Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 100 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M3Pvd2tqdmG|ZTDBd5NigQ>? NEXmc|QyKGh? MVXEUXNQ MmPGZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP NUfiOII5OTF7NkC0PFk>
Friend leukemic cell NE\CUllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkL6OVAh|ryP M2ToNFczKGh? NVvCOZZ3TE2VTx?= NGLD[JVKSzVyPUCuPVkh|ryP M4\TfFEzOTB7OUGz
K562 M{H6ZWtqdmG|ZTDBd5NigQ>? NEe1TGM3KGh? M1fYeGROW09? Ml;HTY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN Mo[1NVI1OTl|OEC=
HT1080 NGPxWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF65b5A4OiCq MmDLSG1UVw>? MUnJR|UxRTJwNDFOwG0> MoHXNVIzPzBzN{W=
H1299 M2HOcWtqdmG|ZTDBd5NigQ>? M4HYWFIxKG2rbh?= NV;IdWhwTE2VTx?= M3m5fWlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJTEGFIHXufplu\SC5aYToJGlEPTBib3[gNE4yQTRizszN NIn5fHcyPDV{MUSyNi=>
H1299 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUO3NkBp MWTEUXNQ MkD3TWM2OD15LkK0JO69VQ>? Ml:zNVQ2OjF2MkK=
HeLa NH\sPYNMcW6jc3WgRZN{[Xl? NVnaUm9HOzBibXnu MUXJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> Mn3VNVU3ODN7NEm=
LOX-IMVI NIHZOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37XXFQ5KGh? MkniTWM2OD1zLkOg{txO NXv2N5oxOTV5MUW0O|A>
NCI-H226 NVnSWpF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHrOFghcA>? NVHINmFqUUN3ME2yMlYh|ryP MVSxOVcyPTR5MB?=
RXF-631L M3TrZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1L4W|Q5KGh? NHP6W3lKSzVyPUKg{txO Mnr0NVU4OTV2N{C=
SNB-78 MlXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG5c4prPDhiaB?= NWPhOJEzUUN3ME2xOkDPxE1? NITERpEyPTdzNUS3NC=>
St-4 NFWwWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn6Uo81QCCq NUS2PJpOUUN3ME21MlIh|ryP Ml\tNVU4OTV2N{C=
ARP1 MVnGeY5kfGmxbjDBd5NigQ>? NXvwfHNqOiEQvF2= NIDtPVM3KGh? NE\hU3NKdmS3Y4Tpc44hd2ZiUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> MknINVQ4OzR6ME[=
CEM NEntZlFMcW6jc3WgRZN{[Xl? NVHJRnNGOSCq MonvSG1UVw>? NV;jdVlPUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM{KM7:TR?= NILicIkyPjR{MEC2OC=>
HCT15 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3Fb5NvPDhiaB?= NG\3UJFIUTVyPUCuPFIh|ryP NVTKT3lLOTZ5MkOyNlc>
NCI-H23 NXnKcI11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jJ[lQ5KGh? M1vt[mdKPTB;MD65NkDPxE1? M{j6dlE3PzJ|MkK3
GM15850 MWnLbY5ie2ViQYPzZZk> M4P3cFIvPSEQvF2= MX65OkBp NYnQ[2pDTE2VTx?= M3LIdmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MYqxOlkzOTN4Nx?=
GM15850 MYrLbY5ie2ViQYPzZZk> M13FVFIvPSEQvF2= MYq5OkBp NHnkbmtFVVOR NX[xbW1[UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= Ml;SNVY6OjF|Nke=
GM15850 NIPRTFRMcW6jc3WgRZN{[Xl? M{naVlIvPSEQvF2= NFfTO|U6PiCq M3e5TWROW09? MmG4TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NEWyO3QyPjl{MUO2Oy=>
GM15850 MULLbY5ie2ViQYPzZZk> MYGyMlUh|ryP NHTrWmE6PiCq M17Nb2ROW09? M4e2R2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTC5JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MXOxOlkzOTN4Nx?=
GM15850 MoD2T4lv[XOnIFHzd4F6 MYKyMlUh|ryP MUm5OkBp NXnmeHRCTE2VTx?= M3PzbmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MluyNVY6OjF|Nke=
GM15850 MVjLbY5ie2ViQYPzZZk> NF[4OGUzNjVizszN NF;kR|Y6PiCq MnXJSG1UVw>? M3iyS2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MnLmNVY6OjF|Nke=
U937 NXz1[IZITnWwY4Tpc44hSXO|YYm= MlTsOUDPxE1? M{HJb|I1KGh? M1LzdmROW09? Mo\UR4VtdCCleXPs[UBienKnc4SgZpkh[WOldX31cIF1cW:wIHH0JHMwTzJxTTDwbIF{\Q>? M4\pelE4ODB2N{G4
H661 M4XvPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHURlQ1QCCq MX\JR|UxRTFizszN NYLDT3R{OTdzNUewNFk>
U937 NEXZe|FHfW6ldHnvckBCe3OjeR?= NITNSpo2KM7:TR?= MmfsNlQhcA>? M2K5OGROW09? NEP0fldKdmO{ZXHz[UBqdiCqaYP0c45mKEh|IHHj[ZR6dGG2aX;u MUixO|Q1Pzd3MB?=
U937 Mn;kSpVv[3Srb36gRZN{[Xl? MYWxJO69VQ>? NFyyO2EzPCCq NH:0OZRFVVOR MoL4SYZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= MkPnNVc1PDd5NUC=
RAW264.7 MYrGeY5kfGmxbjDBd5NigQ>? M2HxOlExKM7:TR?= NEHhVJMzPGh? M1LROZdifGW{ NYnEUXQ2UW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCWTl\hcJBp[SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjd4IN88US=> MVixO|Q4PzVzOB?=
RAW264.7 NWLN[nU2TnWwY4Tpc44hSXO|YYm= M4\LR|ExKM7:TR?= NUfPfnFYOjSq M4DPOJdifGW{ M2LZVWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> M4P6PFE4PDd5NUG4
SC9 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY[0PEBp MXHJR|UxRTBwNkC2JO69VQ>? M{HhTVE4PTB5MkG5
ST14A M2j6UmZ2dmO2aX;uJGF{e2G7 NEjMeJk2KG6P NICw[2I4OiCq NF;N[m1KdmO{ZXHz[UBqdiCURWPUM25TW0ZibWLORUBmgHC{ZYPzbY9v Mle3NVc2PjV7OUO=
ST14A NFq4UI5HfW6ldHnvckBCe3OjeR?= M1nQW|Uhdk1? MkXoO|IhcA>? NGjvc4ZKdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= M37ZUVE4PTZ3OUmz
PANC1 MkTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfNbpRnOSEQvF2= NGDkR5pKSzVyPUCuOFUh|ryP MYmxO|U5QDd2NB?=
PANC1 M1vsR2Z2dmO2aX;uJGF{e2G7 NF7wT|YyKM7:TR?= NVrl[JRKOjRiaB?= MVnJcoNz\WG|ZTDpckBxOjGZQV[xM2NKWDFiZ3Xu[UBmgHC{ZYPzbY9v MYWxO|U5QDd2NB?=
PANC1 MUTGeY5kfGmxbjDBd5NigQ>? NUnPcW83OSEQvF2= MlPrNlQhcA>? NHXlVVdKdmO{ZXHz[UBqdiCyMkfrbZAyKGenbnWg[ZhxemW|c3nvci=> NYfxcYJwOTd3OEi3OFQ>
PT45 MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTRizszN Mk\wNVc2QDh5NES=
ACHN NUTTTJlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWD5SoF5OjFiaB?= NUHiR5ZXT0l3ME2wMlY2KM7:TR?= M2\3S|E4PjZ{NkC2
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SKHEP1 M2HRdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPRdoNvPzJiaB?= NWTvSmVjUUN3ME2zMlQ3KM7:TR?= NUL0eZZjOjBzNEO3O|g>
BJ NXHmbndpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrQfVRnOTByIN88US=> NI\wNZc1QCCq NVXJSpdmTE2VTx?= NV3OdIJGT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> NEHvfnMzODF2M{i0NC=>
MUF MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUKxNFAh|ryP MnLGOFghcA>? MX;EUXNQ NVjPWXlwT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> MW[yNFE1Ozh2MB?=
Caco-2 NX[w[HY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKxNFAh|ryP MYW0PIg> NEDFS3dFVVOR NYjW[WtiUUN3ME24MlEh|ryP NWqxbYhDOjBzNEO4OFA>
Caco-2 MmHIT4lv[XOnIFHzd4F6 MoPOOUDPxE1? M3HmdlQhcA>? NGXlepFFVVOR NIDkW2JKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9vKEmFNUCgc4YhOC5yM{eg{txO MlnFNlAyPDN6NEC=
Caco-2 MXTLbY5ie2ViQYPzZZk> NVnWR2NYOC5|MU[gcm0hfG9iM{GuOkDPxE1? MWO0JIg> NFnI[otFVVOR MlvzSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUNzIIfpeIghUUN3MDDv[kAxNjFzOTFOwG0> M1GxVVIxOTR|OESw
Caco-2 NEf2eYhMcW6jc3WgRZN{[Xl? NVSzc5RCOC5|MU[gcm0hfG9iM{GuOkDPxE1? MlTsOEBp NIXVR5FFVVOR MX3FfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzNid3n0bEBKSzVyIH;mJFAvOTR5IN88US=> Mk\QNlAyPDN6NEC=
Caco-2 MYrLbY5ie2ViQYPzZZk> NXPxXXBTPi5|MjDuUUB1dyB4M{Kg{txO MYG0JIg> M{X4SGROW09? NHHWXGZGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Wge4l1cCCLQ{WwJI9nKDF{Lk[g{txO NFTnU3AzODF2M{i0NC=>
Caco-2 MlTFT4lv[XOnIFHzd4F6 NXv0blkxPi5|MjDuUUB1dyB4M{Kg{txO NUHZcXlVPCCq MV7EUXNQ M1fQemV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNzD3bZRpKEmFNUCgc4YhPDFizszN M3LuSlIxOTR|OESw
Caco-2 M1HmUmtqdmG|ZTDBd5NigQ>? M4S4b|AvOzF4IH7NJJRwKDNzLk[g{txO M{W5TFQhcA>? M2\nRmROW09? NVnmbW5zTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO2 NYjW[IdpOjBzNEO4OFA>
HepG2 M3LzcGtqdmG|ZTDBd5NigQ>? M3rWU|Uh|ryP NWDibohUPmh? MUTEUXNQ MoLETY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDhZ4V1gWyjdHnvci=> MXmyNFE1Ozh2MB?=
HepG2 NIrCR2lMcW6jc3WgRZN{[Xl? MUS1JO69VQ>? M2jwXVZp NX;VTIJlTE2VTx?= MVHJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHj5dIVz[WOndInsZZRqd25? M4PrR|IxOTR|OESw
HepG2 MnXFT4lv[XOnIFHzd4F6 Ml\3OUDPxE1? MlixOog> M{S3O2ROW09? NIKyVmdKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u NGm5dVczODF2M{i0NC=>
HepG2 NV7iOIlKU2mwYYPlJGF{e2G7 M{fF[FUh|ryP M37nclZp MlTrSG1UVw>? NYHhXIlVUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhUDNxSESgbIl{fG:wZTDhZ4V1gWyjdHnvci=> MYSyNFE1Ozh2MB?=
COLO205 NFn0NZpMcW6jc3WgRZN{[Xl? NWDZflZLOTBizszN MYSyOEBp NXexbXBETE2VTx?= MmXzTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiC5aYToJGlEPTBib3[gNk4zKM7:TR?= MYiyNFQ2OTN5OB?=
SCC4 MV7LbY5ie2ViQYPzZZk> Mn;INUDPxE1? MXSyOIg> MYfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5idIXieYxqdiCjY3X0fYxifGmxbh?= NYnYVnJbOjB2NUKyNlU>
SCC4 M1PudWtqdmG|ZTDBd5NigQ>? M1PRZ|Eh|ryP M{G0eVI1cA>? NE\n[lhKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDhZ4V1gWyjdHnvci=> MojlNlA1PTJ{MkW=
SCC4 MmD4SpVv[3Srb36gRZN{[Xl? M4L1RlEh|ryP M134[FUhdWmw MmrURYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= NWrPdHVOOjB2NUKyNlU>
NB4 NHTPVJpHfW6ldHnvckBCe3OjeR?= NIj5c4s2KM7:TR?= MkHuNlQhcA>? M4DqSmROW09? MmC5R4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPjeY12dGG2aX;uJIF1KHC{ZT3HNUBxcGG|ZR?= NX\IUZBYOjB2OUG0OFA>
NB4 M3LMV2tqdmG|ZTDBd5NigQ>? MmGwOUDPxE1? Ml;rNlQhcA>? NHTFbVdFVVOR MnzjTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHHj[ZR6dGG2ZTD0eYJ2dGmwIHzleoVt Ml3vNlA1QTF2NEC=
NB4 NH7pPIFHfW6ldHnvckBCe3OjeR?= MkfYOUDPxE1? Mn3tNlQhcA>? MYLEUXNQ M3vxbGlv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> MoXkNlA1QTF2NEC=
NB4 Ml3OT4lv[XOnIFHzd4F6 NUOzOmFKPSEQvF2= MXyyOEBp M1TjcWROW09? MnfhTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgZYNmfHmuYYTpc44> NHK0TIszODR7MUS0NC=>
NUGC3 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnHTVUxRTJwOUSg{txO NEXrNHEzODh3MEm3NS=>
A549 NXqyXmdUTnWwY4Tpc44hSXO|YYm= M1XidlUh|ryP MkjlN{Bp MlWzSG1UVw>? NEfiT5lKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> MVqyNFg2PTJyOB?=
HUT78 M{H3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\YO|IhcA>? MWrEUXNQ NITkZ4VIUTVyPUCuN{DPxE1? Mn\ENlA5QDR{MEi=
U937 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LQdVczKGh? NF\QcodFVVOR NY\lcJZZT0l3ME2wMlM6KM7:TR?= NWjqfodHOjB6OESyNFg>
A431 NXjuc2U{S3m2b4TvfIlkKEG|c3H5 MYe3NkBp MoPsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjC0MlIh|ryP M{\4NlIyODhyNkK5
A549 NHX5cFJEgXSxdH;4bYMhSXO|YYm= MWS3NkBp NGW3e3lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvQCEQvF2= NX\rN3FnOjFyOEC2Nlk>
CAL27 MXfDfZRwfG:6aXOgRZN{[Xl? M3rRd|czKGh? NUDiXpBGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> MWWyNVA5ODZ{OR?=
HeLa MW\DfZRwfG:6aXOgRZN{[Xl? MnHmO|IhcA>? NVXhR3VuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjVizszN NWTpUJU6OjFyOEC2Nlk>
Sf21 Mn7hT4lv[XOnIFHzd4F6 NXPHNpRvOyCq NV\NTXlKUW6qaXLpeIlwdiCxZjDGcIFoKHSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBJTEGFODDlfJBz\XO|ZXSge4l1cCCLQ{WwJI9nKDFwMjFOwG0> M4LQXlIyODhyNkK5
SKBR3 MX7DfZRwfG:6aXOgRZN{[Xl? M4XrXVczKGh? MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlYh|ryP NGPPd4gzOTB6ME[yPS=>
SKOV3 NVzvcJdxS3m2b4TvfIlkKEG|c3H5 MVy3NkBp MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlIh|ryP Mlj2NlExQDB4Mkm=
COR-L23 MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnTRWgyOCEQvF2= M3nWbVczKGh? M4G0N2ROW09? MlfnS2k2OD1zLkGg{txO M3rnN|IyODhyNkS3
DU145 M{O0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DzU|ExKM7:TR?= NWPUVGVIPzJiaB?= MV7EUXNQ MVrHTVUxRTFwMEWg{txO M4XUWlIyODhyNkS3
LoVo MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnqzNVAh|ryP NFXuNGE4OiCq MlH4SG1UVw>? MVTHTVUxRTFwNzFOwG0> NGX5V2YzOTB6ME[0Oy=>
MCR5-SV2 NYG4XFM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrlNVAh|ryP NFvmV|c4OiCq NWnwXIU3TE2VTx?= MkfMS2k2OD1{LkGg{txO M2CyU|IyODhyNkS3
HCT116 M4jGdWtqdmG|ZTDBd5NigQ>? MnPsN|Ah|ryP M4\CRVMxKGh? M3XHN2ROW09? NGPNNFNKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u NVe5V5JWOjFyOEC2OFc>
HCT116 M4e0XmtqdmG|ZTDBd5NigQ>? M{fWUFMxKM7:TR?= MX6zNEBp MWnEUXNQ NVjJdVZEUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u MWOyNVA5ODZ2Nx?=
U937 NFm4O29McW6jc3WgRZN{[Xl? NETjVIQ2KM7:TR?= NVn6XYNkOjRiaB?= MkftSG1UVw>? M2\TXmlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEt7 MYKyNVI6OjR7Mh?=
U937 MoWzT4lv[XOnIFHzd4F6 M2nWSlUh|ryP MVKyOEBp M{DqcWROW09? MVrJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMOTh? NVLKZWJzOjF{OUK0PVI>
U937 NHPEbJJMcW6jc3WgRZN{[Xl? MnHOOUDPxE1? NVPGVmgzOjRiaB?= NWPTdmd[TE2VTx?= Mn3hTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? M4DoNlIyOjl{NEmy
U937 MU\LbY5ie2ViQYPzZZk> NXSyZ4xPPSEQvF2= M13iVVE2KG2rbh?= NWPPN2JoTE2VTx?= MW\Jcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiCuZY\lcC=> MUKyNVI6OjR7Mh?=
A2780 MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUL0fnc6QTZiaB?= MYPEUXNQ MnexTWM2OD1zLk[yJO69VQ>? Mm\nNlE3OzR2M{C=
COLO205 NUGyZVhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7LPVYhcA>? NI[3RVdFVVOR NHnrXGlKSzVyPUKuNVIh|ryP NG\MU3kzOTZ|NESzNC=>
Hep3B M4fSXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXPdIQ3PDhiaB?= MXnEUXNQ NGjIcoxIUTVyPUGuNlEh|ryP NVSyPFJKOjF5MUKxOFY>
GM11272 MnrZSpVv[3Srb36gRZN{[Xl? MlnNNVAxKG6P M{ixXVczKGh? MULEUXNQ MYDS[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N NHzZeGUzOTh2MEexOi=>
CFBE41o NXq2WHQ{U2mwYYPlJGF{e2G7 NHTkfYY2KM7:TR?= NWHCU3NPTE2VTx?= Mk\HSI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO MXmyNVk5PDl3OB?=
CFBE41o NIPuOFJHfW6ldHnvckBCe3OjeR?= MoDoNUDPxE1? NHG0U|gzPCCq NIrKeWlFVVOR MVTS[ZN1d3KjdHnvckBw\iCFRmTSJIRmdHSjRkWwPEBufXSjboSgeJJi\m[rY3vpcochfG9iY3XscEB{fXKoYXPlJIF{KGeueXPv[o9zdXN? MVGyNVk5PDl3OB?=
DU145 M13ndWtqdmG|ZTDBd5NigQ>? Mn3KNk42KM7:TR?= MUeyOEBp MYTEUXNQ MnP5TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW|c3nvci=> NEHmXmgzOjJ4MEG2Oi=>
DU145 NFy5cXVMcW6jc3WgRZN{[Xl? MkPQOUDPxE1? MlqzNlQhcA>? NEH2NVZFVVOR MnnFTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36= NH;adlYzOjJ4MEG2Oi=>
DU145 MXHLbY5ie2ViQYPzZZk> MoH0OUDPxE1? MkLlNlQhcA>? Mnf2SG1UVw>? M4jzTWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh|IHj5dIVz[WOndInsZZRqd25? Moq3NlIzPjBzNk[=
786-0 NECwZndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkCzOk4zKM7:TR?= M4fjdlczKGh? MUDEUXNQ M4f5Z2dKPTB;Mz6yJO69VQ>? NGfjRXAzOjR|NU[2PS=>
A498 MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXxOk4zKM7:TR?= MXG3NkBp NHm0[GhFVVOR M4XKS2dKPTB;MT62JO69VQ>? MUOyNlQ{PTZ4OR?=
A549/ATCC NHvhcHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUW2MlIh|ryP NHrvcJE4OiCq NH;oc4xFVVOR NXPRZnYzT0l3ME2xMlYh|ryP NIf2PXMzOjR|NU[2PS=>
ACHN Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrWXmVKPi5{IN88US=> MUO3NkBp NHPReYhFVVOR M4PtWGdKPTB;MT6zJO69VQ>? MWKyNlQ{PTZ4OR?=
BT549 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPaOk4zKM7:TR?= NWizVVR[PzJiaB?= MnrSSG1UVw>? M4DQRmdKPTB;MT6zJO69VQ>? NF\afowzOjR|NU[2PS=>
EKVX M131VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfkOk4zKM7:TR?= NIDuc4U4OiCq MXjEUXNQ MnXnS2k2OD1zLkOg{txO MmrWNlI1OzV4Nkm=
HCT15 MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rPR|YvOiEQvF2= M2jXbFczKGh? NVPKOpE5TE2VTx?= NFfQUndIUTVyPUKuOUDPxE1? MUiyNlQ{PTZ4OR?=
HOP92 NUXNbHpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HzXVYvOiEQvF2= NYLQVnFkPzJiaB?= MUfEUXNQ MUfHTVUxRTRizszN M3y4WVIzPDN3Nk[5
IGROV1 NEfaRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{m2dVYvOiEQvF2= M3jORlczKGh? MY\EUXNQ NFnT[nVIUTVyPUGuN{DPxE1? MV2yNlQ{PTZ4OR?=
LOXIMVI M1mw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYm2MlIh|ryP NVfF[5R3PzJiaB?= NXHy[lhuTE2VTx?= Mk\6S2k2OD1zIN88US=> MmS5NlI1OzV4Nkm=
M14 NI\MWYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITvd|E3NjJizszN MWq3NkBp NEHoU5JFVVOR NF\5[lVIUTVyPUGuN{DPxE1? Mnj1NlI1OzV4Nkm=
MALME-3M MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\4OnA3NjJizszN M3rLSFczKGh? MWrEUXNQ NXfmPId{T0l3ME2wMlMzKM7:TR?= NWrMbW9IOjJ2M{W2Olk>
MCF10A M2PrN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3yweFYvOiEQvF2= MnnEOFghcA>? M33PPGROW09? M2POSWdKPTB;OT62JO69VQ>? NWrDWHB4OjJ2M{W2Olk>
MDA-MB-435 MoHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS2blFqPi5{IN88US=> MmHDO|IhcA>? MorPSG1UVw>? MkHOS2k2OD1yLkWg{txO MknJNlI1OzV4Nkm=
MDA-MB-468 NUGydotXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3TdWtEPi5{IN88US=> NGXhd2k4OiCq M13WWWROW09? MmPNS2k2OD1yLk[zJO69VQ>? NGG2NGozOjR|NU[2PS=>
MOLT4 M{HxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHGTI03NjJizszN MVy3NkBp NVrsSoJbTE2VTx?= MnXVS2k2OD1yLkSg{txO NIDrdogzOjR|NU[2PS=>
NCI-ADR-RES M3\HSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\2NldVPi5{IN88US=> Ml\5O|IhcA>? MnrUSG1UVw>? MWTHTVUxRTBwMU[g{txO NV\aRm9NOjJ2M{W2Olk>
NCI-H23 MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTZOk4zKM7:TR?= NGrUfWM4OiCq M{TpemROW09? NVLsd2wxT0l3ME2xJO69VQ>? MVqyNlQ{PTZ4OR?=
NCI-H322M NGTF[VRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH60R4o3NjJizszN MWO3NkBp MWLEUXNQ M4XpVmdKPTB;MD63PUDPxE1? NFrONpEzOjR|NU[2PS=>
NCI-H460 MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnxXWJXPi5{IN88US=> M3SxSlczKGh? MU\EUXNQ MVTHTVUxRTBwN{mg{txO NVy0SXlEOjJ2M{W2Olk>
NCI-H522 M3LLXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nX[|YvOiEQvF2= M3HqWlczKGh? M{\6eGROW09? MUDHTVUxRTBwNTFOwG0> NGG1NIozOjR|NU[2PS=>
OVCAR3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXNRXlYPi5{IN88US=> NIXYTpc4OiCq NUj5Z2l{TE2VTx?= NE\U[5VIUTVyPUGuN{DPxE1? M320[lIzPDN3Nk[5
OVCAR4 M{DWWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXO2MlIh|ryP M3fSb|czKGh? MnPVSG1UVw>? NWfLfGJ1T0l3ME20JO69VQ>? M{LDSVIzPDN3Nk[5
OVCAR5 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEC4dGY3NjJizszN MXi3NkBp M1LINGROW09? MVPHTVUxRTBwN{mg{txO M{LUUFIzPDN3Nk[5
OVCAR8 M2HaZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzZd|lLPi5{IN88US=> NFfuVIY4OiCq NFzmeWdFVVOR MUPHTVUxRTBwNTFOwG0> MorCNlI1OzV4Nkm=
RXF393 NX;1TXZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH4Ok4zKM7:TR?= Ml7kO|IhcA>? MWjEUXNQ MVPHTVUxRTFwMzFOwG0> M2mzbFIzPDN3Nk[5
SF268 NIHv[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PyR|YvOiEQvF2= Mk\oO|IhcA>? MVPEUXNQ Mne4S2k2OD1zLk[g{txO NGLBPVczOjR|NU[2PS=>
SF295 NH7PWG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rTR|YvOiEQvF2= MVy3NkBp MUjEUXNQ NYi2VHBrT0l3ME2xMlYh|ryP NFr0bZIzOjR|NU[2PS=>
SF539 MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYO2MlIh|ryP M2njeFczKGh? NVzhd4ZPTE2VTx?= Mlv0S2k2OD1{IN88US=> MlWwNlI1OzV4Nkm=
SK-MEL-2 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWmyRnB6Pi5{IN88US=> MV[3NkBp NGHuWVBFVVOR NYfiT|ZvT0l3ME2xMlMh|ryP M4rzflIzPDN3Nk[5
SK-MEL-28 M3nDdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVOyZY9kPi5{IN88US=> MonnO|IhcA>? MXTEUXNQ MUDHTVUxRTFizszN NYfCdHMzOjJ2M{W2Olk>
SK-MEL-5 NXPY[olsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYC2MlIh|ryP MkfOO|IhcA>? MnP1SG1UVw>? M33B[mdKPTB;MD62N{DPxE1? MUmyNlQ{PTZ4OR?=
SKOV3 NGPDfItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW3WFE3NjJizszN M1;D[FczKGh? NUD4[2hCTE2VTx?= NI\UcIhIUTVyPUGg{txO M1H5fFIzPDN3Nk[5
SN12C NF[5Z4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXruOHVkPi5{IN88US=> MYO3NkBp M2\1XGROW09? NV7zUY84T0l3ME2yJO69VQ>? M{HDUFIzPDN3Nk[5
SNB19 MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHBOk4zKM7:TR?= M3XLUVczKGh? NWL4OY1ZTE2VTx?= MYXHTVUxRTBwNkOg{txO MVWyNlQ{PTZ4OR?=
SNB75 NFfaWIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;wUlN2Pi5{IN88US=> M{HCXFczKGh? NUfJXWRQTE2VTx?= NFLuSHVIUTVyPUCuO|kh|ryP MUiyNlQ{PTZ4OR?=
SR M2j2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLHco43NjJizszN NXT1fZI3PzJiaB?= NVzWfGpLTE2VTx?= MV3HTVUxRTBwNDFOwG0> MVGyNlQ{PTZ4OR?=
T47D MkPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUm2MlIh|ryP MWG3NkBp MYnEUXNQ NWTNRXVlT0l3ME2wMlUh|ryP NX3Vd5ZoOjJ2M{W2Olk>
TK10 MlLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLEXVFqPi5{IN88US=> M1fY[VczKGh? Ml6zSG1UVw>? MWPHTVUxRTBwNkOg{txO M3:1SlIzPDN3Nk[5
UACC257 NHy3fIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HS[VYvOiEQvF2= M4XIWFczKGh? MoXSSG1UVw>? MWPHTVUxRTBwNTFOwG0> MY[yNlQ{PTZ4OR?=
UACC62 NHK1ZWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULQWm9vPi5{IN88US=> MkDwO|IhcA>? NV7YdFBiTE2VTx?= NVrNSW14T0l3ME2wMlQh|ryP M2XifVIzPDN3Nk[5
UO31 NHfqOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXJUotoPi5{IN88US=> MXy3NkBp MULEUXNQ NFXxR5NIUTVyPUCuOUDPxE1? MnexNlI1OzV4Nkm=
Hep3B NUPVdlJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3MRmQ1QCCq MnLpSG1UVw>? MYXHTVUxRTBwNkmg{txO NVHt[JRZOjJ2M{m4OlM>
BE(2)-C NXX0TJNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWS3NkBp NEP2V5ZFVVOR M1ft[GlEPzB;MjFOwG0> NFHjeXczOjl|MkOxOi=>
Bel7402 MnPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDac5A4OiCq M2jpUGROW09? MoH6S2k6OD1zNzFOwG0> NYnKRYRzOjNyNkGzO|Y>
Bel7404 Ml\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDRUYw1PzJiaB?= Ml;kSG1UVw>? NF\0RpVIUTlyPUG4JO69VQ>? MkjRNlMxPjF|N{[=
BGC823 NFL5fZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHMO|IhcA>? MoiySG1UVw>? MkW1S2k6OD15LkWg{txO MWeyN|A3OTN5Nh?=
MGC803 NF64RmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TqO|czKGh? NXrNdGx[TE2VTx?= NYXtUI9YT0l7ME2xNE45KM7:TR?= MViyN|A3OTN5Nh?=
SGC7901 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXS3NkBp NXnMe|VUTE2VTx?= MYjHTVkxRTlwNDFOwG0> MmLvNlMxPjF|N{[=
SKHEP1 MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInrb|E4OiCq MlLSSG1UVw>? NF;3U21IUTlyPUG3JO69VQ>? MV6yN|A3OTN5Nh?=
SMMC7721 M3;HTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXKxZ|NMPzJiaB?= NEH1SpRFVVOR M4XZNGdKQTB;MkCg{txO M3XqeVI{ODZzM{e2
NUGC3 M4rpfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HuUFExKM7:TR?= MmLtS2k:Oi57NDFOwG0> NIPL[YQzOzF4M{OzNi=>
A2780 CisR MXzLbY5ie2ViQYPzZZk> MYSxPEBp NWLkNYtFUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= NX[xbng{OjN{NUK2NFM>
CAL27 sens NFHsNY1McW6jc3WgRZN{[Xl? NH\J[ZMyQCCq NV7qO3RvUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= NEC5dnQzOzJ3Mk[wNy=>
CAL27 CisR MnfST4lv[XOnIFHzd4F6 M4\3XFE5KGh? MWTJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO Ml7SNlMzPTJ4MEO=
KYSE-510 CisR NInTPXFMcW6jc3WgRZN{[Xl? NHLLNIEyQCCq NWrDTm12UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= NUnp[3ZZOjN{NUK2NFM>
KYSE-510 sens M{nncGtqdmG|ZTDBd5NigQ>? NI\ISGwyQCCq M3LENmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD63JO69VQ>? NHfs[WQzOzJ3Mk[wNy=>
MDA-MB-231 sens M1jzbGtqdmG|ZTDBd5NigQ>? NVO3b4VbOThiaB?= NFn6fHFKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP MnrpNlMzPTJ4MEO=
MDA-MB-231 CisR NYTBTmwxU2mwYYPlJGF{e2G7 NWXLS5pFOThiaB?= MVLJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NX:yNJh6OjN{NUK2NFM>
ES2 NYHYUHh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX3dnE1QCCq M4XTemROW09? MY\JR|UxRTF{Lkeg{txO MYGyN|Q6OzR2OR?=
MDA-MB-231 NH7Jd5lMcW6jc3WgRZN{[Xl? M33aelExKM7:TR?= NI\yTlI{OCCvaX6= M3K4fmROW09? MkmzTY5pcWKrdHnvckBw\iCKRFHDNoE> NWjYSphxOjN2OUO0OFk>
MDA-MB-231 MVXLbY5ie2ViQYPzZZk> MkPMNUDPxE1? NX;ZfIU{OjRiaB?= MWPEUXNQ MX;Jcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw MmjzNlM1QTN2NEm=
HS68 NEHSXYREgXSxdH;4bYMhSXO|YYm= MYWxNEDPxE1? M2fRVlczKGh? M3vPTGROW09? NELvb2hKSzVyPUSuOkDPxE1? MYmyN|U4ODV2Mh?=
MEF NHi0VopEgXSxdH;4bYMhSXO|YYm= NGLoZ5YyOCEQvF2= MVK3NkBp MnPtSG1UVw>? NXnaNFdRUUN3ME20MlQh|ryP MojmNlM2PzB3NEK=
BGC823 NH3Od5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXKyVY1NTE2VTx?= NVfUcnIzT0l3ME2zMlA6KM7:TR?= NYO0U4hUOjN4MEG3NFY>
High5 MVLLbY5ie2ViQYPzZZk> M2D1flI1KGh? MmS5TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDOkB4cXSqIFnDOVAhd2ZiMD6wPUDPxE1? MX2yN|YxOjV{Mx?=
High5 MXTLbY5ie2ViQYPzZZk> MVSyOEBp NEnoXWNKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlEzKM7:TR?= NFO5fYUzOzZyMkWyNy=>
High5 M3TuWGtqdmG|ZTDBd5NigQ>? M1Lhb|I1KGh? NF7sT|VKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= NYTaOIVjOjN4MEK1NlM>
A549 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7zPXB{TE2VTx?= MkewTWM2OD1zLkC3PUDPxE1? MXyyN|Y1PDJzMB?=
HCT116 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO1SG1UVw>? NW\zb|k6UUN3ME2wMlc2PyEQvF2= MVyyN|Y1PDJzMB?=
K562 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7r[oZOTE2VTx?= M3z2SmlEPTB;MD62OFUh|ryP MlO0NlM3PDR{MUC=
GBC-SD MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3MRVZzPSEQvF2= MUi3NkBp MVnEUXNQ NVi1VFZ6UUN3ME2xOE45KM7:TR?= MVeyN|cxPzJ4MB?=
HGC27 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnoVmE2KM7:TR?= NE\0PJg4OiCq M1\VfWROW09? MUXJR|UxRTVwNDFOwG0> NWnuOG9NOjN5MEeyOlA>
HL60 MXvLbY5ie2ViQYPzZZk> MXu1JO69VQ>? NVjk[mdWOjRiaB?= Mlu5SG1UVw>? MYnJcohq[mm2aX;uJI9nKEiGQVO= Ml7pNlM4ODd{NkC=
Vero MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHJO|IhcA>? MWPEUXNQ MnzHTWM2OD1yLkmg{txO NWX4PFBTOjN5OE[0OVI>
NCI60 Mkf5R5l1d3SxeHnjJGF{e2G7 NX3PVZhOPDhiaB?= MWDEUXNQ MXTHTV0xNjV|IN88US=> M3LEVVI1ODF3M{K3
SW620 NUXHR3U3S3m2b4TvfIlkKEG|c3H5 MnXkOFghcA>? NWPTfolnTE2VTx?= MXTHTV0xNjV2IN88US=> NH;TVIkzPDBzNUOyOy=>
U251 NYPjXYpwS3m2b4TvfIlkKEG|c3H5 NIO5Uow1QCCq M2nFU2ROW09? NIS5XXFIUT1zLkWzJO69VQ>? MVmyOFAyPTN{Nx?=
KM12 NEX0SItEgXSxdH;4bYMhSXO|YYm= M4nURlQ5KGh? NX\xZVRITE2VTx?= M4myZmdKRTFwOEig{txO MYeyOFAyPTN{Nx?=
Hs578T NIe1PG9EgXSxdH;4bYMhSXO|YYm= Mk\iOFghcA>? M3X6V2ROW09? MYfHTV01Njh|IN88US=> MVOyOFAyPTN{Nx?=
MDA-MB-231 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;weWo1QCCq NHnGR5lKSzVyPUCuNVYh|ryP NXTSZ|hVOjRyOUWwNVY>
MCF7 M3\Hd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3JOXo5PDhiaB?= NWW1OpdtT0l;MD60OUDPxE1? MnnDNlQyOTl3NUW=
MDA-MB-435 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPuUWxrPDhiaB?= MmryS2k:OC56ODFOwG0> NImzVJozPDFzOUW1OS=>
AsPC1 MorzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLFU2xWOzBizszN NUPIUZpLPDhiaB?= MWXEUXNQ MXHJR|UxRTNwNk[g{txO MWWyOFE5PTN5OB?=
Jurkat E6.1 MU\LbY5ie2ViQYPzZZk> MVuyJIg> MX;EUXNQ NUnwNIgyUW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= NXTLXYRrOjR{NkG4OlI>
KG1 NUK1NXdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L0TlQ5KGh? M4rzfWlEPTB;MT6xOUDPxE1? NFnQWFEzPDV{NUCwNy=>
HEL M2Lwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfLZ5k1QCCq NIf2cJJFVVOR NUTze|BrUUN3ME2wMlQ6KM7:TR?= NXzG[lhLOjR4OUSwOVU>
HSC3 MYLDfZRwfG:6aXOgRZN{[Xl? M{XDVVEzKGh? NFfWS3lFVVOR MXLJR|UxRTBwN{Gg{txO MkLMNlQ4PjZ3NkC=
HT-29 MlHSR5l1d3SxeHnjJGF{e2G7 NEXjXogyOiCq MnfsSG1UVw>? MV3JR|UxRTBwN{Kg{txO M4nFXVI1PzZ4NU[w
KB MY\DfZRwfG:6aXOgRZN{[Xl? NV:3Om5iOTJiaB?= NXvCXXhSTE2VTx?= NIm2RWdKSzVyPUCuO|Uh|ryP M2DiNFI1PzZ4NU[w
H460 NF3xTXlEgXSxdH;4bYMhSXO|YYm= MUKxNkBp M1LDRWROW09? NHjJOpFKSzVyPUCuPFIh|ryP MXyyOFc3PjV4MB?=
MONE1 NGHqfVNEgXSxdH;4bYMhSXO|YYm= NEXtcmkyOiCq MWPEUXNQ MnLBTWM2OD1zLkG4JO69VQ>? NF3ReZYzPDd4NkW2NC=>
MKN45 MYDDfZRwfG:6aXOgRZN{[Xl? NFjVbIwyOiCq MWXEUXNQ M3r3WGlEPTB;MT6yOUDPxE1? NGj0ZY0zPDd4NkW2NC=>
TSGH MVTDfZRwfG:6aXOgRZN{[Xl? NWrhfnd7OTJiaB?= NV3VdZF{TE2VTx?= MYPJR|UxRTJwMEmg{txO MkHNNlQ4PjZ3NkC=
HL60 MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWO3NkBp MlnUSG1UVw>? M1[wSWdKPTB;MD65N{DPxE1? MkjPNlQ6ODB3MEC=
HEK293 M1LMNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jocVczKGh? MonjSG1UVw>? NVfkXppHT0l3ME2xN{DPxE1? Mo\NNlQ6ODB3MEC=
Jurkat NXfBN4UxS3m2b4TvfIlkKEG|c3H5 MWOxNFAh|ryP NHXCRWw4OiCq NHzEdZVIUTVyPUCuPUDPxE1? MXSyOFkxODd2Mx?=
GM15850 NVr6dHBUU2mwYYPlJGF{e2G7 M{X6NFIvPSEQvF2= NIDQb|c6PiCq MVTEUXNQ MYDkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NFPJRo8yPjl{MUO2Oy=>
GM15850 MkHXT4lv[XOnIFHzd4F6 MlW5Nk42KM7:TR?= NIm0[nU6PiCq NH3ZOFNFVVOR MUHkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M4G1S|E3QTJzM{[3
GM15850 NWHkb5NDU2mwYYPlJGF{e2G7 NInZcJczNjVizszN M3\5Rlk3KGh? MWfEUXNQ MkDp[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M{Lzb|E3QTJzM{[3
GM15850 MVPLbY5ie2ViQYPzZZk> NFPDV5ozNjVizszN MlvrPVYhcA>? MnvySG1UVw>? Mmnp[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M2TBRVE3QTJzM{[3
GM15850 NEf2TodMcW6jc3WgRZN{[Xl? MlzuNk42KM7:TR?= MkLJPVYhcA>? NVrre25jTE2VTx?= NHLteYhld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhQCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> M2TqcFE3QTJzM{[3
GM15850 NY\ZR4dMU2mwYYPlJGF{e2G7 M13vOFIvPSEQvF2= NFHZUmQ6PiCq M1q3UGROW09? NHno[|Rld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhOTZiYXPleJlt[XSrb36gc4YhTliQIHflcoU> MmG2NVY6OjF|Nke=
GM15850 MUDGeY5kfGmxbjDBd5NigQ>? NVfkO4NQPSEQvF2= MX6xNkBp NWq1W4o{TE2VTx?= NFnlZWFp[XNibn:g[YZn\WO2IH;uJGZZViCvUl7BJIV5eHKnc4Ppc44> NVHzT4JDOTZ7MkGzOlc>
U937 NUPiWYNLU2mwYYPlJGF{e2G7 MXS1JO69VQ>? MVqyOEBp NUTh[VAyTE2VTx?= NWr4cotVcGG|IH7vJIVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u NYDEUIMzOTd2NEe3OVA>
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SF126 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTFyLkS3Nlch|ryP NHz5XmtUSU6JRWK=
SK-MEL-1 MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnDTWM2OD1zMD63PFM5KM7:TR?= MXjTRW5ITVJ?
ACN M{jyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHKVohKSzVyPUGwMlg3PzlizszN MYTTRW5ITVJ?
BB30-HNC MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonBTWM2OD1zMD64O|EyKM7:TR?= M4HtOnNCVkeHUh?=
NCI-H747 M3O4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[0TWM2OD1zMD64O|Q3KM7:TR?= NVewN4FbW0GQR1XS
KYSE-150 M1PzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFzLkCzPFch|ryP MlHWV2FPT0WU
D-247MG NGLqdlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nJd2lEPTB;MUGuNVAxQSEQvF2= MkTNV2FPT0WU
BxPC-3 M{mzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;OWWlEPTB;MUGuN|c1PyEQvF2= NF\GSVJUSU6JRWK=
SK-MEL-30 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPyT4pIUUN3ME2xNU41ODd7IN88US=> M1jZc3NCVkeHUh?=
CAS-1 NWLOfpFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFzLkSxNFkh|ryP NW\V[GFzW0GQR1XS
no-10 NGPsRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDzNGxKSzVyPUGyMlEzOTdizszN M3;CXXNCVkeHUh?=
NCI-H2405 NXv4ZXFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr3TWM2OD1zMj6yNFM3KM7:TR?= NXj1TVhbW0GQR1XS
KGN NGqxdnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7lbYxKSzVyPUGyMlI6ODFizszN Mnj1V2FPT0WU
BB49-HNC NV3hRlI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXKwb3hUUUN3ME2xNk4{QTV4IN88US=> MW\TRW5ITVJ?
NCI-H1693 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF{LkW4NVYh|ryP M3vjSHNCVkeHUh?=
RO82-W-1 NV7RSZpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGKxO5lKSzVyPUGzMlA3PDlizszN M2nhOnNCVkeHUh?=
CAL-85-1 NWmyTmgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz6TIdKSzVyPUGzMlQ{QTlizszN NV:1U3R1W0GQR1XS
H-EMC-SS NE\Ne5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHUTWM2OD1zMz65NVA1KM7:TR?= MmrPV2FPT0WU
SW1783 NITKdFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCzSZFbUUN3ME2xOE4zOzlzIN88US=> MUjTRW5ITVJ?
LB771-HNC Mke0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1iyWWlEPTB;MUSuOFE6KM7:TR?= NV\5So1wW0GQR1XS
HCC70 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPTPIZoUUN3ME2xOE41OjN|IN88US=> M1riZXNCVkeHUh?=
KNS-81-FD M{ntfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF2LkewOFUh|ryP NV2zcZg1W0GQR1XS
KYSE-520 NHnCfHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnhUYVKSzVyPUG0MlkzPyEQvF2= M13lO3NCVkeHUh?=
TGBC24TKB NGfPN2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[wdG84UUN3ME2xOE46PTN7IN88US=> NGnDTotUSU6JRWK=
SNB75 MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rYVmlEPTB;MUWuNFczQSEQvF2= MmPRV2FPT0WU
SW872 MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7ETFhKSzVyPUG1MlIzOThizszN MlHOV2FPT0WU
U031 NXvVdmpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF3LkiwNlgh|ryP M3\qbXNCVkeHUh?=
ChaGo-K-1 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK4TGlGUUN3ME2xOU45OzV7IN88US=> MknBV2FPT0WU
NCI-H441 NYXMU3NoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTF4LkCwN|kh|ryP NHTEdXZUSU6JRWK=
TE-12 NFfpToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XvUWlEPTB;MU[uNVg4OyEQvF2= MmrYV2FPT0WU
NCI-H1755 NEPE[WNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTF4LkW3N{DPxE1? NFnOOmxUSU6JRWK=
KNS-42 NVj2U5NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jJbGlEPTB;MU[uOlU5QSEQvF2= MkTMV2FPT0WU
SK-PN-DW NFm3VWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHkTWhKSzVyPUG3MlQzODFizszN M3z0fnNCVkeHUh?=
NCI-H226 NFTYTVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HRWWlEPTB;MUeuPVM1PSEQvF2= NXy4Z21tW0GQR1XS
K-562 M{nDbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTF6Lk[zNVch|ryP NHnXcFRUSU6JRWK=
A388 NEHJdFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rDPWlEPTB;MUmuNFMxOyEQvF2= NV3IWJliW0GQR1XS
ZR-75-30 MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf3ZXFKSzVyPUG5MlA6PjhizszN MmfYV2FPT0WU
LU-135 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTF7LkK2N|Yh|ryP NGHTN|ZUSU6JRWK=
NCI-H2029 MnPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP4NGM2UUN3ME2xPU43ODJzIN88US=> MkPIV2FPT0WU
HT-1197 M1TrW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nvdmlEPTB;MUmuPVIzPyEQvF2= Mn23V2FPT0WU
IGR-1 NVLPfYMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJyLkOxNVch|ryP MnvoV2FPT0WU
U-87-MG NWjsZ29NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLL[nJ4UUN3ME2yNE43PDF|IN88US=> NWPkWnhRW0GQR1XS
NCI-H1304 M1\Xe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJyLke1NFEh|ryP NYPPXnd{W0GQR1XS
RCC10RGB M4XXN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\xOmlEPTB;MkGuNlgzQSEQvF2= NHG3TWxUSU6JRWK=
NCI-H520 NULvU|J1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi4TWM2OD1{Mj63OlEyKM7:TR?= Ml3DV2FPT0WU
SK-LU-1 M1z6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJ|LkC3NVgh|ryP M2\RPHNCVkeHUh?=
UACC-893 NVfW[lhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jLU2lEPTB;MkOuNVA{QCEQvF2= NVvRNIlkW0GQR1XS
NCI-H2347 NIrwcYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTJ|LkK2O|Qh|ryP MnfqV2FPT0WU
U-118-MG NWPXc|dXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;zXYlCUUN3ME2yN{44OjF5IN88US=> MVLTRW5ITVJ?
NCI-H596 NH;r[WVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPVTWM2OD1{Mz65NFU2KM7:TR?= M3;TfXNCVkeHUh?=
MZ1-PC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXKTWM2OD1{ND62O|U6KM7:TR?= NIrkSINUSU6JRWK=
SW1417 MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[yZ3ZjUUN3ME2yOU4zPDl6IN88US=> MVnTRW5ITVJ?
NCI-H82 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LFb2lEPTB;Mk[uOFI5QCEQvF2= NVXGVmg2W0GQR1XS
COLO-678 MlX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\5b41KSzVyPUK3MlQ6OTlizszN NFjZNI1USU6JRWK=
KURAMOCHI M3fvPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfpNlRkUUN3ME2yPE4yOjZizszN NXrk[3JtW0GQR1XS
NCI-H1650 M1TZb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzsZldiUUN3ME2zNE4yQTJ2IN88US=> NHzrNVVUSU6JRWK=
HCC1954 Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vKTGlEPTB;M{GuN|Y3PiEQvF2= NIrHd2xUSU6JRWK=
GAK MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PqXGlEPTB;M{KuNlYyPiEQvF2= M1LrOXNCVkeHUh?=
YAPC NV;0VndPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPMd|d[UUN3ME2zN{44PjR6IN88US=> NIXVU3BUSU6JRWK=
NCI-H2228 NXTFOY9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\tTWM2OD1|ND6zOlA2KM7:TR?= NHH3e3VUSU6JRWK=
VMRC-RCZ Mkm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTN4LkOwNlIh|ryP M2f4cnNCVkeHUh?=
NMC-G1 NFXYZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTN5LkC1Nlkh|ryP MkO1V2FPT0WU
D-336MG NV34Z4NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DRNmlEPTB;NEGuPFQ1OiEQvF2= NEXMZVhUSU6JRWK=
UACC-62 NGTmUVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfOVZJ2UUN3ME20Nk42PTB3IN88US=> M2HSVHNCVkeHUh?=
C-33-A NUHiNpRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP1TWM2OD12NT6zNlU3KM7:TR?= MYrTRW5ITVJ?
HCC1937 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX75SWxTUUN3ME20O{4yQTV6IN88US=> Mk\VV2FPT0WU
HDLM-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rjSGlEPTB;NEeuNlI5PyEQvF2= Ml3IV2FPT0WU
NCI-H727 NFKzPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTZbng3UUN3ME20O{4zPDVzIN88US=> NYfPWVZ6W0GQR1XS
NY NFntZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUWwelV[UUN3ME20PU4{QTB6IN88US=> M17MR3NCVkeHUh?=
NCI-H2291 NEC2T2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTR7LkizNFEh|ryP MoPpV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID