Glycyrrhizin (Glycyrrhizic Acid)
Molecular Weight(MW): 822.93
Glycyrrhizin (Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).
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|Description||Glycyrrhizin (Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).|
Glycyrrhizin inhibits monoamine oxidase (MAO) with the IC50 value of 0.16 μM.
|In vivo||Glycyrrhizin increases the levels of monoamines like epinephrine and dopamine in brains of mice.|
|In vitro||DMSO||100 mg/mL (121.51 mM)|
|Ethanol||100 mg/mL (121.51 mM)|
|In vivo||Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01643447||Completed||Hepatocellular Carcinoma||Eastern Hepatobiliary Surgery Hospital||May 2012||--|
|NCT01342185||Unknown status||Chronic Hepatitis B||Nanfang Hospital of Southern Medical University|Tianyi medical instruments limited company, Ningbo, China||March 2010||Phase 3|
|NCT01742702||Unknown status||Primary Hypertension|Secondary Hypertension|Aortic Stenosis|Renal Insufficiency||University of Tampere|Finnish Foundation for Cardiovascular Research|Paavo Nurmi Foundation|Sigrid Juselius Foundation|Finnish Cultural Foundation|Tampere Tuberculosis Foundation|The Competitive Research Funding of Pirkanmaa Hospital District|Aarne Koskelo Foundation|Finnish Medical Foundation|Orion Farmos Research Foundation|Finnish Kidney Foundation||June 2006||Early Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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