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Risedronate Sodium

Cat.No.S1428

Risedronate (NE 58095) sodium, a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis.
Risedronate Sodium Chemical Structure

Chemical Structure

Molecular Weight: 305.09

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Quality Control

Batch: Purity: 99.97%
99.97

Solubility

In vitro
Batch:

Water : 2 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 305.09 Formula

C7H10NNaO7P2

 Storage (From the date of receipt)
CAS No. 115436-72-1 Download SDF Storage of Stock Solutions

Synonyms NE 58095 Sodium Smiles C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]

Mechanism of Action

In vitro
Risedronate causes a total inhibition of colony formation whereas Etidronate has relatively little effect in calcifying fibroblastic colony-forming unit (CFU-f) cultures of rat bone marrow cells in vitro. Risedronate (1 μM) decreases the formation of colonies displaying osteoblastic characteristics such as alkaline phosphatase expression, collagen accumulation, and calcification. Risedronate (1 nM) and alendronate increases the formation of fibroblastic colonies, suggesting a mild anabolic effect, however, the formation of colonies with osteoblastic properties is not affected. Risedronate significantly inhibits expression of c-Fos and nuclear factor of activated T cells (NFAT) c1 induced by RANKL in bone marrow-derived macrophages (BMMs).
In vivo
Risedronate (1 mg/kg) significantly increases the volumetric densities of bone (Vb) and osteoblast Vob and decreases Vm more prominently in rats. Risedronate causes a significant and dose-dependent reduction of tooth movement after the orthodontic force is applied in rats. Risedronate prevents a reduction in periosteal bone formation and an increase in endocortical bone erosion, resulting in prevention of alterations in percent cortical bone and marrow areas. Risedronate increases osteocyte density and lacunar occupancy and prevented a GC-induced increase in cortical porosity. Risedronate and Vitamin K(2) has additive effects on osteocyte density and lacunar occupancy and a synergistic effect on cortical porosity.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/9369378/
  • [5] https://pubmed.ncbi.nlm.nih.gov/18543014/

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