5-HT3 Selective Inhibitors | Agonists | Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2865 VUF 10166

VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.

Selective 5-HT3A, Ki: 0.04 nM; 5-HT3AB, Ki: 22 nM
S2106 Azasetron HCl

Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.

Selective 5-HT3, IC50: 0.33 nM
S1345 Granisetron HCl

Granisetron HCl is a serotonin 5-HT3 receptor antagonist.

Selective
S1898 Tropisetron HCl

Tropisetron HCl is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

Selective
S3050 Palonosetron HCl

Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

Selective
S1390 Ondansetron HCl

Ondansetron HCl is a serotonin 5-HT3 receptor antagonist.

Selective
S1996 Ondansetron

Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.

Selective
S8021 Vortioxetine (Lu AA21004) HBr

Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

Pan 5-HT3A, Ki: 3.7 nM
S2875 Prucalopride

Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes.

Pan 5-HT3, Ki: 3.822 μM
S2691 BMY 7378

BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.

Pan 5-HT3, pIC50: <5.0