Home Neuronal Signaling Serotonin Transporter inhibitor Venlafaxine HCl For research use only.

Venlafaxine HCl

Synonyms: Wy 453 HCl

Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

Venlafaxine HCl Chemical Structure

Venlafaxine HCl Chemical Structure

CAS: 99300-78-4

Selleck's Venlafaxine HCl has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.98%
99.98

Venlafaxine HCl Related Products

Choose Selective Serotonin Transporter Inhibitors

Biological Activity

Description Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
Targets
5-HT [1]
In vitro
In vitro

Venlafaxine has a low potential to inhibit the metabolism of substrates for CYP2D6 such as imipramine and desipramine compared with several of the most widely used SSRIs, as well as the metabolism of substrates for several of the other major human hepatic P450s. [1] Venlafaxine inhibits binding to the human norepinephrine (NE) and serotonin (5-HT) transporters with K(i) values of 2480 nM and 82 nM, respectively, and with a K(i) ratio of 30. Venlafaxine has ED(50) values of 5.9 mg/kg and 94 mg/kg for blocking p-chloramphetamine- and 6-hydroxydopamine-induced monoamine depletion, respectively. [2]
In Vivo
In vivo

Venlafaxine induces a dose-dependent antinociceptive effect following i.p. administration with an ED50 of 46.7 mg/kg in mice. Venlafaxine-induced antinociception is significantly inhibited by naloxone, nor-BNI and naltrindole but not by beta-FNA or naloxonazine, implying involvement of kappa1- and delta-opioid mechanisms in mice. [3] Venlafaxine reverses hyperalgesia in rats with a fully developed neuropathic lesion. Venlafaxine also appears to have a mild non-specific analgesic effect that increased paw withdrawal latency (PWL) in the sham limb. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06131268 Recruiting
Major Depressive Disorder|Bipolar Affective Disorder Currently Depressed Moderate
Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico
 March 1 2022 Phase 4
NCT04708834 Enrolling by invitation
Obsessive Compulsive Disorder
Biohaven Pharmaceuticals Inc.
 March 30 2021 Phase 3
NCT03532477 Recruiting
Obesity Morbid
Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital
 November 2 2016 --
NCT02637193 Completed
Healthy Subjects
Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.|Pfizer
 December 2015 Phase 1
NCT02005107 Completed
Roux en Y Gastric Bypass|Sleeve Gastrectomy
North Dakota State University|Neuropsychiatric Research Institute Fargo North Dakota
 December 2013 Phase 4
NCT01867255 Completed
Bariatric Surgery|Gastric Bypass|Roux-en-Y Gastric Bypass
Mayo Clinic
 October 2013 Phase 1

Chemical Information & Solubility

Molecular Weight 313.86 Formula

C17H27NO2·HCl
CAS No. 99300-78-4 SDF Download Venlafaxine HCl SDF
Smiles CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 63 mg/mL ( (200.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 63 mg/mL

Ethanol : 63 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Venlafaxine HCl | Venlafaxine HCl supplier | purchase Venlafaxine HCl | Venlafaxine HCl cost | Venlafaxine HCl manufacturer | order Venlafaxine HCl | Venlafaxine HCl distributor