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Tinidazole Parasite inhibitor

Cat.No.S4068

Tinidazole (CP12574) is an anti-parasitic drug.
Tinidazole Parasite inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 247.27

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Quality Control

Batch: S406801 DMSO]49 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.94%
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99.94

Solubility

In vitro
Batch:

DMSO : 49 mg/mL (198.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 247.27 Formula

C8H13N3O4S

 Storage (From the date of receipt)
CAS No. 19387-91-8 Download SDF Storage of Stock Solutions

Synonyms CP12574 Smiles CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C

Mechanism of Action

In vitro
Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. This compound exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. It is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. It inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. This chemical slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. It is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/16701592/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05383521 Not yet recruiting
Trichomonas Vaginitis
Shangrong Fan|Peking University Shenzhen Hospital
 December 1 2023 Not Applicable
NCT00324142 Withdrawn
Recurrent Bacterial Vaginosis
Kaiser Permanente
 Phase 2

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