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Triheptanoin

Cat.No.E0018

Triheptanoin (API, IND106011, UX007, Glycerol trienanthate) is a synthetic, medium-chain triglyceride consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. This compound is used for treatment of fatty acid oxidation disorders and GLUT1.
Triheptanoin Chemical Structure

Chemical Structure

Molecular Weight: 428.60

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Quality Control

Batch: E001801 Purity: 99.94%
99.94

Solubility

In vitro
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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 428.60 Formula

C24H44O6

 Storage (From the date of receipt) 2 years -20°C liquid
CAS No. 620-67-7 -- Storage of Stock Solutions

Synonyms IND106011, UX007, Glycerol trienanthate Smiles CCCCCCC(=O)OCC(COC(=O)CCCCCC)OC(=O)CCCCCC

Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05933200 Recruiting
Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)
Ultragenyx Pharmaceutical Inc
 February 28 2023 Phase 3
NCT04632953 Recruiting
Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)
Ultragenyx Pharmaceutical Inc
 November 30 2021 --
NCT03059160 Unknown status
Rett Syndrome
Sheba Medical Center|Ultragenyx Pharmaceutical Inc
 April 1 2017 Phase 2
NCT02919631 Unknown status
Glycogen Storage Disease Type V
Institut National de la Santé Et de la Recherche Médicale France|Rigshospitalet Denmark
 October 2016 Phase 2
NCT02432768 Completed
Glycogen Storage Disease Type V
Rigshospitalet Denmark|Groupe Hospitalier Pitie-Salpetriere|University of Texas Southwestern Medical Center|Ultragenyx Pharmaceutical Inc
 April 2015 Phase 2
NCT02214160 Completed
Carnitine Palmitoyltransferase (CPT I or CPT II) Deficiency|Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Deficiency|Long-chain 3-hydroxy-acyl-CoA Dehydrogenase (LCHAD) Deficiency|Trifunctional Protein (TFP) Deficiency|Carnitine-acylcarnitine Translocase (CACT) Deficiency
Ultragenyx Pharmaceutical Inc
 December 9 2014 Phase 2

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