Catalog No.S4068 Synonyms: CP12574
Molecular Weight(MW): 247.27
Tinidazole is an anti-parasitic drug.
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|Description||Tinidazole is an anti-parasitic drug.|
Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates.  Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells.  Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM.  Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis.  Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL. 
|In vitro||DMSO||49 mg/mL (198.16 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03021590||Not yet recruiting||Helicobacter Pylori Gastrointestinal Tract Infection||Damascus Hospital||February 5, 2017||Phase 4|
|NCT02942485||Not yet recruiting||GIARDIASIS||Helsinki University Central Hospital||December 2017||Phase 4|
|NCT02988089||Not yet recruiting||Helicobacter Pylori Infection|Antimicrobial Susceptibility Testing||Shandong University|Shandong Provincial Hospital|General Hospital of Jinan Military Region|Binzhou Peoples Hospital|Liaocheng Peoples Hospital||December 2016||Phase 4|
|NCT01070277||Unknown status||Chronic Diarrhea|Abdominal Pain|Bloating||Sheba Medical Center||March 2012||--|
|NCT01481844||Completed||Optimization of Second Line Treatment Protocol for H Pylori Eradication||Soroka University Medical Center||November 2011||Phase 3|
|NCT01544517||Completed||Helicobacter Pylori Infection||Second University of Naples||January 2011||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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