Home Microbiology Bacterial inhibitor Pyrazinamide

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Pyrazinamide Bacterial inhibitor

Cat.No.S1762

Pyrazinamide (Pyrazinoic Acid Amide) is an agent used to treat tuberculosis.
Pyrazinamide Bacterial inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 123.11

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Quality Control

Batch: Purity: 99.96%
99.96

Solubility

In vitro
Batch:

DMSO : 25 mg/mL (203.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 12 mg/mL

Ethanol : 2 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 123.11 Formula

C5H5N3O

 Storage (From the date of receipt)
CAS No. 98-96-4 Download SDF Storage of Stock Solutions

Synonyms Pyrazinoic Acid Amide Smiles C1=CN=C(C=N1)C(=O)N

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05329415 Active not recruiting
Tuberculosis|Diabetes Mellitus
London North West Healthcare NHS Trust
 February 1 2022 --
NCT05840809 Recruiting
Tuberculosis Active|Breastfeeding|Tuberculosis
University of Liverpool|Infectious Diseases Institute Makerere University College of Health Sciences
 January 20 2022 --
NCT04972903 Unknown status
Tuberculosis|Pulmonary
Institut National de la Santé Et de la Recherche Médicale France|National Agency for Research on AIDS and Viral Hepatitis (ANRS)
 August 2021 --
NCT04239326 Completed
Tuberculosis Multidrug-Resistant
Foundation for Innovative New Diagnostics Switzerland
 April 16 2021 --
NCT03800381 Recruiting
Tuberculosis|Human Immunodeficiency Virus|Coinfection
University of Florida|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 January 28 2019 --

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