TRIF

Other Immunology & Inflammation Related Inhibitors

CXCR AhR STING COX IL Receptor gp120/CD4 NOD NADPH-oxidase ROS Nrf2

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S7455	Resatorvid (TAK-242)	Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. This compound downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF, and it also inhibits autophagy.	EMBO J, 2025, 10.1038/s44318-025-00515-z Carbohydr Polym, 2025, 350:122980 J Neuroinflammation, 2025, 22(1):38

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7455

Resatorvid (TAK-242)

Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. This compound downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF, and it also inhibits autophagy.

EMBO J, 2025, 10.1038/s44318-025-00515-z

Carbohydr Polym, 2025, 350:122980

J Neuroinflammation, 2025, 22(1):38