Velpatasvir

For research use only.

Catalog No.S3724 Synonyms: GS-5816

1 publication

Velpatasvir Chemical Structure

CAS No. 1377049-84-7

Velpatasvir (GS-5816) is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication.

Size Price Stock Quantity  
EUR 95 In stock
EUR 223 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Velpatasvir has been cited by 1 publication

Purity & Quality Control

Choose Selective HCV Protease Inhibitors

Biological Activity

Description Velpatasvir (GS-5816) is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication.
Targets
NS5A [1]
()
In vitro

Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. It is a selective inhibitor of HCV RNA replication with mean 50% effective concentrations (EC50s) against GT1 to GT6 of 6 to 130 pM[2].

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (113.25 mM)
Water 100 mg/mL (113.25 mM)
Ethanol ''100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 883.00
Formula

C49H54N8O8

CAS No. 1377049-84-7
Storage powder
in solvent
Synonyms GS-5816
Smiles CC1CCC(N1C(=O)C(C(C)C)NC(=O)OC)C2=NC3=C(N2)C=CC4=CC5=C(C=C43)OCC6=C5C=CC(=C6)C7=CN=C(N7)C8CC(CN8C(=O)C(C9=CC=CC=C9)NC(=O)OC)COC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04382404 Not yet recruiting Drug: Sofosbuvir-Velpatasvir Drug Combination Hepatitis C Chronic Catherine Chappell|Gilead Sciences|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|University of Pittsburgh July 1 2020 Phase 1
NCT03801707 Recruiting Drug: Sofosbuvir/Velpatasvir Kidney Transplant|Hepatitis C|HCV Ohio State University January 9 2019 Phase 2|Phase 3
NCT03032666 Completed Drug: sofosbuvir/velpatasvir Thalassemia|Hepatitis C Ala''a Sharara|Gilead Sciences|American University of Beirut Medical Center May 1 2017 Phase 4
NCT03022981 Completed Drug: SOF/VEL Hepatitis C Virus Infection Gilead Sciences January 26 2017 Phase 2
NCT02002767 Completed Drug: GS-5816 Hepatitis C Virus Gilead Sciences December 2013 Phase 1
NCT01817985 Completed Drug: GS-5816 Chronic Hepatitis C Gilead Sciences March 2013 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

HCV Protease Signaling Pathway Map

Related HCV Protease Products

Tags: buy Velpatasvir | Velpatasvir supplier | purchase Velpatasvir | Velpatasvir cost | Velpatasvir manufacturer | order Velpatasvir | Velpatasvir distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID