Home Protein Tyrosine Kinase c-Met

c-Met inhibitors

c-Met is a receptor for HGF (Hepatocyte growth factor) which is essential during many biological processes. The HGF / MET pathway is an excellent target for anti-cancer therapies. Activation of MET results in the recruitment of scaffolding proteins like Gab1 and Grb2, leading to the recruitment of SH2-domain containing signal transducers that in turn activate a number of pathways, like MAPK or PI3K. Branching morphogenesis, the most complex biological response induced by Met requires all signaling pathways and targets including MAPK, Gab1, Grb2, PI3K, Shp2, SH2 (Src-homology-2), Sos (son-of-sevenless), and PLC (phospholipase C).

Other Protein Tyrosine Kinase Related Inhibitors

VEGFR EGFR PDGFR CSF-1R IGF-1R c-Kit ALK Tie-2 HER2 c-RET
Cat.No. Product Name Information Product Use Citations Product Validations
S7067 Tepotinib Tepotinib is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. This compound induces autophagy. Phase 1.
J Biomed Sci, 2025, 32(1):94
Cell Oncol (Dordr), 2025, 10.1007/s13402-025-01097-y
Lung Cancer, 2025, 201:108415
Verified customer review of Tepotinib
E4606 Dihexa Dihexa(PNB-0408), an oligopeptide drug, is an orally active and blood-brain barrier-permeable analog of angiotensin IV. It binds to hepatocyte growth factor (HGF) with high affinity and potentiates its activity at its receptor, c-Met. This compound can also be used as a therapeutic potential in the treatment of Alzheimer’s disease.
S1119 Cabozantinib (XL184) A potent VEGFR2 inhibitor with IC50 of 0.035 nM, Cabozantinib (XL184) also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. It induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.
Nat Commun, 2025, 16(1):509
Cell Death Differ, 2025, 10.1038/s41418-025-01510-x
Cell Death Dis, 2025, 16(1):76
Verified customer review of Cabozantinib (XL184)
S9662 UNC2025 UNC2025 is a potent and orally active dual inhibitor of FLT3 and MER with IC50 of 0.35 nM and 0.46 nM, respectively. This compound also inhibits AXL, TRKA, TRKC, QIK, TYRO3, SLK, NuaK1, Kit (c-Kit) and Met (c-Met) with IC50 of 1.65 nM, 1.67 nM, 4.38 nM, 5.75 nM, 5.83 nM, 6.14 nM, 7.97 nM, 8.18 nM and 364 nM, respectively.
iScience, 2024, 27(7):110226
Commun Biol, 2023, 6(1):916
Commun Biol, 2023, 6(1):916
S1068 PF-02341066 (Crizotinib) Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
Signal Transduct Target Ther, 2025, 10(1):124
Cell Rep Med, 2025, S2666-3791(25)00102-8
Cell Death Differ, 2025, 10.1038/s41418-025-01510-x
Verified customer review of PF-02341066 (Crizotinib)
S1112 SGX-523 SGX-523 is a selective Met (c-Met) inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. Phase 1.
Stem Cell Res Ther, 2025, 16(1):526
iScience, 2025, 28(2):111708
Cancer Immunol Immunother, 2025, 74(2):58
Verified customer review of SGX-523
S1111 Foretinib Foretinib is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
J Microbiol, 2025, 63(2):e2409001
Int J Mol Sci, 2023, 24(1)757
Biol Open, 2023, 12(8)bio059994
Verified customer review of Foretinib
S1070 PHA-665752 PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM in cell-free assays, >50-fold selectivity for c-Met than RTKs or STKs.
Cell Death Dis, 2025, 16(1):76
Aging Cell, 2025, e70042.
Biochim Biophys Acta Mol Cell Res, 2025, 1872(7):120001
Verified customer review of PHA-665752
S2788 Capmatinib (INC280) Capmatinib is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1.
Mol Cancer, 2025, 24(1):272
Cell Rep Med, 2025, 6(9):102335
J Biomed Sci, 2025, 32(1):94
Verified customer review of Capmatinib (INC280)
S5190 Crizotinib hydrochloride Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
Cancer Discov, 2023, 13(3):598-615
Nat Commun, 2023, 14(1):2829
Cancer Res Commun, 2023, 3(4):659-671

Signaling Pathway Map