Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 100 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NXv2VHNWU2mwYYPlJGF{e2G7 NFzEPJIyKGh? MoDkSG1UVw>? M2jh[4FvfGlvSFTBR|Eh[WO2aY\peJkhf2m2aDDJR|UxKG:oIECuNVEzKM7:TR?= MXOxNVk3ODR6OR?=
Friend leukemic cell NHLK[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP5V3hwPTBizszN M1X6bVczKGh? Mk\xSG1UVw>? M2PyTWlEPTB;MD65PUDPxE1? M4XjRlEzOTB7OUGz
K562 MY\LbY5ie2ViQYPzZZk> NH3POlY3KGh? M1nWTGROW09? MXfJcohq[mm2aX;uJI9nKGi3bXHuJIhqe3SxbnWg[IVi[2W2eXzhd4UhMG2reIT1doUhd2ZiSFTBR|Eh[W6mIFjERWMzMSC5aYToJGlEPTBib3[gNE4xOSEQvF2= MWKxNlQyQTN6MB?=
HT1080 NFTUfWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1u3WVczKGh? M1\Se2ROW09? M1LaR2lEPTB;Mj60JO69VQ>? NY\DN5B{OTJ{N{CxO|U>
H1299 M1r4eGtqdmG|ZTDBd5NigQ>? NWHOS252OjBibXnu M4O4T2ROW09? M1nzWmlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJTEGFIHXufplu\SC5aYToJGlEPTBib3[gNE4yQTRizszN NWXN[2t3OTR3MkG0NlI>
H1299 NHXufVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vrTVczKGh? MknKSG1UVw>? MVrJR|UxRTdwMkSg{txO MmDlNVQ2OjF2MkK=
HeLa NH3Ed5JMcW6jc3WgRZN{[Xl? Mmn5N|AhdWmw MXPJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> M4e3cVE2PjB|OUS5
LOX-IMVI MknLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELXdGQ1QCCq MYXJR|UxRTFwMzFOwG0> MoH4NVU4OTV2N{C=
NCI-H226 NFHlZ4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LiTFQ5KGh? NYDEOHNpUUN3ME2yMlYh|ryP NVq1Z28yOTV5MUW0O|A>
RXF-631L MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\p[|Q5KGh? M1raemlEPTB;MjFOwG0> MW[xOVcyPTR5MB?=
SNB-78 NHu2S4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnKWoZ2PDhiaB?= M3rWNWlEPTB;MU[g{txO M1jXflE2PzF3NEew
St-4 M13rXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX20PEBp M4n1NWlEPTB;NT6yJO69VQ>? MVWxOVcyPTR5MB?=
ARP1 NWHlbGpnTnWwY4Tpc44hSXO|YYm= M33GSFIh|ryP M1rwXFYhcA>? NEO0cWFKdmS3Y4Tpc44hd2ZiUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> MYOxOFc{PDhyNh?=
CEM MWHLbY5ie2ViQYPzZZk> MVyxJIg> MmXISG1UVw>? NF7oOIJKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Mh|ryP NXrJb|FqOTZ2MkCwOlQ>
HCT15 NGnQdmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[0PEBp M3nHOWdKPTB;MD64NkDPxE1? MmnxNVY4OjN{Mke=
NCI-H23 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLHUGM1QCCq MXTHTVUxRTBwOUKg{txO MVOxOlczOzJ{Nx?=
GM15850 NUXHbG9SU2mwYYPlJGF{e2G7 NFjvdJAzNjVizszN Mn3zPVYhcA>? MYrEUXNQ Mo[1TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEG0JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NHLmc3IyPjl{MUO2Oy=>
GM15850 NHfHO|dMcW6jc3WgRZN{[Xl? MYmyMlUh|ryP MnXnPVYhcA>? NHzjNHNFVVOR MofRTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEWgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NVjo[5V6OTZ7MkGzOlc>
GM15850 NGDTcoVMcW6jc3WgRZN{[Xl? NILFbWczNjVizszN M1PiZVk3KGh? M2DmUmROW09? Mn\YTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MlTSNVY6OjF|Nke=
GM15850 NXzPVXNqU2mwYYPlJGF{e2G7 M2rERlIvPSEQvF2= MnviPVYhcA>? Mn;ySG1UVw>? MnHSTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M3GzOVE3QTJzM{[3
GM15850 Mn;PT4lv[XOnIFHzd4F6 M2nNVFIvPSEQvF2= NFfkTG46PiCq NYe2SphZTE2VTx?= MV7Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViODDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? NILW[GgyPjl{MUO2Oy=>
GM15850 M13uWWtqdmG|ZTDBd5NigQ>? MmfYNk42KM7:TR?= MXW5OkBp NVzVRXl1TE2VTx?= M3XVPGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NHi4TJMyPjl{MUO2Oy=>
U937 MXrGeY5kfGmxbjDBd5NigQ>? NYXqZnhiPSEQvF2= NH3CRVMzPCCq Mo\ISG1UVw>? NEHQN5ZE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn MVWxO|AxPDdzOB?=
H661 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPh[IE1QCCq M37JUWlEPTB;MTFOwG0> NVThTXAzOTdzNUewNFk>
U937 MkPjSpVv[3Srb36gRZN{[Xl? MkPsOUDPxE1? M1\rU|I1KGh? NUXSdXh7TE2VTx?= MXfJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w MX2xO|Q1Pzd3MB?=
U937 M1TIfGZ2dmO2aX;uJGF{e2G7 NVrQe4l4OSEQvF2= M3;WclI1KGh? MVfEUXNQ MofCSYZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= MVixO|Q1Pzd3MB?=
RAW264.7 NGrwepRHfW6ldHnvckBCe3OjeR?= NF3PNFgyOCEQvF2= NYfEOndlOjSq MXH3ZZRmeg>? MWfJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP M1HpOFE4PDd5NUG4
RAW264.7 NFj2NpJHfW6ldHnvckBCe3OjeR?= M3XaO|ExKM7:TR?= MlvpNlRp M2HCb5difGW{ NF;INo1KdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKE6RIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDFwOEig{txO MVexO|Q4PzVzOB?=
SC9 MniwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXvb3MzPDhiaB?= NWjTRVVKUUN3ME2wMlYxPiEQvF2= Mm\NNVc2ODd{MUm=
ST14A M1\obmZ2dmO2aX;uJGF{e2G7 Ml;jOUBvVQ>? MlnwO|IhcA>? NUDTfGZ3UW6lcnXhd4UhcW5iUlXTWE9PWlOIIH3SUmEh\XiycnXzd4lwdg>? M4L6R|E4PTZ3OUmz
ST14A Mki5SpVv[3Srb36gRZN{[Xl? MYC1JI5O MYS3NkBp MmXKTY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? M1LOPVE4PTZ3OUmz
PANC1 MmjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV6xJO69VQ>? MXzJR|UxRTBwNEWg{txO NGe0So4yPzV6OEe0OC=>
PANC1 MkXBSpVv[3Srb36gRZN{[Xl? NGXqSJIyKM7:TR?= MmH1NlQhcA>? M2PLfGlv[3KnYYPlJIlvKHB{MWfBSlEwS0mSMTDn[Y5mKGW6cILld5Nqd25? MYqxO|U5QDd2NB?=
PANC1 NIDiU21HfW6ldHnvckBCe3OjeR?= NVTvc|RkOSEQvF2= NGfFZlYzPCCq NF3SNG1KdmO{ZXHz[UBqdiCyMkfrbZAyKGenbnWg[ZhxemW|c3nvci=> Ml\LNVc2QDh5NES=
PT45 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn2UJdKSzVyPUSg{txO MnzYNVc2QDh5NES=
ACHN NWXWPWZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSyNUBp NVTpT2JRT0l3ME2wMlY2KM7:TR?= MXixO|Y3OjZyNh?=
PC3 NH22b2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTvboJLOjFiaB?= M2DmZ2dKPTB;MD63NUDPxE1? NFTTUVEyPzZ4Mk[wOi=>
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SKHEP1 M4S2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHSdlR5PzJiaB?= NX75TlJqUUN3ME2zMlQ3KM7:TR?= NEHicVczODF2M{e3PC=>
BJ NUS3U|dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIn5UmsyODBizszN NIrmPFE1QCCq MnqxSG1UVw>? NILwWnpIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> M4DVZlIxOTR|OESw
MUF NEi2WW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17HbVExOCEQvF2= MXW0PEBp NHW2NWVFVVOR NHTnOotIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> NIPwcYwzODF2M{i0NC=>
Caco-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\6cXh5OTByIN88US=> NGS1U4o1QGh? MlfSSG1UVw>? NGniV4RKSzVyPUiuNUDPxE1? M{O0c|IxOTR|OESw
Caco-2 M{LMfGtqdmG|ZTDBd5NigQ>? NIjvVHY2KM7:TR?= NIjRRYI1KGh? MVrEUXNQ M{j5ZWlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgZYNmfHmuYYTpc44hUUN3MDDv[kAxNjB|NzFOwG0> MnrJNlAyPDN6NEC=
Caco-2 M1;oWmtqdmG|ZTDBd5NigQ>? NEjyT|QxNjNzNjDuUUB1dyB|MT62JO69VQ>? M2THd|QhcA>? NH7mbnRFVVOR M3PGTmV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMTD3bZRpKEmFNUCgc4YhOC5zMUmg{txO NHza[IczODF2M{i0NC=>
Caco-2 NWLyNpJxU2mwYYPlJGF{e2G7 NIX2[pkxNjNzNjDuUUB1dyB|MT62JO69VQ>? NEjpOWQ1KGh? MlXSSG1UVw>? M4Pv[mV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMzD3bZRpKEmFNUCgc4YhOC5zNEeg{txO NXe3fnFKOjBzNEO4OFA>
Caco-2 M4DsXWtqdmG|ZTDBd5NigQ>? NI\GZpk3NjN{IH7NJJRwKDZ|MjFOwG0> MnrVOEBp MV3EUXNQ MYTFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzVid3n0bEBKSzVyIH;mJFEzNjZizszN NIPqV4ozODF2M{i0NC=>
Caco-2 MVLLbY5ie2ViQYPzZZk> Ml;QOk4{OiCwTTD0c{A3OzJizszN NEDFTnA1KGh? MXvEUXNQ MWTFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzdid3n0bEBKSzVyIH;mJFQyKM7:TR?= MlXnNlAyPDN6NEC=
Caco-2 MVvLbY5ie2ViQYPzZZk> NYrJTJN2OC5|MU[gcm0hfG9iM{GuOkDPxE1? MXq0JIg> M13rNmROW09? MnqwSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN4 NEi1clQzODF2M{i0NC=>
HepG2 MnPlT4lv[XOnIFHzd4F6 M{G3fVUh|ryP M2TYOFZp M{j6V2ROW09? NGfZSY1KdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9v MnnJNlAyPDN6NEC=
HepG2 NGfuNWxMcW6jc3WgRZN{[Xl? NFnjbWc2KM7:TR?= MkXTOog> MnPqSG1UVw>? MYrJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHj5dIVz[WOndInsZZRqd25? NUe2PIc1OjBzNEO4OFA>
HepG2 NFe5bohMcW6jc3WgRZN{[Xl? NVTUfYZPPSEQvF2= MUm2bC=> NEjIcG1FVVOR MmrrTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= MoG0NlAyPDN6NEC=
HepG2 MXXLbY5ie2ViQYPzZZk> NHGzT3g2KM7:TR?= NHjxSlc3cA>? MkfESG1UVw>? MnywTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgTFMwUDRiaHnzeI9v\SCjY3X0fYxifGmxbh?= MmnXNlAyPDN6NEC=
COLO205 NFn2TZNMcW6jc3WgRZN{[Xl? MWWxNEDPxE1? MlHwNlQhcA>? NXHWZ5BSTE2VTx?= M1XwemlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25id3n0bEBKSzVyIH;mJFIvOiEQvF2= MnP0NlA1PTF|N{i=
SCC4 M1nXU2tqdmG|ZTDBd5NigQ>? MoXrNUDPxE1? NIXjT4IzPGh? NH73NFdKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6geJVjfWyrbjDhZ4V1gWyjdHnvci=> Mo\PNlA1PTJ{MkW=
SCC4 Mn\lT4lv[XOnIFHzd4F6 NF6yZm0yKM7:TR?= MWKyOIg> NWWxPXlbUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44> NFnpb3EzODR3MkKyOS=>
SCC4 MlfnSpVv[3Srb36gRZN{[Xl? MW[xJO69VQ>? MoT1OUBucW5? NWK2[nhrSWexbnnzeEBi[3Srdnn0fUBifCCYRGKgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIFPZVFI1KGenbnWg[ZhxemW|c3nvci=> NVrpVIM5OjB2NUKyNlU>
NB4 MVjGeY5kfGmxbjDBd5NigQ>? NF7xRZE2KM7:TR?= MUeyOEBp MWHEUXNQ NX3tcHY5S2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNkfW23bHH0bY9vKGG2IIDy[U1IOSCyaHHz[S=> NIi2Ro4zODR7MUS0NC=>
NB4 MWHLbY5ie2ViQYPzZZk> MmK0OUDPxE1? MkDQNlQhcA>? NHvoc5VFVVOR NF7XenlKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNmfHmuYYTlJJR2[nWuaX6gcIV3\Wx? NUDsd5hFOjB2OUG0OFA>
NB4 MXTGeY5kfGmxbjDBd5NigQ>? MX61JO69VQ>? MWqyOEBp M33ncGROW09? M4\xbWlv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> NVHFXlZHOjB2OUG0OFA>
NB4 NHyxZmZMcW6jc3WgRZN{[Xl? Mlj6OUDPxE1? MV[yOEBp NIDEW2xFVVOR MmnQTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgZYNmfHmuYYTpc44> NGXuWHYzODR7MUS0NC=>
NUGC3 NFnCO|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYO5SmtUT0l3ME2yMlk1KM7:TR?= MVmyNFg2ODl5MR?=
A549 NGDrd21HfW6ldHnvckBCe3OjeR?= M4D5bFUh|ryP M{nkOVMhcA>? NYXHVlNZTE2VTx?= NHyyV5hKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> M1;YdFIxQDV3MkC4
HUT78 MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVq3NkBp NEPTflJFVVOR M1e1NWdKPTB;MD6zJO69VQ>? NHSwbGszODh6NEKwPC=>
U937 NGPPOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYi3NkBp M1LGT2ROW09? NUDU[IM3T0l3ME2wMlM6KM7:TR?= NH[zXpozODh6NEKwPC=>
A431 MnrQR5l1d3SxeHnjJGF{e2G7 MYm3NkBp MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJI93\XKneIDy[ZN{cW6pIFXHSnIhf2m2aDDJR|UxKG:oIESuNkDPxE1? NIPSW4szOTB6ME[yPS=>
A549 NUnabHJwS3m2b4TvfIlkKEG|c3H5 MV[3NkBp NGruPXFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvQCEQvF2= NGrCVIMzOTB6ME[yPS=>
CAL27 NUPYOpRKS3m2b4TvfIlkKEG|c3H5 NXqxPHk5PzJiaB?= MoDIR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2FNOjdiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gN{4zKM7:TR?= NGD1ZlIzOTB6ME[yPS=>
HeLa MVXDfZRwfG:6aXOgRZN{[Xl? MVO3NkBp NVLVXY9NS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjVizszN NHzMWYwzOTB6ME[yPS=>
Sf21 MkXYT4lv[XOnIFHzd4F6 NVzZcVF4OyCq NGO4OYlKdmirYnn0bY9vKG:oIF\sZYchfGGpZ3XkJIh2dWGwIILlZ49u[mmwYX70JGhFSUN6IHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOS5{IN88US=> MV6yNVA5ODZ{OR?=
SKBR3 NF36VXhEgXSxdH;4bYMhSXO|YYm= MUG3NkBp Ml6zR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= MmP4NlExQDB4Mkm=
SKOV3 MX;DfZRwfG:6aXOgRZN{[Xl? NXPOTmhrPzJiaB?= NX3oS2lyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi5{IN88US=> M{XaWFIyODhyNkK5
COR-L23 NX7PU5BqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\0fIhuOTBizszN NHzW[Ig4OiCq M2\xW2ROW09? NUPtfJRrT0l3ME2xMlEh|ryP NXz6RY5ZOjFyOEC2OFc>
DU145 NITscFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;RfFExKM7:TR?= MkSwO|IhcA>? NXT1U5JrTE2VTx?= NXm1bJBwT0l3ME2xMlA2KM7:TR?= NYG5XpZZOjFyOEC2OFc>
LoVo NXzj[3dOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfydXYyOCEQvF2= NIfnd3o4OiCq NX\nfWI{TE2VTx?= NFHifHFIUTVyPUGuO{DPxE1? NXjnblNuOjFyOEC2OFc>
MCR5-SV2 M362Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfTWo4yOCEQvF2= MljXO|IhcA>? MUfEUXNQ MnrnS2k2OD1{LkGg{txO NV7jS45zOjFyOEC2OFc>
HCT116 M1\QT2tqdmG|ZTDBd5NigQ>? NX31eJQ4OzBizszN MVyzNEBp MmDKSG1UVw>? MX3Jcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w NHzDNWszOTB6ME[0Oy=>
HCT116 MnnmT4lv[XOnIFHzd4F6 M{XJelMxKM7:TR?= MkHrN|AhcA>? MX7EUXNQ NYn0[XE3UW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u MnrVNlExQDB4NEe=
U937 NGrkVGRMcW6jc3WgRZN{[Xl? NWfpVIlTPSEQvF2= NVO1SJFPOjRiaB?= NYPHWnlMTE2VTx?= NUTUZ3JRUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= MVSyNVI6OjR7Mh?=
U937 MXXLbY5ie2ViQYPzZZk> MkDsOUDPxE1? M4naOVI1KGh? NH\nWoVFVVOR M3L0UWlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEtzOB?= NWHYb|FTOjF{OUK0PVI>
U937 M2\ZNGtqdmG|ZTDBd5NigQ>? NGX1bZI2KM7:TR?= NFiz[ogzPCCq Mn6ySG1UVw>? MYHJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gdIFvNWGlZYT5cIF1\WRiaHnzeI9v\SCKNDDs[ZZmdA>? NWOyNZh3OjF{OUK0PVI>
U937 M3LKXGtqdmG|ZTDBd5NigQ>? MnPYOUDPxE1? NILSdpUyPSCvaX6= NHP0W|VFVVOR MnW5TY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25ibHX2[Yw> MXGyNVI6OjR7Mh?=
A2780 MkniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Xje|k3KGh? NVzod5Z1TE2VTx?= NFzVWHJKSzVyPUGuOlIh|ryP NIS4[3YzOTZ|NESzNC=>
COLO205 MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYH2fVk{QTZiaB?= MkHhSG1UVw>? M4DnNmlEPTB;Mj6xNkDPxE1? NWTlZoFNOjF4M{S0N|A>
Hep3B MnHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PzOlQ5KGh? MnH5SG1UVw>? NHr5XI1IUTVyPUGuNlEh|ryP MmjlNlE4OTJzNE[=
GM11272 M2T2XmZ2dmO2aX;uJGF{e2G7 MmrNNVAxKG6P M3jiXlczKGh? NVSwUWRLTE2VTx?= MkfEVoVi[3SrdnH0bY9vKG:oIF3lR5AzKG23dHHueEBmgHC{ZYPzbY9vKGG2IEGwJJRwKDFyMDDuUS=> NW[wRWh5OjF6NEC3NVY>
CFBE41o NFLEfINMcW6jc3WgRZN{[Xl? NV\ZZmxzPSEQvF2= NVm0SFFTTE2VTx?= M3vHOWRwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? NH7nZ5gzOTl6NEm1PC=>
CFBE41o NIDTVYFHfW6ldHnvckBCe3OjeR?= M1fzO|Eh|ryP NG[wZWYzPCCq NGjq[ZZFVVOR NXLzNXBZWmW|dH;yZZRqd25ib3[gR2ZVWiCmZXz0ZWY2ODhibYX0ZY51KHS{YX\mbYNscW6pIITvJINmdGxic4Xy[oFk\SCjczDncJlkd2[xcn3z NXrxU2xLOjF7OES5OVg>
DU145 NULuRZFQU2mwYYPlJGF{e2G7 M4LNbFIvPSEQvF2= M3rOPFI1KGh? M1OyTGROW09? NF;FXG1KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNidYDy[Yd2dGG2aX;uJI9nKHB{MYfh[lEheHKxdHXpckBmgHC{ZYPzbY9v M2XGfFIzOjZyMU[2
DU145 MVrLbY5ie2ViQYPzZZk> MmPKOUDPxE1? NEjObJgzPCCq M3TNNGROW09? M{H2ZmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u NFzqOnQzOjJ4MEG2Oi=>
DU145 NVPZVJBLU2mwYYPlJGF{e2G7 NHXnSIY2KM7:TR?= NH\YW5ozPCCq NFXsXnBFVVOR MUPJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9v NF7wcJQzOjJ4MEG2Oi=>
786-0 M{\mR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInZTWM3NjJizszN NUTVVWd1PzJiaB?= NUnnOHh{TE2VTx?= Mlm1S2k2OD1|LkKg{txO MWqyNlQ{PTZ4OR?=
A498 Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\DeWs3NjJizszN NFXhb5E4OiCq NV\ZOoxrTE2VTx?= NEThO5lIUTVyPUGuOkDPxE1? NFHO[mgzOjR|NU[2PS=>
A549/ATCC NIfPNJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYK2MlIh|ryP M4PxfVczKGh? NVnNOIVlTE2VTx?= MYLHTVUxRTFwNjFOwG0> MYeyNlQ{PTZ4OR?=
ACHN NYHCVldxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYi2MlIh|ryP MXS3NkBp M2fyRWROW09? MVjHTVUxRTFwMzFOwG0> MU[yNlQ{PTZ4OR?=
BT549 MnX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlS1Ok4zKM7:TR?= MkLiO|IhcA>? NIrqSJlFVVOR MXzHTVUxRTFwMzFOwG0> MorhNlI1OzV4Nkm=
EKVX MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX5ZWQ3NjJizszN NWTXeohvPzJiaB?= MkLwSG1UVw>? NWXtW|h2T0l3ME2xMlMh|ryP NXnSO4pMOjJ2M{W2Olk>
HCT15 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPRRWw3NjJizszN NHjyRWI4OiCq Ml7SSG1UVw>? MYHHTVUxRTJwNTFOwG0> MkPsNlI1OzV4Nkm=
HOP92 MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17oZVYvOiEQvF2= MXe3NkBp NX34fmhMTE2VTx?= NYH0[21XT0l3ME20JO69VQ>? NYHL[25yOjJ2M{W2Olk>
IGROV1 M2DUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTqOk4zKM7:TR?= MmXPO|IhcA>? MnvTSG1UVw>? MUDHTVUxRTFwMzFOwG0> NHjiNWUzOjR|NU[2PS=>
LOXIMVI M1i5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LnT|YvOiEQvF2= MV[3NkBp MUnEUXNQ NFTnfJNIUTVyPUGg{txO MVGyNlQ{PTZ4OR?=
M14 NIDCSHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLjdIxyPi5{IN88US=> M33GTlczKGh? M3jqZ2ROW09? NHzpT45IUTVyPUGuN{DPxE1? NFTUPGYzOjR|NU[2PS=>
MALME-3M MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\QOk4zKM7:TR?= NH60enA4OiCq NHTvdFRFVVOR MX\HTVUxRTBwM{Kg{txO NXWw[oEzOjJ2M{W2Olk>
MCF10A MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHw[Wh5Pi5{IN88US=> M3PIU|Q5KGh? MY\EUXNQ MorlS2k2OD17Lk[g{txO MYqyNlQ{PTZ4OR?=
MDA-MB-435 M4D5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7YPYR6Pi5{IN88US=> Mn3WO|IhcA>? NWr5co14TE2VTx?= MnTaS2k2OD1yLkWg{txO MWCyNlQ{PTZ4OR?=
MDA-MB-468 NVftS2dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHsVm9EPi5{IN88US=> M2Tlb|czKGh? MlLtSG1UVw>? Ml3jS2k2OD1yLk[zJO69VQ>? NWr6WldDOjJ2M{W2Olk>
MOLT4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXG2MlIh|ryP M4G2UFczKGh? M4\FW2ROW09? Mn2wS2k2OD1yLkSg{txO NUPIUHNCOjJ2M{W2Olk>
NCI-ADR-RES NGrZXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XrOlYvOiEQvF2= M1PFe|czKGh? MWrEUXNQ NFLzWmNIUTVyPUCuNVYh|ryP MofiNlI1OzV4Nkm=
NCI-H23 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPWVXRUPi5{IN88US=> MkHtO|IhcA>? NXLzemlmTE2VTx?= Mmr6S2k2OD1zIN88US=> MXuyNlQ{PTZ4OR?=
NCI-H322M Mn7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7D[|h4Pi5{IN88US=> MVq3NkBp M{n2OmROW09? M3vVc2dKPTB;MD63PUDPxE1? Mnn0NlI1OzV4Nkm=
NCI-H460 M1vKemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\HUZFIPi5{IN88US=> MV:3NkBp M1[wdmROW09? NF;PSGFIUTVyPUCuO|kh|ryP Mli2NlI1OzV4Nkm=
NCI-H522 MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLGOk4zKM7:TR?= MYC3NkBp NI\BSXhFVVOR MkLiS2k2OD1yLkWg{txO NWTqUnZWOjJ2M{W2Olk>
OVCAR3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUK2MlIh|ryP MmjNO|IhcA>? NVLocXl[TE2VTx?= NEPBeINIUTVyPUGuN{DPxE1? NV;qd|Y4OjJ2M{W2Olk>
OVCAR4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV62MlIh|ryP MkK0O|IhcA>? MX7EUXNQ NYXpS4hFT0l3ME20JO69VQ>? MlHMNlI1OzV4Nkm=
OVCAR5 NFLTS2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTvNYt4Pi5{IN88US=> MmfEO|IhcA>? MkLnSG1UVw>? M1TaNGdKPTB;MD63PUDPxE1? M3\ObVIzPDN3Nk[5
OVCAR8 MnTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWi2MlIh|ryP M1z1UVczKGh? MXHEUXNQ MoTuS2k2OD1yLkWg{txO MlXmNlI1OzV4Nkm=
RXF393 M1X6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYf3VYt2Pi5{IN88US=> MWC3NkBp NYe4b2R5TE2VTx?= MnXpS2k2OD1zLkOg{txO MoOyNlI1OzV4Nkm=
SF268 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLuOk4zKM7:TR?= NH\5XoQ4OiCq M3y5PGROW09? MlnNS2k2OD1zLk[g{txO M4G5ZVIzPDN3Nk[5
SF295 M1THemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXG2MlIh|ryP NFPh[oY4OiCq MWHEUXNQ NWP1OVl1T0l3ME2xMlYh|ryP M{\WXFIzPDN3Nk[5
SF539 NH\VPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUC2MlIh|ryP MnTWO|IhcA>? M13vNWROW09? MX7HTVUxRTJizszN Mn\TNlI1OzV4Nkm=
SK-MEL-2 MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPWV4lCPi5{IN88US=> MmDZO|IhcA>? NYS2Nm5FTE2VTx?= Mn22S2k2OD1zLkOg{txO MmjlNlI1OzV4Nkm=
SK-MEL-28 M3TTc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\UOk4zKM7:TR?= M1TiR|czKGh? MlLuSG1UVw>? NEHJVodIUTVyPUGg{txO NEPVfHYzOjR|NU[2PS=>
SK-MEL-5 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWe2MlIh|ryP M2XYT|czKGh? MlPJSG1UVw>? MmH0S2k2OD1yLk[zJO69VQ>? M4DrWVIzPDN3Nk[5
SKOV3 M4jXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnUNpFSPi5{IN88US=> MYq3NkBp MVjEUXNQ M1fkSWdKPTB;MTFOwG0> MmKzNlI1OzV4Nkm=
SN12C MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYO2MlIh|ryP M1\jb|czKGh? NUDwSnFXTE2VTx?= MXfHTVUxRTJizszN NWjJb3hEOjJ2M{W2Olk>
SNB19 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;ZbW1pPi5{IN88US=> MUS3NkBp MX7EUXNQ NWeyXXVwT0l3ME2wMlY{KM7:TR?= M1nCdlIzPDN3Nk[5
SNB75 NFjwTHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LEb|YvOiEQvF2= NHvFeFk4OiCq M{m0S2ROW09? MkjRS2k2OD1yLke5JO69VQ>? MlvlNlI1OzV4Nkm=
SR NHO2U2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S0c|YvOiEQvF2= M2XQ[lczKGh? NGrZe45FVVOR NI\wZ4lIUTVyPUCuOEDPxE1? MkD1NlI1OzV4Nkm=
T47D NUKzVII4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPsZ3FpPi5{IN88US=> M4npZ|czKGh? NGPvU4dFVVOR NVfrflhXT0l3ME2wMlUh|ryP M1;FeFIzPDN3Nk[5
TK10 NX3COXhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELTSYc3NjJizszN MWG3NkBp Mn2xSG1UVw>? MVjHTVUxRTBwNkOg{txO MYWyNlQ{PTZ4OR?=
UACC257 MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;TXlYvOiEQvF2= NHfQT4I4OiCq M4LOPWROW09? NYLMfohbT0l3ME2wMlUh|ryP M4T6WVIzPDN3Nk[5
UACC62 M4HuTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HMc|YvOiEQvF2= Ml73O|IhcA>? M1XwOmROW09? M2PGOGdKPTB;MD60JO69VQ>? M13INFIzPDN3Nk[5
UO31 M4\jUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL0UHExPi5{IN88US=> NYXObnpUPzJiaB?= MlLSSG1UVw>? MWPHTVUxRTBwNTFOwG0> MlHONlI1OzV4Nkm=
Hep3B M{Lke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LiWlQ5KGh? NXXPNoplTE2VTx?= NXXuTVZyT0l3ME2wMlY6KM7:TR?= MXWyNlQ{QTh4Mx?=
BE(2)-C NFLRenNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWG3NkBp NWXRW2dVTE2VTx?= M3Tq[GlEPzB;MjFOwG0> MlTCNlI6OzJ|MU[=
Bel7402 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXXfZM4OiCq MXLEUXNQ NXXXXJdiT0l7ME2xO{DPxE1? NWnpV3I5OjNyNkGzO|Y>
Bel7404 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTkO|IhcA>? MV\EUXNQ NFTpcYJIUTlyPUG4JO69VQ>? NYnRNFBZOjNyNkGzO|Y>
BGC823 M{TJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nLVlczKGh? M3zNeGROW09? NWHIXGptT0l7ME23MlUh|ryP Mn;GNlMxPjF|N{[=
MGC803 NGrxS5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDEZVY4OiCq MV7EUXNQ NG\ucmJIUTlyPUGwMlgh|ryP MnzWNlMxPjF|N{[=
SGC7901 NV70[Zp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvsO|IhcA>? MUfEUXNQ MUXHTVkxRTlwNDFOwG0> NGW1W|MzOzB4MUO3Oi=>
SKHEP1 NVfqRmR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHWTZc4OiCq MmSySG1UVw>? M2TLNmdKQTB;MUeg{txO M1\SOlI{ODZzM{e2
SMMC7721 Mn;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXW2SHZlPzJiaB?= NIniS2tFVVOR NFfHcYVIUTlyPUKwJO69VQ>? MUGyN|A3OTN5Nh?=
NUGC3 NH;iTpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3O5ZVExKM7:TR?= Mn2yS2k:Oi57NDFOwG0> MoHFNlMyPjN|M{K=
A2780 CisR NVjKR|dYU2mwYYPlJGF{e2G7 M4TCU|E5KGh? M{XrSmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? NXvV[opqOjN{NUK2NFM>
CAL27 sens MlXNT4lv[XOnIFHzd4F6 MUixPEBp NVvhZ3hjUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= MljNNlMzPTJ4MEO=
CAL27 CisR MkDDT4lv[XOnIFHzd4F6 M1S4VlE5KGh? MVrJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NILiNpkzOzJ3Mk[wNy=>
KYSE-510 CisR M2e1VGtqdmG|ZTDBd5NigQ>? MmW4NVghcA>? MXTJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNUmg{txO NVrmWGg5OjN{NUK2NFM>
KYSE-510 sens MWPLbY5ie2ViQYPzZZk> MU[xPEBp NUnEOllGUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlch|ryP M4HFVFI{OjV{NkCz
MDA-MB-231 sens MoPkT4lv[XOnIFHzd4F6 NILvO4wyQCCq MoLvTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NWTDT4dXOjN{NUK2NFM>
MDA-MB-231 CisR M1zX[WtqdmG|ZTDBd5NigQ>? M1\jXlE5KGh? M2npTGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? MUeyN|I2OjZyMx?=
ES2 NGjZN|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYG0PEBp Mnn1SG1UVw>? MoPHTWM2OD1zMj63JO69VQ>? MYGyN|Q6OzR2OR?=
MDA-MB-231 Mo\YT4lv[XOnIFHzd4F6 M37GZ|ExKM7:TR?= NXvwOnhuOzBibXnu NFLwSmRFVVOR NUHtUI5IUW6qaXLpeIlwdiCxZjDISGFEOmF? MomzNlM1QTN2NEm=
MDA-MB-231 NYfaT4g{U2mwYYPlJGF{e2G7 M3nrVVEh|ryP Ml3vNlQhcA>? Mn\FSG1UVw>? MXPJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw NVXET4hGOjN2OUO0OFk>
HS68 NVnyb|dIS3m2b4TvfIlkKEG|c3H5 NYjwWWhbOTBizszN NEjTOYs4OiCq MUTEUXNQ MmPtTWM2OD12Lk[g{txO M1u4ZVI{PTdyNUSy
MEF NFjMUZdEgXSxdH;4bYMhSXO|YYm= NXHENHJtOTBizszN M{LINVczKGh? MUjEUXNQ MYTJR|UxRTRwNDFOwG0> NWDtfXd4OjN3N{C1OFI>
BGC823 NFvBdolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrEUXNQ NVHLc3NDT0l3ME2zMlA6KM7:TR?= NFvmbFczOzZyMUewOi=>
High5 NHmycJJMcW6jc3WgRZN{[Xl? NFvuTYIzPCCq NXrOR5l4UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= MoXvNlM3ODJ3MkO=
High5 NHX0WIJMcW6jc3WgRZN{[Xl? M2DzXVI1KGh? NEGxNopKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlEzKM7:TR?= MYOyN|YxOjV{Mx?=
High5 Mn32T4lv[XOnIFHzd4F6 NIn2Z4UzPCCq NELCZ|FKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= MXmyN|YxOjV{Mx?=
A549 NUHhVFR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XMXWROW09? MVTJR|UxRTFwMEe5JO69VQ>? MWqyN|Y1PDJzMB?=
HCT116 NUGzZ3hDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvEUXNQ NHPuO4VKSzVyPUCuO|U4KM7:TR?= M1W0bFI{PjR2MkGw
K562 NEm1PYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;B[2ROW09? Mmr1TWM2OD1yLk[0OUDPxE1? MYqyN|Y1PDJzMB?=
GBC-SD MmrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWe1JO69VQ>? NITZe5k4OiCq M2PLd2ROW09? MWrJR|UxRTF2Lkig{txO NYrLOXZ1OjN5MEeyOlA>
HGC27 NYnQXHVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUC1JO69VQ>? MVW3NkBp NWnSV2hLTE2VTx?= NF;KcWVKSzVyPUWuOEDPxE1? NHm2U|czOzdyN{K2NC=>
HL60 NY\PbJhjU2mwYYPlJGF{e2G7 NWqzd2F{PSEQvF2= MYGyOEBp M{\tb2ROW09? MUPJcohq[mm2aX;uJI9nKEiGQVO= NVraTohnOjN5MEeyOlA>
Vero NEXyXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\tO|IhcA>? NVjpUYVCTE2VTx?= NGG4clVKSzVyPUCuPUDPxE1? MljmNlM4QDZ2NUK=
NCI60 NGrFRYxEgXSxdH;4bYMhSXO|YYm= MXW0PEBp NG\XUWlFVVOR MXLHTV0xNjV|IN88US=> MmjyNlQxOTV|Mke=
SW620 MVrDfZRwfG:6aXOgRZN{[Xl? M2i2[FQ5KGh? M37ocWROW09? M1vMcGdKRTBwNUSg{txO MYSyOFAyPTN{Nx?=
U251 NFPqSFlEgXSxdH;4bYMhSXO|YYm= NIjYXJo1QCCq M2fDWmROW09? Mn\SS2k:OS53MzFOwG0> NGfUOmQzPDBzNUOyOy=>
KM12 MUnDfZRwfG:6aXOgRZN{[Xl? M4Lo[lQ5KGh? NF;yWXNFVVOR MlzCS2k:OS56ODFOwG0> MofhNlQxOTV|Mke=
Hs578T M1fPWWN6fG:2b4jpZ{BCe3OjeR?= NUTqXHJ7PDhiaB?= NVHHPYx[TE2VTx?= NGPpTG9IUT12LkizJO69VQ>? M{HpN|I1ODF3M{K3
MDA-MB-231 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HCTlQ5KGh? MV7JR|UxRTBwMU[g{txO NF3YPFczPDB7NUCxOi=>
MCF7 M4nmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkewOFghcA>? Mn7JS2k:OC52NTFOwG0> M{G5bFI1OTF7NUW1
MDA-MB-435 M2jpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfPdINIPDhiaB?= MkS3S2k:OC56ODFOwG0> MWCyOFEyQTV3NR?=
AsPC1 NEDJZ21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmiwN|Ah|ryP MlTtOFghcA>? MnToSG1UVw>? Ml21TWM2OD1|Lk[2JO69VQ>? MX:yOFE5PTN5OB?=
Jurkat E6.1 MmLMT4lv[XOnIFHzd4F6 NIf4eY0zKGh? MmDoSG1UVw>? NFLlNVFKdmirYnn0bY9vKG:oIFjERWM1KHerdHigTWM2OCCxZjCwMlA1KM7:TR?= M3jvS|I1OjZzOE[y
KG1 NU\wXVZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYK0PEBp Mn3YTWM2OD1zLkG1JO69VQ>? NF3URngzPDV{NUCwNy=>
HEL MnThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq3OFghcA>? MXvEUXNQ MoKxTWM2OD1yLkS5JO69VQ>? MXWyOFY6PDB3NR?=
HSC3 NEPDbpBEgXSxdH;4bYMhSXO|YYm= NYHh[4JUOTJiaB?= NWPxZ3VQTE2VTx?= MnGwTWM2OD1yLkexJO69VQ>? M2rDVlI1PzZ4NU[w
HT-29 NYPEb3ZNS3m2b4TvfIlkKEG|c3H5 NEDlR|MyOiCq MYPEUXNQ NUPK[3d4UUN3ME2wMlczKM7:TR?= NIX3bWQzPDd4NkW2NC=>
KB MmezR5l1d3SxeHnjJGF{e2G7 MnK5NVIhcA>? NWjRbmRVTE2VTx?= M1fDXGlEPTB;MD63OUDPxE1? NIixTnczPDd4NkW2NC=>
H460 NXjHdlZvS3m2b4TvfIlkKEG|c3H5 NHP1SZkyOiCq NITTWWxFVVOR NH2zPZZKSzVyPUCuPFIh|ryP NWDMcm9FOjR5Nk[1OlA>
MONE1 M1G4fmN6fG:2b4jpZ{BCe3OjeR?= Mm\VNVIhcA>? NGnVOoFFVVOR MWjJR|UxRTFwMUig{txO MnnNNlQ4PjZ3NkC=
MKN45 NITXRmxEgXSxdH;4bYMhSXO|YYm= NHKxc2YyOiCq M{eyTmROW09? MnnxTWM2OD1zLkK1JO69VQ>? NX;lXXZ4OjR5Nk[1OlA>
TSGH NW[3PYg1S3m2b4TvfIlkKEG|c3H5 NFm1ZoUyOiCq MXLEUXNQ MWrJR|UxRTJwMEmg{txO M1zrO|I1PzZ4NU[w
HL60 MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPwdG04OiCq NULjOFBTTE2VTx?= M3viW2dKPTB;MD65N{DPxE1? MU[yOFkxODVyMB?=
HEK293 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonrO|IhcA>? NVzoUoR7TE2VTx?= MX;HTVUxRTF|IN88US=> M2jib|I1QTByNUCw
Jurkat MUnDfZRwfG:6aXOgRZN{[Xl? NU\QblNOOTByIN88US=> NFzyUHM4OiCq NFjtfWRIUTVyPUCuPUDPxE1? NEfibFczPDlyMEe0Ny=>
GM15850 MXvLbY5ie2ViQYPzZZk> M2HaR|IvPSEQvF2= MXi5OkBp M1;KTmROW09? NUnW[3hF\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDNibInzbY5mKDF2IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m M1vNPVE3QTJzM{[3
GM15850 M4H3cmtqdmG|ZTDBd5NigQ>? NYiyd3BNOi53IN88US=> MYm5OkBp NEn0cplFVVOR M1LYVIRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NFLFRpMyPjl{MUO2Oy=>
GM15850 MUTLbY5ie2ViQYPzZZk> Ml3MNk42KM7:TR?= NH3j[mY6PiCq NXroW4J4TE2VTx?= MoCw[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MknhNVY6OjF|Nke=
GM15850 MV\LbY5ie2ViQYPzZZk> NGiwW|kzNjVizszN NVLmcnZyQTZiaB?= MYLEUXNQ Mk\X[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NY\sXZh2OTZ7MkGzOlc>
GM15850 NELVRYRMcW6jc3WgRZN{[Xl? MkO3Nk42KM7:TR?= Ml60PVYhcA>? MULEUXNQ MmrP[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MlTYNVY6OjF|Nke=
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LK-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInzPVlKSzVyPUGwMlQzODhizszN NWHSTnZCW0GQR1XS
SF126 NH;KZoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jOXWlEPTB;MUCuOFczPyEQvF2= MWjTRW5ITVJ?
SK-MEL-1 NV;jbm5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDjTWM2OD1zMD63PFM5KM7:TR?= M3XXOHNCVkeHUh?=
ACN M{HkWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLKNldZUUN3ME2xNE45Pjd7IN88US=> MXvTRW5ITVJ?
BB30-HNC NWXtWWlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnEc5RMUUN3ME2xNE45PzFzIN88US=> MnnvV2FPT0WU
NCI-H747 NFPUNVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\yPJdQUUN3ME2xNE45PzR4IN88US=> NYPzZW5WW0GQR1XS
KYSE-150 NULtb4JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFzLkCzPFch|ryP M4jvO3NCVkeHUh?=
D-247MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILhRmJKSzVyPUGxMlExODlizszN MUDTRW5ITVJ?
BxPC-3 NEK3N49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLzdnlQUUN3ME2xNU4{PzR5IN88US=> Moi3V2FPT0WU
SK-MEL-30 NYDJU2NQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn1b3E4UUN3ME2xNU41ODd7IN88US=> M2nn[HNCVkeHUh?=
CAS-1 NX\rWndTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Lre2lEPTB;MUGuOFExQSEQvF2= MYfTRW5ITVJ?
no-10 MoiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LVUGlEPTB;MUKuNVIyPyEQvF2= NW\uT5ZyW0GQR1XS
NCI-H2405 NXGyTodmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLlTWM2OD1zMj6yNFM3KM7:TR?= NHHEPY1USU6JRWK=
KGN MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D4cGlEPTB;MUKuNlkxOSEQvF2= Mm\TV2FPT0WU
BB49-HNC MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PKd2lEPTB;MUKuN|k2PiEQvF2= MV\TRW5ITVJ?
NCI-H1693 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTF{LkW4NVYh|ryP MVPTRW5ITVJ?
RO82-W-1 M1S5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUGzXW5LUUN3ME2xN{4xPjR7IN88US=> MkSwV2FPT0WU
CAL-85-1 NVHpWG5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XO[WlEPTB;MUOuOFM6QSEQvF2= NHvNdY5USU6JRWK=
H-EMC-SS MmS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonPTWM2OD1zMz65NVA1KM7:TR?= MVXTRW5ITVJ?
SW1783 MkHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvVT|R{UUN3ME2xOE4zOzlzIN88US=> NFvteYxUSU6JRWK=
LB771-HNC NWf2NWdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LOU2lEPTB;MUSuOFE6KM7:TR?= NE\ETWdUSU6JRWK=
HCC70 MlvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HoTmlEPTB;MUSuOFI{OyEQvF2= MV;TRW5ITVJ?
KNS-81-FD NGHxTplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTpTWM2OD1zND63NFQ2KM7:TR?= Mnq5V2FPT0WU
KYSE-520 NWjlVG9KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHETWM2OD1zND65Nlch|ryP M3vYcnNCVkeHUh?=
TGBC24TKB MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTF2Lkm1N|kh|ryP M3zrU3NCVkeHUh?=
SNB75 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13seGlEPTB;MUWuNFczQSEQvF2= Mme3V2FPT0WU
SW872 NHz4XIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TFXWlEPTB;MUWuNlIyQCEQvF2= MkPpV2FPT0WU
U031 M1XBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXtZWxvUUN3ME2xOU45ODJ6IN88US=> NXvrWWl6W0GQR1XS
ChaGo-K-1 M2n1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTF3LkizOVkh|ryP M3z0e3NCVkeHUh?=
NCI-H441 M2LJVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{GyRmlEPTB;MU[uNFA{QSEQvF2= MYHTRW5ITVJ?
TE-12 NY\rdZE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTF4LkG4O|Mh|ryP M{LF[3NCVkeHUh?=
NCI-H1755 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTF4LkW3N{DPxE1? MXvTRW5ITVJ?
KNS-42 M{\pVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP4TWM2OD1zNj62OVg6KM7:TR?= MYPTRW5ITVJ?
SK-PN-DW NHvl[ZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zNRmlEPTB;MUeuOFIxOSEQvF2= MofKV2FPT0WU
NCI-H226 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PBOWlEPTB;MUeuPVM1PSEQvF2= MluyV2FPT0WU
K-562 MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfsR3lSUUN3ME2xPE43OzF5IN88US=> Ml;6V2FPT0WU
A388 NVnLfpJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom1TWM2OD1zOT6wN|A{KM7:TR?= M1nWb3NCVkeHUh?=
ZR-75-30 NE\LOVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Pzb2lEPTB;MUmuNFk3QCEQvF2= M3XrPXNCVkeHUh?=
LU-135 NXPrVYdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTF7LkK2N|Yh|ryP NF\XfG5USU6JRWK=
NCI-H2029 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTF7Lk[wNlEh|ryP NHrpUJJUSU6JRWK=
HT-1197 M3TBVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTOW|RNUUN3ME2xPU46OjJ5IN88US=> Mmi1V2FPT0WU
IGR-1 NWrUZphLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJyLkOxNVch|ryP NYXqWJY1W0GQR1XS
U-87-MG NX7i[ZltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJyLk[0NVMh|ryP MlnrV2FPT0WU
NCI-H1304 NX3LbJFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTFTWM2OD1{MD63OVAyKM7:TR?= NUPHVWdvW0GQR1XS
RCC10RGB M17Ibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;VbY5ZUUN3ME2yNU4zQDJ7IN88US=> NHnIboJUSU6JRWK=
NCI-H520 NVPhfWFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHVTWM2OD1{Mj63OlEyKM7:TR?= M1;jXHNCVkeHUh?=
SK-LU-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJ|LkC3NVgh|ryP MXfTRW5ITVJ?
UACC-893 NXmybpl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XOWWlEPTB;MkOuNVA{QCEQvF2= MW\TRW5ITVJ?
NCI-H2347 NEjacZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3i1VGlEPTB;MkOuNlY4PCEQvF2= Mlu1V2FPT0WU
U-118-MG NXrt[oVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXVOG5KSzVyPUKzMlczOTdizszN NYW5[pBNW0GQR1XS
NCI-H596 NIPUdlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3lVVl3UUN3ME2yN{46ODV3IN88US=> MYrTRW5ITVJ?
MZ1-PC M4XmPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJ2Lk[3OVkh|ryP NILqbZBUSU6JRWK=
SW1417 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ3LkK0PVgh|ryP Moe2V2FPT0WU
NCI-H82 NGLtXopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPTTWM2OD1{Nj60Nlg5KM7:TR?= MkDoV2FPT0WU
COLO-678 NHf0NXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HNNWlEPTB;MkeuOFkyQSEQvF2= NUHCfmpQW0GQR1XS
KURAMOCHI NY\HbY44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jhcGlEPTB;MkiuNVI3KM7:TR?= M37iOXNCVkeHUh?=
NCI-H1650 NE\4fHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnm2TWM2OD1|MD6xPVI1KM7:TR?= MWXTRW5ITVJ?
HCC1954 NWrTRpFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTlTWM2OD1|MT6zOlY3KM7:TR?= MljmV2FPT0WU
GAK NXvpZXpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPzRohEUUN3ME2zNk4zPjF4IN88US=> MnfiV2FPT0WU
YAPC NHvwSYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHlRXhCUUN3ME2zN{44PjR6IN88US=> NH\idZNUSU6JRWK=
NCI-H2228 M1rIc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\oTWM2OD1|ND6zOlA2KM7:TR?= NIXHOVJUSU6JRWK=
VMRC-RCZ NFfoOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPO[XdoUUN3ME2zOk4{ODJ{IN88US=> NUi3[ldIW0GQR1XS
NMC-G1 M13qbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTN5LkC1Nlkh|ryP NXHFXXV6W0GQR1XS
D-336MG MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DTd2lEPTB;NEGuPFQ1OiEQvF2= Mo[0V2FPT0WU
UACC-62 NYnsWHI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTR{LkW1NFUh|ryP NHPyZldUSU6JRWK=
C-33-A MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz3TWM2OD12NT6zNlU3KM7:TR?= MlnqV2FPT0WU
HCC1937 M1Xzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTR5LkG5OVgh|ryP MXTTRW5ITVJ?
HDLM-2 M3HIWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\BTWM2OD12Nz6yNlg4KM7:TR?= MV3TRW5ITVJ?
NCI-H727 M{T2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\pTWM2OD12Nz6yOFUyKM7:TR?= M1fyc3NCVkeHUh?=
NY NIjZVI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PoOWlEPTB;NEmuN|kxQCEQvF2= MV7TRW5ITVJ?
NCI-H2291 M1zKWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTOTWM2OD12OT64N|AyKM7:TR?= NX;mVYZkW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID