Product Categories

Aurora Kinase Inhibitors

Aurora Kinase Inhibitors (24)
water-soluble

Cat.No.	Product Name	Information	Product Citations
S1133	MLN8237 (Alisertib)	MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM.	Cell Stem Cell, 2012, 11(2):179-94 J Cell Biol, 2010, 191(7):1315-32 EMBO J, 2011, 30(5):906-19
S1147	Barasertib (AZD1152-HQPA)	AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM.	Curr Biol, 2011, 21(16), 1356-1365 Clin Cancer Res, 2010, 16(18), 4572-4582 Cell Cycle, 2012, 11(4):807-17
S1048	VX-680 (MK-0457, Tozasertib)	VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with K_i^app of 0.6 nM, 18 nM and 4.6 nM, respectively.	Cell Stem Cell, 2012, 11(2):179-94 Curr Biol, 2011, 21(16), 1356-1365 J Neurosci, 2012, 32(32):11050-66
S1107	Danusertib (PHA-739358)	Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively.	Biochem Pharmacol, 2012, 83(4), 452-461 J Pharmacol Exp Ther, 2012, 343(3):617-27
S1103	ZM-447439	ZM-447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively.	Mol Biol Cell, 2011, 22(22):4227-35 Mol Cancer Ther, 2011, 10(5), 784-794
S4910	ABT-348 (Ilorasertib)	ABT-348 is a novel ATP-competitive inhibitor of Aurora B, Aurora C and Aurora A with IC50 of 7 nM, 1 nM and 120 nM, respectively.
S2018	ENMD-2076 L-(+)-Tartaric acid	ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM, 15.9 nM and 58.2 nM, respectively.
S1249	JNJ-7706621	JNJ-7706621 is a potent and multi-target inhibitor for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, Aurora A and Aurora B with IC50 of 9 nM, 4 nM, 3 nM, 11 nM and 15 nM, respectively.
S1100	MLN8054	MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM.	Dev Cell, 2012, 22(1):52-63 J Cell Biol, 2012, 198(4):591-605 Exp Cell Res, 2012, 318(5), 578-592
S2770	MK-5108 (VX-689)	MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM.	Br J Pharmacol, 2012, 166(3):858-76
S2744	CCT137690	CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM, respectively.
S2740	GSK1070916	GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B and Aurora C with IC50 of 3.5 nM and 6.5 nM, respectively.	Br J Pharmacol, 2012, 166(3):858-76
S2725	PF-03814735	PF-03814735 is a novel, potent and reversible inhibitor of both Aurora A and Aurora B with IC50 of 0.8 nM and 5 nM, respectively.
S2719	AMG 900	AMG 900 is a potent and highly selective pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 5 nM, 4 nM and 1 nM, respectively.	Br J Pharmacol, 2012, 166(3):858-76
S2718	TAK-901	TAK-901 is a novel inhibitor of Aurora A and Aurora B with IC50 of 21 nM and 15 nM, respectively.
S2158	KW 2449	KW-2449 potently inhibits Flt3, Abl and Aurora A with IC50 of 6.6 nM, 14 nM and 48 nM, respectively.
S1529	Hesperadin	Hesperadin inhibits Aurora B and T. brucei Aurora kinase-1 (TbAUK1) with IC50 of 250 nM and 40 nM, respectively.	J Cell Biol, 2012, 199(2):251-68 Curr Biol, 2011, 21(16), 1356-1365 Mol Cell Proteomics, 2012, 11(11):1220-9
S1519	CCT129202	CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.	Mol Pharm, 2012, ahead of print
S1454	PHA-680632	PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, repectively.	Stem Cells, 2012, 30(9):1819-30 J Cell Sci, 2012, 125(Pt 18), 4297-4305
S1451	Aurora A Inhibitor I	Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM.	J Neurosci, 2012, 32(32):11050-66 Carcinogenesis, 2012, 33(2), 285-293
S1181	ENMD-2076	ENMD-2076 is a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM/15.9 nM and 58.2 nM, respectively.
S1171	CYC116	CYC116 is a potent inhibitor of Aurora A/B and VEGFR with K_i of 8.0 nM/9.2 nM and 44 nM, respectively.
S1154	SNS-314	SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3.4 nM, respectively.	Exp Cell Res, 2012, 318(4), 336-349
S1134	AT9283	AT9283 is a potent pan-Aurora inhibitor for Aurora A, Aurora B, JAK3, JAK2 and Abl with IC50 of 3 nM, 3 nM, 1.1 nM, 1.2 nM and 4 nM, respectively.	Cell Stem Cell, 2012, 11(2):179-94 J Cell Mol Med, 2013, ahead of print

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1133	MLN8237 (Alisertib)	<1 mg/mL	1 mg/mL	<1 mg/mL
S1147	Barasertib (AZD1152-HQPA)	<1 mg/mL	102 mg/mL	3 mg/mL
S1048	VX-680 (MK-0457, Tozasertib)	<1 mg/mL	93 mg/mL	<1 mg/mL
S1107	Danusertib (PHA-739358)	<1 mg/mL	95 mg/mL	<1 mg/mL
S1103	ZM-447439	<1 mg/mL	103 mg/mL	<1 mg/mL
S1249	JNJ-7706621	<1 mg/mL	79 mg/mL	<1 mg/mL
S1100	MLN8054	<1 mg/mL	95 mg/mL	<1 mg/mL
S2770	MK-5108 (VX-689)	<1 mg/mL	92 mg/mL	<1 mg/mL
S2744	CCT137690	<1 mg/mL	4 mg/mL	<1 mg/mL
S2740	GSK1070916	<1 mg/mL	102 mg/mL	102 mg/mL
S2725	PF-03814735	<1 mg/mL	0.4 mg/mL	<1 mg/mL
S2719	AMG 900	<1 mg/mL	100 mg/mL	<1 mg/mL
S2718	TAK-901	<1 mg/mL	101 mg/mL	<1 mg/mL
S2158	KW 2449	<1 mg/mL	67 mg/mL	67 mg/mL
S1529	Hesperadin	<1 mg/mL	103 mg/mL	<1 mg/mL
S1519	CCT129202	<1 mg/mL	3 mg/mL	<1 mg/mL
S1454	PHA-680632	<1 mg/mL	100 mg/mL	<1 mg/mL
S1451	Aurora A Inhibitor I	<1 mg/mL	118 mg/mL	<1 mg/mL
S1181	ENMD-2076	1 mg/mL	105 mg/mL	<1 mg/mL
S1171	CYC116	<1 mg/mL	24 mg/mL	<1 mg/mL
S1154	SNS-314	6 mg/mL	105 mg/mL	<1 mg/mL
S1134	AT9283	<1 mg/mL	76 mg/mL	38 mg/mL

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Aurora Kinase Inhibitors

Aurora Kinase Inhibitors (24)water-soluble

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Aurora Kinase Inhibitors (24)
water-soluble