Catalog No.S1467 Synonyms: 1α-hydroxyvitamin D2
Molecular Weight(MW): 412.65
Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.
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|Description||Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.|
|In vivo||Doxercalciferol (100 or 300 pg/g b.w.) normalizes serum calcium and parathyroid hormone (PTH) levels in nephrectomy treated mice. Doxercalciferol (300 pg/g b.w.) significantly reduces osteitis fibrosa in nephrectomy treated mice.  Doxercalciferol results in significant decrease in cardiac hypertrophy and improves cardiac function in rats fed a high salt (HS) diet. Doxercalciferol treatment leads to a significant decrease in plasma brain natriuretic peptide (BNP) level and tissue atrial natriuretic factor (ANF) mRNA level in rats fed a high salt (HS) diet. Doxercalciferol also significantly reduces the level of protein kinase C-α (PKCα) suggesting that PKC-mediated cardiac hypertrophy may be associated with vitamin D deficiency.  Doxercalciferol decreases proteinuria, podocyte injury, mesangial expansion, and extracellular matrix protein accumulation in Diet-induced obesity (DIO) mice. Doxercalciferol also decreases macrophage infiltration, oxidative stress, proinflammatory cytokines, and profibrotic growth factors in DIO mice. Doxercalciferol also prevents the activation of the renin-angiotensin-aldosterone system including the angiotensin II type 1 receptor and the mineralocorticoid receptor in DIO mice.  Doxercalciferol combined with Losartan most effectively prevents albuminuria, restored glomerular filtration barrier structure, and dramatically reduces glomerulosclerosis in a dose-dependent manner in mice. Doxercalciferol combined with Losartan virtually prevents morphological and molecular changes in diabetic kidneys of mice. |
|In vitro||DMSO||83 mg/mL (201.13 mM)|
|Ethanol||70 mg/mL (169.63 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02282813||Completed||Chronic Kidney Disease|Hyperparathyroidism Secondary|Vitamin D Deficiency||OPKO Ireland Global Holdings Ltd.|OPKO Health Inc.||April 2013||Phase 3|
|NCT00792857||Completed||Chronic Kidney Disease|Secondary Hyperparathyroidism|Chronic Renal Insufficiency|Chronic Renal Failure||OPKO IP Holdings II Inc.|OPKO Health Inc.||November 2008||Phase 1|
|NCT00889629||Unknown status||Chronic Kidney Disease|Kidney Transplantation||State University of New York - Downstate Medical Center||November 2008||Phase 4|
|NCT00749736||Completed||Chronic Kidney Disease||Indiana University||July 2008||Phase 4|
|NCT00601107||Completed||Moderate to Severe Chronic Plaque Psoriasis||Genzyme a Sanofi Company|Sanofi||April 2008||Phase 2|
|NCT00646282||Terminated||Hyperparathyroidism Secondary||Emory University||April 2008||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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