TGF-beta/Smad Inhibitors

Cat.No.	Product Name	Information	Product Citations
S1067	SB 431542	SB 431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM.	J Biol Chem, 2013, ahead of print Mol Cancer, 2011, 10, 66 Anticancer Res, 2012, 32(3), 799-806
S2230	LY2157299	LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM.
S2618	LDN193189	LDN193189 is a selective inhibitor of ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively.	J Cell Sci, 2012, ahead of print
S2704	LY2109761	LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with K_i of 38 nM and 300 nM, respectively.
S1476	SB 525334	SB 525334 is a potent and selective inhibitor of TGF-β1 (ALK5) with IC50 of 14.3 nM.	PLoS One, 2013, 8(2):e56585 Anticancer Res, 2012, 32(3), 799-806
S2907	Pirfenidone	Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells.
S2186	SB-505124	SB505124 is a selective inhibitor of ALK4 and ALK5 with IC50 of 129 nM and 47 nM, respectively.
S2750	GW788388	GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM.
S2805	LY364947	LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM.

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