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Mefloquine HCl

Synonyms: Mefloquin hydrochloride

Catalog No.S4420 Purity: 100.00%

Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.

Mefloquine HCl Chemical Structure

CAS: 51773-92-3

Selleck's Mefloquine HCl has been cited by 4 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 100.00%

100.00

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Biological Activity

Description	Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03893097	Completed	Schistosoma Haematobium\|Schistosoma Mansoni	Institute of Tropical Medicine Belgium\|Institut de Recherche en Santé de Surveillance Épidémiologique et de Formation (IRESSEF)	October 14 2019	Phase 3
NCT02895568	Completed	Plasmodium Falciparum	University of Oxford\|Worldwide Antimalarial Resistance Network\|Mahidol University	September 16 2016	--
NCT02524444	Completed	Malaria in Pregnant HIV + Patients	ORIYOMI OMOTOYOSI AKINYOTU\|University of Ibadan	September 2015	Phase 1
NCT01082718	Withdrawn	Malaria\|Pregnancy	Centers for Disease Control and Prevention	March 2010	Phase 2\|Phase 3

Chemical Information & Solubility

Molecular Weight	414.77	Formula	C₁₇H₁₇ClF₆N₂O
CAS No.	51773-92-3	SDF	Download Mefloquine HCl SDF Download Mefloquine HCl SDF
Smiles	C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 82 mg/mL ( (197.69 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 82 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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