Synephrine

Synonyms: Oxedrine

Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.

Synephrine Chemical Structure

Synephrine Chemical Structure

CAS: 94-07-5

Purity & Quality Control

Batch: Purity: 99%
99

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Biological Activity

Description Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
Targets
Adrenergic Receptor [1]
In vitro
In vitro Synephrine is a compound commonly used for weight loss. Synephrine has gained significant popularity as an alternative to ephedrine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions. [1] [2] Synephrine can stimulate glucose consumption (Glut4-dependent glucose uptake) by stimulating AMPK activity, regardless of insulin-stimulated PI3 kinase-Akt activity in L6 skeletal muscle cells. [3]
In Vivo
In vivo LD50: Mice >1000mg/kg (s.c.) [4]

Chemical Information & Solubility

Molecular Weight 167.21 Formula

C9H13NO2

CAS No. 94-07-5 SDF Download Synephrine SDF
Smiles CNCC(C1=CC=C(C=C1)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 33 mg/mL ( (197.35 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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