Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 99 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NHHrRnlMcW6jc3WgRZN{[Xl? NHHhNGkyKGh? NUnsVpQxTE2VTx?= NETxSmNidnSrLVjERWMyKGGldHn2bZR6KHerdHigTWM2OCCxZjCwMlEyOiEQvF2= NGnxcFcyOTl4MES4PS=>
Friend leukemic cell M{G0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTEeVRoPTBizszN NWK5Z4ZEPzJiaB?= MVLEUXNQ MYLJR|UxRTBwOUmg{txO NXrHcFZIOTJzMEm5NVM>
K562 NU[3bnM5U2mwYYPlJGF{e2G7 MXG2JIg> NV7MNYJLTE2VTx?= Mn;RTY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN NFXa[40yOjRzOUO4NC=>
HT1080 NY\6fm1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHmO|IhcA>? Mn7nSG1UVw>? MUHJR|UxRTJwNDFOwG0> MmH4NVIzPzBzN{W=
H1299 NVW1XII5U2mwYYPlJGF{e2G7 M1i3[VIxKG2rbh?= Mo\zSG1UVw>? MVXJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgTGRCSyCnbor5cYUhf2m2aDDJR|UxKG:oIECuNVk1KM7:TR?= NWP2cnNEOTR3MkG0NlI>
H1299 NIXKVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPaW203PzJiaB?= M2jaOWROW09? MWjJR|UxRTdwMkSg{txO MXGxOFUzOTR{Mh?=
HeLa NV7TWoNyU2mwYYPlJGF{e2G7 MX6zNEBucW5? M1HYeGlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHjpd5RwdmViZHXhZ4V1gWyjc3Wge4l1cCCLQ{WwJI9nKDBwMkig{txO Ml23NVU3ODN7NEm=
LOX-IMVI MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC3Z3p[PDhiaB?= NYLVXZpsUUN3ME2xMlMh|ryP M2PGdlE2PzF3NEew
NCI-H226 NGnPUmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX3OFghcA>? MUXJR|UxRTJwNjFOwG0> MlntNVU4OTV2N{C=
RXF-631L MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXW0SIZUPDhiaB?= Mmf3TWM2OD1{IN88US=> MkDwNVU4OTV2N{C=
SNB-78 NEHxXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXG0PEBp MYfJR|UxRTF4IN88US=> MkDMNVU4OTV2N{C=
St-4 M3XyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVS0PEBp MmnJTWM2OD13LkKg{txO M3TFOVE2PzF3NEew
ARP1 MX7GeY5kfGmxbjDBd5NigQ>? Ml:yNkDPxE1? MVq2JIg> NVXiPHE5UW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v MW[xOFc{PDhyNh?=
CEM NGHOW49McW6jc3WgRZN{[Xl? NYHyZVhjOSCq NWjUWnB1TE2VTx?= NGH4O2VKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Mh|ryP M{nNTVE3PDJyME[0
HCT15 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LqR|Q5KGh? NWC1XVZrT0l3ME2wMlgzKM7:TR?= NXfxV5N6OTZ5MkOyNlc>
NCI-H23 M{HaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXG0PEBp MkDDS2k2OD1yLkmyJO69VQ>? NWLiPXVLOTZ5MkOyNlc>
GM15850 M1vYe2tqdmG|ZTDBd5NigQ>? NGrtOnIzNjVizszN NXvSUHcxQTZiaB?= M33BbmROW09? M3XTPWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MkLVNVY6OjF|Nke=
GM15850 NYX2eHJXU2mwYYPlJGF{e2G7 NXPYZW5mOi53IN88US=> M1qx[|k3KGh? M2D3SWROW09? MlOxTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEWgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NXLTTYU4OTZ7MkGzOlc>
GM15850 MX\LbY5ie2ViQYPzZZk> MljENk42KM7:TR?= MluzPVYhcA>? MYHEUXNQ NH71dINKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NYD0NohwOTZ7MkGzOlc>
GM15850 MULLbY5ie2ViQYPzZZk> MlHZNk42KM7:TR?= Moe1PVYhcA>? NXr2TGs6TE2VTx?= NEjFNGNKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= Mn3INVY6OjF|Nke=
GM15850 MX\LbY5ie2ViQYPzZZk> MmTHNk42KM7:TR?= NEjlbJM6PiCq M4jPW2ROW09? Mm[5TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEigZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NWjYe2ZoOTZ7MkGzOlc>
GM15850 NW\qfoU3U2mwYYPlJGF{e2G7 M1zseVIvPSEQvF2= NX3F[G5oQTZiaB?= MV3EUXNQ NYDHeYh4UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M3:xOVE3QTJzM{[3
U937 NYDyTpBnTnWwY4Tpc44hSXO|YYm= M{P4V|Uh|ryP Mlz1NlQhcA>? M4\4e2ROW09? MlzsR4VtdCCleXPs[UBienKnc4SgZpkh[WOldX31cIF1cW:wIHH0JHMwTzJxTTDwbIF{\Q>? MXmxO|AxPDdzOB?=
H661 NGjC[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;EPHg1QCCq M33DcmlEPTB;MTFOwG0> MVqxO|E2PzByOR?=
U937 MX3GeY5kfGmxbjDBd5NigQ>? MYe1JO69VQ>? NFnmS3kzPCCq NX3JcoNHTE2VTx?= NWjMWHpnUW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> NEHpW4oyPzR2N{e1NC=>
U937 NHT1b3RHfW6ldHnvckBCe3OjeR?= MojUNUDPxE1? NXT4V5ZKOjRiaB?= M2j1XmROW09? M{nwXGVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u NFHNbXEyPzR2N{e1NC=>
RAW264.7 MUjGeY5kfGmxbjDBd5NigQ>? M3T4UVExKM7:TR?= MXeyOIg> M{\LdJdifGW{ NFnCTIRKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN Mlr0NVc1Pzd3MUi=
RAW264.7 MVnGeY5kfGmxbjDBd5NigQ>? MUmxNEDPxE1? NYPwdnRwOjSq MVr3ZZRmeg>? NIjaXVNKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKE6RIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDFwOEig{txO Mm\PNVc1Pzd3MUi=
SC9 NGmySXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[0PEBp M4DJdGlEPTB;MD62NFYh|ryP M{PTUlE4PTB5MkG5
ST14A NILQZ5JHfW6ldHnvckBCe3OjeR?= MmLSOUBvVQ>? M4rPXFczKGh? MkPzTY5kemWjc3WgbY4hWkWVVD;OVnNHKG2UTlGg[ZhxemW|c3nvci=> NFTVZncyPzV4NUm5Ny=>
ST14A Mn;VSpVv[3Srb36gRZN{[Xl? NWH1VmR1PSCwTR?= NGnEWFQ4OiCq MVrJcoNz\WG|ZTDpckBGOkZzIH3SUmEh\XiycnXzd4lwdg>? M4PkUlE4PTZ3OUmz
PANC1 NUTRZ2xOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEC2[FUyKM7:TR?= NIO0NY5KSzVyPUCuOFUh|ryP M1rVeVE4PTh6N{S0
PANC1 NUTWZYU{TnWwY4Tpc44hSXO|YYm= M3iwRlEh|ryP MYGyOEBp M4jye2lv[3KnYYPlJIlvKHB{MWfBSlEwS0mSMTDn[Y5mKGW6cILld5Nqd25? MXOxO|U5QDd2NB?=
PANC1 MnTSSpVv[3Srb36gRZN{[Xl? M2\aTFEh|ryP NWnEdoxnOjRiaB?= MVrJcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= MXOxO|U5QDd2NB?=
PT45 M2C5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7OZ4pDUUN3ME20JO69VQ>? MV6xO|U5QDd2NB?=
ACHN M1PERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnxOFNGOjFiaB?= MYTHTVUxRTBwNkWg{txO M1[xZVE4PjZ{NkC2
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SKHEP1 M2XpXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13DSlczKGh? M3\IXGlEPTB;Mz60OkDPxE1? MXqyNFE1Ozd5OB?=
BJ MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jWRlExOCEQvF2= MkDnOFghcA>? NH[5W5VFVVOR MYLHdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= MV[yNFE1Ozh2MB?=
MUF NGXBSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTDcXAyODBizszN MlrSOFghcA>? NHzGTHdFVVOR MV\Hdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= MXiyNFE1Ozh2MB?=
Caco-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHIVoo1OTByIN88US=> NYm1Z3BIPDiq MkTaSG1UVw>? M{S0b2lEPTB;OD6xJO69VQ>? NVuxZVZTOjBzNEO4OFA>
Caco-2 M1K2emtqdmG|ZTDBd5NigQ>? Mm\zOUDPxE1? NUGzZVVWPCCq NUW2b2RjTE2VTx?= MWrJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszN MXyyNFE1Ozh2MB?=
Caco-2 Mlz1T4lv[XOnIFHzd4F6 M3qyNVAvOzF4IH7NJJRwKDNzLk[g{txO MVS0JIg> Mn7MSG1UVw>? NEXGZ25GgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Gge4l1cCCLQ{WwJI9nKDBwMUG5JO69VQ>? Mnv0NlAyPDN6NEC=
Caco-2 MXXLbY5ie2ViQYPzZZk> NVzhRWRyOC5|MU[gcm0hfG9iM{GuOkDPxE1? NGPQU3g1KGh? NV25dZVJTE2VTx?= NWLzb5YxTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOzJJdqfGhiSVO1NEBw\iByLkG0O{DPxE1? NH\H[GMzODF2M{i0NC=>
Caco-2 MkfLT4lv[XOnIFHzd4F6 NXX0W4FVPi5|MjDuUUB1dyB4M{Kg{txO MXW0JIg> MkW1SG1UVw>? MoDVSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN3IIfpeIghUUN3MDDv[kAyOi54IN88US=> MYKyNFE1Ozh2MB?=
Caco-2 M{TVZWtqdmG|ZTDBd5NigQ>? Mlf1Ok4{OiCwTTD0c{A3OzJizszN M4rnXFQhcA>? NXOx[WtoTE2VTx?= MlTFSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2= NFPCR2IzODF2M{i0NC=>
Caco-2 NHn2OWFMcW6jc3WgRZN{[Xl? NXHqcXNnOC5|MU[gcm0hfG9iM{GuOkDPxE1? M2j0TVQhcA>? MlHCSG1UVw>? MWPFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzZ? MnryNlAyPDN6NEC=
HepG2 NV;JdVM{U2mwYYPlJGF{e2G7 NGnpVpo2KM7:TR?= NI\VcXQ3cA>? M2Loc2ROW09? MlXsTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDhZ4V1gWyjdHnvci=> NWrCOYl4OjBzNEO4OFA>
HepG2 NFHzXmFMcW6jc3WgRZN{[Xl? MWO1JO69VQ>? M2jRNVZp MnSwSG1UVw>? MWrJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHj5dIVz[WOndInsZZRqd25? M1r0T|IxOTR|OESw
HepG2 MYLLbY5ie2ViQYPzZZk> MXe1JO69VQ>? M4S3TVZp NWL5cHFoTE2VTx?= NF;DcYlKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u M3vEZ|IxOTR|OESw
HepG2 M1HsfWtqdmG|ZTDBd5NigQ>? Mn7iOUDPxE1? NY\mclZ{Pmh? M3zRZmROW09? NYPrUm1rUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhUDNxSESgbIl{fG:wZTDhZ4V1gWyjdHnvci=> Mlz5NlAyPDN6NEC=
COLO205 MVfLbY5ie2ViQYPzZZk> M1TxRlExKM7:TR?= NELRPXMzPCCq MXzEUXNQ NIPCXYRKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIIfpeIghUUN3MDDv[kAzNjJizszN MYCyNFQ2OTN5OB?=
SCC4 MX7LbY5ie2ViQYPzZZk> NYTR[W5MOSEQvF2= M2npR|I1cA>? NYj1U5pqUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44> NUGwfZJYOjB2NUKyNlU>
SCC4 NV;2TlAxU2mwYYPlJGF{e2G7 NHHPbXIyKM7:TR?= NXu3OIZROjSq NYXHc2QyUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44> NW\ofnZzOjB2NUKyNlU>
SCC4 NFLUSIxHfW6ldHnvckBCe3OjeR?= MlG2NUDPxE1? MV21JI1qdg>? MkXuRYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= NX\YNJB7OjB2NUKyNlU>
NB4 MUjGeY5kfGmxbjDBd5NigQ>? M2rrcFUh|ryP MmexNlQhcA>? M4HUemROW09? NVXTW|IyS2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNkfW23bHH0bY9vKGG2IIDy[U1IOSCyaHHz[S=> NFvzdnozODR7MUS0NC=>
NB4 NVXoWXdxU2mwYYPlJGF{e2G7 MVe1JO69VQ>? MVWyOEBp MVTEUXNQ M1PJR2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? NGnzNlkzODR7MUS0NC=>
NB4 M{TN[GZ2dmO2aX;uJGF{e2G7 MWO1JO69VQ>? NVHBe4g1OjRiaB?= NVyxNFJTTE2VTx?= NVm3fJV[UW6mdXP0bY9vKG:oIICyNXdCTjFxQ1nQNUBmgHC{ZYPzbY9v MXGyNFQ6OTR2MB?=
NB4 NHHsOVJMcW6jc3WgRZN{[Xl? MXy1JO69VQ>? NV\Kd|N6OjRiaB?= NEHsT4lFVVOR NV;BVXI1UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMh[WOndInsZZRqd25? M2LzOVIxPDlzNESw
NUGC3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;HTVUxRTJwOUSg{txO M1;CTlIxQDVyOUex
A549 NXXIN25QTnWwY4Tpc44hSXO|YYm= MVi1JO69VQ>? M17XVVMhcA>? Ml7wSG1UVw>? MknpTY5lfWO2aX;uJI9nKGG3dH;wbIFogSCrbjDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKEyFM1nJ NXG1VFJ3OjB6NUWyNFg>
HUT78 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v4S|czKGh? MkjOSG1UVw>? MV3HTVUxRTBwMzFOwG0> MWOyNFg5PDJyOB?=
U937 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWW3NkBp NWjVeZJ3TE2VTx?= MXPHTVUxRTBwM{mg{txO M2XKWVIxQDh2MkC4
A431 NFq0NmxEgXSxdH;4bYMhSXO|YYm= MkjjO|IhcA>? NV3PWlFuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR|MTDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA1NjJizszN MkCzNlExQDB4Mkm=
A549 MoHOR5l1d3SxeHnjJGF{e2G7 NVP2WnAyPzJiaB?= M1[w[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMhd3[ncnX4dJJme3OrbnegTGRCSyC5aYToJGlEPTBib3[gNU45KM7:TR?= NGK1bJAzOTB6ME[yPS=>
CAL27 MXjDfZRwfG:6aXOgRZN{[Xl? NFm1SW44OiCq NVvyTJc1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> NXq4UGdXOjFyOEC2Nlk>
HeLa NEjNfmxEgXSxdH;4bYMhSXO|YYm= MknzO|IhcA>? MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuOUDPxE1? NUnXUXF3OjFyOEC2Nlk>
Sf21 NYHoRpFjU2mwYYPlJGF{e2G7 M2rnNFMhcA>? NXjSO|R{UW6qaXLpeIlwdiCxZjDGcIFoKHSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBJTEGFODDlfJBz\XO|ZXSge4l1cCCLQ{WwJI9nKDFwMjFOwG0> NUHUUlI2OjFyOEC2Nlk>
SKBR3 M4WwTmN6fG:2b4jpZ{BCe3OjeR?= MWq3NkBp NUTGSGtIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uEUkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi54IN88US=> NYTQc4FbOjFyOEC2Nlk>
SKOV3 M1jVRWN6fG:2b4jpZ{BCe3OjeR?= NFfTNmw4OiCq M1PHe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvOiEQvF2= NVvQPXFoOjFyOEC2Nlk>
COR-L23 M3vtfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV[xNEDPxE1? M1PRXlczKGh? MVPEUXNQ NF\HdmpIUTVyPUGuNUDPxE1? NGrRNoQzOTB6ME[0Oy=>
DU145 NWHyeHdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXuxNEDPxE1? NGnBUZg4OiCq M1G1[mROW09? M3\HOWdKPTB;MT6wOUDPxE1? NITZWpEzOTB6ME[0Oy=>
LoVo NUS4XZU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnoOlhXOTBizszN M4TxRVczKGh? Mo\3SG1UVw>? MmXDS2k2OD1zLkeg{txO M2q4RlIyODhyNkS3
MCR5-SV2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TwZVExKM7:TR?= M3rpflczKGh? NG\0WmVFVVOR MlO5S2k2OD1{LkGg{txO NGPLNXQzOTB6ME[0Oy=>
HCT116 M{fw[2tqdmG|ZTDBd5NigQ>? MUizNEDPxE1? NV3P[HpEOzBiaB?= MX;EUXNQ NHLlSVRKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u M{LaTlIyODhyNkS3
HCT116 MWDLbY5ie2ViQYPzZZk> MWqzNEDPxE1? NWi2U25HOzBiaB?= MVvEUXNQ NHvtd3JKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= M{X6UFIyODhyNkS3
U937 NVXJflIyU2mwYYPlJGF{e2G7 NIHNdHA2KM7:TR?= MUSyOEBp NVzQXIpOTE2VTx?= MXTJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMQQ>? M1SxW|IyOjl{NEmy
U937 MnTGT4lv[XOnIFHzd4F6 NFLwe2Q2KM7:TR?= MUKyOEBp M13VXWROW09? MX;Jcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMOTh? M3i2O|IyOjl{NEmy
U937 NYi5T5h[U2mwYYPlJGF{e2G7 M1nOSFUh|ryP MXqyOEBp MmHESG1UVw>? MoC5TY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? NV7Tb3RMOjF{OUK0PVI>
U937 Mn3OT4lv[XOnIFHzd4F6 MYq1JO69VQ>? MYSxOUBucW5? NEO0fYNFVVOR NYK2d|k2UW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? NULyPYVMOjF{OUK0PVI>
A2780 NIqzPJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3MWnFmQTZiaB?= NIXyfZNFVVOR M1f2dWlEPTB;MT62NkDPxE1? MnO0NlE3OzR2M{C=
COLO205 M4HtN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\UdmlpQTZiaB?= MV7EUXNQ NW\oZlVHUUN3ME2yMlEzKM7:TR?= NXnKfohWOjF4M{S0N|A>
Hep3B MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v0ZVQ5KGh? NGm3NYtFVVOR M2rsfmdKPTB;MT6yNUDPxE1? MmWxNlE4OTJzNE[=
GM11272 M1rMXGZ2dmO2aX;uJGF{e2G7 MlPLNVAxKG6P M3TWTlczKGh? NVHQZotuTE2VTx?= NFXufY5T\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O Mn\PNlE5PDB5MU[=
CFBE41o MWfLbY5ie2ViQYPzZZk> MVi1JO69VQ>? MkfWSG1UVw>? NWXsfIM4TG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP MUmyNVk5PDl3OB?=
CFBE41o NFq1SJpHfW6ldHnvckBCe3OjeR?= NFjnSIkyKM7:TR?= MXWyOEBp NX\VVnBITE2VTx?= MVnS[ZN1d3KjdHnvckBw\iCFRmTSJIRmdHSjRkWwPEBufXSjboSgeJJi\m[rY3vpcochfG9iY3XscEB{fXKoYXPlJIF{KGeueXPv[o9zdXN? NYjh[IdmOjF7OES5OVg>
DU145 M{i4d2tqdmG|ZTDBd5NigQ>? NYfKS2JuOi53IN88US=> NXHzbmJnOjRiaB?= M1PIOGROW09? NFfuO3RKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNidYDy[Yd2dGG2aX;uJI9nKHB{MYfh[lEheHKxdHXpckBmgHC{ZYPzbY9v NW[ybYU6OjJ{NkCxOlY>
DU145 MUHLbY5ie2ViQYPzZZk> MY[1JO69VQ>? M{fYS|I1KGh? MnHQSG1UVw>? MnTGTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36= Mor2NlIzPjBzNk[=
DU145 M2joTmtqdmG|ZTDBd5NigQ>? NEH6[YE2KM7:TR?= NW\oTmE{OjRiaB?= MlnJSG1UVw>? NXj3O416UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSEOgbJlx\XKjY3X0fYxifGmxbh?= MlLVNlIzPjBzNk[=
786-0 M3noOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;TOk4zKM7:TR?= MnHmO|IhcA>? NEm0fWRFVVOR MmHLS2k2OD1|LkKg{txO M3i1SFIzPDN3Nk[5
A498 MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK4OXE3NjJizszN NEjzTHo4OiCq M4\PPWROW09? NHy2WXRIUTVyPUGuOkDPxE1? NFT2fVczOjR|NU[2PS=>
A549/ATCC M3\wRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHWOk4zKM7:TR?= NWDLfZE6PzJiaB?= MljjSG1UVw>? NH\IdoVIUTVyPUGuOkDPxE1? MWmyNlQ{PTZ4OR?=
ACHN NH3UWXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG0OWs3NjJizszN MofNO|IhcA>? MVXEUXNQ MYnHTVUxRTFwMzFOwG0> MoXDNlI1OzV4Nkm=
BT549 MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVi2MlIh|ryP NEnNSFc4OiCq NELEZWpFVVOR NYrDOI84T0l3ME2xMlMh|ryP M1fxXVIzPDN3Nk[5
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HCT15 NF60ZZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof3Ok4zKM7:TR?= NWe4cIJLPzJiaB?= NGr0cWhFVVOR Ml3pS2k2OD1{LkWg{txO MlXYNlI1OzV4Nkm=
HOP92 M2nKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfpTlc3NjJizszN M2jCd|czKGh? MmHJSG1UVw>? NF70Ro9IUTVyPUSg{txO MYCyNlQ{PTZ4OR?=
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LOXIMVI M3y0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3T4[FYvOiEQvF2= NXKxW2Q{PzJiaB?= MXrEUXNQ M3;MNmdKPTB;MTFOwG0> M{HCeVIzPDN3Nk[5
M14 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HCe|YvOiEQvF2= MmfvO|IhcA>? MWDEUXNQ M2PnOmdKPTB;MT6zJO69VQ>? NEfB[40zOjR|NU[2PS=>
MALME-3M MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS4NFk3NjJizszN MVy3NkBp M3;QeGROW09? NGPUVItIUTVyPUCuN|Ih|ryP NVnU[pdMOjJ2M{W2Olk>
MCF10A NWfrb5Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWi2MlIh|ryP Mn3HOFghcA>? M{L2TmROW09? NVvwWFk2T0l3ME25MlYh|ryP MYWyNlQ{PTZ4OR?=
MDA-MB-435 NYXnc3poT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFyzd|k3NjJizszN MnnsO|IhcA>? Mo[2SG1UVw>? MWTHTVUxRTBwNTFOwG0> NIDEblUzOjR|NU[2PS=>
MDA-MB-468 M2XTS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYi2MlIh|ryP NYrqWFRHPzJiaB?= NEf0cGNFVVOR Mmi4S2k2OD1yLk[zJO69VQ>? MYGyNlQ{PTZ4OR?=
MOLT4 NWjVTpB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYiyOWh[Pi5{IN88US=> MUC3NkBp NFvJVXFFVVOR NVny[3M{T0l3ME2wMlQh|ryP MkLMNlI1OzV4Nkm=
NCI-ADR-RES MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWq2MlIh|ryP NUDhO|RsPzJiaB?= MoLpSG1UVw>? M1nXcGdKPTB;MD6xOkDPxE1? M{PXbVIzPDN3Nk[5
NCI-H23 M3Lufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrYe|RTPi5{IN88US=> NVu0ZnZXPzJiaB?= NVPDVJY6TE2VTx?= M2fmZmdKPTB;MTFOwG0> M1;aT|IzPDN3Nk[5
NCI-H322M MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDjOk4zKM7:TR?= MmLBO|IhcA>? NX\XTm9ITE2VTx?= MXvHTVUxRTBwN{mg{txO NInzWpczOjR|NU[2PS=>
NCI-H460 MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYm2MlIh|ryP M2e3R|czKGh? M1TJeWROW09? M4Xze2dKPTB;MD63PUDPxE1? M2Pmb|IzPDN3Nk[5
NCI-H522 M4fNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWO2MlIh|ryP MXi3NkBp NI\4[oJFVVOR MkK3S2k2OD1yLkWg{txO NH;DT2QzOjR|NU[2PS=>
OVCAR3 NH\s[oRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLUV2xUPi5{IN88US=> NEjUR3g4OiCq M{jRO2ROW09? MVjHTVUxRTFwMzFOwG0> MmqxNlI1OzV4Nkm=
OVCAR4 M3XqOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjVPWY3NjJizszN MYW3NkBp M{foPGROW09? NWL4XJBvT0l3ME20JO69VQ>? M{XNVlIzPDN3Nk[5
OVCAR5 NUW4TlhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLJOk4zKM7:TR?= M3;6bVczKGh? NYPZXHVbTE2VTx?= MVPHTVUxRTBwN{mg{txO MVqyNlQ{PTZ4OR?=
OVCAR8 M3vJVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MluxOk4zKM7:TR?= NXvlTVVzPzJiaB?= NH7BZWFFVVOR M3y0cmdKPTB;MD61JO69VQ>? NI\we4EzOjR|NU[2PS=>
RXF393 M4KzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzjZlk3NjJizszN NWS1cW5nPzJiaB?= MnrySG1UVw>? NIfEcoNIUTVyPUGuN{DPxE1? Mk\ENlI1OzV4Nkm=
SF268 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LHblYvOiEQvF2= NWrJTZAzPzJiaB?= MXXEUXNQ NYnJWGd{T0l3ME2xMlYh|ryP MmjMNlI1OzV4Nkm=
SF295 NX3ZdY5MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzNS3NHPi5{IN88US=> MXq3NkBp MYnEUXNQ MXzHTVUxRTFwNjFOwG0> MmroNlI1OzV4Nkm=
SF539 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXq2MlIh|ryP M3m4U|czKGh? M4HsVGROW09? MmWyS2k2OD1{IN88US=> MYiyNlQ{PTZ4OR?=
SK-MEL-2 M{HCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzQUJg1Pi5{IN88US=> NFz5OWc4OiCq MkTPSG1UVw>? NEHTOWNIUTVyPUGuN{DPxE1? MVqyNlQ{PTZ4OR?=
SK-MEL-28 NXHkV2xJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\o[W5yPi5{IN88US=> M4\YdVczKGh? MoXoSG1UVw>? NWjkO4J5T0l3ME2xJO69VQ>? MUGyNlQ{PTZ4OR?=
SK-MEL-5 MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf3d|JFPi5{IN88US=> NIHkcGc4OiCq M{HzT2ROW09? M2fKWGdKPTB;MD62N{DPxE1? Mn[yNlI1OzV4Nkm=
SKOV3 MnKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXG2MlIh|ryP MoqxO|IhcA>? NW\RTpdKTE2VTx?= MV;HTVUxRTFizszN MYqyNlQ{PTZ4OR?=
SN12C NFm2RYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ywNlYvOiEQvF2= NHztUFA4OiCq NETjT2FFVVOR MWnHTVUxRTJizszN MXyyNlQ{PTZ4OR?=
SNB19 NHPHZVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj5Uph5Pi5{IN88US=> M4nTcVczKGh? MX;EUXNQ MnHiS2k2OD1yLk[zJO69VQ>? MX6yNlQ{PTZ4OR?=
SNB75 NYHmUFV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[4RlYvOiEQvF2= NV;XPVlbPzJiaB?= NVvQ[ms6TE2VTx?= M4faPGdKPTB;MD63PUDPxE1? MmTSNlI1OzV4Nkm=
SR NVu1cWszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP3TFI3NjJizszN NUDXOJlvPzJiaB?= MnXGSG1UVw>? MmjiS2k2OD1yLkSg{txO M163bFIzPDN3Nk[5
T47D NWXsZlVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXW2MlIh|ryP MkXVO|IhcA>? NELKOI5FVVOR MofXS2k2OD1yLkWg{txO NYfjNXo1OjJ2M{W2Olk>
TK10 M4O5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVS2MlIh|ryP MnLkO|IhcA>? NEHCSpNFVVOR M1rXbmdKPTB;MD62N{DPxE1? MUCyNlQ{PTZ4OR?=
UACC257 NHT0[ZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH3R494Pi5{IN88US=> MWK3NkBp NUnVcY5sTE2VTx?= NGjPRXhIUTVyPUCuOUDPxE1? NFLqN5QzOjR|NU[2PS=>
UACC62 NGS1dlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXuOk4zKM7:TR?= Moi5O|IhcA>? NVPqb2tLTE2VTx?= M1ezS2dKPTB;MD60JO69VQ>? M1mzXlIzPDN3Nk[5
UO31 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW3NJF2Pi5{IN88US=> MWC3NkBp M{jt[2ROW09? NF3QUGNIUTVyPUCuOUDPxE1? NVrFNotTOjJ2M{W2Olk>
Hep3B MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrzTYNpPDhiaB?= MUHEUXNQ NXnqT2NyT0l3ME2wMlY6KM7:TR?= M2fCTFIzPDN7OE[z
BE(2)-C MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX23NkBp NVu5b2RtTE2VTx?= NIHWeWJKSzdyPUKg{txO MnzFNlI6OzJ|MU[=
Bel7402 M1PjNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU[3NkBp MYnEUXNQ NUfrNFk{T0l7ME2xO{DPxE1? Mm\aNlMxPjF|N{[=
Bel7404 NEnlblRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWW3NkBp M4HWPWROW09? NFjjVJRIUTlyPUG4JO69VQ>? MXOyN|A3OTN5Nh?=
BGC823 NGS2cZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\TO|k4OiCq NHTnS|JFVVOR M2r5WmdKQTB;Nz61JO69VQ>? NFu0WWczOzB4MUO3Oi=>
MGC803 NFywUWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUe3NkBp NFTXOYdFVVOR MlHPS2k6OD1zMD64JO69VQ>? MWCyN|A3OTN5Nh?=
SGC7901 M{HOVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVi3NkBp MWTEUXNQ M1voS2dKQTB;OT60JO69VQ>? MYGyN|A3OTN5Nh?=
SKHEP1 NHPMNG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT1O|IhcA>? NF3w[4xFVVOR MVHHTVkxRTF5IN88US=> MoOwNlMxPjF|N{[=
SMMC7721 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUG3NkBp NXv0e|FOTE2VTx?= M1\BZWdKQTB;MkCg{txO NGK3bJgzOzB4MUO3Oi=>
NUGC3 M1fBVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvrNVAh|ryP NWX2O|A4T0l;Mj65OEDPxE1? NV3uTZJoOjNzNkOzN|I>
A2780 CisR NHyxS3dMcW6jc3WgRZN{[Xl? NYTiUFduOThiaB?= Mmm3TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkS0JO69VQ>? MoDJNlMzPTJ4MEO=
CAL27 sens NGr5fHFMcW6jc3WgRZN{[Xl? MlH4NVghcA>? NYPhZmtlUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= NYXhdGxvOjN{NUK2NFM>
CAL27 CisR M2Dye2tqdmG|ZTDBd5NigQ>? NIG4W40yQCCq NHjvSIdKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP M2D4cFI{OjV{NkCz
KYSE-510 CisR M2X3cmtqdmG|ZTDBd5NigQ>? MWqxPEBp M4PzTmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? NG\sfFQzOzJ3Mk[wNy=>
KYSE-510 sens MnTiT4lv[XOnIFHzd4F6 NWnXN29EOThiaB?= Mo[2TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO MW[yN|I2OjZyMx?=
MDA-MB-231 sens M1LhfmtqdmG|ZTDBd5NigQ>? MYSxPEBp MVjJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NXrJfFRyOjN{NUK2NFM>
MDA-MB-231 CisR MlTBT4lv[XOnIFHzd4F6 M1;nWlE5KGh? MV;Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO MWWyN|I2OjZyMx?=
ES2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYS0PEBp NH;rXIJFVVOR M375fmlEPTB;MUKuO{DPxE1? M{nMN|I{PDl|NES5
MDA-MB-231 M{ewWmtqdmG|ZTDBd5NigQ>? MY[xNEDPxE1? MX[zNEBucW5? M2LCd2ROW09? MYXJcohq[mm2aX;uJI9nKEiGQVOyZS=> NVnwclkzOjN2OUO0OFk>
MDA-MB-231 NWPGc3FTU2mwYYPlJGF{e2G7 M1jW[FEh|ryP MYSyOEBp NH\Gd5FFVVOR NEXCZ4hKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHHj[ZR6dGG2aX;uJIxmfmWuczDv[kB1fWK3bHnu NUHqN2diOjN2OUO0OFk>
HS68 Mnr0R5l1d3SxeHnjJGF{e2G7 M1nmO|ExKM7:TR?= M3XHWFczKGh? MVXEUXNQ MUfJR|UxRTRwNjFOwG0> NVXQVIVCOjN3N{C1OFI>
MEF NELIVnFEgXSxdH;4bYMhSXO|YYm= M1\LT|ExKM7:TR?= MUe3NkBp M4rYd2ROW09? NYLOU3dKUUN3ME20MlQh|ryP MmjpNlM2PzB3NEK=
BGC823 MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPCPHZFVVOR NGLHVWhIUTVyPUOuNFkh|ryP MUGyN|YxOTdyNh?=
High5 M3zjemtqdmG|ZTDBd5NigQ>? MWSyOEBp M33YeWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Yhf2m2aDDJR|UxKG:oIECuNFkh|ryP MUWyN|YxOjV{Mx?=
High5 MWHLbY5ie2ViQYPzZZk> NXHFVGcxOjRiaB?= MVrJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? NG[zSJozOzZyMkWyNy=>
High5 NWTkZoN4U2mwYYPlJGF{e2G7 MWqyOEBp NXP0cYJFUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOyC5aYToJGlEPTBib3[gNE4yPyEQvF2= NHzmUpUzOzZyMkWyNy=>
A549 M1;2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInUTHBFVVOR MYjJR|UxRTFwMEe5JO69VQ>? NX3XbYRCOjN4NESyNVA>
HCT116 M4fnSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTrOYRmTE2VTx?= MojrTWM2OD1yLke1O{DPxE1? M1PrfFI{PjR2MkGw
K562 MkLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITaZ|NFVVOR NF3nOoNKSzVyPUCuOlQ2KM7:TR?= MmD3NlM3PDR{MUC=
GBC-SD MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrvUok2KM7:TR?= NHPvNHI4OiCq M{PQd2ROW09? MmPUTWM2OD1zND64JO69VQ>? NHjSTlUzOzdyN{K2NC=>
HGC27 NFrhPHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVy1JO69VQ>? MWm3NkBp M3n0WGROW09? MoDoTWM2OD13LkSg{txO M1fpVVI{PzB5Mk[w
HL60 NYXIWYZHU2mwYYPlJGF{e2G7 MmTGOUDPxE1? MkexNlQhcA>? NED5VGFFVVOR MYrJcohq[mm2aX;uJI9nKEiGQVO= MUOyN|cxPzJ4MB?=
Vero NXjTUXppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXiZ|doPzJiaB?= MmfnSG1UVw>? Mo\YTWM2OD1yLkmg{txO MonENlM4QDZ2NUK=
NCI60 NGTsTGREgXSxdH;4bYMhSXO|YYm= MoD6OFghcA>? M4PzZWROW09? NVPuOIxNT0l;MD61N{DPxE1? NEe0TIgzPDBzNUOyOy=>
SW620 NI\ZVlZEgXSxdH;4bYMhSXO|YYm= MYW0PEBp MmfsSG1UVw>? MWnHTV0xNjV2IN88US=> NWrkXm53OjRyMUWzNlc>
U251 NWLrXFhSS3m2b4TvfIlkKEG|c3H5 M3y4U|Q5KGh? NHnpVWZFVVOR MUfHTV0yNjV|IN88US=> MorGNlQxOTV|Mke=
KM12 NX[3OWpRS3m2b4TvfIlkKEG|c3H5 Mo\GOFghcA>? MYfEUXNQ MmnjS2k:OS56ODFOwG0> MkH3NlQxOTV|Mke=
Hs578T MlzxR5l1d3SxeHnjJGF{e2G7 M1jBXVQ5KGh? M3nE[GROW09? NGTGOWVIUT12LkizJO69VQ>? NFSzVpUzPDBzNUOyOy=>
MDA-MB-231 NHjkeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3myTVQ5KGh? MWnJR|UxRTBwMU[g{txO MYGyOFA6PTBzNh?=
MCF7 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHn1RXk1QCCq MXjHTV0xNjR3IN88US=> M3G3cFI1OTF7NUW1
MDA-MB-435 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\HbnI1QCCq NUmyR2ZxT0l;MD64PEDPxE1? NU\QUG9IOjRzMUm1OVU>
AsPC1 NEHYbXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH1N|Ah|ryP MXy0PEBp NWK0bnJoTE2VTx?= NH7je3hKSzVyPUOuOlYh|ryP NUTsRmdmOjRzOEWzO|g>
Jurkat E6.1 NGS0S2xMcW6jc3WgRZN{[Xl? NVfKNpJlOiCq NXjaSJVtTE2VTx?= NX;EUIJ4UW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= NGDPR4IzPDJ4MUi2Ni=>
KG1 M4HjUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonlOFghcA>? NGXDR21KSzVyPUGuNVUh|ryP MWiyOFUzPTByMx?=
HEL NYiwU3J4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX6OFghcA>? NWjvSWZ{TE2VTx?= MYLJR|UxRTBwNEmg{txO NXLFO3p6OjR4OUSwOVU>
HSC3 Mlr1R5l1d3SxeHnjJGF{e2G7 MWGxNkBp MmX5SG1UVw>? NVjhWI83UUN3ME2wMlcyKM7:TR?= M3TwOVI1PzZ4NU[w
HT-29 M{DGNmN6fG:2b4jpZ{BCe3OjeR?= M4TKO|EzKGh? NYOwXJEyTE2VTx?= M17USmlEPTB;MD63NkDPxE1? M1zYSFI1PzZ4NU[w
KB M1TKb2N6fG:2b4jpZ{BCe3OjeR?= Mo\rNVIhcA>? M4DKV2ROW09? NVvpO4RwUUN3ME2wMlc2KM7:TR?= MnrsNlQ4PjZ3NkC=
H460 M4[2UGN6fG:2b4jpZ{BCe3OjeR?= NYHEOoxEOTJiaB?= NXvwSoFiTE2VTx?= NVy5Vo1lUUN3ME2wMlgzKM7:TR?= NYfmXm84OjR5Nk[1OlA>
MONE1 MknJR5l1d3SxeHnjJGF{e2G7 MojUNVIhcA>? NGP4N3RFVVOR M4rTTWlEPTB;MT6xPEDPxE1? MUiyOFc3PjV4MB?=
MKN45 NGrJS5BEgXSxdH;4bYMhSXO|YYm= MXGxNkBp NFPaXZhFVVOR MUjJR|UxRTFwMkWg{txO M4\wOFI1PzZ4NU[w
TSGH NWfWUYVqS3m2b4TvfIlkKEG|c3H5 MmPPNVIhcA>? NVzxZ4M1TE2VTx?= MWHJR|UxRTJwMEmg{txO MVKyOFc3PjV4MB?=
HL60 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nucVczKGh? NHexeFBFVVOR NE\3[HVIUTVyPUCuPVMh|ryP Mmr1NlQ6ODB3MEC=
HEK293 NYLkWZBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL1O|IhcA>? M1z0bmROW09? NHH5cYpIUTVyPUGzJO69VQ>? MUeyOFkxODVyMB?=
Jurkat MYXDfZRwfG:6aXOgRZN{[Xl? NV70Sot3OTByIN88US=> NX:wV5h4PzJiaB?= M1nEbmdKPTB;MD65JO69VQ>? MlPjNlQ6ODB5NEO=
GM15850 MYrLbY5ie2ViQYPzZZk> NVm3fJZnOi53IN88US=> MYi5OkBp MXzEUXNQ NGHE[XZld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhOTRiYXPleJlt[XSrb36gc4YhTliQIHflcoU> NVPqVVd5OTZ7MkGzOlc>
GM15850 NY\qRodEU2mwYYPlJGF{e2G7 MoLVNk42KM7:TR?= MnLqPVYhcA>? NVexc3BWTE2VTx?= M3LZbIRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MUexOlkzOTN4Nx?=
GM15850 MXfLbY5ie2ViQYPzZZk> MoPzNk42KM7:TR?= MVm5OkBp NIrUS3hFVVOR NWL3V5V6\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF{IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m MXuxOlkzOTN4Nx?=
GM15850 M{jvcGtqdmG|ZTDBd5NigQ>? NH\x[Y0zNjVizszN MljNPVYhcA>? NFLTPWZFVVOR MnLr[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MYqxOlkzOTN4Nx?=
GM15850 NIjYZ|RMcW6jc3WgRZN{[Xl? MUWyMlUh|ryP Mln3PVYhcA>? M1XoR2ROW09? NVjoVlZZ\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDhiYXPleJlt[XSrb36gc4YhTliQIHflcoU> NF7TZYwyPjl{MUO2Oy=>
GM15850 MoLLT4lv[XOnIFHzd4F6 M3HXW|IvPSEQvF2= MYS5OkBp MkDFSG1UVw>? NH7W[Vlld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhOTZiYXPleJlt[XSrb36gc4YhTliQIHflcoU> M3v5Z|E3QTJzM{[3
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U937 NYDtV3c5U2mwYYPlJGF{e2G7 M17l[VUh|ryP MVKyOEBp NGTNRmNFVVOR MWXoZZMhdm9iZX\m[YN1KG:wIHHsdIhiKHS3YoXsbY4h[WOndInsZZRqd25? MXGxO|Q1Pzd3MB?=
U937 M1XUeWtqdmG|ZTDBd5NigQ>? NFmybmcyKM7:TR?= NW\ncJo5OjRiaB?= NXfDe4x{TE2VTx?= NEXkfldp[XNibn:g[YZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= M17TUlE4PDR5N{Ww
PANC1 NYjUbmZmTnWwY4Tpc44hSXO|YYm= NGrhNlQyKM7:TR?= MUCyOEBp NXXCSXdP\G:nczDuc5QhcW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> MWixO|U5QDd2NB?=
PANC1 NYHWOI8{TnWwY4Tpc44hSXO|YYm= MUKxJO69VQ>? Ml61OFghKGh? NXfHRWky\G:nczDuc5QhcW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> M33GclE4PTh6N{S0
Caco-2 MkfZSpVv[3Srb36gRZN{[Xl? M17N[|Uh|ryP NYP4[HE2OjRiaB?= M2r3emROW09? NYDDfIZL\G:nczDuc5QhcW6mdXPlJHAzOVeDRkGg[4Vv\SCneIDy[ZN{cW:w NGLnSI0zODF2M{i0NC=>
SCC4 Ml7aSpVv[3Srb36gRZN{[Xl? M{fFT|Eh|ryP M3PLRlExKG2rbh?= NUXGNoZVTE2VTx?= M33FN4hieyCwbzDh[49vcXO2IHHjeIl3cXS7IHH0JHZFWiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhS1mSMkSg[4Vv\SCneIDy[ZN{cW:w MYmyNFQ2OjJ{NR?=
A549 M3XmOWZ2dmO2aX;uJGF{e2G7 NIW3dHQ2KM7:TR?= NXzsdGhxOyCq MW\EUXNQ M4TJe4Rw\XNibn;0JIlv\HWlZTDheZRweGijZ4mgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> MkPNNlA5PTV{MEi=
HCT116 M4XSNGtqdmG|ZTDBd5NigQ>? M3vjZ|AvOyEQvF2= MUWzNEBp NVLNUopPTE2VTx?= MWTkc4V{KG6xdDDpcohq[mm2IFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= MoLhNlExQDB4NEe=
HepG2 MlT2SpVv[3Srb36gRZN{[Xl? NEjkXG8yOCEQvF2= MkKxNlQhcA>? M4LNOWROW09? NHfoVYxld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KGi7cHXyZYNmfHmuYYTpc44hd2ZicEWz Mn3YNlE2PDh3OEK=
GM11272 NFrTRmdHfW6ldHnvckBCe3OjeR?= NInBVZIxNjFizszN MofwO|IhcA>? MUXEUXNQ MV3kc4V{KG6xdDDy[YFkfGm4YYTlJG1mS3B{IH31eIFvfCCneIDy[ZN{cW:w MXqyNVg1ODdzNh?=
MDA-MB-231 NV;TfYRCU2mwYYPlJGF{e2G7 NHnzSlUyOCEQvF2= M17JSVUhdWmw NFjKRW5FVVOR MnTv[I9meyCwb4SgbY5pcWKrdDDISGFEOmF? MmHrNlM1QTN2NEm=
MDA-MB-231 M4HXUmtqdmG|ZTDBd5NigQ>? NXX3U5lrOSEQvF2= NUj6dm45OjRiaB?= M3LZTGROW09? Mk\Y[I9meyCwb4SgbY5pcWKrdDDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> NUjYXZd3OjN2OUO0OFk>
K562 M2fHXWtqdmG|ZTDBd5NigQ>? MXrkc4V{KG6xdDDpcohq[mm2IFjERWM> NVLodHRWOjN3OUGxNVE>
Jurkat MnH4R5l1d3SxeHnjJGF{e2G7 MV6yNEDPxE1? NIjveFA4OiCq MXrEUXNQ MmDoco8h[3m2b4TvfIlkcXS7IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;u M{jJO|I1OzB2M{S4
HCT116 Mn7aRZBweHSxc3nzJGF{e2G7 M4i3O|Mh|ryP M1PWW|I1KGh? MoeySG1UVw>? NHHJU4pld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIC1N{Bxem:2ZXnuJIxmfmWu NVTRU|BpOjR5Nk[1OlA>
KASUMI-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDNOWZKUUN3ME25PU4yPyCwTR?= NGXvdWlUSU6JRWK=
KARPAS-45 NF7oclRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnsZZg1UUN3ME2xO|MvQDlibl2= NV\RPYhIW0GQR1XS
BHT-101 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJ2ND6xPEBvVQ>? MoHKV2FPT0WU
H9 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTBTmtmUUN3ME2yOVUvODRibl2= MVjTRW5ITVJ?
PA-1 MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jEVGlEPTB;Mki2MlI3KG6P MUXTRW5ITVJ?
NEC8 M12zZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M323emlEPTB;Mki5MlM5KG6P NYnUVGRmW0GQR1XS
MHH-PREB-1 M1;jRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDYSnlKSzVyPUK5OE42OyCwTR?= NFvkZlZUSU6JRWK=
NB7 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7uPXdKSzVyPUO0OU44PCCwTR?= NEXKTZpUSU6JRWK=
A3-KAW M4[xOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;JWnBKSzVyPUSwNE42QSCwTR?= NGL2PG1USU6JRWK=
NB69 NUjPNIFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTRzMT63NUBvVQ>? MoTOV2FPT0WU
EoL-1-cell NEfCUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P6PWlEPTB;NEW0NlUhdk1? MUfTRW5ITVJ?
CHP-212 M3L0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml35TWM2OD12NUeuOVMhdk1? M1\GNnNCVkeHUh?=
C2BBe1 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PUZWlEPTB;NEeyMlE6KG6P M{nkOnNCVkeHUh?=
697 Mkf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\veXBKSzVyPUS3N{41OSCwTR?= MonwV2FPT0WU
BCPAP MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\yZmZkUUN3ME21NFEvPDJibl2= MkDLV2FPT0WU
L-363 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX0TWM2OD13MEOuNUBvVQ>? MY\TRW5ITVJ?
ES8 NF\S[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTV{Mz61N{BvVQ>? M1u0d3NCVkeHUh?=
BE-13 NGjlUm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTjTWM2OD13Mk[uPVYhdk1? NHf4fnJUSU6JRWK=
CTB-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL1cXQ1UUN3ME21N|cvQTJibl2= NFTlOmFUSU6JRWK=
HD-MY-Z M2roPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTV|OD6xN{BvVQ>? NW\5eXVCW0GQR1XS
NKM-1 NVrtOGdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXkeYh1UUN3ME21OFQvOjdibl2= NX\TfWp3W0GQR1XS
NCI-H720 MmG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHRSW1kUUN3ME21OlAvOThibl2= MWnTRW5ITVJ?
KY821 NFjzWYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWn3ZY9RUUN3ME21OlMvOjVibl2= M2nhUXNCVkeHUh?=
OVCAR-5 NHXOS5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTV5Nj6xNUBvVQ>? M2XEcHNCVkeHUh?=
CTV-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTV6MT61OkBvVQ>? M3joRnNCVkeHUh?=
P12-ICHIKAWA MkX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP4OIJEUUN3ME21PVYvPTFibl2= NUHaSmRRW0GQR1XS
DB M4XiSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTV7OD61O{BvVQ>? NIWxdpVUSU6JRWK=
CHL-1 NV7BOXdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PoVmlEPTB;NkSyMlA5KG6P MlLaV2FPT0WU
A4-Fuk M{TOZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTZ2ND65NUBvVQ>? M3PrWHNCVkeHUh?=
MV-4-11 NHLUbIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO3NlYzUUN3ME22OVkvOSCwTR?= MX\TRW5ITVJ?
RPMI-8226 MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPi[nZKSzVyPU[3PE4yQCCwTR?= MUXTRW5ITVJ?
NB14 M2Pubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTZ7Nj65OUBvVQ>? MnX2V2FPT0WU
DOHH-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDN[WxKSzVyPUewOk43QCCwTR?= NYfFblVpW0GQR1XS
D-423MG NVq5b5ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTdyNj64PUBvVQ>? M4PRWHNCVkeHUh?=
D-283MED Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW5NnFKSzVyPUexOE4yPCCwTR?= NYCzeI1VW0GQR1XS
ES1 NVTyRnNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDP[Jk1UUN3ME23NlQvPCCwTR?= NG\0V4hUSU6JRWK=
GOTO NHTXTlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzzNJpKSzVyPUeyPU4yOiCwTR?= NH71OGdUSU6JRWK=
NCI-H209 M1fvcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDUTWM2OD15MkmuPUBvVQ>? M2HCRnNCVkeHUh?=
MOLT-13 M2Pjc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYSzUlJiUUN3ME23N|gvQThibl2= MWPTRW5ITVJ?
ATN-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC3TWM2OD15NECuNlghdk1? MoTiV2FPT0WU
DU-4475 NV7pWVg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTd3MT65NUBvVQ>? MXfTRW5ITVJ?
NB10 NHXRSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn5PJVKSzVyPUe1NU46OiCwTR?= MV\TRW5ITVJ?
KG-1 NF3rRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDWTWM2OD15N{WuOFUhdk1? MnrhV2FPT0WU
MOLT-4 MnW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnPRm1KSzVyPUe4O{41PiCwTR?= Mni3V2FPT0WU
TE-1 M1HQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jsSmlEPTB;N{mxMlEhdk1? NFTHXo1USU6JRWK=
SBC-1 M2njdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTjXYV5UUN3ME23PVMvQDRibl2= NVjEPIp6W0GQR1XS
HEL NVrjVJRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmL0TWM2OD16ME[uNFghdk1? MmfzV2FPT0WU
SK-MEL-2 NHraeGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHmTWM2OD16MEmuOFQhdk1? NXnLVFc4W0GQR1XS
KU812 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q0NGlEPTB;OEGzMlEhdk1? MXXTRW5ITVJ?
RPMI-8866 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LKeWlEPTB;OEGzMlY4KG6P Mo\TV2FPT0WU
ALL-PO NWXSNm9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHT1b41KSzVyPUixOE43PiCwTR?= MoDXV2FPT0WU
LU-139 NFPHS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\OPGRKSzVyPUiyNk45PiCwTR?= MXLTRW5ITVJ?
RS4-11 NIDUcllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPFXlZUUUN3ME24N|IvPDVibl2= Mn3IV2FPT0WU
EW-18 NGLlVYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3NTWM2OD16M{KuPVYhdk1? M4XGW3NCVkeHUh?=
P30-OHK Ml3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTh|NT63JI5O Mnm5V2FPT0WU
D-566MG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnnTWM2OD16M{iuOlIhdk1? MVHTRW5ITVJ?
HSC-4 NIDhb3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1m5bWlEPTB;OES2MlUyKG6P MVzTRW5ITVJ?
QIMR-WIL M4nXT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfQTWM2OD16NkKuNFMhdk1? NFiyN2RUSU6JRWK=
SW954 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HOUWlEPTB;OE[zMlE3KG6P NFHhWXpUSU6JRWK=
HGC-27 NX7HSnJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXYW2txUUN3ME24O|IvOzRibl2= NVjhZm9wW0GQR1XS
HH MnrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3SyeGlEPTB;OEm0MlEzKG6P MkflV2FPT0WU
KE-37 MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nOTGlEPTB;OEm0MlYzKG6P M4DEW3NCVkeHUh?=
SK-N-DZ MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXhd|VKSzVyPUmwNE41OyCwTR?= NX\qZoNYW0GQR1XS
J-RT3-T3-5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTlzMD60PUBvVQ>? NUnNVHljW0GQR1XS
A427 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzFdlFKSzVyPUmyNE45PCCwTR?= NUnzPWRYW0GQR1XS
ECC10 M2PVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP0TWM2OD17NEWuPFchdk1? M{[1Z3NCVkeHUh?=
EW-1 M1fWPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\LXIpKSzVyPUm0O{4zPiCwTR?= M13VOHNCVkeHUh?=
MIA-PaCa-2 M4LIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPMO4RKSzVyPUm0PU4yOiCwTR?= Ml25V2FPT0WU
HCC2218 NF3TPVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTl3OD60PEBvVQ>? Mn;pV2FPT0WU
HAL-01 MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDJT4ZKSzVyPUm2PE4xPCCwTR?= NWjhOlF[W0GQR1XS
RD MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIT4PXFKSzVyPUm3OE41PSCwTR?= M371XnNCVkeHUh?=
SK-N-AS M{HONGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTl6OD6xJI5O NU\RXWd{W0GQR1XS
ML-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXMOI9UUUN3ME2xMlAxPDB5IN88US=> M2nG[nNCVkeHUh?=
MEL-HO MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjSdlBKSzVyPUGuNFA2QDJizszN MYXTRW5ITVJ?
MS-1 MkfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojJTWM2OD1zLkCwOlE4KM7:TR?= Mom3V2FPT0WU
NCI-SNU-1 M4DGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFOwemxKSzVyPUGuNFI{OzFizszN MYnTRW5ITVJ?
8505C NIH6W4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnkeWV1UUN3ME2xMlAzOzNzIN88US=> MU\TRW5ITVJ?
MN-60 NFTSWG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK4TWM2OD1zLkCyOlgh|ryP NF3KT2ZUSU6JRWK=
SAS NIHJbVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS3S|lKSzVyPUGuNFQxQDFizszN NEK5c2VUSU6JRWK=
EFM-19 NX\ZO2h{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKxTWM2OD1zLkC0PFc6KM7:TR?= Mlf3V2FPT0WU
Ca9-22 MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTGTWM2OD1zLkC1NVA4KM7:TR?= MVXTRW5ITVJ?
NBsusSR NFqxV21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwMEWxOlYh|ryP NWS1S2VJW0GQR1XS
NB13 Mm\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP4e3ZYUUN3ME2xMlA2PTBzIN88US=> MWXTRW5ITVJ?
SF295 MlzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYS3eIs4UUN3ME2xMlA3PjJ2IN88US=> NH;tfFNUSU6JRWK=
U-2-OS NH\kNYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTFwMEe5NVEh|ryP M3HtcXNCVkeHUh?=
NCI-H526 NH3zZmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P6RWlEPTB;MT6wPFI6OSEQvF2= M3raVXNCVkeHUh?=
KMOE-2 M2fzVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkezTWM2OD1zLkC5OFIzKM7:TR?= NXf1fZJyW0GQR1XS
RCM-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPmeHVKSzVyPUGuNVIyODJizszN NVHFV|d[W0GQR1XS
MC116 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jIW2lEPTB;MT6xN|YzOSEQvF2= NIex[WJUSU6JRWK=
NCI-H1092 M4\zeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7vTWM2OD1zLkG1OFA3KM7:TR?= M1O1N3NCVkeHUh?=
EW-3 M37qVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH0RZN4UUN3ME2xMlE4OjF{IN88US=> MlPDV2FPT0WU
HCT-116 NX3zWGQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HGTmlEPTB;MT6xO|c2KM7:TR?= M{PBPXNCVkeHUh?=
MC-IXC M1\oZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXlTWpIUUN3ME2xMlE4QDhzIN88US=> M2jNUHNCVkeHUh?=
LB1047-RCC NIjlbI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXKTWM2OD1zLkG4N|EzKM7:TR?= NVjmZpRXW0GQR1XS
VM-CUB-1 M{Hq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPWU|dKSzVyPUGuNVkyODhizszN NHHl[VNUSU6JRWK=
NB5 Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rPPWlEPTB;MT6xPVg2PiEQvF2= MkfnV2FPT0WU
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CAL-12T MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[xZmg4UUN3ME20MlE{OTB|IN88US=> MYrTRW5ITVJ?
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HMV-II NH7XZXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\SdmlEPTB;ND61NVc{KM7:TR?= NI\OSm5USU6JRWK=
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OAW-28 MlqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrOWFh2UUN3ME20MlU5Ozl6IN88US=> M2LrS3NCVkeHUh?=
OCI-AML2 NHTF[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PBTGlEPTB;ND62OVI{QCEQvF2= MVzTRW5ITVJ?
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LK-2 M2LVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLxTWM2OD1zMD60NlA5KM7:TR?= M2LEWHNCVkeHUh?=
SF126 MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXLSYpnUUN3ME2xNE41PzJ5IN88US=> MXzTRW5ITVJ?
SK-MEL-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnyTWM2OD1zMD63PFM5KM7:TR?= NIX1WolUSU6JRWK=
ACN NVPadoU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L1ZmlEPTB;MUCuPFY4QSEQvF2= M{DNNnNCVkeHUh?=
BB30-HNC M2i5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTFyLki3NVEh|ryP NWjITJN{W0GQR1XS
NCI-H747 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXZfmVKSzVyPUGwMlg4PDZizszN M37xdXNCVkeHUh?=
KYSE-150 NIPNc3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXuTWM2OD1zMT6wN|g4KM7:TR?= M2SxZnNCVkeHUh?=
D-247MG M4m4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELRfXBKSzVyPUGxMlExODlizszN MlTOV2FPT0WU
BxPC-3 NW[5VI5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4KybGlEPTB;MUGuN|c1PyEQvF2= MonuV2FPT0WU
SK-MEL-30 NWCxZ4V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVX6bFhZUUN3ME2xNU41ODd7IN88US=> NXLG[5ZVW0GQR1XS
CAS-1 M1TtSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XnSmlEPTB;MUGuOFExQSEQvF2= MUHTRW5ITVJ?
no-10 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\DZWlEPTB;MUKuNVIyPyEQvF2= M1;ae3NCVkeHUh?=
NCI-H2405 MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF{LkKwN|Yh|ryP M1G3SHNCVkeHUh?=
KGN NV7GVWt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnEUIFQUUN3ME2xNk4zQTBzIN88US=> NE\WZ4VUSU6JRWK=
BB49-HNC NHfrTmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXvTWM2OD1zMj6zPVU3KM7:TR?= NHfvU4lUSU6JRWK=
NCI-H1693 NWfiSog{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTF{LkW4NVYh|ryP MUHTRW5ITVJ?
RO82-W-1 NHfyUJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j2[2lEPTB;MUOuNFY1QSEQvF2= MnHPV2FPT0WU
CAL-85-1 NX\4[XpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;IdJJKSzVyPUGzMlQ{QTlizszN MonNV2FPT0WU
H-EMC-SS MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPXO5hKSzVyPUGzMlkyODRizszN NEXSVmdUSU6JRWK=
SW1783 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnDSWFKSzVyPUG0MlI{QTFizszN NXLzRYxmW0GQR1XS
LB771-HNC MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF2LkSxPUDPxE1? MmnrV2FPT0WU
HCC70 M4DKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTF2LkSyN|Mh|ryP NEi4bllUSU6JRWK=
KNS-81-FD NX;jb5FxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXvUHVKSzVyPUG0MlcxPDVizszN NUXLbog4W0GQR1XS
KYSE-520 M1;NR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjmTppKSzVyPUG0MlkzPyEQvF2= MkO2V2FPT0WU
TGBC24TKB NYLwbJA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvLVWhKSzVyPUG0Mlk2OzlizszN MWfTRW5ITVJ?
SNB75 NX7UbZVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnlPIQ3UUN3ME2xOU4xPzJ7IN88US=> NH3USFFUSU6JRWK=
SW872 M{DIR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4K2cGlEPTB;MUWuNlIyQCEQvF2= M1;uNnNCVkeHUh?=
U031 NGLRWHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLPTWM2OD1zNT64NFI5KM7:TR?= NV;nXno3W0GQR1XS
ChaGo-K-1 MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PrZ2lEPTB;MUWuPFM2QSEQvF2= NYCyU5pCW0GQR1XS
NCI-H441 NEnzXWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3CXopKSzVyPUG2MlAxOzlizszN M{PKenNCVkeHUh?=
TE-12 MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPqTWM2OD1zNj6xPFc{KM7:TR?= M1ezU3NCVkeHUh?=
NCI-H1755 NEXVempIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjQNolKSzVyPUG2MlU4OyEQvF2= MVHTRW5ITVJ?
KNS-42 M1PNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHSwS2NKSzVyPUG2MlY2QDlizszN NW\CS2pRW0GQR1XS
SK-PN-DW MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7jfIFKSzVyPUG3MlQzODFizszN MVfTRW5ITVJ?
NCI-H226 MoPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Ppc2lEPTB;MUeuPVM1PSEQvF2= MVjTRW5ITVJ?
K-562 Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTF6Lk[zNVch|ryP MVPTRW5ITVJ?
A388 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nIW2lEPTB;MUmuNFMxOyEQvF2= M4\ST3NCVkeHUh?=
ZR-75-30 MlP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn3O29JUUN3ME2xPU4xQTZ6IN88US=> NWXXNHR7W0GQR1XS
LU-135 NEHwWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHoTWM2OD1zOT6yOlM3KM7:TR?= MmrGV2FPT0WU
NCI-H2029 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjBZlJlUUN3ME2xPU43ODJzIN88US=> MYTTRW5ITVJ?
HT-1197 NF3GdWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnRVoVKSzVyPUG5MlkzOjdizszN Mo\oV2FPT0WU
IGR-1 NIfVUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTCVJlKSzVyPUKwMlMyOTdizszN NWm5[2pPW0GQR1XS
U-87-MG MnG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJyLk[0NVMh|ryP MWjTRW5ITVJ?
NCI-H1304 NXnkbIJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLrcldKSzVyPUKwMlc2ODFizszN MYDTRW5ITVJ?
RCC10RGB MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\vTWM2OD1{MT6yPFI6KM7:TR?= M2fETnNCVkeHUh?=
NCI-H520 M{nQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTUTWM2OD1{Mj63OlEyKM7:TR?= NXe0Wo81W0GQR1XS
SK-LU-1 NEixZ21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofJTWM2OD1{Mz6wO|E5KM7:TR?= MX;TRW5ITVJ?
UACC-893 NFfpb|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvvbZlKSzVyPUKzMlExOzhizszN NYjGVGEyW0GQR1XS
NCI-H2347 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrHTWM2OD1{Mz6yOlc1KM7:TR?= MlnQV2FPT0WU
U-118-MG NWPYbVdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDsdVZEUUN3ME2yN{44OjF5IN88US=> MXLTRW5ITVJ?
NCI-H596 NFX3SGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTJ|LkmwOVUh|ryP MVTTRW5ITVJ?
MZ1-PC M{CybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPDd5hKSzVyPUK0MlY4PTlizszN MVTTRW5ITVJ?
SW1417 NVTwWGRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJ3LkK0PVgh|ryP NVG5[2NqW0GQR1XS
NCI-H82 MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJ4LkSyPFgh|ryP NXnGR3dIW0GQR1XS
COLO-678 MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXCflNSUUN3ME2yO{41QTF7IN88US=> NWW5bYlEW0GQR1XS
KURAMOCHI M{TPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7HPXk6UUN3ME2yPE4yOjZizszN Mm\oV2FPT0WU
NCI-H1650 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\VTWM2OD1|MD6xPVI1KM7:TR?= Mk\SV2FPT0WU
HCC1954 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzJRVBKSzVyPUOxMlM3PjZizszN MWTTRW5ITVJ?
GAK MlPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7zTGk6UUN3ME2zNk4zPjF4IN88US=> M4P6b3NCVkeHUh?=
YAPC NEPaUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHufZlYUUN3ME2zN{44PjR6IN88US=> M1PCPHNCVkeHUh?=
NCI-H2228 M3Ltc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\oTYtjUUN3ME2zOE4{PjB3IN88US=> M4fTbnNCVkeHUh?=
VMRC-RCZ M1KzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTN4LkOwNlIh|ryP MVzTRW5ITVJ?
NMC-G1 MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTN5LkC1Nlkh|ryP Mm\UV2FPT0WU
D-336MG NX3WTGprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\2UmlEPTB;NEGuPFQ1OiEQvF2= NFm4[nhUSU6JRWK=
UACC-62 NYXId41GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\GTWM2OD12Mj61OVA2KM7:TR?= MXfTRW5ITVJ?
C-33-A NX6zRlY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnrc25KSzVyPUS1MlMzPTZizszN NXzq[WhlW0GQR1XS
HCC1937 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPNZZJNUUN3ME20O{4yQTV6IN88US=> MnLsV2FPT0WU
HDLM-2 M4LSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHJTWM2OD12Nz6yNlg4KM7:TR?= NHTqUppUSU6JRWK=
NCI-H727 NEO1fWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDJTWM2OD12Nz6yOFUyKM7:TR?= NEficYNUSU6JRWK=
NY NHK2RXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTR7LkO5NFgh|ryP NHi5Z|FUSU6JRWK=
NCI-H2291 M3\nSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLmTWM2OD12OT64N|AyKM7:TR?= Mk\YV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+ddH2O
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID