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IGF-1R Insulin-like Growth Factor 1 Receptor

Compare IGF-1R Inhibitors

Compare IGF-1R Inhibitors

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1091	Linsitinib (OSI-906)	<1 mg/mL	84 mg/mL	<1 mg/mL
S1093	GSK1904529A	<1 mg/mL	124 mg/mL	<1 mg/mL
S1088	NVP-ADW742	<1 mg/mL	10 mg/mL	3 mg/mL
S1034	NVP-AEW541	<1 mg/mL	88 mg/mL	24 mg/mL
S1012	BMS-536924	<1 mg/mL	96 mg/mL	<1 mg/mL
S2703	GSK1838705A	<1 mg/mL	107 mg/mL	<1 mg/mL
S1234	AG-1024	<1 mg/mL	61 mg/mL	<1 mg/mL
S8003	PQ 401	<1 mg/mL	32 mg/mL	<1 mg/mL

Research Area
Research Area

IGF-1R Inhibitors (10)
water-soluble

Cat.No.	Product Name	Information	Product Citations	Customer Reviews
S1091	Linsitinib (OSI-906)	OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R and IR with IC50 of 35 nM and 75 nM, respectively.	Cancer Res, 2012, ahead of print Cancer Res, 2011, 71(21):6773-84
S1093	GSK1904529A	GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively.	Cell Death Dis, 2012, 3, e336
S1088	NVP-ADW742	NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.
S1034	NVP-AEW541	NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM.	J Clin Invest, 2011, 121(11), 4311-4321 Cancer Res, 2011, 71(21):6773-84 Clin Cancer Res, 2011, 17(8), 2237-2249
S1012	BMS-536924	BMS-536924 is an ATP-competitive IGF-1R and IR inhibitor with IC50 of 100 nM and 73 nM, respectively.	Clin Cancer Res, 2011, 17(8), 2237-2249 Breast Cancer Res, 2011, 13(3), R52 Cell Death Dis, 2012, 3, e336
S7078	Picropodophyllotoxin (Picropodophyllin, AXL1717)	AXL1717 (picropodophyllin, Picropodophyllotoxin, PPP) is a non-competitive, potent, and specific inhibitor of IGF-1Rα/β with IC50 of 1 nM.
S2703	GSK1838705A	GSK1838705A is a potent inhibitor of IGF-1R, IR and ALK with IC50 of 2.0 nM, 1.6 nM and 0.5 nM, respectively
S1124	BMS-754807	BMS-754807 is a potent and reversible inhibitor of IGF-1R/IR family kinases, inhibits IGF-1R, IR, Met, TrkA and TrkB with IC50 of 1.8 nM, 1.7 nM, 5.6 nM, 7.4 nM and 4.1 nM, respectively.
S1234	AG-1024	AG-1024 (Tyrphostin) is a specific IGF-1R and IR inhibitor with IC50 of 0.4 μM and 0.1 μM, respectively.
S8003	PQ 401	PQ 401 is an IGF-1R inhibitor with IC50 of <1 μM.

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1091	Linsitinib (OSI-906)	<1 mg/mL	84 mg/mL	<1 mg/mL
S1093	GSK1904529A	<1 mg/mL	124 mg/mL	<1 mg/mL
S1088	NVP-ADW742	<1 mg/mL	10 mg/mL	3 mg/mL
S1034	NVP-AEW541	<1 mg/mL	88 mg/mL	24 mg/mL
S1012	BMS-536924	<1 mg/mL	96 mg/mL	<1 mg/mL
S2703	GSK1838705A	<1 mg/mL	107 mg/mL	<1 mg/mL
S1234	AG-1024	<1 mg/mL	61 mg/mL	<1 mg/mL
S8003	PQ 401	<1 mg/mL	32 mg/mL	<1 mg/mL

Tags: IGF-1R pathway | IGF-1R cancer | IGF-1R signaling | IGF-1R pathway | IGF-1R phosphorylation | IGF-1 receptor signaling | IGF-1R signaling pathway | IGF-1 receptor signaling pathway | IGF-1R inhibitor review