Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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In DMSO USD 191 In stock
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Cited by 99 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M3PDUWtqdmG|ZTDBd5NigQ>? M{nm[lEhcA>? MlHtSG1UVw>? MXPhcpRqNUiGQVOxJIFkfGm4aYT5JJdqfGhiSVO1NEBw\iByLkGxNkDPxE1? MXSxNVk3ODR6OR?=
Friend leukemic cell M1;OTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf5e2I2OCEQvF2= MW[3NkBp NYjEO21uTE2VTx?= MlTqTWM2OD1yLkm5JO69VQ>? NIPRPIwyOjFyOUmxNy=>
K562 MXTLbY5ie2ViQYPzZZk> NH3HOWI3KGh? Mkj0SG1UVw>? NES4fXlKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> NV[5UWJkOTJ2MUmzPFA>
HT1080 MnTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fpbFczKGh? NYXDTHVsTE2VTx?= NHvrV|RKSzVyPUKuOEDPxE1? M17mPFEzOjdyMUe1
H1299 MVnLbY5ie2ViQYPzZZk> NIjz[pEzOCCvaX6= Mnm3SG1UVw>? MnTHTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= MorYNVQ2OjF2MkK=
H1299 MkLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;RRY84OiCq MW\EUXNQ Mlj5TWM2OD15LkK0JO69VQ>? NVHESZN3OTR3MkG0NlI>
HeLa NGPXRYFMcW6jc3WgRZN{[Xl? M3j1XFMxKG2rbh?= MXnJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> NYnyXWxOOTV4MEO5OFk>
LOX-IMVI M1\JR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV60PEBp M1TVUmlEPTB;MT6zJO69VQ>? MoPENVU4OTV2N{C=
NCI-H226 M{Tq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\6epk1QCCq M2rJfGlEPTB;Mj62JO69VQ>? MXexOVcyPTR5MB?=
RXF-631L MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\nboI1QCCq Mn\HTWM2OD1{IN88US=> MoHsNVU4OTV2N{C=
SNB-78 NGnicFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\0OFghcA>? MX\JR|UxRTF4IN88US=> NYrtPZZsOTV5MUW0O|A>
St-4 MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX60PEBp NGDEZmZKSzVyPUWuNkDPxE1? MnjvNVU4OTV2N{C=
ARP1 MXPGeY5kfGmxbjDBd5NigQ>? M{XMPVIh|ryP MnnCOkBp M3nNOmlv\HWldHnvckBw\iCSMkHXRWYyKGenbnWg[ZhxemW|c3nvci=> NVXwZlV1OTR5M{S4NFY>
CEM MUXLbY5ie2ViQYPzZZk> MlfHNUBp NHf6OIpFVVOR NUfhTpJGUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM{KM7:TR?= NY\2Z|lOOTZ2MkCwOlQ>
HCT15 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zhRVQ5KGh? NWPRS5NkT0l3ME2wMlgzKM7:TR?= Mmj4NVY4OjN{Mke=
NCI-H23 NFLKeHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIezRmM1QCCq MonvS2k2OD1yLkmyJO69VQ>? M{\OUVE3PzJ|MkK3
GM15850 NHrvcWRMcW6jc3WgRZN{[Xl? MUKyMlUh|ryP NGXONos6PiCq MVzEUXNQ MXfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViMUSgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MnXZNVY6OjF|Nke=
GM15850 NGjhd3RMcW6jc3WgRZN{[Xl? M{LhTFIvPSEQvF2= Mn3rPVYhcA>? Mm\PSG1UVw>? NIPsbJpKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NVm2[JR{OTZ7MkGzOlc>
GM15850 NFnhT|VMcW6jc3WgRZN{[Xl? M{L1b|IvPSEQvF2= NIDDUlg6PiCq NXXSelhYTE2VTx?= MlrPTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MUCxOlkzOTN4Nx?=
GM15850 M1HFdmtqdmG|ZTDBd5NigQ>? NVjmRYh{Oi53IN88US=> NHu4RoY6PiCq NELKcWFFVVOR NHnFWWJKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MXuxOlkzOTN4Nx?=
GM15850 NX:3PVBPU2mwYYPlJGF{e2G7 NGD6c5IzNjVizszN NFjT[FE6PiCq MmPtSG1UVw>? MmDJTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEigZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MoHuNVY6OjF|Nke=
GM15850 Mn[4T4lv[XOnIFHzd4F6 M2nvZ|IvPSEQvF2= M4H1b|k3KGh? M4OzTWROW09? NUXyPWZKUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M1myWVE3QTJzM{[3
U937 MlfBSpVv[3Srb36gRZN{[Xl? M{L2bVUh|ryP Mo\pNlQhcA>? NH3oPI9FVVOR NGm2UG5E\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn MoTVNVcxODR5MUi=
H661 NXPkXmp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrGUGY1QCCq M4ntbGlEPTB;MTFOwG0> MoW1NVcyPTdyMEm=
U937 NXnjeZRrTnWwY4Tpc44hSXO|YYm= MU[1JO69VQ>? MWmyOEBp MVXEUXNQ M2XFOmlv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= MkfNNVc1PDd5NUC=
U937 MnTiSpVv[3Srb36gRZN{[Xl? Ml74NUDPxE1? NIrZSJEzPCCq MXLEUXNQ MoS3SYZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= MV2xO|Q1Pzd3MB?=
RAW264.7 MlzYSpVv[3Srb36gRZN{[Xl? M1nH[|ExKM7:TR?= MmW4NlRp MkXLe4F1\XJ? MnPjTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBVVk[jbIDoZUBxem:mdXP0bY9vKHerdHigTWM2OCCxZjCwMlc3KM7:TR?= MmjrNVc1Pzd3MUi=
RAW264.7 NH7MXVRHfW6ldHnvckBCe3OjeR?= MYOxNEDPxE1? NF3GXXYzPGh? NVvnSY9lf2G2ZYK= NUXl[5B[UW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJJdqfGhiSVO1NEBw\iBzLki4JO69VQ>? NYPENIExOTd2N{e1NVg>
SC9 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDCPZpiPDhiaB?= NX7LdWpvUUN3ME2wMlYxPiEQvF2= NXXSUY17OTd3MEeyNVk>
ST14A MYTGeY5kfGmxbjDBd5NigQ>? NIjjWJM2KG6P MoHSO|IhcA>? M{GxdWlv[3KnYYPlJIlvKFKHU2SvUnJUTiCvUl7BJIV5eHKnc4Ppc44> MVSxO|U3PTl7Mx?=
ST14A NGnsfJNHfW6ldHnvckBCe3OjeR?= NF3pOmU2KG6P M4Ln[FczKGh? MX;JcoNz\WG|ZTDpckBGOkZzIH3SUmEh\XiycnXzd4lwdg>? M17IWVE4PTZ3OUmz
PANC1 NUDac5ZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTnNUDPxE1? MVLJR|UxRTBwNEWg{txO NFu4NWwyPzV6OEe0OC=>
PANC1 MVvGeY5kfGmxbjDBd5NigQ>? MmrLNUDPxE1? M{TyVVI1KGh? MYHJcoNz\WG|ZTDpckBxOjGZQV[xM2NKWDFiZ3Xu[UBmgHC{ZYPzbY9v NYrSTm5nOTd3OEi3OFQ>
PANC1 M{T5UmZ2dmO2aX;uJGF{e2G7 NETYOmEyKM7:TR?= NXPrbWo3OjRiaB?= MkTDTY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36= NWfqRVBmOTd3OEi3OFQ>
PT45 MkDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLqeFVYUUN3ME20JO69VQ>? NXq0WYVkOTd3OEi3OFQ>
ACHN NEfUS4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVWyNUBp Mm\oS2k2OD1yLk[1JO69VQ>? MkDmNVc3PjJ4ME[=
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SKHEP1 MmfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXm3NkBp M37HeGlEPTB;Mz60OkDPxE1? MXyyNFE1Ozd5OB?=
BJ NG\qcnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\TdlExOCEQvF2= M37ue|Q5KGh? M{fKdmROW09? MmXoS5Jwf3SqIHnubIljcXSrb36gZZQhOC5yNTD0c{AyODBidV2= NXPXVGZ3OjBzNEO4OFA>
MUF Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWxNFAh|ryP NX7wXW9wPDhiaB?= MVHEUXNQ NYrJTY5GT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> NW\lXHVOOjBzNEO4OFA>
Caco-2 NEKxVG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUGxNFAh|ryP MV60PIg> NXfibm9DTE2VTx?= NVzW[nRDUUN3ME24MlEh|ryP MUmyNFE1Ozh2MB?=
Caco-2 MmLRT4lv[XOnIFHzd4F6 MnfSOUDPxE1? NVL4RnI2PCCq NUPQTYZYTE2VTx?= Ml;RTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDhZ4V1gWyjdHnvckBKSzVyIH;mJFAvODN5IN88US=> M4P1OFIxOTR|OESw
Caco-2 NWTUdJI2U2mwYYPlJGF{e2G7 NGrBXFUxNjNzNjDuUUB1dyB|MT62JO69VQ>? NFKxSGM1KGh? MnrPSG1UVw>? NGfxOHBGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Gge4l1cCCLQ{WwJI9nKDBwMUG5JO69VQ>? NG\HZ5MzODF2M{i0NC=>
Caco-2 M1fTWmtqdmG|ZTDBd5NigQ>? NGTB[2MxNjNzNjDuUUB1dyB|MT62JO69VQ>? MY[0JIg> M2T4S2ROW09? MUfFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzNid3n0bEBKSzVyIH;mJFAvOTR5IN88US=> M{Dj[|IxOTR|OESw
Caco-2 M2nWXWtqdmG|ZTDBd5NigQ>? NF3yfHg3NjN{IH7NJJRwKDZ|MjFOwG0> NGLGS481KGh? M37Qd2ROW09? M2j6N2V5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNTD3bZRpKEmFNUCgc4YhOTJwNjFOwG0> NIi4NXgzODF2M{i0NC=>
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Caco-2 NX7oPI1KU2mwYYPlJGF{e2G7 M3H1O|AvOzF4IH7NJJRwKDNzLk[g{txO M3LO[|QhcA>? Mm[1SG1UVw>? MmDYSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN4 M2DqUlIxOTR|OESw
HepG2 MlvoT4lv[XOnIFHzd4F6 MmX0OUDPxE1? M2jQSlZp NEHTXIxFVVOR NF;oWZBKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9v MUSyNFE1Ozh2MB?=
HepG2 MXHLbY5ie2ViQYPzZZk> MlfqOUDPxE1? M{npXlZp MVjEUXNQ NX[4eHlrUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBpgXCncnHj[ZR6dGG2aX;u NYjLSVVjOjBzNEO4OFA>
HepG2 MVnLbY5ie2ViQYPzZZk> NF;henA2KM7:TR?= MX62bC=> M2P1U2ROW09? MmXSTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= M1[yTlIxOTR|OESw
HepG2 MXvLbY5ie2ViQYPzZZk> NXrkRpZGPSEQvF2= NIr1emE3cA>? MYXEUXNQ M3[2[mlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= MV[yNFE1Ozh2MB?=
COLO205 Mn;CT4lv[XOnIFHzd4F6 NW[wcVZMOTBizszN Ml73NlQhcA>? MWDEUXNQ MlTpTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiC5aYToJGlEPTBib3[gNk4zKM7:TR?= MXKyNFQ2OTN5OB?=
SCC4 Mmn0T4lv[XOnIFHzd4F6 NWK4WWdtOSEQvF2= Mn;2NlRp NIfMeoFKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6geJVjfWyrbjDhZ4V1gWyjdHnvci=> MmjMNlA1PTJ{MkW=
SCC4 MonuT4lv[XOnIFHzd4F6 M1T4XlEh|ryP NIXqWpczPGh? NFz1c5pKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDhZ4V1gWyjdHnvci=> MYmyNFQ2OjJ{NR?=
SCC4 NVy3e5N5TnWwY4Tpc44hSXO|YYm= NEXEUVcyKM7:TR?= MkX2OUBucW5? NEK3VFdC\2:waYP0JIFkfGm4aYT5JIF1KF[GUjDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiQ2nQNlQh\2WwZTDlfJBz\XO|aX;u MV2yNFQ2OjJ{NR?=
NB4 MYnGeY5kfGmxbjDBd5NigQ>? MVK1JO69VQ>? MkTwNlQhcA>? NFLm[3NFVVOR MmrDR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPjeY12dGG2aX;uJIF1KHC{ZT3HNUBxcGG|ZR?= MlvjNlA1QTF2NEC=
NB4 MUPLbY5ie2ViQYPzZZk> NYO3TZVUPSEQvF2= NYLkT5l7OjRiaB?= NWCwNHB2TE2VTx?= M1npcWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? NVTRdGF5OjB2OUG0OFA>
NB4 NV3mO2E{TnWwY4Tpc44hSXO|YYm= NX;JZXdmPSEQvF2= MkjyNlQhcA>? M4HZXGROW09? NV31fVJFUW6mdXP0bY9vKG:oIICyNXdCTjFxQ1nQNUBmgHC{ZYPzbY9v NGPyUWczODR7MUS0NC=>
NB4 MVLLbY5ie2ViQYPzZZk> MXW1JO69VQ>? MXeyOEBp M3fZVGROW09? MXjJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> M1nTeFIxPDlzNESw
NUGC3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLsO|lVT0l3ME2yMlk1KM7:TR?= MXyyNFg2ODl5MR?=
A549 MWnGeY5kfGmxbjDBd5NigQ>? M1rz[lUh|ryP NYjBN4QyOyCq NF7MTW9FVVOR M{T4Tmlv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCOQ{PJTS=> MWSyNFg2PTJyOB?=
HUT78 Ml\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP3O|IhcA>? MlnGSG1UVw>? NHTCNnhIUTVyPUCuN{DPxE1? NWixeFlSOjB6OESyNFg>
U937 NXrNSHNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDWO|IhcA>? MWHEUXNQ M4\LVmdKPTB;MD6zPUDPxE1? M37xUVIxQDh2MkC4
A431 MXnDfZRwfG:6aXOgRZN{[Xl? MVe3NkBp MnnhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjC0MlIh|ryP MmfxNlExQDB4Mkm=
A549 NGTwVlhEgXSxdH;4bYMhSXO|YYm= NGjVcXQ4OiCq M4DVPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMhd3[ncnX4dJJme3OrbnegTGRCSyC5aYToJGlEPTBib3[gNU45KM7:TR?= M3y3Z|IyODhyNkK5
CAL27 M1H4eGN6fG:2b4jpZ{BCe3OjeR?= M{fMO|czKGh? MVfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRWwzPyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjCzMlIh|ryP NELXT24zOTB6ME[yPS=>
HeLa MlvDR5l1d3SxeHnjJGF{e2G7 Ml;SO|IhcA>? NEDr[Y1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2= NGPORlUzOTB6ME[yPS=>
Sf21 NWHCcVBNU2mwYYPlJGF{e2G7 NGjUPZY{KGh? NFXZN5VKdmirYnn0bY9vKG:oIF\sZYchfGGpZ3XkJIh2dWGwIILlZ49u[mmwYX70JGhFSUN6IHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOS5{IN88US=> NIrKfJIzOTB6ME[yPS=>
SKBR3 NHO1VJJEgXSxdH;4bYMhSXO|YYm= MUG3NkBp Ml:0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= NHn5PJgzOTB6ME[yPS=>
SKOV3 MXzDfZRwfG:6aXOgRZN{[Xl? NUPySYlIPzJiaB?= NHP3OYJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjJizszN NX;DV484OjFyOEC2Nlk>
COR-L23 M3jvU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\rblExKM7:TR?= M{f0W|czKGh? NIPHdG1FVVOR MkTMS2k2OD1zLkGg{txO Ml;2NlExQDB4NEe=
DU145 M2fPVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qxdVExKM7:TR?= M1fNRlczKGh? NHHjdGZFVVOR MoPuS2k2OD1zLkC1JO69VQ>? Mn\LNlExQDB4NEe=
LoVo NWH3fnF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrBN3YyOCEQvF2= MmnLO|IhcA>? MmfRSG1UVw>? NWHyR4J3T0l3ME2xMlch|ryP MmPWNlExQDB4NEe=
MCR5-SV2 NG\MR4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HxOVExKM7:TR?= MYK3NkBp MkXlSG1UVw>? MV7HTVUxRTJwMTFOwG0> MmXWNlExQDB4NEe=
HCT116 NEDWPVhMcW6jc3WgRZN{[Xl? MWWzNEDPxE1? MXuzNEBp NGn3PZJFVVOR M2DDVWlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= NYjlcmNKOjFyOEC2OFc>
HCT116 NGPPNI1McW6jc3WgRZN{[Xl? M17MWFMxKM7:TR?= Ml\qN|AhcA>? MVTEUXNQ NHKyZW5KdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= MonVNlExQDB4NEe=
U937 MUPLbY5ie2ViQYPzZZk> MlOzOUDPxE1? M1H2RlI1KGh? MWTEUXNQ NX3LUYJuUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= MY[yNVI6OjR7Mh?=
U937 Mly3T4lv[XOnIFHzd4F6 MXm1JO69VQ>? M{KyU|I1KGh? NViyWZo2TE2VTx?= M3zhdmlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEtzOB?= M4DtNVIyOjl{NEmy
U937 MXjLbY5ie2ViQYPzZZk> NVyxV5RWPSEQvF2= NGXnNY4zPCCq NEPJSmtFVVOR MmHwTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? NFnaTG0zOTJ7MkS5Ni=>
U937 MX3LbY5ie2ViQYPzZZk> M2LORlUh|ryP NEC4cXUyPSCvaX6= NVPSfGRJTE2VTx?= NYrYXGZsUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? NUnzPHhQOjF{OUK0PVI>
A2780 NV7JUoxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUS4TG9xQTZiaB?= NVnYTpBlTE2VTx?= NF2zOlJKSzVyPUGuOlIh|ryP MkjaNlE3OzR2M{C=
COLO205 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV[5OkBp M3z1NGROW09? Mkm0TWM2OD1{LkGyJO69VQ>? MnzDNlE3OzR2M{C=
Hep3B NE\YRYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULkTopwPDhiaB?= MW\EUXNQ M32xW2dKPTB;MT6yNUDPxE1? MXOyNVcyOjF2Nh?=
GM11272 M{jTUWZ2dmO2aX;uJGF{e2G7 M{\VXVExOCCwTR?= NUDic|NqPzJiaB?= NEH4R3NFVVOR MUHS[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N NWjkUoFsOjF6NEC3NVY>
CFBE41o M3PjWGtqdmG|ZTDBd5NigQ>? NFrIU3g2KM7:TR?= M{WxT2ROW09? MlrWSI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO M3X3SVIyQTh2OUW4
CFBE41o NHrRbFRHfW6ldHnvckBCe3OjeR?= MVuxJO69VQ>? MoP3NlQhcA>? NUTUUYttTE2VTx?= MnraVoV{fG:{YYTpc44hd2ZiQ1\UVkBl\Wy2YV[1NFghdXW2YX70JJRz[W[oaXPrbY5oKHSxIHPlcIwhe3W{ZnHj[UBieyCpbInjc4Zwem2| MVeyNVk5PDl3OB?=
DU145 MWXLbY5ie2ViQYPzZZk> MmLHNk42KM7:TR?= Mln4NlQhcA>? MXLEUXNQ NUnYcII5UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? MnfINlIzPjBzNk[=
DU145 M4jmfmtqdmG|ZTDBd5NigQ>? MYO1JO69VQ>? MXiyOEBp M{XGbmROW09? M{iwO2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u NHXafpEzOjJ4MEG2Oi=>
DU145 M1TNfmtqdmG|ZTDBd5NigQ>? M1\sO|Uh|ryP MWWyOEBp M17OPWROW09? MYfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9v Mo\qNlIzPjBzNk[=
786-0 NX\HSZR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Xp[VYvOiEQvF2= MojUO|IhcA>? MkPTSG1UVw>? MnPUS2k2OD1|LkKg{txO MYGyNlQ{PTZ4OR?=
A498 MoHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWK2MlIh|ryP M3XvclczKGh? MnHLSG1UVw>? NHXsVJBIUTVyPUGuOkDPxE1? M3vtW|IzPDN3Nk[5
A549/ATCC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH64Wlg3NjJizszN NV7XTVU1PzJiaB?= NFrQTHpFVVOR MXfHTVUxRTFwNjFOwG0> NV\lRndkOjJ2M{W2Olk>
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HCT15 M3LXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\OOk4zKM7:TR?= NE\1XIw4OiCq M4ThWWROW09? MYLHTVUxRTJwNTFOwG0> Ml;1NlI1OzV4Nkm=
HOP92 NHL1eZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfq[ZY3NjJizszN NXTTWG1uPzJiaB?= NY\PPWxSTE2VTx?= M{PDVmdKPTB;NDFOwG0> NF[3O2YzOjR|NU[2PS=>
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LOXIMVI M1PMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGr5W4c3NjJizszN MoXzO|IhcA>? MnPWSG1UVw>? NG\Bb2pIUTVyPUGg{txO Moi3NlI1OzV4Nkm=
M14 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTYOk4zKM7:TR?= NHXxUGI4OiCq M4HheWROW09? MV3HTVUxRTFwMzFOwG0> Mm\PNlI1OzV4Nkm=
MALME-3M M4PpfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX62MlIh|ryP MU[3NkBp Moj0SG1UVw>? MofMS2k2OD1yLkOyJO69VQ>? MVWyNlQ{PTZ4OR?=
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MDA-MB-468 Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXpbYo3NjJizszN NXjBbng6PzJiaB?= MX;EUXNQ Mny4S2k2OD1yLk[zJO69VQ>? MnLNNlI1OzV4Nkm=
MOLT4 NHPodIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVS2MlIh|ryP MmrpO|IhcA>? M4Pqd2ROW09? NF63WXFIUTVyPUCuOEDPxE1? NVzr[FVKOjJ2M{W2Olk>
NCI-ADR-RES NXf6SZdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHEVmE3NjJizszN NIDyR|k4OiCq MoC4SG1UVw>? NELNc49IUTVyPUCuNVYh|ryP NF7CN3EzOjR|NU[2PS=>
NCI-H23 NF[5eZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Kx[|YvOiEQvF2= Ml3GO|IhcA>? NFOzOIRFVVOR MkHTS2k2OD1zIN88US=> M3PPRlIzPDN3Nk[5
NCI-H322M NXzZcIIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD6Ok4zKM7:TR?= M3TsRVczKGh? NXewO2xuTE2VTx?= M17sbGdKPTB;MD63PUDPxE1? NIPCVnYzOjR|NU[2PS=>
NCI-H460 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHjNoc3NjJizszN MX63NkBp MXHEUXNQ MWfHTVUxRTBwN{mg{txO M2CyelIzPDN3Nk[5
NCI-H522 NVHvTWdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjKb2ZtPi5{IN88US=> MVG3NkBp NGDQOpVFVVOR NULkfYVbT0l3ME2wMlUh|ryP M1vUTFIzPDN3Nk[5
OVCAR3 MmXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LBdlYvOiEQvF2= MX[3NkBp NFHuV3VFVVOR MonYS2k2OD1zLkOg{txO MUSyNlQ{PTZ4OR?=
OVCAR4 NHH4S4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWS2MlIh|ryP M1HleFczKGh? M3PnNmROW09? MlfMS2k2OD12IN88US=> NYXHN3d[OjJ2M{W2Olk>
OVCAR5 M{TpNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFmxenY3NjJizszN NXrle|Q1PzJiaB?= NH[2dVJFVVOR M2qzNWdKPTB;MD63PUDPxE1? NEC2VYwzOjR|NU[2PS=>
OVCAR8 MkHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P4TFYvOiEQvF2= Mn7xO|IhcA>? NYTyZY1bTE2VTx?= NVLne|d1T0l3ME2wMlUh|ryP M2\I[lIzPDN3Nk[5
RXF393 NX\YdoxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Gw[lYvOiEQvF2= MYG3NkBp M1PVO2ROW09? MYHHTVUxRTFwMzFOwG0> M{j4TVIzPDN3Nk[5
SF268 MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXu2MlIh|ryP MlPsO|IhcA>? NFLKW3dFVVOR M2TQVGdKPTB;MT62JO69VQ>? MoPoNlI1OzV4Nkm=
SF295 NVXMVHM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NECyUG43NjJizszN NYXn[pVGPzJiaB?= MUXEUXNQ MlfHS2k2OD1zLk[g{txO MlHnNlI1OzV4Nkm=
SF539 M{XiNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzncGJUPi5{IN88US=> MkLnO|IhcA>? NHW1XI5FVVOR MmDzS2k2OD1{IN88US=> NF:zZY4zOjR|NU[2PS=>
SK-MEL-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLkUoJQPi5{IN88US=> NHrWZW44OiCq M3\QdWROW09? M3zWPWdKPTB;MT6zJO69VQ>? MVWyNlQ{PTZ4OR?=
SK-MEL-28 NX60T5ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWe2MlIh|ryP MmCzO|IhcA>? MWnEUXNQ MVPHTVUxRTFizszN NHPjb2wzOjR|NU[2PS=>
SK-MEL-5 NVTSN21LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXiycJVkPi5{IN88US=> NFnXfnU4OiCq MXzEUXNQ MXzHTVUxRTBwNkOg{txO MUSyNlQ{PTZ4OR?=
SKOV3 NETMfJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTuO4E3NjJizszN MWW3NkBp M13pXGROW09? MVjHTVUxRTFizszN M2PPZ|IzPDN3Nk[5
SN12C NUnsNZNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUe2MlIh|ryP NVLPcnF7PzJiaB?= M13TUmROW09? MVPHTVUxRTJizszN MlW2NlI1OzV4Nkm=
SNB19 M{OwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWq2MlIh|ryP MXe3NkBp NEH3dJRFVVOR NFmwRXpIUTVyPUCuOlMh|ryP MkjCNlI1OzV4Nkm=
SNB75 Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[wdlYvOiEQvF2= MlTTO|IhcA>? NYPJWIxbTE2VTx?= MVLHTVUxRTBwN{mg{txO M3;WT|IzPDN3Nk[5
SR MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1e0PVYvOiEQvF2= NGi4UHk4OiCq NXG0Nm43TE2VTx?= NYnVOpd[T0l3ME2wMlQh|ryP MUiyNlQ{PTZ4OR?=
T47D M1PxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3IOk4zKM7:TR?= M3voRlczKGh? MmnzSG1UVw>? NIiwO29IUTVyPUCuOUDPxE1? M{\ld|IzPDN3Nk[5
TK10 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[2MlIh|ryP MXW3NkBp M1TxPGROW09? Ml\3S2k2OD1yLk[zJO69VQ>? NG\6UG8zOjR|NU[2PS=>
UACC257 NYfHbll5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rkXVYvOiEQvF2= M4fZR|czKGh? Mn7PSG1UVw>? M4PDN2dKPTB;MD61JO69VQ>? MXGyNlQ{PTZ4OR?=
UACC62 NXrYSJNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X5SlYvOiEQvF2= M3j6flczKGh? NYjPXZV7TE2VTx?= MmW0S2k2OD1yLkSg{txO MoXiNlI1OzV4Nkm=
UO31 NF2wcpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljyOk4zKM7:TR?= M1iwR|czKGh? NFv5Rm1FVVOR NGOyVJpIUTVyPUCuOUDPxE1? NEjESFczOjR|NU[2PS=>
Hep3B MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;0blQ5KGh? NETaR3NFVVOR M4nFVWdKPTB;MD62PUDPxE1? M{H3bVIzPDN7OE[z
BE(2)-C NECyR5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HNUVczKGh? MV;EUXNQ M4HsSmlEPzB;MjFOwG0> NV\rUI5DOjJ7M{KzNVY>
Bel7402 NYDMRXhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVm3NkBp NV\1NFBbTE2VTx?= MVHHTVkxRTF5IN88US=> Mkm2NlMxPjF|N{[=
Bel7404 NGPIU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zYOFczKGh? M3HlW2ROW09? NGHTfmhIUTlyPUG4JO69VQ>? M4fFS|I{ODZzM{e2
BGC823 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fLV|czKGh? MmjGSG1UVw>? MV\HTVkxRTdwNTFOwG0> MoX1NlMxPjF|N{[=
MGC803 NHL0OVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPwO|IhcA>? Mmr5SG1UVw>? NXnTcmdKT0l7ME2xNE45KM7:TR?= MkT0NlMxPjF|N{[=
SGC7901 MnTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33vWlczKGh? Mn20SG1UVw>? NHTRcHVIUTlyPUmuOEDPxE1? MlvxNlMxPjF|N{[=
SKHEP1 NWr2XlVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TNVVczKGh? M{HjTmROW09? MmrUS2k6OD1zNzFOwG0> Mn2zNlMxPjF|N{[=
SMMC7721 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfsO|IhcA>? MXLEUXNQ NF;YcJhIUTlyPUKwJO69VQ>? MUiyN|A3OTN5Nh?=
NUGC3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfod453OTBizszN NHH2WVhIUT1{Lkm0JO69VQ>? MkXQNlMyPjN|M{K=
A2780 CisR NXjqbZpLU2mwYYPlJGF{e2G7 MnTBNVghcA>? M{TGdGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? MWiyN|I2OjZyMx?=
CAL27 sens MVLLbY5ie2ViQYPzZZk> MX:xPEBp NUHjZ4UzUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= M{XjbFI{OjV{NkCz
CAL27 CisR M3vEcWtqdmG|ZTDBd5NigQ>? NGryTmkyQCCq MkjUTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? M3vMOFI{OjV{NkCz
KYSE-510 CisR M37ySWtqdmG|ZTDBd5NigQ>? M3i2WFE5KGh? NF7QU29KdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOVkh|ryP MV[yN|I2OjZyMx?=
KYSE-510 sens MX7LbY5ie2ViQYPzZZk> MWexPEBp NUDy[Gw3UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlch|ryP MYGyN|I2OjZyMx?=
MDA-MB-231 sens NFPCWmVMcW6jc3WgRZN{[Xl? NF7uR5kyQCCq M2m3NmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M1rKVVI{OjV{NkCz
MDA-MB-231 CisR NUjle3E3U2mwYYPlJGF{e2G7 NEfrXWsyQCCq MYPJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NH:wOnkzOzJ3Mk[wNy=>
ES2 M1HFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWC0PEBp NIfnem1FVVOR MYDJR|UxRTF{Lkeg{txO NV;SZ49[OjN2OUO0OFk>
MDA-MB-231 NFHHUm1McW6jc3WgRZN{[Xl? MWKxNEDPxE1? NG\4WGE{OCCvaX6= NH;TWXlFVVOR NWfleY9CUW6qaXLpeIlwdiCxZjDISGFEOmF? NV\kfIpjOjN2OUO0OFk>
MDA-MB-231 Mmj0T4lv[XOnIFHzd4F6 MV6xJO69VQ>? M4rWdVI1KGh? NF3wUJBFVVOR NYjGU4NmUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> M2ewflI{PDl|NES5
HS68 NHLOWYJEgXSxdH;4bYMhSXO|YYm= NY\ybY1DOTBizszN NXHmT294PzJiaB?= NFPFdo9FVVOR MmLBTWM2OD12Lk[g{txO NFnsTVEzOzV5MEW0Ni=>
MEF NVXOfWFiS3m2b4TvfIlkKEG|c3H5 MUixNEDPxE1? M3\EPFczKGh? MYXEUXNQ NFToNJNKSzVyPUSuOEDPxE1? M{i5U|I{PTdyNUSy
BGC823 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHzSG1UVw>? NVnpfHpqT0l3ME2zMlA6KM7:TR?= NUTDUmFMOjN4MEG3NFY>
High5 NF;WZo5McW6jc3WgRZN{[Xl? MXOyOEBp NYmxRnk{UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= MojFNlM3ODJ3MkO=
High5 NFnhfZlMcW6jc3WgRZN{[Xl? MXSyOEBp NXrUWJE5UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4yOiEQvF2= MX6yN|YxOjV{Mx?=
High5 M1H3WmtqdmG|ZTDBd5NigQ>? Mme1NlQhcA>? Mn7UTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDN{B4cXSqIFnDOVAhd2ZiMD6xO{DPxE1? MmPvNlM3ODJ3MkO=
A549 NETMZ3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnrSG1UVw>? NUDZWplNUUN3ME2xMlA4QSEQvF2= MoPBNlM3PDR{MUC=
HCT116 NHPhVZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXniZlZ6TE2VTx?= NIHCR3lKSzVyPUCuO|U4KM7:TR?= MnvXNlM3PDR{MUC=
K562 M1O4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fBSGROW09? M4jSW2lEPTB;MD62OFUh|ryP M{PzNVI{PjR2MkGw
GBC-SD NYTVfHIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVS1JO69VQ>? MVS3NkBp MXLEUXNQ M4X2RWlEPTB;MUSuPEDPxE1? M4O4UlI{PzB5Mk[w
HGC27 NHHqflBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXe1JO69VQ>? NHLEVXM4OiCq NVrS[VRTTE2VTx?= M{PZVmlEPTB;NT60JO69VQ>? Mlr5NlM4ODd{NkC=
HL60 M1G1TmtqdmG|ZTDBd5NigQ>? NHfF[mM2KM7:TR?= NILZOlUzPCCq NInZUmRFVVOR MXnJcohq[mm2aX;uJI9nKEiGQVO= NYfocHZZOjN5MEeyOlA>
Vero NISybJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHjO|IhcA>? M4\DWGROW09? MoHWTWM2OD1yLkmg{txO M1z2SVI{Pzh4NEWy
NCI60 NUPJZmx7S3m2b4TvfIlkKEG|c3H5 MkDoOFghcA>? MYLEUXNQ MnK5S2k:OC53MzFOwG0> NUTsTZNyOjRyMUWzNlc>
SW620 M{HCNmN6fG:2b4jpZ{BCe3OjeR?= Mn3yOFghcA>? M3zrVmROW09? NUL1c|ZZT0l;MD61OEDPxE1? NYfrU4l1OjRyMUWzNlc>
U251 MYDDfZRwfG:6aXOgRZN{[Xl? MX:0PEBp MXPEUXNQ M2rqOWdKRTFwNUOg{txO MYCyOFAyPTN{Nx?=
KM12 MWDDfZRwfG:6aXOgRZN{[Xl? MnK3OFghcA>? Ml;ESG1UVw>? MnL3S2k:OS56ODFOwG0> Mk\sNlQxOTV|Mke=
Hs578T NXPYNnBZS3m2b4TvfIlkKEG|c3H5 NYTw[5Z7PDhiaB?= NEXlWodFVVOR Mn3sS2k:PC56MzFOwG0> NYPqcY9bOjRyMUWzNlc>
MDA-MB-231 NFXDXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi5O5RjPDhiaB?= MlLMTWM2OD1yLkG2JO69VQ>? NXjqTGZMOjRyOUWwNVY>
MCF7 Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnCOFghcA>? NHH0WIVIUT1yLkS1JO69VQ>? MnH5NlQyOTl3NUW=
MDA-MB-435 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXi0PEBp NUX0OGk1T0l;MD64PEDPxE1? MVOyOFEyQTV3NR?=
AsPC1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWezNEDPxE1? MmHKOFghcA>? NFTtfVJFVVOR MX3JR|UxRTNwNk[g{txO NFn6fXEzPDF6NUO3PC=>
Jurkat E6.1 MVHLbY5ie2ViQYPzZZk> NYDEc3pCOiCq Ml\6SG1UVw>? M2jhXGlvcGmkaYTpc44hd2ZiSFTBR|Qhf2m2aDDJR|UxKG:oIECuNFQh|ryP NHLn[VczPDJ4MUi2Ni=>
KG1 NVXuW40zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLhXWJRPDhiaB?= NFvqfFRKSzVyPUGuNVUh|ryP MYKyOFUzPTByMx?=
HEL NYfM[VNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nKUFQ5KGh? NIXadmNFVVOR NInqNHhKSzVyPUCuOFkh|ryP M3z1dFI1Pjl2MEW1
HSC3 M4PlXWN6fG:2b4jpZ{BCe3OjeR?= NWXwNpExOTJiaB?= MXrEUXNQ Ml[3TWM2OD1yLkexJO69VQ>? NIjwcGIzPDd4NkW2NC=>
HT-29 NG\wOmREgXSxdH;4bYMhSXO|YYm= NVi5PHllOTJiaB?= NVzWW4ltTE2VTx?= NXnjenk3UUN3ME2wMlczKM7:TR?= M3;uSFI1PzZ4NU[w
KB MUjDfZRwfG:6aXOgRZN{[Xl? NHTYe3QyOiCq MV3EUXNQ MV;JR|UxRTBwN{Wg{txO MYeyOFc3PjV4MB?=
H460 M37rXWN6fG:2b4jpZ{BCe3OjeR?= MX6xNkBp MVnEUXNQ NEjFcG9KSzVyPUCuPFIh|ryP MmX4NlQ4PjZ3NkC=
MONE1 MVXDfZRwfG:6aXOgRZN{[Xl? M1fQOVEzKGh? MlnoSG1UVw>? MoTiTWM2OD1zLkG4JO69VQ>? M1jieVI1PzZ4NU[w
MKN45 M{\UZ2N6fG:2b4jpZ{BCe3OjeR?= MWSxNkBp MnzJSG1UVw>? MXrJR|UxRTFwMkWg{txO MX:yOFc3PjV4MB?=
TSGH MWDDfZRwfG:6aXOgRZN{[Xl? MVOxNkBp MnHxSG1UVw>? MnHvTWM2OD1{LkC5JO69VQ>? MlraNlQ4PjZ3NkC=
HL60 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jF[lczKGh? NWm2TYluTE2VTx?= NXTKPJppT0l3ME2wMlk{KM7:TR?= NEPoZYEzPDlyMEWwNC=>
HEK293 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYm3NkBp MlvoSG1UVw>? MXvHTVUxRTF|IN88US=> NFfpR3UzPDlyMEWwNC=>
Jurkat MoPwR5l1d3SxeHnjJGF{e2G7 NW\ZdndqOTByIN88US=> NHr5Ulc4OiCq MlPjS2k2OD1yLkmg{txO NU\HbZhROjR7MEC3OFM>
GM15850 MlPUT4lv[XOnIFHzd4F6 M4nBbFIvPSEQvF2= MofBPVYhcA>? MWfEUXNQ NHr2PXhld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhOTRiYXPleJlt[XSrb36gc4YhTliQIHflcoU> M3XWdlE3QTJzM{[3
GM15850 NISzem5McW6jc3WgRZN{[Xl? MX:yMlUh|ryP M13HWVk3KGh? M13EO2ROW09? M13aToRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MknINVY6OjF|Nke=
GM15850 MnjyT4lv[XOnIFHzd4F6 M1\RblIvPSEQvF2= NYrCTJlDQTZiaB?= M2jwbWROW09? Mlnt[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NFfMPZcyPjl{MUO2Oy=>
GM15850 Mk[3T4lv[XOnIFHzd4F6 MWGyMlUh|ryP MYm5OkBp NWXxVWhtTE2VTx?= MVzkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MWqxOlkzOTN4Nx?=
GM15850 M{f5NGtqdmG|ZTDBd5NigQ>? NV22O|lFOi53IN88US=> MWK5OkBp MYrEUXNQ NF3xR4dld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhQCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> M2izdlE3QTJzM{[3
GM15850 MlHaT4lv[XOnIFHzd4F6 NWTUOpBHOi53IN88US=> MlOwPVYhcA>? Mn\TSG1UVw>? NX\TSJdK\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF4IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m M3O5OFE3QTJzM{[3
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MHH-NB-11 NUXFeWN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M334WWlEPTB;MT6yPFMzQSEQvF2= NUP4OolDW0GQR1XS
SW620 Ml3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjybohzUUN3ME2xMlI6ODF6IN88US=> NXTqS|JzW0GQR1XS
MOLT-16 M2TzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7F[2pKSzVyPUGuNlk4QTdizszN M2XHRXNCVkeHUh?=
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VA-ES-BJ NWfXNFl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojXTWM2OD1zLkOyOFc4KM7:TR?= NV7EWFVyW0GQR1XS
HCC1419 NF20T49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv2TWM2OD1zLkO0NFI4KM7:TR?= M1zSTHNCVkeHUh?=
NCI-H69 NYTySFVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXYVGlRUUN3ME2xMlM1OTF{IN88US=> NEDuNHNUSU6JRWK=
DEL NEnldo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zKbWlEPTB;MT6zOVE3OiEQvF2= NHziOmRUSU6JRWK=
LXF-289 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rzUmlEPTB;MT6zOVI1KM7:TR?= MkLVV2FPT0WU
EW-11 MmnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTFwM{[wNlYh|ryP MkHNV2FPT0WU
KP-4 NG[0bJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rlWWlEPTB;MT6zO|A5PSEQvF2= MnH4V2FPT0WU
NOS-1 NESycnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHrTWM2OD1zLkSxNVk1KM7:TR?= M1r6cnNCVkeHUh?=
SK-NEP-1 Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXlbVQ5UUN3ME2xMlQyPjl|IN88US=> M2TjUXNCVkeHUh?=
LAMA-84 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXmTWM2OD1zLkSzPVQ2KM7:TR?= NXq1Unh3W0GQR1XS
ES5 M3fWXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3npVGlEPTB;MT60OFMh|ryP M33MfnNCVkeHUh?=
HuO9 M1T6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP5b|VKSzVyPUGuOFU{PjJizszN MXHTRW5ITVJ?
COLO-684 M1j1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfMfZBmUUN3ME2xMlQ3OTF6IN88US=> MX3TRW5ITVJ?
EW-24 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnUXIVKSzVyPUGuOFY2OzFizszN NELGco5USU6JRWK=
BV-173 NHrZNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID0eGRKSzVyPUGuOFczQTFizszN MoTEV2FPT0WU
NCI-H1770 M{CwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFwNEi1N|Yh|ryP NGDQXnVUSU6JRWK=
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TYK-nu NFjpWIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\MZWlEPTB;MT60PVg2OSEQvF2= MVXTRW5ITVJ?
YH-13 Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rIfWlEPTB;MT60PVg6PCEQvF2= NF7mOWlUSU6JRWK=
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OVCAR-8 MkfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInGNVRKSzVyPUGuOVQ1PzdizszN MoDmV2FPT0WU
NCI-H23 M1XnOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfk[pdlUUN3ME2xMlU1PjR3IN88US=> M4TqVnNCVkeHUh?=
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COR-L88 NV;R[5JlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7DSJFKSzVyPUGuOVY1OjRizszN Ml73V2FPT0WU
TI-73 NGfvPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTFwNUmwOkDPxE1? NYfIdpNmW0GQR1XS
RT-112 NF3lOoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTFwNUmyPFQh|ryP MXvTRW5ITVJ?
HuO-3N1 M2P1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFwNUmzPFUh|ryP MXnTRW5ITVJ?
HC-1 NXG1VVJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXWzcFF3UUN3ME2xMlU6QDZ4IN88US=> MWTTRW5ITVJ?
HT55 NWnzXI16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfiVGdKSzVyPUGuOlUyOzFizszN M37G[XNCVkeHUh?=
IA-LM NEOzcmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzqTWM2UUN3ME2xMlY6Ojd6IN88US=> MlzEV2FPT0WU
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MHH-ES-1 M4X2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDMR4NKUUN3ME2xMlcxPDN3IN88US=> M1LEUHNCVkeHUh?=
CAL-27 MlLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MomyTWM2OD1zLkewOlIyKM7:TR?= M17wdnNCVkeHUh?=
COLO-800 NHeyU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\6e2ZQUUN3ME2xMlcyOTd7IN88US=> NHLtZnlUSU6JRWK=
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CAMA-1 M2faWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j3PWlEPTB;MT63NVk4OSEQvF2= M3POPHNCVkeHUh?=
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NH-12 NF\5[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTFwN{K2PVEh|ryP M{PpWHNCVkeHUh?=
TCCSUP NELRbGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jENGlEPTB;MT63NlgzQSEQvF2= MmSyV2FPT0WU
MDA-MB-361 NVLnW4MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHpTWM2OD1zLkezNVU4KM7:TR?= MWrTRW5ITVJ?
EW-16 NVftSW57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTFwN{SxNFch|ryP NFTaN5BUSU6JRWK=
SNU-423 MnfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PBNGlEPTB;MT63OVgzPyEQvF2= MYPTRW5ITVJ?
Daoy NVW1UpQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7OTWM2OD1zLke2N|E6KM7:TR?= NGHwepBUSU6JRWK=
ES4 NUnhUHJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3mwcGlEPTB;MT63PFc1OSEQvF2= NVHzNJg1W0GQR1XS
PFSK-1 NEPWR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn3TWM2OD1zLkiwN|ch|ryP NYnySpFoW0GQR1XS
ES3 M2HCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofWTWM2OD1zLkiyOlgyKM7:TR?= NXXmNnVIW0GQR1XS
ONS-76 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP1RmExUUN3ME2xMlgzQDl5IN88US=> MoiwV2FPT0WU
JVM-3 NIX6WFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXFNGpQUUN3ME2xMlg2PDVzIN88US=> M3;2N3NCVkeHUh?=
OS-RC-2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFwOEexOVEh|ryP MWTTRW5ITVJ?
COLO-320-HSR MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnTS21KSzVyPUGuPFgyQTdizszN MkC2V2FPT0WU
HN MoHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTFwOEi3NlUh|ryP NYryNG1xW0GQR1XS
HT M2L0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK2XlBqUUN3ME2xMlg5QTR5IN88US=> NF7YRWdUSU6JRWK=
LoVo NVvNcG5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFwOEm4NUDPxE1? NIDPcJNUSU6JRWK=
CGTH-W-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTFwOEm5OFYh|ryP NGroUlJUSU6JRWK=
NB6 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vZcmlEPTB;MT65NVI6QCEQvF2= M2H3PHNCVkeHUh?=
EW-22 NYm3c2s{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zBT2lEPTB;MT65Nlg5PyEQvF2= MmmzV2FPT0WU
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SCC-15 NW\aVZFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PvXmlEPTB;MT65N|gyQSEQvF2= M4\RWHNCVkeHUh?=
HL-60 MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXaWGxKSzVyPUGuPVM6ODJizszN NWPWT5R7W0GQR1XS
human HOP-92 M4j3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLDVYtFUUN3ME2xMlk1ODZ3IN88US=> M{e4TnNCVkeHUh?=
SW626 M3\NN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;x[XpKSzVyPUGuPVQ5QTlizszN M3PaWXNCVkeHUh?=
HEC-1 M2TEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1frVmlEPTB;MT65OVM3KM7:TR?= NXPjXINKW0GQR1XS
LB2241-RCC NH7EUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTFwOUiyN|Eh|ryP NHXrbFJUSU6JRWK=
Ramos-2G6-4C10 Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\STWM2OD1zLkm5OFk{KM7:TR?= NWPlcJFNW0GQR1XS
A101D M{\pTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjjdXE4UUN3ME2yMlIxOzB|IN88US=> MVPTRW5ITVJ?
NCI-H446 M4jEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXS4Oml[UUN3ME2yMlA1PTl7IN88US=> M1vqR3NCVkeHUh?=
SBC-5 NF3uOmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJwME[xOFch|ryP NFvxUpFUSU6JRWK=
HOS NGGxdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJwMEe2OVMh|ryP NUC1PJBCW0GQR1XS
K5 M1jsXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfpRmlKSzVyPUKuNFc5OTFizszN NGXWWWZUSU6JRWK=
HLE MnfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmKzTWM2OD1{LkC4OVI6KM7:TR?= MV3TRW5ITVJ?
HSC-2 NHjRN3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHaTWM2OD1{LkGyPFk5KM7:TR?= NHPHelJUSU6JRWK=
LCLC-97TM1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknRTWM2OD1{LkG0OVg{KM7:TR?= Mo\ZV2FPT0WU
DMS-273 NEHhdFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLHTWM2OD1{LkG0PFM4KM7:TR?= NEi0fGZUSU6JRWK=
TE-8 NWrl[HpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjQSYhKSzVyPUKuNVU4PjVizszN MkK0V2FPT0WU
DSH1 MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H2cWlEPTB;Mj6xOlM6QCEQvF2= MX\TRW5ITVJ?
CAL-51 MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7Zd2REUUN3ME2yMlE3Pjl7IN88US=> NYPEUIppW0GQR1XS
IST-SL1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPaTWM2OD1{LkG2PFQ1KM7:TR?= MkPCV2FPT0WU
GCT NV3CVYV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW1U3l4UUN3ME2yMlE4PzdizszN M1j6OHNCVkeHUh?=
SW948 Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJwMUi0OVYh|ryP Mn72V2FPT0WU
NOMO-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJwMUmzNVch|ryP NFXPZmJUSU6JRWK=
C8166 NGjmTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXZVWZKSzVyPUKuNlE{OzRizszN MojpV2FPT0WU
OC-314 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJwMkOyOVkh|ryP NXW5bIxQW0GQR1XS
CAL-39 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[1fGlEPTB;Mj6yN|YzPiEQvF2= M2X1XXNCVkeHUh?=
MDA-MB-453 Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJwMkSyO|Uh|ryP MmfQV2FPT0WU
A673 NInLS5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPCepJKSzVyPUKuNlU5PjJizszN M1rvUHNCVkeHUh?=
HTC-C3 NHXwZVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLufnF[UUN3ME2yMlI3QDVizszN NEK4SnNUSU6JRWK=
NCI-H1666 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\VfpJLUUN3ME2yMlI5OTFzIN88US=> NXfwfIZ2W0GQR1XS
PSN1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJwMki5NVMh|ryP NGXiVGJUSU6JRWK=
GI-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjIfYNZUUN3ME2yMlMxPTR|IN88US=> NWnFXYRjW0GQR1XS
HuH-7 NWTMd41DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIftTHVKSzVyPUKuN|A3OzdizszN M2ewO3NCVkeHUh?=
JAR NXvJfY1PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\YcWlEPTB;Mj6zNVk5PyEQvF2= M1\oU3NCVkeHUh?=
5637 M2TJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly1TWM2OD1{LkOyNVI6KM7:TR?= NXf5TXpPW0GQR1XS
GB-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXKcWJHUUN3ME2yMlMzOzN3IN88US=> MX\TRW5ITVJ?
KP-N-YS NGL3dYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjuTWM2OD1{LkOyOlE2KM7:TR?= MX3TRW5ITVJ?
OAW-42 NGTQZ2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJwM{O0NVYh|ryP MY\TRW5ITVJ?
8-MG-BA NIPJ[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTjTWM2OD1{LkOzPVA3KM7:TR?= MnzwV2FPT0WU
RH-18 NULzOlZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvDb3RKSzVyPUKuN|UxOjJizszN MWPTRW5ITVJ?
NCI-H1155 NYT3fZVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmwTWM2OD1{LkO2O|I2KM7:TR?= MmXvV2FPT0WU
NB17 MmrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJwM{iyOFMh|ryP MUHTRW5ITVJ?
NCI-H1437 NXftcHUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L0WWlEPTB;Mj60NVg4OyEQvF2= NH;Ieo1USU6JRWK=
SN12C NG\ZOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPWTWM2OD1{LkSzNlE1KM7:TR?= M2\FT3NCVkeHUh?=
HSC-3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;mTWM2OD1{LkS0OVA6KM7:TR?= M3Hyd3NCVkeHUh?=
GAMG NIXmVGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvNXFNKSzVyPUKuOFQ2PjFizszN M3O4RnNCVkeHUh?=
HT-1080 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;SZoJKSzVyPUKuOFQ5PjRizszN NX7LXGhKW0GQR1XS
A549 NWH2ZlBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjUfllsUUN3ME2yMlQ1QDl|IN88US=> NVLsN4I1W0GQR1XS
KNS-62 M4OzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF2zN5NKSzVyPUKuOFUxPjFizszN NVrWeHZ2W0GQR1XS
YKG-1 NX;KV3J6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTJwNEW0N|ch|ryP NGnQV5BUSU6JRWK=
LU-134-A NHnzbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ntVWlEPTB;Mj60O|AxQCEQvF2= NEjNXIJUSU6JRWK=
FADU NFzmfHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTJwNEexOlIh|ryP M1XIeHNCVkeHUh?=
TGBC11TKB NEnQZlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;oTWM2OD1{LkS3NVc4KM7:TR?= MXXTRW5ITVJ?
HT-3 NIrTSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJwNEm1N|Uh|ryP NHfNO3hUSU6JRWK=
NCI-H2170 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJwNUC1OFkh|ryP MVzTRW5ITVJ?
Mo-T NGHkNYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3EcmlKSzVyPUKuOVA6OjdizszN MmnsV2FPT0WU
CCRF-CEM MmfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTJwNUOwOFMh|ryP NWTaZ5VOW0GQR1XS
KU-19-19 Mn3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP2fnRKSzVyPUKuOVM2OTNizszN M4rPVnNCVkeHUh?=
NCI-H1048 M{DlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvR[o5KSzVyPUKuOVUxOjVizszN M1;aT3NCVkeHUh?=
KOSC-2 M322Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPkTWM2OD1{LkW2NFc3KM7:TR?= MWXTRW5ITVJ?
A431 Mmj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJwNU[zN|Uh|ryP M4rCPHNCVkeHUh?=
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SK-MEL-1 NHPFTGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7NTWM2OD1zMD63PFM5KM7:TR?= MnTFV2FPT0WU
ACN NFvGS5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTFyLki2O|kh|ryP MX\TRW5ITVJ?
BB30-HNC M4f6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj6O3Y2UUN3ME2xNE45PzFzIN88US=> MUHTRW5ITVJ?
NCI-H747 NXrTZndyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:zPVFnUUN3ME2xNE45PzR4IN88US=> NULTflNuW0GQR1XS
KYSE-150 NH3VPIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\PTWM2OD1zMT6wN|g4KM7:TR?= MXPTRW5ITVJ?
D-247MG MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnuWVdKSzVyPUGxMlExODlizszN Mn7PV2FPT0WU
BxPC-3 NXfKSIlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfZb4JKSzVyPUGxMlM4PDdizszN MXHTRW5ITVJ?
SK-MEL-30 NF3TZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnOcHhKSzVyPUGxMlQxPzlizszN NHHKb|ZUSU6JRWK=
CAS-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXCd2V5UUN3ME2xNU41OTB7IN88US=> NYjtc|QyW0GQR1XS
no-10 M2TNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD1TWM2OD1zMj6xNlE4KM7:TR?= M{DnTHNCVkeHUh?=
NCI-H2405 M17KXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTF{LkKwN|Yh|ryP MWXTRW5ITVJ?
KGN NWCxc2czT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\rUHRKSzVyPUGyMlI6ODFizszN NG[ySYhUSU6JRWK=
BB49-HNC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTF{LkO5OVYh|ryP MULTRW5ITVJ?
NCI-H1693 M1P3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDyTWM2OD1zMj61PFE3KM7:TR?= NILFenhUSU6JRWK=
RO82-W-1 NWDBZZFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH4U3ExUUN3ME2xN{4xPjR7IN88US=> NWXFbpBWW0GQR1XS
CAL-85-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfwPYlFUUN3ME2xN{41Ozl7IN88US=> MnrXV2FPT0WU
H-EMC-SS NH7LUYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LLd2lEPTB;MUOuPVExPCEQvF2= MoW3V2FPT0WU
SW1783 M{Xm[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi4dWZ4UUN3ME2xOE4zOzlzIN88US=> MkjMV2FPT0WU
LB771-HNC Mk\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;LTWM2OD1zND60NVkh|ryP NVLQXmdMW0GQR1XS
HCC70 MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDaTWM2OD1zND60NlM{KM7:TR?= NFnuXFBUSU6JRWK=
KNS-81-FD NG\3cIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nTdWlEPTB;MUSuO|A1PSEQvF2= MWfTRW5ITVJ?
KYSE-520 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfjc29mUUN3ME2xOE46OjdizszN MoHPV2FPT0WU
TGBC24TKB NXi1dYdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWj3OGZlUUN3ME2xOE46PTN7IN88US=> NXLFUHNZW0GQR1XS
SNB75 NX70OHl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF3LkC3Nlkh|ryP NWfFRmlFW0GQR1XS
SW872 MnjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjyTIdoUUN3ME2xOU4zOjF6IN88US=> Mor3V2FPT0WU
U031 NFvPd3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfodlRKSzVyPUG1MlgxOjhizszN NV3k[G5oW0GQR1XS
ChaGo-K-1 M3nSUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXJTWM2OD1zNT64N|U6KM7:TR?= MVvTRW5ITVJ?
NCI-H441 NVPVeG9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW5TIdKSzVyPUG2MlAxOzlizszN NF;ufIdUSU6JRWK=
TE-12 NVj0RpJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi4e4tKSzVyPUG2MlE5PzNizszN M13MUXNCVkeHUh?=
NCI-H1755 MlrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jTOGlEPTB;MU[uOVc{KM7:TR?= M3Ti[3NCVkeHUh?=
KNS-42 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTF4Lk[1PFkh|ryP MnvGV2FPT0WU
SK-PN-DW M4rYS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF5LkSyNFEh|ryP NGXRZ5RUSU6JRWK=
NCI-H226 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M334d2lEPTB;MUeuPVM1PSEQvF2= NF3HOppUSU6JRWK=
K-562 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nFVGlEPTB;MUiuOlMyPyEQvF2= NUPaTlFxW0GQR1XS
A388 M1XpbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXiTWM2OD1zOT6wN|A{KM7:TR?= NILJTXNUSU6JRWK=
ZR-75-30 M{PueWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljXTWM2OD1zOT6wPVY5KM7:TR?= MYrTRW5ITVJ?
LU-135 NWrpR5FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PSVGlEPTB;MUmuNlY{PiEQvF2= MkX3V2FPT0WU
NCI-H2029 Ml3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLZVlU5UUN3ME2xPU43ODJzIN88US=> NGXtU3JUSU6JRWK=
HT-1197 MnjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml21TWM2OD1zOT65NlI4KM7:TR?= NEXS[YRUSU6JRWK=
IGR-1 MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJyLkOxNVch|ryP MWTTRW5ITVJ?
U-87-MG NV3QVFVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfLUXc4UUN3ME2yNE43PDF|IN88US=> MmrXV2FPT0WU
NCI-H1304 NV:3V|dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHTbI5CUUN3ME2yNE44PTBzIN88US=> NXXR[|hqW0GQR1XS
RCC10RGB M3rHW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrjV3lZUUN3ME2yNU4zQDJ7IN88US=> NX\0Z2RTW0GQR1XS
NCI-H520 NVzUdo9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJ{Lke2NVEh|ryP NWrDcm5CW0GQR1XS
SK-LU-1 M1PSXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzUTIRKSzVyPUKzMlA4OThizszN M4\3enNCVkeHUh?=
UACC-893 NYPBdGFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfWTWM2OD1{Mz6xNFM5KM7:TR?= M1jqN3NCVkeHUh?=
NCI-H2347 Moi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ|LkK2O|Qh|ryP NU[1XXJQW0GQR1XS
U-118-MG M1nxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXN[XRDUUN3ME2yN{44OjF5IN88US=> M{DoWXNCVkeHUh?=
NCI-H596 MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJ|LkmwOVUh|ryP MoLHV2FPT0WU
MZ1-PC Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHLTWM2OD1{ND62O|U6KM7:TR?= NFH4V4RUSU6JRWK=
SW1417 M1TL[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XMT2lEPTB;MkWuNlQ6QCEQvF2= NGD6NHBUSU6JRWK=
NCI-H82 NYXlVZZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPyVJZSUUN3ME2yOk41Ojh6IN88US=> M{LhdnNCVkeHUh?=
COLO-678 MnnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrsOVFKSzVyPUK3MlQ6OTlizszN NUj0bol6W0GQR1XS
KURAMOCHI MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJ6LkGyOkDPxE1? MnPCV2FPT0WU
NCI-H1650 NIrZfpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTNyLkG5NlQh|ryP NV7UO3FJW0GQR1XS
HCC1954 NVqwNIE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zl[GlEPTB;M{GuN|Y3PiEQvF2= MoTrV2FPT0WU
GAK MnflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH6TWM2OD1|Mj6yOlE3KM7:TR?= NH7XWFJUSU6JRWK=
YAPC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnflTWM2OD1|Mz63OlQ5KM7:TR?= M3XRSHNCVkeHUh?=
NCI-H2228 NWCxeWtCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\GXHlKSzVyPUO0MlM3ODVizszN MX\TRW5ITVJ?
VMRC-RCZ NFyyZoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTyTWM2OD1|Nj6zNFIzKM7:TR?= MYLTRW5ITVJ?
NMC-G1 NGKzWo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTCb|JKSzVyPUO3MlA2OjlizszN NHnJUlVUSU6JRWK=
D-336MG NX7lWYFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LFcmlEPTB;NEGuPFQ1OiEQvF2= M1naPHNCVkeHUh?=
UACC-62 M2PGNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D4T2lEPTB;NEKuOVUxPSEQvF2= NV;q[WhWW0GQR1XS
C-33-A M{n6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;4VWlEPTB;NEWuN|I2PiEQvF2= M2Ww[HNCVkeHUh?=
HCC1937 NXjkVFRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfD[GgyUUN3ME20O{4yQTV6IN88US=> MmjpV2FPT0WU
HDLM-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XvemlEPTB;NEeuNlI5PyEQvF2= M{exPHNCVkeHUh?=
NCI-H727 M3nJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHKyVpBKSzVyPUS3MlI1PTFizszN NXLmcYhQW0GQR1XS
NY NF;ISm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPqcWxKSzVyPUS5MlM6ODhizszN Mlu2V2FPT0WU
NCI-H2291 NFPQcmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfuWoxKSzVyPUS5Mlg{ODFizszN NGnmSYVUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 53 mg/mL (200.52 mM)
Ethanol 3 mg/mL (11.35 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 5mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID