Glycyrrhizin (Glycyrrhizic Acid)

Catalog No.S2302

Glycyrrhizin (Glycyrrhizic Acid) Chemical Structure

Molecular Weight(MW): 822.93

Glycyrrhizin (Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 120 In stock
USD 370 In stock
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1 Customer Review

  • Western blot analysis of TLR2 and CXCR4 after direct inhibition with glycyrrhizin.

    DNA Cell Biol, 2017, 36(1):67-76. Glycyrrhizin (Glycyrrhizic Acid) purchased from Selleck.

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Biological Activity

Description Glycyrrhizin (Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).
Targets
11 beta-hydroxysteroid dehydrogenase [1] HMGB1 [2] MAO [4]
(Cell-free)
0.16 μM
In vitro

Glycyrrhizin inhibits monoamine oxidase (MAO) with the IC50 value of 0.16 μM[4].

In vivo Glycyrrhizin increases the levels of monoamines like epinephrine and dopamine in brains of mice[3].

Protocol

Animal Research:

[3]

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  • Animal Models: Swiss albino mice
  • Formulation: hot normal saline (60-62°C)
  • Dosages: 1.5, 3.0 and 6.0 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (121.51 mM)
Ethanol 100 mg/mL (121.51 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 822.93
Formula

C42H62O16

CAS No. 1405-86-3
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01643447 Completed Hepatocellular Carcinoma Eastern Hepatobiliary Surgery Hospital May 2012 --
NCT01342185 Unknown status Chronic Hepatitis B Nanfang Hospital of Southern Medical University|Tianyi medical instruments limited company, Ningbo, China March 2010 Phase 3
NCT01742702 Unknown status Primary Hypertension|Secondary Hypertension|Aortic Stenosis|Renal Insufficiency University of Tampere|Finnish Foundation for Cardiovascular Research|Paavo Nurmi Foundation|Sigrid Juselius Foundation|Finnish Cultural Foundation|Tampere Tuberculosis Foundation|The Competitive Research Funding of Pirkanmaa Hospital District|Aarne Koskelo Foundation|Finnish Medical Foundation|Orion Farmos Research Foundation|Finnish Kidney Foundation June 2006 Early Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Dehydrogenase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID