Product Categories

Raf Inhibitors

Raf Inhibitors (16)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S1267 Vemurafenib (PLX4032) PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.
S1040 Sorafenib (Nexavar) Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.
S1178 Regorafenib (BAY 73-4506) Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
S1152 PLX-4720 PLX-4720 is a potent and selective inhibitor of B-RafV600E and c-Raf-1Y340D/Y341D with IC50 of 13 nM and 6.7 nM, respectively.
S2807 Dabrafenib (GSK2118436) Dabrafenib (GSK2118436) is a potent ATP-competitive inhibitor of B-Raf, B-RafV600E and c-Raf with IC50 of 3.2 nM, 0.8 nM and 5.0 nM, respectively.
S7121 MLN2480 MLN-2480 (BIIB-024) is a pan-Raf inhibitor.
S7001 PF-04880594 PF-04880594 is a RAF inhibitor for BRAF and c-RAF with IC50 of 0.19 nM and 0.39 nM, respectively.
S1104 GDC-0879 GDC-0879 is a novel potent, selective B-Raf inhibitor for B-RafV600E with IC50 of 0.13 nM.
S2161 RAF265 (CHIR-265) RAF265 (CHIR-265) is a selective and potent inhibitor of B-Raf and VEGFR2 with IC50 of 3-60 nM and EC50 of 30 nM, respectively.
S2872 GW5074 GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM.
S8015 CEP-32496 CEP-32496 is a RAF inhibitor for BRAF(V600E), BRAF(WT), c-Raf, Abl-1 and CSF-1R with IC50 of 14 nM, 36 nM, 39 nM, 3 nM and 9 nM, respectively.
S2746 AZ628 AZ628 is a potent inhibitor for wild-type CRAF and BRAFV600E with IC50 of 29 nM and 34 nM, respectively.
S2720 ZM 336372 ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM.
S2220 SB590885 SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM.
S2202 NVP-BHG712 NVP-BHG712 is a specific inhibitor of c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM and also inhibits EphB4 and VEGFR2 with ED50 of 25 nM and 4.2 μM, respectively.
S2200 Raf265 derivative A derivative of Raf265. But the effects of this derivative is not known.
Tags: Raf Inhibitors | braf inhibitor | raf kinase inhibitor | Raf inhibitor | B-Raf inhibitor | B-Raf inhibitors | Raf kinase inhibitor | B-Raf kinase inhibitor | c-Raf inhibitor | pan Raf inhibitor | a-Raf inhibitor | pan Raf inhibitor | ATP-competitive Raf inhibitor | reversible Raf inhibitor