Doxercalciferol

Catalog No.S1467 Synonyms: 1α-hydroxyvitamin D2

Doxercalciferol Chemical Structure

Molecular Weight(MW): 412.65

Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.

Size Price Stock Quantity  
In DMSO USD 430 In stock
USD 70 In stock
USD 270 In stock
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Description Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.
In vivo Doxercalciferol (100 or 300 pg/g b.w.) normalizes serum calcium and parathyroid hormone (PTH) levels in nephrectomy treated mice. Doxercalciferol (300 pg/g b.w.) significantly reduces osteitis fibrosa in nephrectomy treated mice. [1] Doxercalciferol results in significant decrease in cardiac hypertrophy and improves cardiac function in rats fed a high salt (HS) diet. Doxercalciferol treatment leads to a significant decrease in plasma brain natriuretic peptide (BNP) level and tissue atrial natriuretic factor (ANF) mRNA level in rats fed a high salt (HS) diet. Doxercalciferol also significantly reduces the level of protein kinase C-α (PKCα) suggesting that PKC-mediated cardiac hypertrophy may be associated with vitamin D deficiency. [2] Doxercalciferol decreases proteinuria, podocyte injury, mesangial expansion, and extracellular matrix protein accumulation in Diet-induced obesity (DIO) mice. Doxercalciferol also decreases macrophage infiltration, oxidative stress, proinflammatory cytokines, and profibrotic growth factors in DIO mice. Doxercalciferol also prevents the activation of the renin-angiotensin-aldosterone system including the angiotensin II type 1 receptor and the mineralocorticoid receptor in DIO mice. [3] Doxercalciferol combined with Losartan most effectively prevents albuminuria, restored glomerular filtration barrier structure, and dramatically reduces glomerulosclerosis in a dose-dependent manner in mice. Doxercalciferol combined with Losartan virtually prevents morphological and molecular changes in diabetic kidneys of mice. [4]

Protocol

Solubility (25°C)

In vitro DMSO 83 mg/mL (201.13 mM)
Ethanol 70 mg/mL (169.63 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 412.65
Formula

C28H44O2

CAS No. 54573-75-0
Storage powder
Synonyms 1α-hydroxyvitamin D2

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02282813 Completed Chronic Kidney Disease|Hyperparathyroidism, Secondary|Vitamin D Deficiency OPKO Ireland Global Holdings Ltd.|OPKO Health, Inc. April 2013 Phase 3
NCT00792857 Completed Chronic Kidney Disease|Secondary Hyperparathyroidism|Chronic Renal Insufficiency|Chronic Renal Failure OPKO IP Holdings II, Inc.|OPKO Health, Inc. November 2008 Phase 1
NCT00889629 Unknown status Chronic Kidney Disease|Kidney Transplantation State University of New York - Downstate Medical Center November 2008 Phase 4
NCT00749736 Completed Chronic Kidney Disease Indiana University July 2008 Phase 4
NCT00601107 Completed Moderate to Severe Chronic Plaque Psoriasis Genzyme, a Sanofi Company|Sanofi April 2008 Phase 2
NCT00646282 Terminated Hyperparathyroidism, Secondary Emory University April 2008 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID