Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 99 Publications

20 Customer Reviews

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NWrqZYtSU2mwYYPlJGF{e2G7 NVXKPVAxOSCq NYfzV2ZOTE2VTx?= NV7UcJZj[W62aT3ISGFEOSCjY4Tpeol1gSC5aYToJGlEPTBib3[gNE4yOTJizszN NUGyc3g3OTF7NkC0PFk>
Friend leukemic cell MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrBbWF2PTBizszN NXr2dFl{PzJiaB?= NE[2TZBFVVOR NHqx[3dKSzVyPUCuPVkh|ryP NYm1ZopyOTJzMEm5NVM>
K562 NWDtPWx[U2mwYYPlJGF{e2G7 MVi2JIg> MYPEUXNQ Mn7ETY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN MUmxNlQyQTN6MB?=
HT1080 MknRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzYdm9TPzJiaB?= MlLrSG1UVw>? NHf6VmtKSzVyPUKuOEDPxE1? NV3RS4VtOTJ{N{CxO|U>
H1299 M4TL[2tqdmG|ZTDBd5NigQ>? NYDiXIR{OjBibXnu MX;EUXNQ NIPwR2pKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> MYKxOFUzOTR{Mh?=
H1299 NGrJUFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDoXGE4OiCq M3;0fWROW09? NInwWphKSzVyPUeuNlQh|ryP NIPWVY0yPDV{MUSyNi=>
HeLa MVHLbY5ie2ViQYPzZZk> M2TVdFMxKG2rbh?= NYjNUoJLUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbIl{fG:wZTDk[YFk\XS7bHHz[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? MnmxNVU3ODN7NEm=
LOX-IMVI MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfBUmo1QCCq NFPER5lKSzVyPUGuN{DPxE1? MlHsNVU4OTV2N{C=
NCI-H226 MlfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7PeYp[PDhiaB?= NH7Qe2hKSzVyPUKuOkDPxE1? M1roWVE2PzF3NEew
RXF-631L NFK0O2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLkb3JSPDhiaB?= M3LROGlEPTB;MjFOwG0> NH\2ZWEyPTdzNUS3NC=>
SNB-78 M3jlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jveVQ5KGh? M4TK[WlEPTB;MU[g{txO NF[2RnAyPTdzNUS3NC=>
St-4 NGXkW|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYO0PEBp Mkn4TWM2OD13LkKg{txO NFf1c2gyPTdzNUS3NC=>
ARP1 MnixSpVv[3Srb36gRZN{[Xl? MnrpNkDPxE1? M{DI[|YhcA>? M4DkS2lv\HWldHnvckBw\iCSMkHXRWYyKGenbnWg[ZhxemW|c3nvci=> NX3xXndkOTR5M{S4NFY>
CEM M1;4RWtqdmG|ZTDBd5NigQ>? NHnx[2YyKGh? NYq2[GI1TE2VTx?= M12xPGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? NFW2blAyPjR{MEC2OC=>
HCT15 NV3ocot4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjMOFghcA>? MmHCS2k2OD1yLkiyJO69VQ>? NWPOOIlUOTZ5MkOyNlc>
NCI-H23 NHPaUnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\QWG01QCCq NHrSN2pIUTVyPUCuPVIh|ryP MVSxOlczOzJ{Nx?=
GM15850 NXn3UHM5U2mwYYPlJGF{e2G7 MXOyMlUh|ryP MY[5OkBp Mn33SG1UVw>? NFHPTWVKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M1;iN|E3QTJzM{[3
GM15850 NE\0eo1McW6jc3WgRZN{[Xl? MUeyMlUh|ryP MUW5OkBp NGDS[GNFVVOR Ml34TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEWgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M3\1OFE3QTJzM{[3
GM15850 Mn3rT4lv[XOnIFHzd4F6 M2KzUFIvPSEQvF2= M1nYV|k3KGh? NGjoNFFFVVOR MWnJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMUKgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NEnXc|UyPjl{MUO2Oy=>
GM15850 NWH0UopYU2mwYYPlJGF{e2G7 NGXwU2YzNjVizszN Mo\sPVYhcA>? MnfhSG1UVw>? NXLZUm9TUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NWTHN2syOTZ7MkGzOlc>
GM15850 MnHKT4lv[XOnIFHzd4F6 NEjoe2gzNjVizszN MVS5OkBp NYLycI9YTE2VTx?= M1XRcGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MV[xOlkzOTN4Nx?=
GM15850 NGq4SpJMcW6jc3WgRZN{[Xl? MnjQNk42KM7:TR?= M{fKVFk3KGh? M2jWd2ROW09? MnHaTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEG2JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M{XTXlE3QTJzM{[3
U937 MlnQSpVv[3Srb36gRZN{[Xl? NYHqbVhIPSEQvF2= MmrlNlQhcA>? NYL2W2RCTE2VTx?= MX\D[YxtKGO7Y3zlJIFzemW|dDDifUBi[2O3bYXsZZRqd25iYYSgV{9IOi:PIIDoZZNm MWWxO|AxPDdzOB?=
H661 NFLjS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPOOFghcA>? M1rmOGlEPTB;MTFOwG0> M17h[VE4OTV5MEC5
U937 NV\WelNlTnWwY4Tpc44hSXO|YYm= MkD6OUDPxE1? NYnkUoY3OjRiaB?= NIqxRo1FVVOR Mn60TY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= MmraNVc1PDd5NUC=
U937 NYTyU3ZJTnWwY4Tpc44hSXO|YYm= NEm3TooyKM7:TR?= MlvENlQhcA>? MWnEUXNQ NGTxU3ZG\m[nY4Sgc44h[WyyaHGgeJVjfWyrbjDhZ4V1gWyjdHnvci=> NUK0R5ZDOTd2NEe3OVA>
RAW264.7 M2TIU2Z2dmO2aX;uJGF{e2G7 MUexNEDPxE1? NF[xVpIzPGh? MYX3ZZRmeg>? NGq0PJJKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN NXfoW3ZmOTd2N{e1NVg>
RAW264.7 NIDqe|BHfW6ldHnvckBCe3OjeR?= Mo\UNVAh|ryP MUeyOIg> NXHiWGpTf2G2ZYK= NHH4VItKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKE6RIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDFwOEig{txO MlmwNVc1Pzd3MUi=
SC9 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PPcVQ5KGh? M2HzeWlEPTB;MD62NFYh|ryP MX2xO|UxPzJzOR?=
ST14A NVjhdIcyTnWwY4Tpc44hSXO|YYm= Mmj2OUBvVQ>? NXrMW4M4PzJiaB?= NHPMNndKdmO{ZXHz[UBqdiCURWPUM25TW0ZibWLORUBmgHC{ZYPzbY9v M3\ue|E4PTZ3OUmz
ST14A NWT0OWxlTnWwY4Tpc44hSXO|YYm= NV;mbGV6PSCwTR?= NFPsRok4OiCq MnzjTY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? NFHkTJQyPzV4NUm5Ny=>
PANC1 M4\j[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLqNUDPxE1? NV7MW5BKUUN3ME2wMlQ2KM7:TR?= Mnn1NVc2QDh5NES=
PANC1 MnHaSpVv[3Srb36gRZN{[Xl? NIW5eGEyKM7:TR?= NULK[YJTOjRiaB?= MmTpTY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? MnfsNVc2QDh5NES=
PANC1 M2nXO2Z2dmO2aX;uJGF{e2G7 MkH5NUDPxE1? NXqxWXRPOjRiaB?= MX\JcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= M4nYeFE4PTh6N{S0
PT45 NX7rT5VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;mTWM2OD12IN88US=> MVexO|U5QDd2NB?=
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NCI-H358 NGLVOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDtO|IhcA>? M2TXSWlEPTB;Mj61JO69VQ>? MWKyNFE1Ozd5OB?=
SCC15 NInTdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrJblk4OiCq M4\NUGlEPTB;Mj60PUDPxE1? MkL4NlAyPDN5N{i=
SCC25 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonrO|IhcA>? M2P0VWlEPTB;MT65N{DPxE1? NHK0OnMzODF2M{e3PC=>
SKHEP1 NELqTldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3L1eVczKGh? M4qxZWlEPTB;Mz60OkDPxE1? MWCyNFE1Ozd5OB?=
BJ NFvDe2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\2VFExOCEQvF2= M1PROVQ5KGh? NXrpW5ZLTE2VTx?= NXnFTYd3T3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> M1;NXVIxOTR|OESw
MUF MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWexNFAh|ryP MXq0PEBp NGL6e25FVVOR NWXQcYpMT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> NVP6W29zOjBzNEO4OFA>
Caco-2 NYn2SFJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLBVncyODBizszN M3zFflQ5cA>? MX3EUXNQ NGLCcWFKSzVyPUiuNUDPxE1? MXOyNFE1Ozh2MB?=
Caco-2 M1zaeWtqdmG|ZTDBd5NigQ>? NHjLUoQ2KM7:TR?= NVPCOXVQPCCq NEnhXmVFVVOR M2rUPGlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgZYNmfHmuYYTpc44hUUN3MDDv[kAxNjB|NzFOwG0> M4D6eVIxOTR|OESw
Caco-2 M2TLNmtqdmG|ZTDBd5NigQ>? NXH4WYhpOC5|MU[gcm0hfG9iM{GuOkDPxE1? MVG0JIg> MoK1SG1UVw>? NYjLdG1UTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOxJJdqfGhiSVO1NEBw\iByLkGxPUDPxE1? MU[yNFE1Ozh2MB?=
Caco-2 NIXtOYJMcW6jc3WgRZN{[Xl? MVGwMlMyPiCwTTD0c{A{OS54IN88US=> MVS0JIg> MV3EUXNQ NWr3Z3RVTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOzJJdqfGhiSVO1NEBw\iByLkG0O{DPxE1? NGTxc2QzODF2M{i0NC=>
Caco-2 NFf1TJJMcW6jc3WgRZN{[Xl? M1zOcFYvOzJibl2geI8hPjN{IN88US=> NFS0O|Y1KGh? MmfRSG1UVw>? NHzXfGZGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Wge4l1cCCLQ{WwJI9nKDF{Lk[g{txO MkTtNlAyPDN6NEC=
Caco-2 NV\yc3ZFU2mwYYPlJGF{e2G7 NV3VWHdPPi5|MjDuUUB1dyB4M{Kg{txO NVizTHVVPCCq Ml\sSG1UVw>? NHLL[GFGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{ege4l1cCCLQ{WwJI9nKDRzIN88US=> MYKyNFE1Ozh2MB?=
Caco-2 MnLkT4lv[XOnIFHzd4F6 NYX0VI16OC5|MU[gcm0hfG9iM{GuOkDPxE1? NVXUUJV3PCCq MX\EUXNQ Mn:ySZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN4 NHnvVokzODF2M{i0NC=>
HepG2 M3PBW2tqdmG|ZTDBd5NigQ>? NF7OZ2U2KM7:TR?= M3i0flZp MoHESG1UVw>? NEm3NFVKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9v NWDwbJRYOjBzNEO4OFA>
HepG2 NHXVfZhMcW6jc3WgRZN{[Xl? NIfrO2s2KM7:TR?= MV:2bC=> M4HJSmROW09? MVLJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHj5dIVz[WOndInsZZRqd25? MoXTNlAyPDN6NEC=
HepG2 MlzNT4lv[XOnIFHzd4F6 NH3oPXE2KM7:TR?= NF[wTo03cA>? NVjDdYduTE2VTx?= M3fuSGlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= MUKyNFE1Ozh2MB?=
HepG2 MWPLbY5ie2ViQYPzZZk> Mn34OUDPxE1? M3vZeFZp NVvKOYlYTE2VTx?= MXTJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDIN{9JPCCqaYP0c45mKGGlZYT5cIF1cW:w M4DibVIxOTR|OESw
COLO205 M3i0NGtqdmG|ZTDBd5NigQ>? NH7mPXAyOCEQvF2= M4rPVVI1KGh? MkLySG1UVw>? M2D2c2lvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25id3n0bEBKSzVyIH;mJFIvOiEQvF2= MWmyNFQ2OTN5OB?=
SCC4 MoS5T4lv[XOnIFHzd4F6 MVexJO69VQ>? M4rCfFI1cA>? NFjJRpVKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6geJVjfWyrbjDhZ4V1gWyjdHnvci=> NGTkUIozODR3MkKyOS=>
SCC4 NXm0d|hpU2mwYYPlJGF{e2G7 NHziZVUyKM7:TR?= MYWyOIg> NVXjUJFnUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44> NVrRe|RMOjB2NUKyNlU>
SCC4 NVLYOm5qTnWwY4Tpc44hSXO|YYm= MlTJNUDPxE1? NITHb2I2KG2rbh?= MVLB[49vcXO2IHHjeIl3cXS7IHH0JHZFWiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhS1mSMkSg[4Vv\SCneIDy[ZN{cW:w NH3lR|kzODR3MkKyOS=>
NB4 MYjGeY5kfGmxbjDBd5NigQ>? NGfJWlM2KM7:TR?= MV6yOEBp M4TEN2ROW09? MVfD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn NUSyRZZ6OjB2OUG0OFA>
NB4 M3XKRmtqdmG|ZTDBd5NigQ>? NXvufoFNPSEQvF2= MlnyNlQhcA>? MnrFSG1UVw>? M3m2VWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? M4HCXVIxPDlzNESw
NB4 Ml;KSpVv[3Srb36gRZN{[Xl? NUTmTWVLPSEQvF2= MXiyOEBp M{X1TmROW09? Mkm5TY5lfWO2aX;uJI9nKHB{MWfBSlEwS0mSMTDlfJBz\XO|aX;u NGD0ZXgzODR7MUS0NC=>
NB4 MlP3T4lv[XOnIFHzd4F6 NW\X[lBTPSEQvF2= NWHNV|h6OjRiaB?= NWfKbINETE2VTx?= M1fqNmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIFk\XS7bHH0bY9v M2TRb|IxPDlzNESw
NUGC3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;zfG9IUTVyPUKuPVQh|ryP MYGyNFg2ODl5MR?=
A549 NVK2dXE4TnWwY4Tpc44hSXO|YYm= Mn21OUDPxE1? M{XERVMhcA>? Mn;iSG1UVw>? M3\QTGlv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCOQ{PJTS=> M{fMT|IxQDV3MkC4
HUT78 M4jtV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWi3NkBp MXPEUXNQ MmLHS2k2OD1yLkOg{txO MlnUNlA5QDR{MEi=
U937 NVjVVnNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlq1O|IhcA>? NIXYbFVFVVOR MkfLS2k2OD1yLkO5JO69VQ>? M3XNZ|IxQDh2MkC4
A431 MU\DfZRwfG:6aXOgRZN{[Xl? MVu3NkBp MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJI93\XKneIDy[ZN{cW6pIFXHSnIhf2m2aDDJR|UxKG:oIESuNkDPxE1? Mnq4NlExQDB4Mkm=
A549 M2SwcWN6fG:2b4jpZ{BCe3OjeR?= Mor6O|IhcA>? MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuPEDPxE1? MYqyNVA5ODZ{OR?=
CAL27 NUO4O4UxS3m2b4TvfIlkKEG|c3H5 NYnyNHpwPzJiaB?= MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRWwzPyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjCzMlIh|ryP NXLRdWVUOjFyOEC2Nlk>
HeLa M1zpV2N6fG:2b4jpZ{BCe3OjeR?= M1HjVVczKGh? NGm0UFZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2= M2Ljd|IyODhyNkK5
Sf21 M4K2W2tqdmG|ZTDBd5NigQ>? MlPnN{Bp MVPJcohq[mm2aX;uJI9nKE[uYXegeIFo\2WmIHj1cYFvKHKnY3;tZolv[W62IFjERWM5KGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4zKM7:TR?= NXjpS4o{OjFyOEC2Nlk>
SKBR3 NVP1fnJMS3m2b4TvfIlkKEG|c3H5 M4PFRlczKGh? NFHlWJVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjZizszN MnvHNlExQDB4Mkm=
SKOV3 MYPDfZRwfG:6aXOgRZN{[Xl? M2jW[|czKGh? MkHXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= MU[yNVA5ODZ{OR?=
COR-L23 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;ZTo9iOTBizszN NYXRb3FtPzJiaB?= MoLwSG1UVw>? NES4SXJIUTVyPUGuNUDPxE1? NXXnd5FUOjFyOEC2OFc>
DU145 NWqxdphxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV60WXF{OTBizszN NFPydoE4OiCq MUDEUXNQ NV:2U4hOT0l3ME2xMlA2KM7:TR?= NUjLSWprOjFyOEC2OFc>
LoVo MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\zbVExKM7:TR?= MXq3NkBp NEjGZVhFVVOR M1\UZWdKPTB;MT63JO69VQ>? M3eyfVIyODhyNkS3
MCR5-SV2 NX3TdnNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnG4NVAh|ryP NVLUfWhbPzJiaB?= M2j0U2ROW09? M1fh[2dKPTB;Mj6xJO69VQ>? NFnXcW4zOTB6ME[0Oy=>
HCT116 M1vUNWtqdmG|ZTDBd5NigQ>? NGThcpE{OCEQvF2= NFXZRWM{OCCq NFPRTIZFVVOR NETGbmRKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u MnX5NlExQDB4NEe=
HCT116 MUHLbY5ie2ViQYPzZZk> NHzTdXI{OCEQvF2= MoHtN|AhcA>? Ml;LSG1UVw>? M1z1OWlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFNMQSCjY3X0fYxifGmxbh?= M3T2V|IyODhyNkS3
U937 Mn;hT4lv[XOnIFHzd4F6 M3XqO|Uh|ryP MVWyOEBp M1Tz[WROW09? NXrZ[5VGUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= M3nUSlIyOjl{NEmy
U937 MlXDT4lv[XOnIFHzd4F6 NVniO5A3PSEQvF2= NGWxblgzPCCq Mn24SG1UVw>? MnvrTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzF6 MVOyNVI6OjR7Mh?=
U937 NYnUd5ljU2mwYYPlJGF{e2G7 M13STFUh|ryP M1G4XlI1KGh? NHTwTlVFVVOR MnfWTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? Mn;qNlEzQTJ2OUK=
U937 Ml;vT4lv[XOnIFHzd4F6 NFmyTGg2KM7:TR?= M{fuZ|E2KG2rbh?= NIPkeHZFVVOR NX25RpBmUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? M{nRTlIyOjl{NEmy
A2780 MnXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XtbVk3KGh? MUTEUXNQ MXXJR|UxRTFwNkKg{txO M4TvXFIyPjN2NEOw
COLO205 M2rESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7vPVYhcA>? MVrEUXNQ NVi0[|RpUUN3ME2yMlEzKM7:TR?= M4n6WlIyPjN2NEOw
Hep3B MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi0OFghcA>? Ml\KSG1UVw>? NWWzc5FJT0l3ME2xMlIyKM7:TR?= M{[xb|IyPzF{MUS2
GM11272 NYPTcXNXTnWwY4Tpc44hSXO|YYm= MoD2NVAxKG6P NYrPOYxHPzJiaB?= M17lfWROW09? MXzS[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N MWKyNVg1ODdzNh?=
CFBE41o MVjLbY5ie2ViQYPzZZk> M2X2[FUh|ryP MULEUXNQ Mmi4SI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO Mkm3NlE6QDR7NUi=
CFBE41o NUjLWItFTnWwY4Tpc44hSXO|YYm= M1HaOlEh|ryP NIOxXmQzPCCq MkDkSG1UVw>? M33mSnJme3SxcnH0bY9vKG:oIFPGWHIh\GWudHHGOVA5KG23dHHueEB1emGoZnnjb4lv\yC2bzDj[YxtKHO3cn\hZ4Uh[XNiZ3z5Z49nd3Kvcx?= M1PBSFIyQTh2OUW4
DU145 MYDLbY5ie2ViQYPzZZk> MljjNk42KM7:TR?= M4jNbVI1KGh? NFmz[2dFVVOR M4qwc2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YheDJzd3HmNUBxem:2ZXnuJIV5eHKnc4Ppc44> MlraNlIzPjBzNk[=
DU145 MWjLbY5ie2ViQYPzZZk> NUHTfYtMPSEQvF2= NEjZU3gzPCCq M{DsWGROW09? Mkj0TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36= M3\mXlIzOjZyMU[2
DU145 NFPlfmNMcW6jc3WgRZN{[Xl? MXq1JO69VQ>? MonnNlQhcA>? MWXEUXNQ NIjKcWpKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaHnzeI9v\SCKMzDofZBmemGlZYT5cIF1cW:w MnfLNlIzPjBzNk[=
786-0 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnmNVAxPi5{IN88US=> M4XK[lczKGh? MXHEUXNQ M2PTOGdKPTB;Mz6yJO69VQ>? MXqyNlQ{PTZ4OR?=
A498 MmfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHSfGY3NjJizszN NGLidos4OiCq M2m1RmROW09? NEXCSo9IUTVyPUGuOkDPxE1? NUH0enYyOjJ2M{W2Olk>
A549/ATCC MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXS2MlIh|ryP NVf3NIZmPzJiaB?= NEXDWHlFVVOR M4PhNmdKPTB;MT62JO69VQ>? M{\LflIzPDN3Nk[5
ACHN MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVm2MlIh|ryP M3XDUVczKGh? M{ny[mROW09? MUjHTVUxRTFwMzFOwG0> NVX4TlJZOjJ2M{W2Olk>
BT549 MmrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LRb|YvOiEQvF2= MlnLO|IhcA>? M{G5O2ROW09? MkLMS2k2OD1zLkOg{txO MlPaNlI1OzV4Nkm=
EKVX MnK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjHPVM3NjJizszN MWq3NkBp NFfk[|ZFVVOR M2m0b2dKPTB;MT6zJO69VQ>? MnOyNlI1OzV4Nkm=
HCT15 NUHPfWQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfMOk4zKM7:TR?= NVfrNIttPzJiaB?= MYTEUXNQ NYXGeIVvT0l3ME2yMlUh|ryP M1XKWlIzPDN3Nk[5
HOP92 MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjpOk4zKM7:TR?= NVrjdI82PzJiaB?= MWnEUXNQ NUjqfHFpT0l3ME20JO69VQ>? MV[yNlQ{PTZ4OR?=
IGROV1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S5[VYvOiEQvF2= NYXreow6PzJiaB?= NFPDdGtFVVOR NHzwSYNIUTVyPUGuN{DPxE1? M4n0RlIzPDN3Nk[5
LOXIMVI NWLseGFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\0U|Y3NjJizszN MkTxO|IhcA>? Ml7TSG1UVw>? NY\0OlJiT0l3ME2xJO69VQ>? MorSNlI1OzV4Nkm=
M14 M3r2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ewWVYvOiEQvF2= M1nBO|czKGh? MmmzSG1UVw>? NV3sZ5ZlT0l3ME2xMlMh|ryP MmTmNlI1OzV4Nkm=
MALME-3M NHXle3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX74eGliPi5{IN88US=> M4jHbVczKGh? M2\uWmROW09? MWXHTVUxRTBwM{Kg{txO NFTGdZEzOjR|NU[2PS=>
MCF10A MmLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPDUmg3NjJizszN M331O|Q5KGh? MoPLSG1UVw>? M1XQOWdKPTB;OT62JO69VQ>? NHz1[FEzOjR|NU[2PS=>
MDA-MB-435 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmWwOk4zKM7:TR?= Mn3xO|IhcA>? M1rvd2ROW09? NXfxOlBkT0l3ME2wMlUh|ryP MW[yNlQ{PTZ4OR?=
MDA-MB-468 NILubndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Tk[FYvOiEQvF2= MXu3NkBp NYDuUlc1TE2VTx?= NIPaU25IUTVyPUCuOlMh|ryP MlrhNlI1OzV4Nkm=
MOLT4 MkW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPwRmdIPi5{IN88US=> M3\NPVczKGh? MnjuSG1UVw>? M3LZPGdKPTB;MD60JO69VQ>? M1j0V|IzPDN3Nk[5
NCI-ADR-RES NGj1d4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHjOk4zKM7:TR?= NVvXd5hWPzJiaB?= M3XGN2ROW09? NF:yVIJIUTVyPUCuNVYh|ryP NWLXW4psOjJ2M{W2Olk>
NCI-H23 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13BO|YvOiEQvF2= NIL1cVk4OiCq Mkf3SG1UVw>? M3jhcWdKPTB;MTFOwG0> MlLsNlI1OzV4Nkm=
NCI-H322M M3f1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvPNGdvPi5{IN88US=> NYLhcHNLPzJiaB?= MYrEUXNQ NGK1SXJIUTVyPUCuO|kh|ryP M{TEbVIzPDN3Nk[5
NCI-H460 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPNNpM3NjJizszN NI\lbVQ4OiCq NIPGeJVFVVOR M4nRd2dKPTB;MD63PUDPxE1? NWr6d2xsOjJ2M{W2Olk>
NCI-H522 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj1fXcyPi5{IN88US=> MYC3NkBp M1mwRmROW09? NGDNNIxIUTVyPUCuOUDPxE1? MXmyNlQ{PTZ4OR?=
OVCAR3 NXLLVnlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnCU3o3NjJizszN MoLMO|IhcA>? MU\EUXNQ NFT3PJNIUTVyPUGuN{DPxE1? NITMO5UzOjR|NU[2PS=>
OVCAR4 MkjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;ZeFc3NjJizszN NIfmRYc4OiCq MXXEUXNQ MW\HTVUxRTRizszN NVjIV5E1OjJ2M{W2Olk>
OVCAR5 M17RdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHoN4E3NjJizszN NV36TWR5PzJiaB?= NEjYZXJFVVOR NFjyXGZIUTVyPUCuO|kh|ryP M2CwXlIzPDN3Nk[5
OVCAR8 NYXJWVlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELQSY03NjJizszN MWS3NkBp MmTiSG1UVw>? NF3wWHJIUTVyPUCuOUDPxE1? NW\SbGlPOjJ2M{W2Olk>
RXF393 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUG2MlIh|ryP MmTmO|IhcA>? MoDOSG1UVw>? NWnHdo5NT0l3ME2xMlMh|ryP NVLGNnJmOjJ2M{W2Olk>
SF268 NVL3cnliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLn[4JsPi5{IN88US=> Mo\HO|IhcA>? MXXEUXNQ Mo\WS2k2OD1zLk[g{txO M1HyNlIzPDN3Nk[5
SF295 M4f5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUK2MlIh|ryP NF\PNmk4OiCq MVLEUXNQ NGP5WnpIUTVyPUGuOkDPxE1? MX[yNlQ{PTZ4OR?=
SF539 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGOxfIc3NjJizszN NYL5VotpPzJiaB?= MmrnSG1UVw>? Mn\5S2k2OD1{IN88US=> MX6yNlQ{PTZ4OR?=
SK-MEL-2 NUXGRXdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYC2MlIh|ryP MnXyO|IhcA>? M1nNSWROW09? MmnwS2k2OD1zLkOg{txO M1y2N|IzPDN3Nk[5
SK-MEL-28 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7LUm83NjJizszN MljnO|IhcA>? NH3m[W1FVVOR NGDCSWlIUTVyPUGg{txO NIDBTHkzOjR|NU[2PS=>
SK-MEL-5 MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn3PWw3NjJizszN NFPqSVM4OiCq Mn7iSG1UVw>? MXLHTVUxRTBwNkOg{txO NUHZOVg2OjJ2M{W2Olk>
SKOV3 Mle4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjV[Yx1Pi5{IN88US=> M1ftR|czKGh? NVnjfVVtTE2VTx?= MV7HTVUxRTFizszN NELwVmEzOjR|NU[2PS=>
SN12C MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUO2MlIh|ryP NITzUGw4OiCq NXv2e5p{TE2VTx?= MnvjS2k2OD1{IN88US=> M1jPSlIzPDN3Nk[5
SNB19 NYnMOFZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXhW2dGPi5{IN88US=> NGK5THg4OiCq NWqxepd2TE2VTx?= NVi1eWdkT0l3ME2wMlY{KM7:TR?= MV:yNlQ{PTZ4OR?=
SNB75 MlPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfEXXY3NjJizszN NWD2OYFzPzJiaB?= M1vtSmROW09? M1HwR2dKPTB;MD63PUDPxE1? NGTTcoMzOjR|NU[2PS=>
SR M1nwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmOyOk4zKM7:TR?= NUXMdGtvPzJiaB?= Mnz3SG1UVw>? NYiyTIUzT0l3ME2wMlQh|ryP Mn36NlI1OzV4Nkm=
T47D M1;ERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPvTIduPi5{IN88US=> NGLsbYE4OiCq MYjEUXNQ MlT3S2k2OD1yLkWg{txO NVPSWYhZOjJ2M{W2Olk>
TK10 NVTtRXZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LH[|YvOiEQvF2= Mof3O|IhcA>? NVHIcJJETE2VTx?= M37BTGdKPTB;MD62N{DPxE1? MYOyNlQ{PTZ4OR?=
UACC257 M2e1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XB[FYvOiEQvF2= MnvMO|IhcA>? NGHSOplFVVOR NHTnbmxIUTVyPUCuOUDPxE1? M4L0SlIzPDN3Nk[5
UACC62 NGLaPYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPBOk4zKM7:TR?= M{PLbVczKGh? MV\EUXNQ M4X0dWdKPTB;MD60JO69VQ>? NH;Hd2szOjR|NU[2PS=>
UO31 NV;ybI5CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTyOk4zKM7:TR?= NVrmPWp3PzJiaB?= M4XzUmROW09? NWDnW2ZVT0l3ME2wMlUh|ryP Mn24NlI1OzV4Nkm=
Hep3B MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnROFghcA>? NWLZVYFuTE2VTx?= M2[zVmdKPTB;MD62PUDPxE1? MmPZNlI1Ozl6NkO=
BE(2)-C NW\uWo52T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzCRXA4OiCq M2rx[WROW09? MXHJR|cxRTJizszN NF;jc48zOjl|MkOxOi=>
Bel7402 NELGS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nQVVczKGh? MlP1SG1UVw>? MmjwS2k6OD1zNzFOwG0> NFuw[5QzOzB4MUO3Oi=>
Bel7404 NGLrXZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nmOVczKGh? MXTEUXNQ NVGwemF2T0l7ME2xPEDPxE1? M{HwelI{ODZzM{e2
BGC823 NYC4Z4ttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUC3NkBp MmWwSG1UVw>? NX3Oc3E4T0l7ME23MlUh|ryP MlL5NlMxPjF|N{[=
MGC803 MmXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUm3NkBp MoT4SG1UVw>? MX7HTVkxRTFyLkig{txO MVOyN|A3OTN5Nh?=
SGC7901 NE\kfIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\zTVczKGh? NV3scIFCTE2VTx?= MWPHTVkxRTlwNDFOwG0> M3viRVI{ODZzM{e2
SKHEP1 NUjxWIJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfIc2E4OiCq M1z3V2ROW09? MkfWS2k6OD1zNzFOwG0> M3XvOlI{ODZzM{e2
SMMC7721 M{nwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jOS|czKGh? M3vZXmROW09? NH3pUINIUTlyPUKwJO69VQ>? NITle2szOzB4MUO3Oi=>
NUGC3 NWLBNIJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDRXpoyOCEQvF2= NX;tUZNjT0l;Mj65OEDPxE1? MXyyN|E3OzN|Mh?=
A2780 CisR MoT5T4lv[XOnIFHzd4F6 MWCxPEBp MWfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNESg{txO MYSyN|I2OjZyMx?=
CAL27 sens NH\WXldMcW6jc3WgRZN{[Xl? MXyxPEBp NWDneXc1UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= M{f1WlI{OjV{NkCz
CAL27 CisR MV3LbY5ie2ViQYPzZZk> MoHDNVghcA>? NHHsTZJKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP MnHONlMzPTJ4MEO=
KYSE-510 CisR NXXmW4gyU2mwYYPlJGF{e2G7 MVKxPEBp NHLvNppKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOVkh|ryP NH;QXnMzOzJ3Mk[wNy=>
KYSE-510 sens NHvBNHJMcW6jc3WgRZN{[Xl? Mkm2NVghcA>? MX\Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNzFOwG0> MleyNlMzPTJ4MEO=
MDA-MB-231 sens NHXxU5BMcW6jc3WgRZN{[Xl? NUDKWnFTOThiaB?= M2fxRWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NF7YO2YzOzJ3Mk[wNy=>
MDA-MB-231 CisR NI\EXlFMcW6jc3WgRZN{[Xl? MVGxPEBp M1PVcWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M1jvclI{OjV{NkCz
ES2 M2Xhd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T4eFQ5KGh? NHniSHdFVVOR M3jSN2lEPTB;MUKuO{DPxE1? M{TCblI{PDl|NES5
MDA-MB-231 NEPSZYVMcW6jc3WgRZN{[Xl? NH[ydlgyOCEQvF2= NWWxcoxKOzBibXnu NH;UNoJFVVOR NIjabFRKdmirYnn0bY9vKG:oIFjERWMz[Q>? M3PPTVI{PDl|NES5
MDA-MB-231 NUTW[lJTU2mwYYPlJGF{e2G7 NXLoXWZEOSEQvF2= MVSyOEBp MmnTSG1UVw>? MUDJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw M4nMbVI{PDl|NES5
HS68 MlHxR5l1d3SxeHnjJGF{e2G7 NUToRVVnOTBizszN M4\nclczKGh? MlLOSG1UVw>? MkD4TWM2OD12Lk[g{txO MXmyN|U4ODV2Mh?=
MEF M1H0eWN6fG:2b4jpZ{BCe3OjeR?= M1jIeFExKM7:TR?= M13IPFczKGh? NV\aZYw4TE2VTx?= MYPJR|UxRTRwNDFOwG0> MYSyN|U4ODV2Mh?=
BGC823 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH1bGd4TE2VTx?= NXGzNoZXT0l3ME2zMlA6KM7:TR?= Ml22NlM3ODF5ME[=
High5 MYjLbY5ie2ViQYPzZZk> NHuyWmczPCCq NWrrOFI3UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= NF7m[m0zOzZyMkWyNy=>
High5 NU[2b2ViU2mwYYPlJGF{e2G7 M4HmcFI1KGh? MUDJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? Mo\PNlM3ODJ3MkO=
High5 MXLLbY5ie2ViQYPzZZk> M4fmdVI1KGh? NGPrfJdKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= Mm\NNlM3ODJ3MkO=
A549 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe4N2JpTE2VTx?= MnnkTWM2OD1zLkC3PUDPxE1? MoqyNlM3PDR{MUC=
HCT116 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L4XmROW09? NHrXcnJKSzVyPUCuO|U4KM7:TR?= NUnTTJhCOjN4NESyNVA>
K562 NYnXW4FtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jORWROW09? M4DXUWlEPTB;MD62OFUh|ryP NYfiWYRKOjN4NESyNVA>
GBC-SD NGTUU5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fLW|Uh|ryP MmC3O|IhcA>? MmPjSG1UVw>? MV\JR|UxRTF2Lkig{txO M{WwbVI{PzB5Mk[w
HGC27 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDtWIdkPSEQvF2= MmnGO|IhcA>? M2\BdmROW09? M4DsemlEPTB;NT60JO69VQ>? NF70bGUzOzdyN{K2NC=>
HL60 MnrIT4lv[XOnIFHzd4F6 Mo\HOUDPxE1? M4nJTVI1KGh? NW\NU|E{TE2VTx?= NWfUfHdvUW6qaXLpeIlwdiCxZjDISGFE M3qxcFI{PzB5Mk[w
Vero NV;JfnB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYi3NkBp M1PqbWROW09? NITxNppKSzVyPUCuPUDPxE1? M37zVFI{Pzh4NEWy
NCI60 MmTVR5l1d3SxeHnjJGF{e2G7 NFXaPFg1QCCq M3;l[mROW09? M4H6XmdKRTBwNUOg{txO NGfSXlYzPDBzNUOyOy=>
SW620 MVTDfZRwfG:6aXOgRZN{[Xl? NHnmXGc1QCCq NG\seXpFVVOR NYLNVGRST0l;MD61OEDPxE1? NYewS4JQOjRyMUWzNlc>
U251 NGWzTVBEgXSxdH;4bYMhSXO|YYm= Mn7COFghcA>? NGP3[pJFVVOR MYXHTV0yNjV|IN88US=> M{nERVI1ODF3M{K3
KM12 M2nRO2N6fG:2b4jpZ{BCe3OjeR?= NXX5XmJDPDhiaB?= M1PPSmROW09? NY\Ie|JmT0l;MT64PEDPxE1? NWjMT5BXOjRyMUWzNlc>
Hs578T M3LmOGN6fG:2b4jpZ{BCe3OjeR?= NWPYTpNtPDhiaB?= Mlr2SG1UVw>? MYHHTV01Njh|IN88US=> NFTJcVUzPDBzNUOyOy=>
MDA-MB-231 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq5OFghcA>? MWTJR|UxRTBwMU[g{txO NX;sZ5BmOjRyOUWwNVY>
MCF7 M2Xoe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV20PEBp M1rlfmdKRTBwNEWg{txO NW[4[5JbOjRzMUm1OVU>
MDA-MB-435 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjVXWhCPDhiaB?= MXjHTV0xNjh6IN88US=> MlK3NlQyOTl3NUW=
AsPC1 NYrhW3hoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLZS3poOzBizszN NWnxVGo4PDhiaB?= M2\qNmROW09? MWXJR|UxRTNwNk[g{txO M3nPUlI1OTh3M{e4
Jurkat E6.1 MkjMT4lv[XOnIFHzd4F6 MnzXNkBp MXvEUXNQ MmD6TY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1? NIXKZmEzPDJ4MUi2Ni=>
KG1 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjHPWc1QCCq NFnoe21KSzVyPUGuNVUh|ryP M3nuc|I1PTJ3MECz
HEL M{S2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkWwOFghcA>? NVywOlBZTE2VTx?= NETYXJZKSzVyPUCuOFkh|ryP M{frUFI1Pjl2MEW1
HSC3 MkfWR5l1d3SxeHnjJGF{e2G7 NVXqe49QOTJiaB?= MnjnSG1UVw>? MV\JR|UxRTBwN{Gg{txO NUPVfoFnOjR5Nk[1OlA>
HT-29 NWnWXlFWS3m2b4TvfIlkKEG|c3H5 MWGxNkBp Mn3SSG1UVw>? NWnIV5pVUUN3ME2wMlczKM7:TR?= NGHNdVYzPDd4NkW2NC=>
KB MlPwR5l1d3SxeHnjJGF{e2G7 MWixNkBp MWTEUXNQ NY\rcpRIUUN3ME2wMlc2KM7:TR?= NXL4dZMyOjR5Nk[1OlA>
H460 NHHuO4hEgXSxdH;4bYMhSXO|YYm= NVTlSWROOTJiaB?= MorGSG1UVw>? NYjpWpRxUUN3ME2wMlgzKM7:TR?= MVKyOFc3PjV4MB?=
MONE1 NUXWcFFnS3m2b4TvfIlkKEG|c3H5 MkHpNVIhcA>? MX;EUXNQ M2riOmlEPTB;MT6xPEDPxE1? MWeyOFc3PjV4MB?=
MKN45 M3fKfGN6fG:2b4jpZ{BCe3OjeR?= NEnOOHkyOiCq MkLnSG1UVw>? NGfsN4pKSzVyPUGuNlUh|ryP Ml\GNlQ4PjZ3NkC=
TSGH NVqzVJdqS3m2b4TvfIlkKEG|c3H5 MYmxNkBp NGmzb5pFVVOR M4LYUmlEPTB;Mj6wPUDPxE1? NVLMXpBqOjR5Nk[1OlA>
HL60 NXHEWoVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDISGJSPzJiaB?= M3rGXGROW09? NU\QemEzT0l3ME2wMlk{KM7:TR?= NIP5OlEzPDlyMEWwNC=>
HEK293 NF3kcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTSeo9EPzJiaB?= M3\nW2ROW09? MXjHTVUxRTF|IN88US=> NWX0PXJoOjR7MEC1NFA>
Jurkat MUDDfZRwfG:6aXOgRZN{[Xl? MXOxNFAh|ryP M2HaT|czKGh? NF6zTlNIUTVyPUCuPUDPxE1? MYGyOFkxODd2Mx?=
GM15850 MX7LbY5ie2ViQYPzZZk> M3r1ZVIvPSEQvF2= NHP5Wnk6PiCq NInoVZBFVVOR NF;YXJpld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhOTRiYXPleJlt[XSrb36gc4YhTliQIHflcoU> NIPpeoEyPjl{MUO2Oy=>
GM15850 NH3YXYpMcW6jc3WgRZN{[Xl? NH[5c24zNjVizszN M{fMOVk3KGh? NVX2T2ZrTE2VTx?= Mlm5[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NUTvW|B6OTZ7MkGzOlc>
GM15850 MUXLbY5ie2ViQYPzZZk> MXSyMlUh|ryP MVS5OkBp MnjuSG1UVw>? NYWwVoMz\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF{IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m MYOxOlkzOTN4Nx?=
GM15850 NWC2XoxnU2mwYYPlJGF{e2G7 MXyyMlUh|ryP NUPYTYd{QTZiaB?= NHPUN2JFVVOR NWLLV2pM\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDNibInzbY5mKDliYXPleJlt[XSrb36gc4YhTliQIHflcoU> MVyxOlkzOTN4Nx?=
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LB1047-RCC MofLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWj1bpJqUUN3ME2xMlE5OzF{IN88US=> NUDrVotQW0GQR1XS
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SW620 Mk\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPCSmJTUUN3ME2xMlI6ODF6IN88US=> MoWxV2FPT0WU
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VA-ES-BJ MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDIPHZkUUN3ME2xMlMzPDd5IN88US=> M1;qfXNCVkeHUh?=
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H4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwNUC5NVIh|ryP MkDpV2FPT0WU
OVCAR-8 NX\xeolnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\RRoJKSzVyPUGuOVQ1PzdizszN MnvDV2FPT0WU
NCI-H23 M{[wfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTtTWM2OD1zLkW0OlQ2KM7:TR?= NILqSoZUSU6JRWK=
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HT55 NWrqdHVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;2NYxYUUN3ME2xMlY2OTNzIN88US=> M1\UUXNCVkeHUh?=
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EM-2 M2LWcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H1ZWlEPTB;MT63NFAyPCEQvF2= M1XtSHNCVkeHUh?=
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CAL-27 M4jaS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rufWlEPTB;MT63NFYzOSEQvF2= MXrTRW5ITVJ?
COLO-800 NVW1dml7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\LZmlEPTB;MT63NVE4QSEQvF2= Ml7KV2FPT0WU
HCE-T MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzFcVNKSzVyPUGuO|E2KM7:TR?= M1;hNnNCVkeHUh?=
CAMA-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PUbWlEPTB;MT63NVk4OSEQvF2= MoS3V2FPT0WU
LOXIMVI NYi0RowyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXlTWM2OD1zLkeyNVEh|ryP MkfPV2FPT0WU
NH-12 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PVOmlEPTB;MT63NlY6OSEQvF2= NV\VbldJW0GQR1XS
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MDA-MB-361 NWrYV|B2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLGV3ZnUUN3ME2xMlc{OTV5IN88US=> NYLkdXp6W0GQR1XS
EW-16 MnXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXCTWM2OD1zLke0NVA4KM7:TR?= MVvTRW5ITVJ?
SNU-423 MonnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXlTFZ[UUN3ME2xMlc2QDJ5IN88US=> NX\6ZmN2W0GQR1XS
Daoy MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPwTWM2OD1zLke2N|E6KM7:TR?= Mn\MV2FPT0WU
ES4 MlmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DiNmlEPTB;MT63PFc1OSEQvF2= MkjZV2FPT0WU
PFSK-1 MoW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLPTWM2OD1zLkiwN|ch|ryP NHfLeYpUSU6JRWK=
ES3 M33vUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fsfWlEPTB;MT64NlY5OSEQvF2= MoXSV2FPT0WU
ONS-76 NYD3OoRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFwOEK4PVch|ryP M{T3V3NCVkeHUh?=
JVM-3 NXnKTGQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIW4U|lKSzVyPUGuPFU1PTFizszN MYjTRW5ITVJ?
OS-RC-2 NUHR[4lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHacXJKSzVyPUGuPFcyPTFizszN M4nHO3NCVkeHUh?=
COLO-320-HSR MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWqzT2tQUUN3ME2xMlg5OTl5IN88US=> MUTTRW5ITVJ?
HN MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj0Uo1kUUN3ME2xMlg5PzJ3IN88US=> MojaV2FPT0WU
HT MnXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkWyTWM2OD1zLki4PVQ4KM7:TR?= NFzleIpUSU6JRWK=
LoVo MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnyPGdyUUN3ME2xMlg6QDFizszN MULTRW5ITVJ?
CGTH-W-1 MmPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PBU2lEPTB;MT64PVk1PiEQvF2= NHXFZ|RUSU6JRWK=
NB6 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LP[2lEPTB;MT65NVI6QCEQvF2= NIT5SY1USU6JRWK=
EW-22 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3QToRKSzVyPUGuPVI5QDdizszN NHraOnFUSU6JRWK=
ES6 MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTFwOUO2N|Eh|ryP NWDvOXNVW0GQR1XS
SCC-15 MlexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\pRmlEPTB;MT65N|gyQSEQvF2= M{TPTHNCVkeHUh?=
HL-60 NWL4[mVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPkTWM2OD1zLkmzPVAzKM7:TR?= NFq5NmdUSU6JRWK=
human HOP-92 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzwe|hKSzVyPUGuPVQxPjVizszN MnvWV2FPT0WU
SW626 NIHBfZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\LVJVIUUN3ME2xMlk1QDl7IN88US=> NV;1UpFsW0GQR1XS
HEC-1 NIPXVVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXMTWM2OD1zLkm1N|Yh|ryP NFrmT|JUSU6JRWK=
LB2241-RCC M2XIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XySWlEPTB;MT65PFI{OSEQvF2= Mn\rV2FPT0WU
Ramos-2G6-4C10 MkTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTFwOUm0PVMh|ryP MXvTRW5ITVJ?
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NCI-H446 M17PW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;XbmlEPTB;Mj6wOFU6QSEQvF2= NH;GbVlUSU6JRWK=
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K5 MkTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn3UZJSUUN3ME2yMlA4QDFzIN88US=> M1jPXnNCVkeHUh?=
HLE NW\2clZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmixTWM2OD1{LkC4OVI6KM7:TR?= M4mzNHNCVkeHUh?=
HSC-2 NULyRlVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJwMUK4PVgh|ryP MnzMV2FPT0WU
LCLC-97TM1 NFHFUYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJwMUS1PFMh|ryP MVTTRW5ITVJ?
DMS-273 Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1KzUmlEPTB;Mj6xOFg{PyEQvF2= M2S3cnNCVkeHUh?=
TE-8 MmDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjwTWM2OD1{LkG1O|Y2KM7:TR?= NInteYlUSU6JRWK=
DSH1 M3PaZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{f1[mlEPTB;Mj6xOlM6QCEQvF2= NI\XT2lUSU6JRWK=
CAL-51 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M161Z2lEPTB;Mj6xOlY6QSEQvF2= MoXmV2FPT0WU
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GCT M4\aN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwMUe3O{DPxE1? MnLDV2FPT0WU
SW948 NHnwN2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvrTWM2OD1{LkG4OFU3KM7:TR?= NH:xXWlUSU6JRWK=
NOMO-1 NEfUSpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJwMUmzNVch|ryP NIruU2NUSU6JRWK=
C8166 NGDiUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDTZXZnUUN3ME2yMlIyOzN2IN88US=> NYD3[IN[W0GQR1XS
OC-314 MmXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\GNpFKSzVyPUKuNlMzPTlizszN MlHCV2FPT0WU
CAL-39 Mk\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;CR2ZKSzVyPUKuNlM3OjZizszN NGnGflFUSU6JRWK=
MDA-MB-453 NUTMdnQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLDTWM2OD1{LkK0Nlc2KM7:TR?= NWLIU4dQW0GQR1XS
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HTC-C3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLTTWM2OD1{LkK2PFUh|ryP M3zKRnNCVkeHUh?=
NCI-H1666 Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjDUpFIUUN3ME2yMlI5OTFzIN88US=> NUGwXmNZW0GQR1XS
PSN1 NYLjdVRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17xNWlEPTB;Mj6yPFkyOyEQvF2= NYjYOlF{W0GQR1XS
GI-1 M4X1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHSw[2ZKSzVyPUKuN|A2PDNizszN NIT4XppUSU6JRWK=
HuH-7 MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILaS|NKSzVyPUKuN|A3OzdizszN MWLTRW5ITVJ?
JAR NV3INXlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJwM{G5PFch|ryP MlfzV2FPT0WU
5637 NWPybFNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPjNm9EUUN3ME2yMlMzOTJ7IN88US=> NH;3[JlUSU6JRWK=
GB-1 M3Xtfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\jdnZwUUN3ME2yMlMzOzN3IN88US=> MlHZV2FPT0WU
KP-N-YS M2nzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjEcXZpUUN3ME2yMlMzPjF3IN88US=> MnP3V2FPT0WU
OAW-42 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJwM{O0NVYh|ryP NH2ydJVUSU6JRWK=
8-MG-BA MkfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\STWM2OD1{LkOzPVA3KM7:TR?= Mn3oV2FPT0WU
RH-18 MmLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTFTWM2OD1{LkO1NFIzKM7:TR?= M{DWd3NCVkeHUh?=
NCI-H1155 NGrvT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJwM{[3NlUh|ryP MWXTRW5ITVJ?
NB17 M{f1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTJwM{iyOFMh|ryP NVfCSFBLW0GQR1XS
NCI-H1437 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofDTWM2OD1{LkSxPFc{KM7:TR?= MmTiV2FPT0WU
SN12C NUm0[lYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP6UZBKSzVyPUKuOFMzOTRizszN MmW0V2FPT0WU
HSC-3 NFrLPIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlraTWM2OD1{LkS0OVA6KM7:TR?= MmTMV2FPT0WU
GAMG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP5W|dKSzVyPUKuOFQ2PjFizszN M3qxenNCVkeHUh?=
HT-1080 MoCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfqe41mUUN3ME2yMlQ1QDZ2IN88US=> M4HlXnNCVkeHUh?=
A549 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJwNES4PVMh|ryP Mmn6V2FPT0WU
KNS-62 NG\3fVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljETWM2OD1{LkS1NFYyKM7:TR?= M4PPfnNCVkeHUh?=
YKG-1 M3W2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\BV5RKSzVyPUKuOFU1OzdizszN NWXzUo5mW0GQR1XS
LU-134-A NEnlbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL0TWM2OD1{LkS3NFA5KM7:TR?= NEezRYZUSU6JRWK=
FADU M{LVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfHTWM2OD1{LkS3NVYzKM7:TR?= NYO4dHFUW0GQR1XS
TGBC11TKB MoTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq2VWZsUUN3ME2yMlQ4OTd5IN88US=> MULTRW5ITVJ?
HT-3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLjTWM2OD1{LkS5OVM2KM7:TR?= NVW5fHNZW0GQR1XS
NCI-H2170 NV\uSWVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PQNmlEPTB;Mj61NFU1QSEQvF2= MoHkV2FPT0WU
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BB65-RCC M2jEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTDWFRKSzVyPUOuNFM{OTRizszN MkHGV2FPT0WU
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NCI-H1563 NWPBU|IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rwWmlEPTB;Mz6zN|AyQCEQvF2= MX;TRW5ITVJ?
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NCI-H2122 M{\WSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTNwNEGzNVIh|ryP MULTRW5ITVJ?
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EW-13 M3y3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf3eIdKSzVyPUOuOVI2OSEQvF2= NIPDcWtUSU6JRWK=
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CAL-62 M4f1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP4TWM2OD1|LkW0OVE1KM7:TR?= MoXCV2FPT0WU
OCUB-M M4XiNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkeyTWM2OD1|LkW0OlY2KM7:TR?= NH;jTYhUSU6JRWK=
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KYSE-180 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nHc2lEPTB;Mz62N|M4OiEQvF2= Mm\aV2FPT0WU
NCI-H650 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTNwNkSyPFch|ryP NYO0VpZWW0GQR1XS
Detroit562 MlGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTNwNkWwNlIh|ryP MnzmV2FPT0WU
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KYSE-510 NFHnUIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTNwN{KxPFEh|ryP MVzTRW5ITVJ?
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RPMI-7951 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj5OY5KSzVyPUOuO|Q4OjNizszN MWrTRW5ITVJ?
Becker MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjs[oNuUUN3ME2zMlc2ODF{IN88US=> NGOwUnlUSU6JRWK=
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SW982 M2PWSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTNwOEC1OVEh|ryP MmX3V2FPT0WU
D-263MG MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTNwOEKwOVEh|ryP NE[4eZRUSU6JRWK=
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LS-123 M1K0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HZeGlEPTB;Mz64O|kxQSEQvF2= MVrTRW5ITVJ?
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HCE-4 MkntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PBXmlEPTB;Mz65NVY3OyEQvF2= NViwTGNYW0GQR1XS
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OVCAR-4 M2W3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[5[WlEPTB;Mz65Nlg5QSEQvF2= M2HCWnNCVkeHUh?=
ETK-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTNwOUS2N|Uh|ryP NI\5ZY9USU6JRWK=
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COR-L105 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTRwMUOwOVEh|ryP NVn2UGk4W0GQR1XS
CAL-12T M33rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPkeYFKSzVyPUSuNVMyODNizszN MnX0V2FPT0WU
SCH NYDMeZE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13OfmlEPTB;ND6xOVc1OyEQvF2= MX;TRW5ITVJ?
CW-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTRwMUmwNFEh|ryP NIHieFBUSU6JRWK=
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KYSE-70 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLPcplKSzVyPUSuNlk{PCEQvF2= NETCWHpUSU6JRWK=
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EPLC-272H NYX4R5ExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XlV2lEPTB;ND6zPFk2KM7:TR?= MYXTRW5ITVJ?
CAL-120 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\2eJpKSzVyPUSuN|g6QTJizszN Ml;kV2FPT0WU
LS-513 M2PyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PVSWlEPTB;ND60NlE6QCEQvF2= MVPTRW5ITVJ?
CAPAN-1 M{TaT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\JRlhJUUN3ME20MlQzOzh{IN88US=> MmTXV2FPT0WU
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GMS-10 M2i4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDDfmVKSzVyPUSuOFI5OTlizszN M4TobHNCVkeHUh?=
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NCI-H1395 NUOwVnpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPhUmNKSzVyPUGwMlE4QCEQvF2= NWrKbZk4W0GQR1XS
NCI-H2052 M1G1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjlXIhMUUN3ME2xNE4yQDh{IN88US=> NFLnbmlUSU6JRWK=
A375 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFyLkK0OVIh|ryP MXfTRW5ITVJ?
HCC38 Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFyLkOyNkDPxE1? MVHTRW5ITVJ?
LK-2 NVewOFBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTFyLkSyNFgh|ryP NUXWc3E6W0GQR1XS
SF126 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrmclhnUUN3ME2xNE41PzJ5IN88US=> MXfTRW5ITVJ?
SK-MEL-1 NFrqem5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn21TWM2OD1zMD63PFM5KM7:TR?= NU\YTmt1W0GQR1XS
ACN NYDNeWI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFznZoxKSzVyPUGwMlg3PzlizszN NG\vcWVUSU6JRWK=
BB30-HNC NIf2S2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHRUZlKSzVyPUGwMlg4OTFizszN MkDNV2FPT0WU
NCI-H747 NVLRd3NjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XjUWlEPTB;MUCuPFc1PiEQvF2= MVjTRW5ITVJ?
KYSE-150 M1j3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTFzLkCzPFch|ryP NHXXdVNUSU6JRWK=
D-247MG M4DOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInmN4RKSzVyPUGxMlExODlizszN NUnLfnY1W0GQR1XS
BxPC-3 MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LZeWlEPTB;MUGuN|c1PyEQvF2= MVnTRW5ITVJ?
SK-MEL-30 NWTpWpByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XhT2lEPTB;MUGuOFA4QSEQvF2= M{jPeXNCVkeHUh?=
CAS-1 NIXPbWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzaTWM2OD1zMT60NVA6KM7:TR?= Mme5V2FPT0WU
no-10 M1jvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{f0e2lEPTB;MUKuNVIyPyEQvF2= MUHTRW5ITVJ?
NCI-H2405 MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvjfphKUUN3ME2xNk4zODN4IN88US=> MWLTRW5ITVJ?
KGN NX\HfodjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzrXI9EUUN3ME2xNk4zQTBzIN88US=> MWnTRW5ITVJ?
BB49-HNC NYTjRYFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrFTFhKSzVyPUGyMlM6PTZizszN NVz3Nod6W0GQR1XS
NCI-H1693 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF{LkW4NVYh|ryP NHjTc41USU6JRWK=
RO82-W-1 NX;RdnBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTF|LkC2OFkh|ryP Ml7aV2FPT0WU
CAL-85-1 MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfHZY45UUN3ME2xN{41Ozl7IN88US=> NVzG[pI{W0GQR1XS
H-EMC-SS NXrZToU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G5XmlEPTB;MUOuPVExPCEQvF2= NYHnfm5QW0GQR1XS
SW1783 NEDHVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW5TWM2OD1zND6yN|kyKM7:TR?= NXXvTFA1W0GQR1XS
LB771-HNC MmewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG5TWM2OD1zND60NVkh|ryP NEf1TXNUSU6JRWK=
HCC70 NGP0XHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i1ZmlEPTB;MUSuOFI{OyEQvF2= MUjTRW5ITVJ?
KNS-81-FD M2m2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7pTWM2OD1zND63NFQ2KM7:TR?= NGfjclBUSU6JRWK=
KYSE-520 NVnafpg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPpbWFKSzVyPUG0MlkzPyEQvF2= NGLHPZVUSU6JRWK=
TGBC24TKB NGq4XVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\ZWGlEPTB;MUSuPVU{QSEQvF2= Mn\oV2FPT0WU
SNB75 NGDwfplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvnTWM2OD1zNT6wO|I6KM7:TR?= MmSxV2FPT0WU
SW872 NX72eYVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTF3LkKyNVgh|ryP NULNd4JYW0GQR1XS
U031 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjVdY5kUUN3ME2xOU45ODJ6IN88US=> MljTV2FPT0WU
ChaGo-K-1 NF;ZXVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnX5TWM2OD1zNT64N|U6KM7:TR?= NH;jTY9USU6JRWK=
NCI-H441 MlixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHkSlJKSzVyPUG2MlAxOzlizszN MlzlV2FPT0WU
TE-12 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTF4LkG4O|Mh|ryP NUfyZXE2W0GQR1XS
NCI-H1755 MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHxRVlJUUN3ME2xOk42PzNizszN NXnNN4tbW0GQR1XS
KNS-42 M2f3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDKTWM2OD1zNj62OVg6KM7:TR?= NEHt[FZUSU6JRWK=
SK-PN-DW NWi1dpR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTF5LkSyNFEh|ryP MXHTRW5ITVJ?
NCI-H226 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;j[2lEPTB;MUeuPVM1PSEQvF2= NXnQPW9iW0GQR1XS
K-562 MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3XNmhKUUN3ME2xPE43OzF5IN88US=> MWrTRW5ITVJ?
A388 M1:yS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTF7LkCzNFMh|ryP MWnTRW5ITVJ?
ZR-75-30 NHzTXIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF7LkC5Olgh|ryP MnjHV2FPT0WU
LU-135 M3XQNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ftXGlEPTB;MUmuNlY{PiEQvF2= NEjmdXZUSU6JRWK=
NCI-H2029 MmXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\3UmlEPTB;MUmuOlAzOSEQvF2= NWLxc4VxW0GQR1XS
HT-1197 NInXOYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTF7LkmyNlch|ryP MXHTRW5ITVJ?
IGR-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJyLkOxNVch|ryP M3;icHNCVkeHUh?=
U-87-MG MlTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTJyLk[0NVMh|ryP MYrTRW5ITVJ?
NCI-H1304 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TmfGlEPTB;MkCuO|UxOSEQvF2= NIi2RVRUSU6JRWK=
RCC10RGB MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULpd41bUUN3ME2yNU4zQDJ7IN88US=> NYPLSoFyW0GQR1XS
NCI-H520 NYrz[nA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTJ{Lke2NVEh|ryP MVnTRW5ITVJ?
SK-LU-1 NIPHeWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M374bGlEPTB;MkOuNFcyQCEQvF2= M4LqVnNCVkeHUh?=
UACC-893 M1HlW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33pXGlEPTB;MkOuNVA{QCEQvF2= M2fi[3NCVkeHUh?=
NCI-H2347 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfjSHhKSzVyPUKzMlI3PzRizszN MWTTRW5ITVJ?
U-118-MG MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJ|LkeyNVch|ryP M4SwU3NCVkeHUh?=
NCI-H596 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fFV2lEPTB;MkOuPVA2PSEQvF2= MnPVV2FPT0WU
MZ1-PC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rZ[GlEPTB;MkSuOlc2QSEQvF2= NV\4WG9GW0GQR1XS
SW1417 NEnyR4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPjc|V4UUN3ME2yOU4zPDl6IN88US=> NVz5R|RlW0GQR1XS
NCI-H82 M{G0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[0TWM2OD1{Nj60Nlg5KM7:TR?= NIHTR5ZUSU6JRWK=
COLO-678 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrQTWM2OD1{Nz60PVE6KM7:TR?= Mo\TV2FPT0WU
KURAMOCHI NGPKVFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnjRlE2UUN3ME2yPE4yOjZizszN NXLle3ZYW0GQR1XS
NCI-H1650 M3PE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLWUnZKSzVyPUOwMlE6OjRizszN NYPoS5ZkW0GQR1XS
HCC1954 M4j0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37QU2lEPTB;M{GuN|Y3PiEQvF2= M33QRnNCVkeHUh?=
GAK MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPwOZRKSzVyPUOyMlI3OTZizszN NV6zeG9OW0GQR1XS
YAPC NXvMW4RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILrdZBKSzVyPUOzMlc3PDhizszN M2P2Z3NCVkeHUh?=
NCI-H2228 M4n3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzzXXVKSzVyPUO0MlM3ODVizszN MmPPV2FPT0WU
VMRC-RCZ Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLsTWM2OD1|Nj6zNFIzKM7:TR?= NV3JUIUxW0GQR1XS
NMC-G1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe2cG5PUUN3ME2zO{4xPTJ7IN88US=> NYTHdFRoW0GQR1XS
D-336MG NEDSb3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TDTGlEPTB;NEGuPFQ1OiEQvF2= NFy2OnVUSU6JRWK=
UACC-62 M3LoVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHjeVV1UUN3ME20Nk42PTB3IN88US=> NU\ESo9OW0GQR1XS
C-33-A NH3pcZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\sTohKSzVyPUS1MlMzPTZizszN NEXKeG9USU6JRWK=
HCC1937 M4TsbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\XTWM2OD12Nz6xPVU5KM7:TR?= MW\TRW5ITVJ?
HDLM-2 M1vBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{e1d2lEPTB;NEeuNlI5PyEQvF2= MkjiV2FPT0WU
NCI-H727 NXzGbJI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTR5LkK0OVEh|ryP MYDTRW5ITVJ?
NY NUjjSHFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfzPJJKSzVyPUS5MlM6ODhizszN NGf6TZhUSU6JRWK=
NCI-H2291 M{DxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HCbmlEPTB;NEmuPFMxOSEQvF2= Ml:xV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay
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Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research
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  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research
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  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 53 mg/mL (200.52 mM)
Ethanol 3 mg/mL (11.35 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 5mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02707900 Not yet recruiting HIV-1 Infection Cynthia L Gay, MD|National Institute of Allergy and Infectious Diseases (NIAID)|University of North Carolina, Chapel Hill March 2016 Phase 1
NCT02638090 Recruiting Lung Cancer|Non-small Cell Lung Cancer H. Lee Moffitt Cancer Center and Research Institute|Merck Sharp & Dohme Corp. February 2016 Phase 1|Phase 2
NCT02619253 Recruiting Renal Cell Carcinoma|Urinary Bladder Neoplasms Roberto Pili|Indiana University January 2016 Phase 1|Phase 2
NCT02336074 Recruiting HIV Imperial College London|Medical Research Council|University of Oxford|University of Cambridge|Chelsea and Westminster NHS Foundation Trust|Royal Free Hospital NHS Foundation Trust|Brighton and Sussex University Hospitals NHS Trust|Guys and St Thomas NHS Foundation Trust|Central and North West London NHS Foundation Trust November 2015 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID