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Pyrazinamide Bacterial inhibitor

Name: Pyrazinamide
Brand: Selleck Chemicals
SKU: S1762
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S1762

Pyrazinamide (Pyrazinoic Acid Amide) is an agent used to treat tuberculosis.

Chemical Structure

Molecular Weight: 123.11

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: Purity: 99.96%

99.96

Related Targets	Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease SARS-CoV HIV Protease ribosome Influenza Virus β-lactamase Integrase HBV CMV Neuraminidase HCV Thioredoxin Reductase HSV RSV Enterovirus DprE1 3C-Like Protease Ribosomal Peptidyl Transferase HPV
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Chemical Information, Storage & Stability

Molecular Weight	123.11	Formula	C₅H₅N₃O	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	98-96-4	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Pyrazinoic Acid Amide			Smiles	C1=CN=C(C=N1)C(=O)N

Solubility

In vitro
Batch:

DMSO : 25 mg/mL (203.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 12 mg/mL

Ethanol : 2 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05329415	Active not recruiting	Tuberculosis\|Diabetes Mellitus	London North West Healthcare NHS Trust	February 1 2022	--
NCT05840809	Recruiting	Tuberculosis Active\|Breastfeeding\|Tuberculosis	University of Liverpool\|Infectious Diseases Institute Makerere University College of Health Sciences	January 20 2022	--
NCT04972903	Unknown status	Tuberculosis\|Pulmonary	Institut National de la Santé Et de la Recherche Médicale France\|National Agency for Research on AIDS and Viral Hepatitis (ANRS)	August 2021	--
NCT04239326	Completed	Tuberculosis Multidrug-Resistant	Foundation for Innovative New Diagnostics Switzerland	April 16 2021	--
NCT03800381	Recruiting	Tuberculosis\|Human Immunodeficiency Virus\|Coinfection	University of Florida\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	January 28 2019	--

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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