Mebendazole

Catalog No.S4610 Synonyms: Vermox, Telmin, Pantelmin, Mebenvet

Mebendazole Chemical Structure

Molecular Weight(MW): 295.29

Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.

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Biological Activity

Description Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.
In vitro

mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis. MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells[2].

In vivo When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis. MZ treatment significantly reduces vessel densities in mice compared with those in control mice[2].

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: A549, WI38 normal fibroblasts, H1299 and H460 cancer cell line
  • Concentrations: 0, 0.2, 0.5, 1 μM
  • Incubation Time: 48 h
  • Method: When grown to 40–50% confluence, the cells are exposed to MZ dissolved in DMSO. Cell growth is monitored by counting the viable cells using a hemacytometer.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mice
  • Formulation: 1 % tragacanth solution
  • Dosages: 12.5 and 25 mg/kg/day
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 6 mg/mL (20.31 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 295.29
Formula

C16H13N3O3

CAS No. 31431-39-7
Storage powder
in solvent
Synonyms Vermox, Telmin, Pantelmin, Mebenvet

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID