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VQW-765

Cat.No.E8329

VQW-765 (AQW-051) is an orally active agonist targeting the alpha-7 nicotinic acetylcholine receptor (α7-nAChR), exhibiting a pKD of 7.56 for the human recombinant α7-nAChR. This compound demonstrates anxiolytic-like activity in animal models. VQW-765 has potential applications in anxiety disorder and acute performance anxiety studies.
VQW-765 Chemical Structure

Chemical Structure

Molecular Weight: 294.39

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Quality Control

Chemical Information, Storage & Stability

Molecular Weight 294.39 Formula C19H22N2O Storage (From the date of receipt)
CAS No. 669770-29-0 Download SDF Storage of Stock Solutions

Synonyms AQW-051 Smiles CC1=CC=C(C2=CC=C(O[C@H]3CN4CCC3CC4)C=N2)C=C1

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Mechanism of Action

In vivo
VQW-765 (0.03 and 0.3 mg/kg; oral administration once) increases cognitive effect and learning/memory performance in mice. VQW-765 (1 mg/kg; oral administration once) shows anxiolytic-like effect with increasing the social exploration time in rats with a duration of at least 6 h.
References

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