Home Immunology & Inflammation Anti-infection inhibitor Delafloxacin (ABT-492)

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Delafloxacin (ABT-492) Anti-infection inhibitor

Cat.No.S1553

Delafloxacin (ABT-492, RX-3341, WQ-3034) is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.
Delafloxacin (ABT-492) Anti-infection inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 440.76

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Quality Control

Batch: S155301 DMSO]88 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.70%
99.70

Solubility

In vitro
Batch:

DMSO : 88 mg/mL (199.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 440.76 Formula

C18H12ClF3N4O4

 Storage (From the date of receipt)
CAS No. 189279-58-1 -- Storage of Stock Solutions

Synonyms RX-3341J, WQ-3034 Smiles C1C(CN1C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4=C(C=C(C(=N4)N)F)F)F)O

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03534622 Completed
Pneumonia
Melinta Therapeutics Inc.
 April 30 2018 Phase 1
NCT01283581 Completed
Skin and Subcutaneous Tissue Bacterial Infections
Melinta Therapeutics Inc.
 January 2011 Phase 2

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Frequently Asked Questions

Question 1:
What's the difference between S1533 and S2194?

Answer:
S1533 and S2194 are two different forms of it. S1533 is the free base form, meaning it contains only the molecule without an acid added to it. S2194 has an additional C6H6O3S acid on it which makes the molecule a salt form. The free base and salt forms have same biology activities. Free base has a lower molecular weight and salt form has a better solubility in DMSO.