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Hexamethonium Dibromide

Name: Hexamethonium Dibromide
Brand: Selleck Chemicals
SKU: S4069
Rating: 5 (1 reviews)

Catalog No.S4069 Purity: 100.00%

Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

Hexamethonium Dibromide Chemical Structure

CAS: 55-97-0

Purity & Quality Control

Batch: S406901 Water] 73 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 100.00%

100.00

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Signaling Pathway

AChR Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description

Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

Targets

Dopamine subtype 2 receptor ^[1]

AChR ^[1]

In vitro
In vitro	Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide (50-200 μM) causes an increase in the amplitude of nerve-evoked endplate currents (e.p.cs) recorded in the presence of 0.6 μM tubocurarine. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM. ^[1] Hexamethonium Bromide (200 μM) decreases the time constant of decay of both endplate currents (e.p.cs) (by ~25%) and miniature endplate currents (m.e.p.cs) (by ~20%) in the rat hemi-diaphragm muscle. At low frequencies of stimulation (0.5-2 Hz), Hexamethonium Bromide (200 μM) increases e.p.c. quantal content by 30-40%. ^[2]

References

[4] Kimura T, et al. J Cardiovasc Pharmacol, 1992, 20(6), 870-874.

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Chemical Information & Solubility

Molecular Weight	362.19	Formula	C₁₂H₃₀N₂.2Br
CAS No.	55-97-0	SDF	Download Hexamethonium Dibromide SDF
Smiles	C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 73 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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