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Catalog No. Product Name Information Product Use Citations Product Validations
S7455 Resatorvid (TAK-242) Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.
Nat Commun, 2022, 13(1):3321
Gut Microbes, 2022, 14(1):2091369
Cell Death Dis, 2022, 13(4):333
S7455 Resatorvid (TAK-242) Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.
Nat Commun, 2022, 13(1):3321
Gut Microbes, 2022, 14(1):2091369
Cell Death Dis, 2022, 13(4):333
Tags: TRIF inhibitor|TRIF agonist|TRIF activator|TRIF inducer|TRIF antagonist|TRIF signaling pathway|TRIF assay kit