Research Area
Product Type
United States ( Change Country )
Adrucil(Fluorouracil) Chemical Structure
Pemetrexed (Alimta)
Pemetrexed (Alimta) is a thymidylate synthase, DHFR and glycinamide ribonucleotide formyltransferase inhibitor with an IC50 of 25, 34, 220 nM.
Gemcitabine HCl (Gemzar)
Gemcitabine HCl (Gemzar) is an antimetabolites inhibiting DNA synthesis(cell IC50 of 0.06 μM).
Capecitabine (Xeloda)
Capecitabine (Xeloda) is an orally-administered chemotherapeutic agent (IC50 = 0.7~5 mM) and prodrug of 5-fluorouracil which is a DNA synthesis inhibitor with an IC50 for 5.0 ± 1.8 μM.
Raltitrexed (Tomudex)
Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
Cladribine
Cladribine is an adenosine deaminase inhibitor with an IC50 of about 0.2 μM.
Decitabine
Decitabine is an available nucleoside-based DNA methyltransferase (DNMT) inhibitor with IC50 of 490, 400 and 100 nM for A549, LoVo and LoVo-DX cell lines.
Fludarabine Phosphate (Fludara)
Fludarabine Phosphate (Fludara) is a nucleoside analogue and formulated as the monophosphate form of F-ara-AMP(fludarabine, IC50 < 3 μM).
Flupirtine maleate
Flupirtine is an aminopyridine is a centrally acting nonopioid analgesic.
Fludarabine (Fludara)
Fludarabine (Fludara) is a purine analog and a chemotherapy compound with IC50 < 3 μM.
Daphnetin
Daphnetin is a dihydroxycoumarin and a novel antimalarial agent.
Biological Activity
Fluorouracil (5-FU or f5U) is a chemotherapy drug that is a pyrimidine analog which is used in the treatment of cancer. It works through noncompetitive inhibition of thymidylate synthase. Due to its noncompetitive nature and effects on thymidine synthesis, 5-FU is frequently referred to as the "suicide inactivator". It belongs to the family of drugs called antimetabolites. It is typically administered with leucovorin. [1] Fluorouracil IC50 values were observed across the National Cancer Institute NCI60 panel of human tumor cell lines, which exhibit a mean IC50 of 17.6 μM, with a range of 1–501 μM. [2]
Product Information
| Molecular Weight (WM): | 130.08 |
|---|---|
| Formula: | C4H3FN2O2 |
| CAS No.: | 51-21-8 |
| Synonyms: |
Fluorouracil, 5-FU, Carac, Efudex, Fluoroplex
|
| Dissolve in (25°C): | DMSO ≥26mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
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