Aurora

Cat.No.	Product Name	Added

S2719	AMG 900	Nov 2011
AMG 900 is a novel potent and highly selective Pan-aurora kinase inhibitor with an IC50 of median 3.5 nM.

S1134	AT9283	Dec 2009
AT9283 is a small molecule a multi-targeted c-ABL, JAK2, Aurora A and B inhibitor with of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl(T3151), Jak2 and Jak3, aurora A and B, respectively.

S1451	Aurora A Inhibitor I	Jul 2010
Aurora A Inhibitor I is a selective Aurora A inhibitor (Aurora A: IC50 at 0.0034 μM; Aurora B: IC50 at 3.4 μM), (B / A ratio=1000).

S1051	AZD1152	Apr 2009
AZD1152 is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM.

S1147	AZD1152-HQPA (Barasertib)	Jan 2010
AZD1152-HQPA (Barasertib) is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM.

S1519	CCT129202	Sep 2010
CCT129202 is a Aurora kinase inhibitor with IC50 of 0.042 ± 0.022, 0.198 ± 0.05, and 0.227 ± 0.064 μmol/L for Aurora A, Aurora B, and Aurora C, respectively.

S1171	CYC116	Apr 2010
CYC116 is an Aurora kinase/VEGFR2 inhibitor

S1107	Danusertib (PHA-739358)	Aug 2009
Danusertib (PHA-739358) is a pyrrolo-pyrazole and small molecule Aurora kinases and Bcr-Abl kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively.

S1181	ENMD-2076	Apr 2010
ENMD-2076 is a antiangiogenic and Aurora kinase inhibitor with IC50 of 3, 13, 350, 23, 40, 93 and 120 nM for Flt-3, AurA, AurB, Src, KDR/VEGFR2 and FGFR1.

S2740	GSK1070916	Nov 2011
GSK1070916 is a novel, highly potent and selective Aurora B/C kinases ATP competitive inhibitor with an EC50 of <10 nM.

S1529	Hesperadin	Oct 2010
Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate.

S1249	JNJ-7706621	May 2010
JNJ-7706621 is a dual cyclin-dependent kinases and aurora kinases inhibitor with IC50 of 9 and 11 nM for CDK1/Cyclin B and aurora-A, respectively.

S2158	KW 2449	Jan 2011
KW-2449 is a multi-kinase inhibitor of FLT3(IC50 at 6.6pM), ABL(IC50 at 14pM), ABL-T315I and Aurora kinase.

S1100	MLN8054	Aug 2009
Aurora inhibitor, Aurora A (IC50 = 0.004 uM) over Aurora B (IC50 = 0.172 uM).

S1133	MLN8237 (Alisertib)	Dec 2009
MLN8237 (Alisertib) is a selective Aurora kinase A inhibitor with median IC50 of 61 nM.

S2725	PF-03814735	Nov 2011
PF-03814735 is a novel, potent, orally bioavailable, reversible small-molecule Aurora kinase inhibitor with IC50 of 0.8, 5, 10 and 22 nM for Aurora 1, Aurora 2, Flt 1 and FAk, respectively.

S1454	PHA-680632	Jul 2010
PHA-680632 is the first representative of a new class of Aurora inhibitors (Aurora A/B/C IC50 at 27,135 and 120 nM, respectively).

S1154	SNS-314	Feb 2010
Inhibitor of Aurora kinases A(IC50=9.0nM),B(IC50=31nM),and C(IC50=3.4nM)

S2718	TAK-901	Oct 2011
TAK-901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity.

S1048	VX-680 (MK-0457, Tozasertib)	Apr 2009
VX-680 (MK-0457, Tozasertib) is the inhibitor of Aurora-A,-B,-C kinases with apparent inhibition constant values of 0.6,18,4.6 nM respectively.

S1103	ZM-447439	Aug 2009
ZM-447439 is a poten, selective ATP-competitive Aurora B kinase inhibitor with an IC50 of 50 nM, 1 μM and 250 nM for Aurora B, A and C, respectively.