Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 99 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M1;v[2tqdmG|ZTDBd5NigQ>? NHHWXHMyKGh? NWXyR|BDTE2VTx?= MYjhcpRqNUiGQVOxJIFkfGm4aYT5JJdqfGhiSVO1NEBw\iByLkGxNkDPxE1? M4fse|EyQTZyNEi5
Friend leukemic cell NHfoTVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInwRmk2OCEQvF2= NF[0WYo4OiCq NH\nbnlFVVOR NXzWXopEUUN3ME2wMlk6KM7:TR?= NEiySGoyOjFyOUmxNy=>
K562 NITyWVJMcW6jc3WgRZN{[Xl? NHHqU|Y3KGh? NGnrbVVFVVOR MXfJcohq[mm2aX;uJI9nKGi3bXHuJIhqe3SxbnWg[IVi[2W2eXzhd4UhMG2reIT1doUhd2ZiSFTBR|Eh[W6mIFjERWMzMSC5aYToJGlEPTBib3[gNE4xOSEQvF2= M4jqRlEzPDF7M{iw
HT1080 Mn7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHsOoFvPzJiaB?= NIPucmdFVVOR MXHJR|UxRTJwNDFOwG0> MV[xNlI4ODF5NR?=
H1299 NXPTPFlIU2mwYYPlJGF{e2G7 NXryO5ppOjBibXnu NF3YZpBFVVOR NHi0XpRKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> MWWxOFUzOTR{Mh?=
H1299 NVrte4s3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHOyZmg4OiCq MWDEUXNQ NHjFRWJKSzVyPUeuNlQh|ryP NWrhOHFuOTR3MkG0NlI>
HeLa M13F[WtqdmG|ZTDBd5NigQ>? MUOzNEBucW5? M1mwdWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHjpd5RwdmViZHXhZ4V1gWyjc3Wge4l1cCCLQ{WwJI9nKDBwMkig{txO NF3vfYwyPTZyM{m0PS=>
LOX-IMVI NXHyTG1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[0PEBp M{fDRmlEPTB;MT6zJO69VQ>? MX[xOVcyPTR5MB?=
NCI-H226 NV3QZ|J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PSZVQ5KGh? M1TJW2lEPTB;Mj62JO69VQ>? NXfPfnZwOTV5MUW0O|A>
RXF-631L MkLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVe0PEBp MlrKTWM2OD1{IN88US=> MlHGNVU4OTV2N{C=
SNB-78 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnCRpM1QCCq NIO3VYVKSzVyPUG2JO69VQ>? MofoNVU4OTV2N{C=
St-4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPndItHPDhiaB?= Ml7QTWM2OD13LkKg{txO MXSxOVcyPTR5MB?=
ARP1 NIe0[oxHfW6ldHnvckBCe3OjeR?= M4DRRVIh|ryP MmLwOkBp MojiTY5lfWO2aX;uJI9nKFB{MWfBSlEh\2WwZTDlfJBz\XO|aX;u M2LuVFE1PzN2OEC2
CEM NHjzO|lMcW6jc3WgRZN{[Xl? NHuyRXgyKGh? M{TxWWROW09? MXfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{Og{txO MorkNVY1OjByNkS=
HCT15 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUW0PEBp M{fud2dKPTB;MD64NkDPxE1? MmPXNVY4OjN{Mke=
NCI-H23 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlWzOFghcA>? MnPSS2k2OD1yLkmyJO69VQ>? Ml;XNVY4OjN{Mke=
GM15850 MUDLbY5ie2ViQYPzZZk> MoTyNk42KM7:TR?= MmDIPVYhcA>? MoTBSG1UVw>? NWXSPWo5UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MVqxOlkzOTN4Nx?=
GM15850 M{HPTmtqdmG|ZTDBd5NigQ>? NVvONoJFOi53IN88US=> MVW5OkBp NYHPNWdHTE2VTx?= M1O3TWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC1JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M3PMSVE3QTJzM{[3
GM15850 M3L0eGtqdmG|ZTDBd5NigQ>? MXqyMlUh|ryP M4jPdlk3KGh? NH7SUZBFVVOR MV\Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMUKgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? Mn\UNVY6OjF|Nke=
GM15850 NGfLT2pMcW6jc3WgRZN{[Xl? NVnESng5Oi53IN88US=> Mn;iPVYhcA>? NELoTYlFVVOR M3Xi[2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTC5JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M3nGfFE3QTJzM{[3
GM15850 NWCze24zU2mwYYPlJGF{e2G7 NYjGXIF7Oi53IN88US=> NHzN[XU6PiCq NGHkRmNFVVOR M1nMXGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NEfHemsyPjl{MUO2Oy=>
GM15850 NVTMN3RIU2mwYYPlJGF{e2G7 MljTNk42KM7:TR?= Ml[yPVYhcA>? NXrlXGxuTE2VTx?= MYTJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMU[gZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NVi5UY5bOTZ7MkGzOlc>
U937 MULGeY5kfGmxbjDBd5NigQ>? MmPsOUDPxE1? NGi3XnQzPCCq MnLmSG1UVw>? MXXD[YxtKGO7Y3zlJIFzemW|dDDifUBi[2O3bYXsZZRqd25iYYSgV{9IOi:PIIDoZZNm M2rIe|E4ODB2N{G4
H661 MmfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3pc4JQPDhiaB?= NV7Db3pxUUN3ME2xJO69VQ>? NFT3S|kyPzF3N{CwPS=>
U937 MmnMSpVv[3Srb36gRZN{[Xl? Mnq0OUDPxE1? M1[1VVI1KGh? NH\UZphFVVOR NUjSbW1FUW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> MoPvNVc1PDd5NUC=
U937 MUfGeY5kfGmxbjDBd5NigQ>? NYDSXY9UOSEQvF2= MVGyOEBp NYPLWppzTE2VTx?= NIS1eW5G\m[nY4Sgc44h[WyyaHGgeJVjfWyrbjDhZ4V1gWyjdHnvci=> M33hVVE4PDR5N{Ww
RAW264.7 MlTLSpVv[3Srb36gRZN{[Xl? MXOxNEDPxE1? NEnrOXMzPGh? NWnUVHFXf2G2ZYK= NF[3UJVKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN NV:5fJhkOTd2N{e1NVg>
RAW264.7 M{iyW2Z2dmO2aX;uJGF{e2G7 NEfsSWoyOCEQvF2= NFXXZW8zPGh? MmHEe4F1\XJ? M1jabWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> MoTlNVc1Pzd3MUi=
SC9 NH7yT2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXO0PEBp NGnnNlBKSzVyPUCuOlA3KM7:TR?= NGC4WYkyPzVyN{KxPS=>
ST14A M3fje2Z2dmO2aX;uJGF{e2G7 NEi1Spo2KG6P NHH1ZmI4OiCq M{HqS2lv[3KnYYPlJIlvKFKHU2SvUnJUTiCvUl7BJIV5eHKnc4Ppc44> MnTDNVc2PjV7OUO=
ST14A NWriVllVTnWwY4Tpc44hSXO|YYm= M2LyUlUhdk1? M335b|czKGh? M17Nfmlv[3KnYYPlJIlvKEV{RkGgcXJPSSCneIDy[ZN{cW:w NH;mfmUyPzV4NUm5Ny=>
PANC1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTEcGNSOSEQvF2= NFrrXHFKSzVyPUCuOFUh|ryP NFfTUGYyPzV6OEe0OC=>
PANC1 M1jtPWZ2dmO2aX;uJGF{e2G7 MlXsNUDPxE1? MX[yOEBp NWrwVXp2UW6lcnXhd4UhcW5icEKxW2FHOS:FSWCxJIdmdmViZYjwdoV{e2mxbh?= MV2xO|U5QDd2NB?=
PANC1 MVnGeY5kfGmxbjDBd5NigQ>? MlXzNUDPxE1? NED5SJczPCCq Mm\ETY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36= M{\BZ|E4PTh6N{S0
PT45 NHv5S25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWexdXZUUUN3ME20JO69VQ>? MV[xO|U5QDd2NB?=
ACHN M{XEcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWKyNUBp NUjETVRrT0l3ME2wMlY2KM7:TR?= MYixO|Y3OjZyNh?=
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SCC25 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rLfVczKGh? NUn2O45pUUN3ME2xMlk{KM7:TR?= Mn;zNlAyPDN5N{i=
SKHEP1 NHHpPWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV63NkBp NVjZXVJWUUN3ME2zMlQ3KM7:TR?= MVSyNFE1Ozd5OB?=
BJ NH:3WVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUftR5ZMOTByIN88US=> NY\BdIwzPDhiaB?= MkCxSG1UVw>? MYjHdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= MY[yNFE1Ozh2MB?=
MUF MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWOxNFAh|ryP M2L1RVQ5KGh? M3vHWGROW09? MWXHdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= M2PFV|IxOTR|OESw
Caco-2 NIHqSoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYSxNFAh|ryP MlrlOFhp M3nXNWROW09? MUDJR|UxRThwMTFOwG0> M2HJ[|IxOTR|OESw
Caco-2 MoTwT4lv[XOnIFHzd4F6 MnvHOUDPxE1? NELiOHE1KGh? M2HqXWROW09? NGjrNYtKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9vKEmFNUCgc4YhOC5yM{eg{txO NGHVSHIzODF2M{i0NC=>
Caco-2 MnO1T4lv[XOnIFHzd4F6 M3PhWFAvOzF4IH7NJJRwKDNzLk[g{txO M2fy[VQhcA>? MlnSSG1UVw>? NELjbWpGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Gge4l1cCCLQ{WwJI9nKDBwMUG5JO69VQ>? M3rnelIxOTR|OESw
Caco-2 MXTLbY5ie2ViQYPzZZk> NYjZNo51OC5|MU[gcm0hfG9iM{GuOkDPxE1? MWe0JIg> MkW5SG1UVw>? MlTFSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN|IIfpeIghUUN3MDDv[kAxNjF2NzFOwG0> NGfwfWkzODF2M{i0NC=>
Caco-2 NInPOmpMcW6jc3WgRZN{[Xl? NVTaR|I3Pi5|MjDuUUB1dyB4M{Kg{txO M4HwPVQhcA>? NYD3SlY6TE2VTx?= MoXNSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN3IIfpeIghUUN3MDDv[kAyOi54IN88US=> MXSyNFE1Ozh2MB?=
Caco-2 MVjLbY5ie2ViQYPzZZk> NUP6ZlBkPi5|MjDuUUB1dyB4M{Kg{txO MYW0JIg> M13P[WROW09? MVTFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzdid3n0bEBKSzVyIH;mJFQyKM7:TR?= MXiyNFE1Ozh2MB?=
Caco-2 NYC5bIFkU2mwYYPlJGF{e2G7 NYDs[ZB2OC5|MU[gcm0hfG9iM{GuOkDPxE1? MV:0JIg> NIrGcXhFVVOR M3O5TGV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNh?= M3XuelIxOTR|OESw
HepG2 M2KzUWtqdmG|ZTDBd5NigQ>? NInKN2I2KM7:TR?= M{DTSFZp MU\EUXNQ NGO1c4hKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9v MX6yNFE1Ozh2MB?=
HepG2 MlH4T4lv[XOnIFHzd4F6 MYq1JO69VQ>? MWe2bC=> NHr3dXNFVVOR NU\lZ3dIUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBpgXCncnHj[ZR6dGG2aX;u M4LMVVIxOTR|OESw
HepG2 M1r2PGtqdmG|ZTDBd5NigQ>? MmPZOUDPxE1? NYSwdm1PPmh? MojySG1UVw>? MkO3TY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= NXzXSG83OjBzNEO4OFA>
HepG2 Ml;4T4lv[XOnIFHzd4F6 NFraWoI2KM7:TR?= M1PxTVZp M{[0PWROW09? NUTQblBWUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhUDNxSESgbIl{fG:wZTDhZ4V1gWyjdHnvci=> M4XQTlIxOTR|OESw
COLO205 Mo\wT4lv[XOnIFHzd4F6 M2L5e|ExKM7:TR?= MnLINlQhcA>? MXjEUXNQ M2TiNmlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25id3n0bEBKSzVyIH;mJFIvOiEQvF2= MoDTNlA1PTF|N{i=
SCC4 MnT3T4lv[XOnIFHzd4F6 NWnyZ4hKOSEQvF2= NXrzXlR2OjSq NE\xVmVKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6geJVjfWyrbjDhZ4V1gWyjdHnvci=> MlLLNlA1PTJ{MkW=
SCC4 NVLIZZVPU2mwYYPlJGF{e2G7 NIDBXpgyKM7:TR?= MlHpNlRp MoHtTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViYXPleJlt[XSrb36= MXmyNFQ2OjJ{NR?=
SCC4 NYnLPXRETnWwY4Tpc44hSXO|YYm= MVqxJO69VQ>? NY\OZYd2PSCvaX6= Mk\TRYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= MUmyNFQ2OjJ{NR?=
NB4 MWfGeY5kfGmxbjDBd5NigQ>? NWTlcpBOPSEQvF2= NFHHN3EzPCCq NWnNfpJ1TE2VTx?= NI\OcpJE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl MYKyNFQ6OTR2MB?=
NB4 NUTwfph[U2mwYYPlJGF{e2G7 M4q5U|Uh|ryP NIL2OG0zPCCq MXPEUXNQ M{PXXWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? MVmyNFQ6OTR2MB?=
NB4 NV74[VE{TnWwY4Tpc44hSXO|YYm= MoO4OUDPxE1? M4nhOVI1KGh? MVzEUXNQ M2PFe2lv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> NIf5SlczODR7MUS0NC=>
NB4 NHrtTZRMcW6jc3WgRZN{[Xl? MW[1JO69VQ>? M4\DTlI1KGh? NWKz[oQ3TE2VTx?= MWLJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> M2L3d|IxPDlzNESw
NUGC3 M1;ydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\BWXloT0l3ME2yMlk1KM7:TR?= MorWNlA5PTB7N{G=
A549 MVHGeY5kfGmxbjDBd5NigQ>? NHX3Ulc2KM7:TR?= MoPGN{Bp MlfTSG1UVw>? NEXFXoVKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> MUiyNFg2PTJyOB?=
HUT78 M3W2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUK3NkBp NGr5U3hFVVOR Mnq0S2k2OD1yLkOg{txO NEjieVYzODh6NEKwPC=>
U937 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TlclczKGh? NHLs[ohFVVOR NHPUTpZIUTVyPUCuN|kh|ryP MnruNlA5QDR{MEi=
A431 NUDoTlFFS3m2b4TvfIlkKEG|c3H5 MkHFO|IhcA>? Mn7QR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjC0MlIh|ryP NVPHUWxXOjFyOEC2Nlk>
A549 MXHDfZRwfG:6aXOgRZN{[Xl? MYG3NkBp NF7UW5VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvQCEQvF2= MYqyNVA5ODZ{OR?=
CAL27 NH30VI1EgXSxdH;4bYMhSXO|YYm= M4XoR|czKGh? NYPFUIE2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> MnG5NlExQDB4Mkm=
HeLa M1XvcWN6fG:2b4jpZ{BCe3OjeR?= NVXzd5AzPzJiaB?= MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuOUDPxE1? NV3CelFXOjFyOEC2Nlk>
Sf21 MoHET4lv[XOnIFHzd4F6 MmSwN{Bp MYXJcohq[mm2aX;uJI9nKE[uYXegeIFo\2WmIHj1cYFvKHKnY3;tZolv[W62IFjERWM5KGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4zKM7:TR?= MXeyNVA5ODZ{OR?=
SKBR3 NHvEWpNEgXSxdH;4bYMhSXO|YYm= M3XRfFczKGh? MmT6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= NUX5[lJGOjFyOEC2Nlk>
SKOV3 MlX5R5l1d3SxeHnjJGF{e2G7 Mne1O|IhcA>? NVnaVmJpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi5{IN88US=> MX[yNVA5ODZ{OR?=
COR-L23 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LtXVExKM7:TR?= NX7jbINbPzJiaB?= MnX3SG1UVw>? NEjqdndIUTVyPUGuNUDPxE1? MknKNlExQDB4NEe=
DU145 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUCyT5NHOTBizszN M2ThSFczKGh? NYrmcYsyTE2VTx?= M2TZNmdKPTB;MT6wOUDPxE1? MVWyNVA5ODZ2Nx?=
LoVo MmDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrYSm9LOTBizszN M2nRe|czKGh? MV;EUXNQ Ml;rS2k2OD1zLkeg{txO NGq2OYkzOTB6ME[0Oy=>
MCR5-SV2 NFzqUFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2xNVAh|ryP M4fJUFczKGh? M4PoPGROW09? NVnrSIVnT0l3ME2yMlEh|ryP NYnIXWk5OjFyOEC2OFc>
HCT116 NYTvNnFSU2mwYYPlJGF{e2G7 NGjzPGg{OCEQvF2= NImyfGs{OCCq NFy1NppFVVOR MnizTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= M{HYR|IyODhyNkS3
HCT116 MonkT4lv[XOnIFHzd4F6 NVLhdFdtOzBizszN MoD0N|AhcA>? MX7EUXNQ NGLGeZhKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= MoPpNlExQDB4NEe=
U937 NFTWV|dMcW6jc3WgRZN{[Xl? M1zBZVUh|ryP NWTKTJNEOjRiaB?= NIfIWnhFVVOR NYCweohUUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= M{P5elIyOjl{NEmy
U937 M3KwdmtqdmG|ZTDBd5NigQ>? M1f4TVUh|ryP M2HFTFI1KGh? NYfYV|RuTE2VTx?= NXXqVGtvUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 NUfmb5VSOjF{OUK0PVI>
U937 MUXLbY5ie2ViQYPzZZk> NV2xfmxKPSEQvF2= MnLDNlQhcA>? MX7EUXNQ M3i5bGlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBx[W5vYXPleJlt[XSnZDDobZN1d26nIFi0JIxmfmWu MkX1NlEzQTJ2OUK=
U937 MX;LbY5ie2ViQYPzZZk> MUG1JO69VQ>? MXKxOUBucW5? NYrCNVJwTE2VTx?= NGmzOHJKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? Ml3sNlEzQTJ2OUK=
A2780 M3jodGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jIWFk3KGh? NV\v[4txTE2VTx?= Mon6TWM2OD1zLk[yJO69VQ>? NVnFT4lJOjF4M{S0N|A>
COLO205 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLaPVYhcA>? MX;EUXNQ NYr5UGtoUUN3ME2yMlEzKM7:TR?= MkHrNlE3OzR2M{C=
Hep3B NXvWXVBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jscFQ5KGh? NV34U2d6TE2VTx?= M3LhTGdKPTB;MT6yNUDPxE1? MoPXNlE4OTJzNE[=
GM11272 NGj5bZdHfW6ldHnvckBCe3OjeR?= MmPSNVAxKG6P MXe3NkBp M4jnSGROW09? MnfVVoVi[3SrdnH0bY9vKG:oIF3lR5AzKG23dHHueEBmgHC{ZYPzbY9vKGG2IEGwJJRwKDFyMDDuUS=> NXG5SJJzOjF6NEC3NVY>
CFBE41o Mni3T4lv[XOnIFHzd4F6 MkLjOUDPxE1? MorESG1UVw>? NFjDXpBFd3ewIILl[5Vt[XSrb36gc4YhUESDQ{egZZQhOC5{IITvJFUhfU1? MnHjNlE6QDR7NUi=
CFBE41o NY\ETmJHTnWwY4Tpc44hSXO|YYm= MVixJO69VQ>? NXHiTpJiOjRiaB?= NVm0N3NvTE2VTx?= Ml3YVoV{fG:{YYTpc44hd2ZiQ1\UVkBl\Wy2YV[1NFghdXW2YX70JJRz[W[oaXPrbY5oKHSxIHPlcIwhe3W{ZnHj[UBieyCpbInjc4Zwem2| Mnj1NlE6QDR7NUi=
DU145 NXLQdItzU2mwYYPlJGF{e2G7 NHfEfY4zNjVizszN M1vPcFI1KGh? M2XZT2ROW09? M2TSemlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YheDJzd3HmNUBxem:2ZXnuJIV5eHKnc4Ppc44> MUOyNlI3ODF4Nh?=
DU145 Mn3zT4lv[XOnIFHzd4F6 NUfySnQyPSEQvF2= NX7h[2N5OjRiaB?= M2j6OWROW09? NV73WJBmUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSESgZYNmfHmuYYTpc44> NGXEfJMzOjJ4MEG2Oi=>
DU145 M1rhdmtqdmG|ZTDBd5NigQ>? MYS1JO69VQ>? NWXVemlyOjRiaB?= MWLEUXNQ M3vlNWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh|IHj5dIVz[WOndInsZZRqd25? NHX5e2szOjJ4MEG2Oi=>
786-0 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrROk4zKM7:TR?= Ml7OO|IhcA>? M3n5WWROW09? NET4e3JIUTVyPUOuNkDPxE1? M1jtclIzPDN3Nk[5
A498 M{HI[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWC2MlIh|ryP M1XYZVczKGh? NIq2O|lFVVOR NF\jVWtIUTVyPUGuOkDPxE1? NEjuelYzOjR|NU[2PS=>
A549/ATCC MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLr[I9bPi5{IN88US=> MV23NkBp NI\VZW9FVVOR M2P3SmdKPTB;MT62JO69VQ>? NIm1TVEzOjR|NU[2PS=>
ACHN NX7sdnMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDGXXkyPi5{IN88US=> NUTlc3dtPzJiaB?= M{nyOmROW09? MYjHTVUxRTFwMzFOwG0> MYKyNlQ{PTZ4OR?=
BT549 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NESzW5Y3NjJizszN MkXuO|IhcA>? MVvEUXNQ Mn7ZS2k2OD1zLkOg{txO MWOyNlQ{PTZ4OR?=
EKVX NEPUVG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD3Ok4zKM7:TR?= MUW3NkBp M4TCWmROW09? MoD0S2k2OD1zLkOg{txO Mk\ONlI1OzV4Nkm=
HCT15 NEPxXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjV[mVsPi5{IN88US=> NUHJb5pkPzJiaB?= MUfEUXNQ NFHRXGNIUTVyPUKuOUDPxE1? MWCyNlQ{PTZ4OR?=
HOP92 NYjVZnR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH2WHQ3NjJizszN M3\ZfVczKGh? NWnBXZpVTE2VTx?= MWPHTVUxRTRizszN NH;qXnIzOjR|NU[2PS=>
IGROV1 NUe4SoFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXSOk4zKM7:TR?= MkLaO|IhcA>? M2TzcmROW09? NHjsWVVIUTVyPUGuN{DPxE1? MoK4NlI1OzV4Nkm=
LOXIMVI MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWe2MlIh|ryP MnzSO|IhcA>? NX;pb4VUTE2VTx?= Mn7nS2k2OD1zIN88US=> NHj2elQzOjR|NU[2PS=>
M14 M3G1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWS2MlIh|ryP NHzTXIU4OiCq M33RT2ROW09? MlrUS2k2OD1zLkOg{txO NXz6O2M1OjJ2M{W2Olk>
MALME-3M NWG3dldUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXW2MlIh|ryP M1jzWFczKGh? MYrEUXNQ NFm0[XNIUTVyPUCuN|Ih|ryP NVLIeGJkOjJ2M{W2Olk>
MCF10A NYC5bWJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TlUVYvOiEQvF2= NF3xOYo1QCCq MVTEUXNQ MXLHTVUxRTlwNjFOwG0> M2C4T|IzPDN3Nk[5
MDA-MB-435 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWO2MlIh|ryP NH\PSlM4OiCq Ml7kSG1UVw>? MX3HTVUxRTBwNTFOwG0> NGPGdIEzOjR|NU[2PS=>
MDA-MB-468 NETuWXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\QUms3NjJizszN NYLKZZlbPzJiaB?= NEXLPW9FVVOR NXTTPYw6T0l3ME2wMlY{KM7:TR?= MXmyNlQ{PTZ4OR?=
MOLT4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjGUmNyPi5{IN88US=> NF;k[|E4OiCq M1Lue2ROW09? MWnHTVUxRTBwNDFOwG0> NF7J[FUzOjR|NU[2PS=>
NCI-ADR-RES NGr0[nNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4L5V|YvOiEQvF2= M{nEfFczKGh? NGDCUlBFVVOR M3W0emdKPTB;MD6xOkDPxE1? MYiyNlQ{PTZ4OR?=
NCI-H23 NV7RUGk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PxU|YvOiEQvF2= NInZTVY4OiCq MnjoSG1UVw>? MVvHTVUxRTFizszN NGrUU24zOjR|NU[2PS=>
NCI-H322M M3y0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrHdmVFPi5{IN88US=> NGHpRXU4OiCq NH3PNGVFVVOR Ml\CS2k2OD1yLke5JO69VQ>? NGHxOYszOjR|NU[2PS=>
NCI-H460 M{Xy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjHZ4NrPi5{IN88US=> NFu2RVg4OiCq NWPFZ5E4TE2VTx?= NWjJdHg4T0l3ME2wMlc6KM7:TR?= MmnoNlI1OzV4Nkm=
NCI-H522 NELNRoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\6[|g3NjJizszN M3zIdFczKGh? NFLqOZdFVVOR MW\HTVUxRTBwNTFOwG0> MWmyNlQ{PTZ4OR?=
OVCAR3 NFvkPFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TVXVYvOiEQvF2= MWO3NkBp Mm\qSG1UVw>? M3v4PGdKPTB;MT6zJO69VQ>? NXfaNlltOjJ2M{W2Olk>
OVCAR4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnv6Ok4zKM7:TR?= NYn0T|Z3PzJiaB?= NVfMW|N[TE2VTx?= NGXFOIdIUTVyPUSg{txO M37sblIzPDN3Nk[5
OVCAR5 MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3qOk4zKM7:TR?= NI\ZVm84OiCq NHnDRXlFVVOR MkSyS2k2OD1yLke5JO69VQ>? NWWzdYhyOjJ2M{W2Olk>
OVCAR8 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYq2MlIh|ryP MVS3NkBp MkDQSG1UVw>? MWXHTVUxRTBwNTFOwG0> MnjTNlI1OzV4Nkm=
RXF393 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjTOk4zKM7:TR?= MkjPO|IhcA>? MkL6SG1UVw>? NIrCeHpIUTVyPUGuN{DPxE1? NI\IXWozOjR|NU[2PS=>
SF268 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUK2MlIh|ryP Ml25O|IhcA>? MoTKSG1UVw>? Mm[3S2k2OD1zLk[g{txO MorqNlI1OzV4Nkm=
SF295 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWW2MlIh|ryP M4DlRVczKGh? MWfEUXNQ MWjHTVUxRTFwNjFOwG0> NUTrV4gyOjJ2M{W2Olk>
SF539 NX;WR4pXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;rOk4zKM7:TR?= MVq3NkBp MonxSG1UVw>? Mm[4S2k2OD1{IN88US=> NUnzbmZ6OjJ2M{W2Olk>
SK-MEL-2 NGHlR29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3Nd2xjPi5{IN88US=> Ml7FO|IhcA>? M{LiR2ROW09? NYe3Spp6T0l3ME2xMlMh|ryP NYS1TYR[OjJ2M{W2Olk>
SK-MEL-28 MnHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjJUpJKPi5{IN88US=> M2DUe|czKGh? NFLFS3JFVVOR MkTNS2k2OD1zIN88US=> M3PQZ|IzPDN3Nk[5
SK-MEL-5 Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWm2MlIh|ryP Mn\uO|IhcA>? M2n6U2ROW09? NX;ScFN4T0l3ME2wMlY{KM7:TR?= NVvDR5NQOjJ2M{W2Olk>
SKOV3 NWrEVIt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTHN5A3NjJizszN MXK3NkBp NWnjSZNDTE2VTx?= MknZS2k2OD1zIN88US=> M1zwcVIzPDN3Nk[5
SN12C NIXPXWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVG2MlIh|ryP NG\qV2g4OiCq M3jKXmROW09? NELw[o1IUTVyPUKg{txO NX3ubmlXOjJ2M{W2Olk>
SNB19 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfuepo2Pi5{IN88US=> NH3S[2k4OiCq MXPEUXNQ MUHHTVUxRTBwNkOg{txO MWmyNlQ{PTZ4OR?=
SNB75 M{HR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTuOk4zKM7:TR?= M3XpZVczKGh? MmfZSG1UVw>? M3T4TWdKPTB;MD63PUDPxE1? NHvQcIszOjR|NU[2PS=>
SR MlLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHae3k3NjJizszN NE\SdnE4OiCq MkX0SG1UVw>? NUP1NoRLT0l3ME2wMlQh|ryP MlPBNlI1OzV4Nkm=
T47D NYnZV|JsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\H[FYvOiEQvF2= NUTXfHRuPzJiaB?= MY\EUXNQ MlzRS2k2OD1yLkWg{txO M1vNN|IzPDN3Nk[5
TK10 M1n0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLROk4zKM7:TR?= MkfWO|IhcA>? M3PV[2ROW09? NXL2NXJCT0l3ME2wMlY{KM7:TR?= NGjlcpEzOjR|NU[2PS=>
UACC257 NIrHbpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknFOk4zKM7:TR?= MoS2O|IhcA>? MVXEUXNQ MkPRS2k2OD1yLkWg{txO NFPYeo8zOjR|NU[2PS=>
UACC62 NEjnbIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljDOk4zKM7:TR?= NImzNWQ4OiCq M2PFRWROW09? MY\HTVUxRTBwNDFOwG0> MnnjNlI1OzV4Nkm=
UO31 NYfn[lZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH4[GxQPi5{IN88US=> NETzboM4OiCq MkLDSG1UVw>? NGjPdXhIUTVyPUCuOUDPxE1? NHTucW0zOjR|NU[2PS=>
Hep3B NH[zeXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HjdlQ5KGh? MUPEUXNQ M4nYeWdKPTB;MD62PUDPxE1? Ml\YNlI1Ozl6NkO=
BE(2)-C M1fJ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn2O|IhcA>? M1H2WmROW09? NHrqc2ZKSzdyPUKg{txO MY[yNlk{OjNzNh?=
Bel7402 NH3xcYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7Y[484OiCq MWnEUXNQ NVrzT4w5T0l7ME2xO{DPxE1? M173TFI{ODZzM{e2
Bel7404 MoTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXuZpJTPzJiaB?= MnXOSG1UVw>? M{P6NGdKQTB;MUig{txO NX\mVXM5OjNyNkGzO|Y>
BGC823 NX:yPHRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHWO|IhcA>? MXvEUXNQ MmW3S2k6OD15LkWg{txO M2fYVVI{ODZzM{e2
MGC803 Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHBO|IhcA>? NXriXmhuTE2VTx?= NX64WnlZT0l7ME2xNE45KM7:TR?= MkD5NlMxPjF|N{[=
SGC7901 NYe0OWQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\hO|IhcA>? M4X5eGROW09? MV;HTVkxRTlwNDFOwG0> MojUNlMxPjF|N{[=
SKHEP1 M3nyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzNTXM6PzJiaB?= NFrRR4FFVVOR NWTyXnFxT0l7ME2xO{DPxE1? NXvlTmI{OjNyNkGzO|Y>
SMMC7721 M3zSWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DQOFczKGh? NH\UR2JFVVOR NGXWeVhIUTlyPUKwJO69VQ>? NIP2VVczOzB4MUO3Oi=>
NUGC3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXQSVRWOTBizszN MU\HTV0zNjl2IN88US=> NVznNYxVOjNzNkOzN|I>
A2780 CisR M4rUTWtqdmG|ZTDBd5NigQ>? NUT1enpMOThiaB?= NIWwXlJKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOFQh|ryP M3e2XlI{OjV{NkCz
CAL27 sens NYnUW5JIU2mwYYPlJGF{e2G7 NF71dHQyQCCq MUfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{[g{txO MXKyN|I2OjZyMx?=
CAL27 CisR NV3G[4I1U2mwYYPlJGF{e2G7 M{H4U|E5KGh? M2T1e2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M1[2elI{OjV{NkCz
KYSE-510 CisR NWXvdlVjU2mwYYPlJGF{e2G7 M3yzXVE5KGh? MmXmTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkW5JO69VQ>? NWK4cotEOjN{NUK2NFM>
KYSE-510 sens NWfnUZROU2mwYYPlJGF{e2G7 MnzyNVghcA>? MYjJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNzFOwG0> NEDWWZQzOzJ3Mk[wNy=>
MDA-MB-231 sens NFrG[mpMcW6jc3WgRZN{[Xl? NVjQZWwzOThiaB?= NVTQRlc2UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MnLiNlMzPTJ4MEO=
MDA-MB-231 CisR M3fXSWtqdmG|ZTDBd5NigQ>? M3GxSVE5KGh? MlX6TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NVLQVYZbOjN{NUK2NFM>
ES2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW5XXI1QCCq MnXCSG1UVw>? M4P2NWlEPTB;MUKuO{DPxE1? MoraNlM1QTN2NEm=
MDA-MB-231 NY\ESm5TU2mwYYPlJGF{e2G7 NHm1RXUyOCEQvF2= MVOzNEBucW5? M2ixeGROW09? MoPSTY5pcWKrdHnvckBw\iCKRFHDNoE> MUKyN|Q6OzR2OR?=
MDA-MB-231 M4r5OWtqdmG|ZTDBd5NigQ>? MWCxJO69VQ>? NFu1OXUzPCCq NE\aZnBFVVOR NVyzR5dlUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> MmjLNlM1QTN2NEm=
HS68 NGLwdnVEgXSxdH;4bYMhSXO|YYm= Ml\DNVAh|ryP NHnwW2g4OiCq NXPHVW1TTE2VTx?= M2DsXmlEPTB;ND62JO69VQ>? MX:yN|U4ODV2Mh?=
MEF M3HBN2N6fG:2b4jpZ{BCe3OjeR?= MnzaNVAh|ryP NXPlRoVxPzJiaB?= M3zFcmROW09? MoXvTWM2OD12LkSg{txO MmD3NlM2PzB3NEK=
BGC823 MoOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj4SG1UVw>? NEL0cnBIUTVyPUOuNFkh|ryP NFHufVczOzZyMUewOi=>
High5 MkTOT4lv[XOnIFHzd4F6 MXSyOEBp MUDJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>? NIP3WmYzOzZyMkWyNy=>
High5 NE[2NJpMcW6jc3WgRZN{[Xl? NIHYb3ozPCCq MnTQTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6xNkDPxE1? NW\YcYJDOjN4MEK1NlM>
High5 Mo\tT4lv[XOnIFHzd4F6 Mk\ZNlQhcA>? MVvJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? MXeyN|YxOjV{Mx?=
A549 NW[4PXRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;EUXNQ M3rmcWlEPTB;MT6wO|kh|ryP MX6yN|Y1PDJzMB?=
HCT116 NGH6UWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2C5SmROW09? MX;JR|UxRTBwN{W3JO69VQ>? NVLzblRQOjN4NESyNVA>
K562 MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7W[IJGTE2VTx?= M4i0SmlEPTB;MD62OFUh|ryP NEjCVVUzOzZ2NEKxNC=>
GBC-SD M2\pR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjRb3FxPSEQvF2= NX3kOFhGPzJiaB?= NV3IOIN3TE2VTx?= M2\Uc2lEPTB;MUSuPEDPxE1? M4Xy[|I{PzB5Mk[w
HGC27 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFuycnE2KM7:TR?= NWDTfW0xPzJiaB?= NWfjelNVTE2VTx?= M{fzcGlEPTB;NT60JO69VQ>? M1G4cFI{PzB5Mk[w
HL60 Mki3T4lv[XOnIFHzd4F6 MX:1JO69VQ>? NWj3Ool5OjRiaB?= NVTGT2RZTE2VTx?= MoW2TY5pcWKrdHnvckBw\iCKRFHD MUGyN|cxPzJ4MB?=
Vero NHrC[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfSNmw{PzJiaB?= M3n0ZWROW09? NF3Od|VKSzVyPUCuPUDPxE1? MVmyN|c5PjR3Mh?=
NCI60 MVrDfZRwfG:6aXOgRZN{[Xl? NV;IfYxpPDhiaB?= NIfLZnJFVVOR M3jtOWdKRTBwNUOg{txO M{HsfFI1ODF3M{K3
SW620 M1TIS2N6fG:2b4jpZ{BCe3OjeR?= M2nnc|Q5KGh? MVLEUXNQ MXXHTV0xNjV2IN88US=> MVmyOFAyPTN{Nx?=
U251 NYTaeHBPS3m2b4TvfIlkKEG|c3H5 NHrPTnY1QCCq NVjvWo1pTE2VTx?= NX\GO4FrT0l;MT61N{DPxE1? NV7NN4I3OjRyMUWzNlc>
KM12 MUTDfZRwfG:6aXOgRZN{[Xl? NU\yTllzPDhiaB?= MUXEUXNQ MX3HTV0yNjh6IN88US=> NYDBd|BZOjRyMUWzNlc>
Hs578T NVm5OpltS3m2b4TvfIlkKEG|c3H5 NYfwem5oPDhiaB?= M3r0dWROW09? NIrIUGJIUT12LkizJO69VQ>? M1XKVVI1ODF3M{K3
MDA-MB-231 NGO0foxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXu0PEBp M3HP[mlEPTB;MD6xOkDPxE1? NXuwTIRTOjRyOUWwNVY>
MCF7 NWq3T3VtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV2wNHNKPDhiaB?= NYLPfVkyT0l;MD60OUDPxE1? MVKyOFEyQTV3NR?=
MDA-MB-435 M4LKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HJelQ5KGh? M3nrcGdKRTBwOEig{txO M1ywNFI1OTF7NUW1
AsPC1 NEHoZppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX2zNEDPxE1? NHv6Slk1QCCq M4T5TWROW09? Mni3TWM2OD1|Lk[2JO69VQ>? NYHwcWMxOjRzOEWzO|g>
Jurkat E6.1 NVe2epZ2U2mwYYPlJGF{e2G7 MnnaNkBp M4D1bWROW09? NYDQT5UzUW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= NFLvNXUzPDJ4MUi2Ni=>
KG1 NV7MT49KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXPXFM1PDhiaB?= M3yyVGlEPTB;MT6xOUDPxE1? MX2yOFUzPTByMx?=
HEL MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXPdopwPDhiaB?= M2H4cGROW09? MXnJR|UxRTBwNEmg{txO NVzhfHZxOjR4OUSwOVU>
HSC3 MnfuR5l1d3SxeHnjJGF{e2G7 NEO1TnEyOiCq MnWxSG1UVw>? NGfoZZVKSzVyPUCuO|Eh|ryP Ml;rNlQ4PjZ3NkC=
HT-29 NWXoc2VvS3m2b4TvfIlkKEG|c3H5 MmPKNVIhcA>? MUHEUXNQ MmP3TWM2OD1yLkeyJO69VQ>? MmrINlQ4PjZ3NkC=
KB M3XCUGN6fG:2b4jpZ{BCe3OjeR?= Mnq2NVIhcA>? NYn4WWZ4TE2VTx?= M3:1XWlEPTB;MD63OUDPxE1? NIr3Z3EzPDd4NkW2NC=>
H460 NHK2dnJEgXSxdH;4bYMhSXO|YYm= NUSxXIRUOTJiaB?= M{HmXmROW09? MlrrTWM2OD1yLkiyJO69VQ>? M3W4dVI1PzZ4NU[w
MONE1 MkfYR5l1d3SxeHnjJGF{e2G7 NXOy[HRpOTJiaB?= MXvEUXNQ NXS0fYNNUUN3ME2xMlE5KM7:TR?= MXmyOFc3PjV4MB?=
MKN45 M{DiVmN6fG:2b4jpZ{BCe3OjeR?= MYqxNkBp NHLtelBFVVOR MX3JR|UxRTFwMkWg{txO MkDiNlQ4PjZ3NkC=
TSGH NVnnN4VQS3m2b4TvfIlkKEG|c3H5 MUmxNkBp NH3teYZFVVOR MkXpTWM2OD1{LkC5JO69VQ>? MVyyOFc3PjV4MB?=
HL60 MnXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfLO|IhcA>? M3\6OGROW09? MoK2S2k2OD1yLkmzJO69VQ>? Mn65NlQ6ODB3MEC=
HEK293 NXTtXG5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHxeZk4OiCq M4rjcWROW09? NHq5U2tIUTVyPUGzJO69VQ>? M{DKOVI1QTByNUCw
Jurkat M1;iOmN6fG:2b4jpZ{BCe3OjeR?= MmnnNVAxKM7:TR?= MVK3NkBp MYfHTVUxRTBwOTFOwG0> NUi4WI0{OjR7MEC3OFM>
GM15850 NHHUZ3RMcW6jc3WgRZN{[Xl? MlLoNk42KM7:TR?= NX3HT5dWQTZiaB?= M3L0[WROW09? NIXYcpVld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhOTRiYXPleJlt[XSrb36gc4YhTliQIHflcoU> MVKxOlkzOTN4Nx?=
GM15850 NEfVSJpMcW6jc3WgRZN{[Xl? NWPtdolMOi53IN88US=> NXPyZpBiQTZiaB?= MmrlSG1UVw>? M3TIRYRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MmLsNVY6OjF|Nke=
GM15850 MmDVT4lv[XOnIFHzd4F6 NWrSR4pYOi53IN88US=> NHvhZVQ6PiCq MVjEUXNQ M3XyNYRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UAyOiCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> M37tdlE3QTJzM{[3
GM15850 MorCT4lv[XOnIFHzd4F6 M13rSFIvPSEQvF2= NIP6[Jg6PiCq NXnYb|dpTE2VTx?= MUjkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MlPTNVY6OjF|Nke=
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HCC1419 MmjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTvflRzUUN3ME2xMlM1ODJ5IN88US=> NGjpZWFUSU6JRWK=
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OVCAR-8 MnPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrJTWM2OD1zLkW0OFc4KM7:TR?= NXr1XpBNW0GQR1XS
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CAL-27 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz6TWM2OD1zLkewOlIyKM7:TR?= NFi3OHJUSU6JRWK=
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Daoy MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVryN4JZUUN3ME2xMlc3OzF7IN88US=> NUj4WXZoW0GQR1XS
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CGTH-W-1 M1j2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWq1T3prUUN3ME2xMlg6QTR4IN88US=> MVLTRW5ITVJ?
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human HOP-92 M4\ic2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PhdmlEPTB;MT65OFA3PSEQvF2= M2juc3NCVkeHUh?=
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LB2241-RCC M1nnRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DzXWlEPTB;MT65PFI{OSEQvF2= NUDNNmJuW0GQR1XS
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LCLC-97TM1 NGP6flhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPvToRKUUN3ME2yMlE1PTh|IN88US=> NGiwcmtUSU6JRWK=
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GCT NV7WV4Y1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3vTWM2OD1{LkG3O|ch|ryP NXfsOZlkW0GQR1XS
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MDA-MB-453 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HX[2lEPTB;Mj6yOFI4PSEQvF2= MYrTRW5ITVJ?
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HT-1080 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\pRpU2UUN3ME2yMlQ1QDZ2IN88US=> MlzvV2FPT0WU
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NCI-H2170 NUTOUpRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHITWM2OD1{LkWwOVQ6KM7:TR?= MoS4V2FPT0WU
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NCI-H2452 MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXvTWM2OD1zMD6xOkDPxE1? MomzV2FPT0WU
NCI-H1395 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\4TWM2OD1zMD6xO|gh|ryP NFvXW4NUSU6JRWK=
NCI-H2052 NVnseYNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XtNWlEPTB;MUCuNVg5OiEQvF2= M4rmd3NCVkeHUh?=
A375 NWXXNYdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TsTmlEPTB;MUCuNlQ2OiEQvF2= MnLuV2FPT0WU
HCC38 NWDYeJFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1K5S2lEPTB;MUCuN|IzKM7:TR?= NHf6S5lUSU6JRWK=
LK-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFyLkSyNFgh|ryP M3\sTHNCVkeHUh?=
SF126 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDldWNKSzVyPUGwMlQ4OjdizszN MVnTRW5ITVJ?
SK-MEL-1 NUjsNYZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTFyLke4N|gh|ryP M{\qXHNCVkeHUh?=
ACN NHWwN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\IS4NKSzVyPUGwMlg3PzlizszN M2m4TXNCVkeHUh?=
BB30-HNC NUnzOo43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DT[GlEPTB;MUCuPFcyOSEQvF2= NGjqfWlUSU6JRWK=
NCI-H747 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT1VWZKSzVyPUGwMlg4PDZizszN M4C5bHNCVkeHUh?=
KYSE-150 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvITWM2OD1zMT6wN|g4KM7:TR?= M4DHbXNCVkeHUh?=
D-247MG M4roUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvrNIZKSzVyPUGxMlExODlizszN NUC2eW1DW0GQR1XS
BxPC-3 NFvIXnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTwc21KSzVyPUGxMlM4PDdizszN MmPhV2FPT0WU
SK-MEL-30 NITZ[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3JRohKSzVyPUGxMlQxPzlizszN NVXFdVlsW0GQR1XS
CAS-1 M4jUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDEfJdKSzVyPUGxMlQyODlizszN MmDXV2FPT0WU
no-10 Ml3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{i5S2lEPTB;MUKuNVIyPyEQvF2= NEWxTXFUSU6JRWK=
NCI-H2405 M3LpfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXKTWM2OD1zMj6yNFM3KM7:TR?= MWDTRW5ITVJ?
KGN M3fBTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvDRlVKSzVyPUGyMlI6ODFizszN MVHTRW5ITVJ?
BB49-HNC NGDqS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vyV2lEPTB;MUKuN|k2PiEQvF2= MlGwV2FPT0WU
NCI-H1693 M3;hRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nST2lEPTB;MUKuOVgyPiEQvF2= NXvwfGxoW0GQR1XS
RO82-W-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEeyZ3dKSzVyPUGzMlA3PDlizszN MYrTRW5ITVJ?
CAL-85-1 NVfDN4piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jvWWlEPTB;MUOuOFM6QSEQvF2= M{XCVnNCVkeHUh?=
H-EMC-SS MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGH5No1KSzVyPUGzMlkyODRizszN MonkV2FPT0WU
SW1783 NHTCe4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\T[4NjUUN3ME2xOE4zOzlzIN88US=> NWD3NHBHW0GQR1XS
LB771-HNC MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PjWmlEPTB;MUSuOFE6KM7:TR?= NVz3[mYyW0GQR1XS
HCC70 MomzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzkbJBMUUN3ME2xOE41OjN|IN88US=> M17OTHNCVkeHUh?=
KNS-81-FD M2\GUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvQPFFRUUN3ME2xOE44ODR3IN88US=> MYTTRW5ITVJ?
KYSE-520 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTF2LkmyO{DPxE1? NFLIdlZUSU6JRWK=
TGBC24TKB M{jIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX1UZpNUUN3ME2xOE46PTN7IN88US=> NIHOdZJUSU6JRWK=
SNB75 MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfNTWM2OD1zNT6wO|I6KM7:TR?= M{LlTXNCVkeHUh?=
SW872 MlHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLjVJFKSzVyPUG1MlIzOThizszN M3HSXXNCVkeHUh?=
U031 NILWc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPhVVVKSzVyPUG1MlgxOjhizszN MlriV2FPT0WU
ChaGo-K-1 NIi0b45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDSOnNRUUN3ME2xOU45OzV7IN88US=> NVv2PFBnW0GQR1XS
NCI-H441 MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nZbWlEPTB;MU[uNFA{QSEQvF2= NVq5NHhWW0GQR1XS
TE-12 NEX5cGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLvUGdKSzVyPUG2MlE5PzNizszN NFXuWWJUSU6JRWK=
NCI-H1755 NIXROmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\yemlEPTB;MU[uOVc{KM7:TR?= Mnf0V2FPT0WU
KNS-42 NWG1T2tXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvRTFdNUUN3ME2xOk43PTh7IN88US=> NVHJSpE4W0GQR1XS
SK-PN-DW MmXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFL5Z4hKSzVyPUG3MlQzODFizszN NGHzTY5USU6JRWK=
NCI-H226 NVK3UFZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTF5LkmzOFUh|ryP NULQUVI{W0GQR1XS
K-562 M1P1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz1b5Y{UUN3ME2xPE43OzF5IN88US=> NVrScYZyW0GQR1XS
A388 NWf0S29kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTEe4NKSzVyPUG5MlA{ODNizszN NIjFZ2pUSU6JRWK=
ZR-75-30 NUHBXHdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OzcGlEPTB;MUmuNFk3QCEQvF2= NVrhU4ZzW0GQR1XS
LU-135 Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTF7LkK2N|Yh|ryP MYPTRW5ITVJ?
NCI-H2029 NWDjV5ZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf1TWM2OD1zOT62NFIyKM7:TR?= MkDQV2FPT0WU
HT-1197 NI\leVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfvWmdKSzVyPUG5MlkzOjdizszN MVfTRW5ITVJ?
IGR-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJyLkOxNVch|ryP MV\TRW5ITVJ?
U-87-MG M4DzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnNTWM2OD1{MD62OFE{KM7:TR?= M13NPHNCVkeHUh?=
NCI-H1304 M4TqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHid5FKSzVyPUKwMlc2ODFizszN MV\TRW5ITVJ?
RCC10RGB MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrOdlh3UUN3ME2yNU4zQDJ7IN88US=> NIqwZnVUSU6JRWK=
NCI-H520 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfqUVJjUUN3ME2yNk44PjFzIN88US=> NFfzWFZUSU6JRWK=
SK-LU-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3iTWM2OD1{Mz6wO|E5KM7:TR?= NWTIWFFbW0GQR1XS
UACC-893 NH2zeJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDkTWM2OD1{Mz6xNFM5KM7:TR?= MmjhV2FPT0WU
NCI-H2347 MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;r[XlKSzVyPUKzMlI3PzRizszN MUHTRW5ITVJ?
U-118-MG NIGybYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTJ|LkeyNVch|ryP NET1UJhUSU6JRWK=
NCI-H596 NFHiNmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{mwN2lEPTB;MkOuPVA2PSEQvF2= MVXTRW5ITVJ?
MZ1-PC NUW4OW5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfqTWM2OD1{ND62O|U6KM7:TR?= NX\OXWxqW0GQR1XS
SW1417 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJ3LkK0PVgh|ryP NWjOZnA4W0GQR1XS
NCI-H82 MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33XcmlEPTB;Mk[uOFI5QCEQvF2= NWHE[GFbW0GQR1XS
COLO-678 NHrZd2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPSOYRKSzVyPUK3MlQ6OTlizszN Mor0V2FPT0WU
KURAMOCHI MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJ6LkGyOkDPxE1? NHKwO4tUSU6JRWK=
NCI-H1650 NF\3eJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjQdYN3UUN3ME2zNE4yQTJ2IN88US=> M{\6b3NCVkeHUh?=
HCC1954 NWn6[npGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTNzLkO2OlYh|ryP MmrNV2FPT0WU
GAK MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HRO2lEPTB;M{KuNlYyPiEQvF2= NHzzPFJUSU6JRWK=
YAPC NVfOPIZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrZTWM2OD1|Mz63OlQ5KM7:TR?= NG\ROZRUSU6JRWK=
NCI-H2228 NUGzZZJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmm0TWM2OD1|ND6zOlA2KM7:TR?= M3:ze3NCVkeHUh?=
VMRC-RCZ MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nYXmlEPTB;M{[uN|AzOiEQvF2= Mn3TV2FPT0WU
NMC-G1 NV;tS2h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;TNGlEPTB;M{euNFUzQSEQvF2= Ml6zV2FPT0WU
D-336MG NEn6b4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTvbIU1UUN3ME20NU45PDR{IN88US=> NU\RNmlbW0GQR1XS
UACC-62 M{nZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7oNlFKSzVyPUSyMlU2ODVizszN NXi1ZoRGW0GQR1XS
C-33-A MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4f1bmlEPTB;NEWuN|I2PiEQvF2= MYHTRW5ITVJ?
HCC1937 NHPxXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTR5LkG5OVgh|ryP NYC0V5BUW0GQR1XS
HDLM-2 M2rQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3STWM2OD12Nz6yNlg4KM7:TR?= M3[wNHNCVkeHUh?=
NCI-H727 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED5RndKSzVyPUS3MlI1PTFizszN NWO5[HpDW0GQR1XS
NY MoTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkX3TWM2OD12OT6zPVA5KM7:TR?= M{jzNHNCVkeHUh?=
NCI-H2291 NXuyb5dlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PZO2lEPTB;NEmuPFMxOSEQvF2= MnPzV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 53 mg/mL (200.52 mM)
Ethanol 3 mg/mL (11.35 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 5mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID