Home Epigenetics Epigenetic Reader Domain inhibitor TEN-010 (RG6146,Ro-6870810,(S)-JQ-35) For research use only.

TEN-010 (RG6146,Ro-6870810,(S)-JQ-35)

Synonyms: RG6146, Ro-6870810, (S)-JQ-35

TEN-010 (RG6146, Ro-6870810,(S)-JQ-35) is an inhibitor of the Bromodomain and Extra-Terminal(BET) family bromodomain-containing proteins with potential antineoplastic activity.

TEN-010 (RG6146,Ro-6870810,(S)-JQ-35) Chemical Structure

TEN-010 (RG6146,Ro-6870810,(S)-JQ-35) Chemical Structure

CAS: 1349719-98-7

Purity & Quality Control

Batch: S854501 Water] 100 mg/mL] false] DMSO] 33 mg/mL] false] Ethanol] 4 mg/mL] false Purity: 99.39%
99.39

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Signaling Pathway

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Biological Activity

Description TEN-010 (RG6146, Ro-6870810,(S)-JQ-35) is an inhibitor of the Bromodomain and Extra-Terminal(BET) family bromodomain-containing proteins with potential antineoplastic activity.
Targets
BET [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03292172 Terminated
Advanced Ovarian Cancer|Triple Negative Breast Cancer
Hoffmann-La Roche
 November 8 2017 Phase 1
NCT03255096 Completed
Diffuse Large B-cell Lymphoma|High-Grade B-cell Lymphoma
Hoffmann-La Roche
 August 28 2017 Phase 1
NCT03068351 Completed
Multiple Myeloma
Hoffmann-La Roche
 June 26 2017 Phase 1
NCT02308761 Completed
Acute Myeloid Leukemia|Myelodysplastic Syndromes
Hoffmann-La Roche
 November 6 2014 Phase 1
NCT01987362 Completed
Solid Tumors Advanced Solid Tumors
Hoffmann-La Roche
 October 16 2013 Phase 1

Chemical Information & Solubility

Molecular Weight 540.13 Formula

C27H34ClN7OS
CAS No. 1349719-98-7 SDF Download TEN-010 (RG6146,Ro-6870810,(S)-JQ-35) SDF
Storage (From the date of receipt) Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

Water : 100 mg/mL

DMSO : 33 mg/mL ( (61.09 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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