Research Area
Product Type
United States ( Change Country )
PHA-680632 Chemical Structure
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Biological Activity
PHA-680632 is the first representative of a new class of Aurora inhibitors (Aurora A/B/C IC50 at 27, 135 and 120 nM, respectively). This agent has a high potential for further development as an anticancer therapeutic.
PHA-680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses. The IC50 of PHA-680632 for cell anti-proliferation ranged from 0.11 µM to 5.6 µM. [1]
References on PHA-680632
- [1] Clin Cancer Res 2006;12:4080-4089
Chemical Information
| Molecular Weight (WM): | 501.62 |
|---|---|
| Formula: | C28H35N7O2 |
| CAS No.: | 398493-79-3 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥100mg/mL |
| Water <1mg/mL | |
| Ethanol ≥100mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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Western blot analysis of Histone H3 and Aurora. 0-5μM PHA 680632 was added.
Western blot analysis of Histone H3 and Aurora. 0-5μM PHA 680632 was added.
Data independently produced by Dr. Zhang of Tianjin Medical University PHA-680632 purchased from Selleck
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Western blot analysis of Histone H3 and Aurora. 0-5μM PHA 680632 was added.
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Data independently produced by Dr. Zhang of Tianjin Medical University
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