126 M4jnS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq5TlhKSzVyPUGwMlQ4OjdizszN NHHrSJVUSU6JRWK=
SK-MEL-1 NWnudXVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm3TWM2OD1zMD63PFM5KM7:TR?= NHr0VoFUSU6JRWK=
ACN NUHkcHRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGCwPXNKSzVyPUGwMlg3PzlizszN MkPCV2FPT0WU
BB30-HNC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHUWZpKSzVyPUGwMlg4OTFizszN NX2ze3BPW0GQR1XS
NCI-H747 MmPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\HSGlEPTB;MUCuPFc1PiEQvF2= MVHTRW5ITVJ?
KYSE-150 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4C1fmlEPTB;MUGuNFM5PyEQvF2= NX7YW5Q3W0GQR1XS
D-247MG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLFfpQ{UUN3ME2xNU4yODB7IN88US=> MkniV2FPT0WU
BxPC-3 MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXtTWM2OD1zMT6zO|Q4KM7:TR?= M2qxVXNCVkeHUh?=
SK-MEL-30 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTwVWw1UUN3ME2xNU41ODd7IN88US=> MlPrV2FPT0WU
CAS-1 NWjCdo1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zmXWlEPTB;MUGuOFExQSEQvF2= NEPvNodUSU6JRWK=
no-10 NX75N3N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTF{LkGyNVch|ryP NHS1elNUSU6JRWK=
NCI-H2405 NHjxUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVm0U|RVUUN3ME2xNk4zODN4IN88US=> NWiyNmpnW0GQR1XS
KGN MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zxZWlEPTB;MUKuNlkxOSEQvF2= NUDpN216W0GQR1XS
BB49-HNC NYL0eYNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSwO4Z3UUN3ME2xNk4{QTV4IN88US=> NFH4RZhUSU6JRWK=
NCI-H1693 Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF{LkW4NVYh|ryP MV\TRW5ITVJ?
RO82-W-1 NF25WI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rvemlEPTB;MUOuNFY1QSEQvF2= NITtXFFUSU6JRWK=
CAL-85-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfOTWM2OD1zMz60N|k6KM7:TR?= NG\sR|ZUSU6JRWK=
H-EMC-SS MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLSTWM2OD1zMz65NVA1KM7:TR?= MnLsV2FPT0WU
SW1783 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fGO2lEPTB;MUSuNlM6OSEQvF2= MoToV2FPT0WU
LB771-HNC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrmUohKSzVyPUG0MlQyQSEQvF2= Mni3V2FPT0WU
HCC70 MlT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTF2LkSyN|Mh|ryP NYHZVmNHW0GQR1XS
KNS-81-FD MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfl[mU{UUN3ME2xOE44ODR3IN88US=> M3jCdHNCVkeHUh?=
KYSE-520 M3PzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnviTWM2OD1zND65Nlch|ryP M{X6b3NCVkeHUh?=
TGBC24TKB M1HWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r2R2lEPTB;MUSuPVU{QSEQvF2= Mn7iV2FPT0WU
SNB75 NFzINWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;LSmlEPTB;MUWuNFczQSEQvF2= Mn;oV2FPT0WU
SW872 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTF3LkKyNVgh|ryP NUOy[4g2W0GQR1XS
U031 M3fNOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnIOIxjUUN3ME2xOU45ODJ6IN88US=> NETUeoxUSU6JRWK=
ChaGo-K-1 Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTi[nJKSzVyPUG1Mlg{PTlizszN NWrwW4JZW0GQR1XS
NCI-H441 NEHwRWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGf2bY1KSzVyPUG2MlAxOzlizszN MWHTRW5ITVJ?
TE-12 NFvBPHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjKc25JUUN3ME2xOk4yQDd|IN88US=> MYfTRW5ITVJ?
NCI-H1755 NIfPPVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jXXmlEPTB;MU[uOVc{KM7:TR?= M13oSHNCVkeHUh?=
KNS-42 M3PlcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF4Lk[1PFkh|ryP MULTRW5ITVJ?
SK-PN-DW M2PMdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HWXGlEPTB;MUeuOFIxOSEQvF2= M3fXVXNCVkeHUh?=
NCI-H226 M3;lNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF5LkmzOFUh|ryP NYW5RoQ4W0GQR1XS
K-562 M1\CTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLvToNwUUN3ME2xPE43OzF5IN88US=> M{TP[HNCVkeHUh?=
A388 M2C1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y3VWlEPTB;MUmuNFMxOyEQvF2= MXzTRW5ITVJ?
ZR-75-30 M2m0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1yxSGlEPTB;MUmuNFk3QCEQvF2= M4n5c3NCVkeHUh?=
LU-135 MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDHdm9[UUN3ME2xPU4zPjN4IN88US=> NULoWm04W0GQR1XS
NCI-H2029 NYLvWndDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrRTWM2OD1zOT62NFIyKM7:TR?= MlnKV2FPT0WU
HT-1197 NF\iNoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjrTWM2OD1zOT65NlI4KM7:TR?= NEjkTWJUSU6JRWK=
IGR-1 MkPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJyLkOxNVch|ryP MXrTRW5ITVJ?
U-87-MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv0VGxKSzVyPUKwMlY1OTNizszN NYO1fGtCW0GQR1XS
NCI-H1304 NHrvc4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHOTWM2OD1{MD63OVAyKM7:TR?= NYW0PHQ4W0GQR1XS
RCC10RGB MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfpS3NxUUN3ME2yNU4zQDJ7IN88US=> MWLTRW5ITVJ?
NCI-H520 NInSb4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJ{Lke2NVEh|ryP MkS4V2FPT0WU
SK-LU-1 NGX5VmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rFTmlEPTB;MkOuNFcyQCEQvF2= NHTVZXNUSU6JRWK=
UACC-893 MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonaTWM2OD1{Mz6xNFM5KM7:TR?= M{DMUHNCVkeHUh?=
NCI-H2347 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\sd4lKSzVyPUKzMlI3PzRizszN MVfTRW5ITVJ?
U-118-MG NUHQ[pR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHJTIFXUUN3ME2yN{44OjF5IN88US=> M1vIO3NCVkeHUh?=
NCI-H596 MofuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXGVW9KSzVyPUKzMlkxPTVizszN M4P6OXNCVkeHUh?=
MZ1-PC MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnFTWM2OD1{ND62O|U6KM7:TR?= MXvTRW5ITVJ?
SW1417 M3v3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGGxWWhKSzVyPUK1MlI1QThizszN NGfJS2tUSU6JRWK=
NCI-H82 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJ4LkSyPFgh|ryP MoXPV2FPT0WU
COLO-678 MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\tN|VKSzVyPUK3MlQ6OTlizszN NILYblRUSU6JRWK=
KURAMOCHI MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnGbFZKSzVyPUK4MlEzPiEQvF2= MmXxV2FPT0WU
NCI-H1650 M4f1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTNyLkG5NlQh|ryP NFzjVpJUSU6JRWK=
HCC1954 M17TT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDTRpBiUUN3ME2zNU4{PjZ4IN88US=> MlPkV2FPT0WU
GAK Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor0TWM2OD1|Mj6yOlE3KM7:TR?= M1Pkb3NCVkeHUh?=
YAPC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfZSJRKSzVyPUOzMlc3PDhizszN NF7GNW9USU6JRWK=
NCI-H2228 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTN2LkO2NFUh|ryP NWHPTJFHW0GQR1XS
VMRC-RCZ MofLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PsV2lEPTB;M{[uN|AzOiEQvF2= MVXTRW5ITVJ?
NMC-G1 M{jpRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTN5LkC1Nlkh|ryP NYTUSVkxW0GQR1XS
D-336MG NX3hUHd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LYXGlEPTB;NEGuPFQ1OiEQvF2= MVnTRW5ITVJ?
UACC-62 M2fBXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTR{LkW1NFUh|ryP M2frTXNCVkeHUh?=
C-33-A NGTC[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDoTYZYUUN3ME20OU4{OjV4IN88US=> NI\JSZpUSU6JRWK=
HCC1937 MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\TTWM2OD12Nz6xPVU5KM7:TR?= NF7Pd|lUSU6JRWK=
HDLM-2 M2LtWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X3TWlEPTB;NEeuNlI5PyEQvF2= NVLreodRW0GQR1XS
NCI-H727 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfF[XE{UUN3ME20O{4zPDVzIN88US=> NXfHSmJTW0GQR1XS
NY NV\nTpFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3BS2tKSzVyPUS5MlM6ODhizszN MVPTRW5ITVJ?
NCI-H2291 NGfmNJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q5WmlEPTB;NEmuPFMxOSEQvF2= M1HSe3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID