Tinidazole

Catalog No.S4068 Synonyms: CP12574

Tinidazole Chemical Structure

Molecular Weight(MW): 247.27

Tinidazole is an anti-parasitic drug.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock

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Purity & Quality Control

Biological Activity

Description Tinidazole is an anti-parasitic drug.
In vitro

Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. [1] Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. [2] Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. [3] Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. [4] Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL. [5]

Protocol

Solubility (25°C)

In vitro DMSO 49 mg/mL (198.16 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 247.27
Formula

C8H13N3O4S

CAS No. 19387-91-8
Storage powder
in solvent
Synonyms CP12574

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03021590 Not yet recruiting Helicobacter Pylori Gastrointestinal Tract Infection Damascus Hospital February 5, 2017 Phase 4
NCT02942485 Not yet recruiting GIARDIASIS Helsinki University Central Hospital December 2017 Phase 4
NCT02988089 Not yet recruiting Helicobacter Pylori Infection|Antimicrobial Susceptibility Testing Shandong University|Shandong Provincial Hospital|General Hospital of Jinan Military Region|Binzhou Peoples Hospital|Liaocheng Peoples Hospital December 2016 Phase 4
NCT01070277 Unknown status Chronic Diarrhea|Abdominal Pain|Bloating Sheba Medical Center March 2012 --
NCT01481844 Completed Optimization of Second Line Treatment Protocol for H Pylori Eradication Soroka University Medical Center November 2011 Phase 3
NCT01544517 Completed Helicobacter Pylori Infection Second University of Naples January 2011 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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