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B-Raf
| Cat.No. | Product Name | Feedback | Added |
|---|---|---|---|
| S1104 | GDC-0879 |  | Aug 2009 |
| GDC-0879 is an B-Raf inhibitor( EC50 = 0.75 µM). | |||
| S1152 | PLX-4720 | | Feb 2010 |
| PLX-4720 is a B-raf inhibitor with IC50 of 160 nM. | |||
| S1267 | PLX4032 (Vemurafenib) | | Jun 2010 |
| PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204 & RO5185426. PLX4032A is a B-raf inhibitor with an IC50 of 44 nM. | |||
| S2161 | RAF265 (CHIR-265) | Jan 2011 | |
| RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. | |||
| S2200 | Raf265 derivative | Mar 2011 | |
| Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. | |||
| S1178 | Regorafenib (BAY 73-4506) | Apr 2010 | |
| Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. | |||
| S2220 | SB590885 | Apr 2011 | |
| SB590885 is a novel, potent and selective small molecule B-Raf kinase inhibitor with a Ki app of 0.16 ± 0.03 nM. | |||
| S1040 | Sorafenib (Nexavar) | | May 2009 |
| Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. | |||
| S2720 | ZM 336372 | Nov 2011 | |
| Zm 336372 is a potent, selective c-Raf inhibitor with an IC50 of 70 nM for inhibition of human c-Raf in vitro. | |||
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Customer's Feedback
| Dongfeng Chen, The Rausing Lab |
| "Your product U0126(Cat.NO S1102) works well in our experiments. I hope I can get more excellent products from your company in future." |
| R.B. Cambridge |
| "I have used the chemical that I bought from you(Selleck,PTC-124) and it worked well.So we will eventually be ordering more." |
| Zhenghe John Wang Assistant Professor, Case Western Reserve University |
| "We have purchased LBH-589, Saha and MS-275 from you and they all worked well." |
| Jenny Sun |
| "We used the LBH-589 in our experiments. The compound is easy to use with excellent reproducibility." |
| Yu Wang, Harvard University |
| "The GDC0449 compound worked very well. The results in my hands are equally good as what's been published. Thanks for this great resource for our research." |
| Dung-Fang Lee |
| "Based on our preliminary data, I found MLN8237 and VX-680 have good effects in inhibiting Aurka-maintaining ESC self-renewal in mouse ES cells." |
Latest Catalog
| May 2010 Selleck Latest Catalog |  |
