Home Epigenetics BET inhibitor TEN-010 ((S)-JQ-35)

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TEN-010 ((S)-JQ-35) BET inhibitor

Cat.No.S8545

TEN-010 (RG6146, Ro-6870810,(S)-JQ-35) is an inhibitor of the Bromodomain and Extra-Terminal(BET) family bromodomain-containing proteins with potential antineoplastic activity.
TEN-010 ((S)-JQ-35) BET inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 540.13

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Quality Control

Batch: S854501 Water]100 mg/mL]false]DMSO]33 mg/mL]false]Ethanol]4 mg/mL]false Purity: 99.39%
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99.39

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : 33 mg/mL (61.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 4 mg/mL

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 540.13 Formula

C27H34ClN7OS

 Storage (From the date of receipt)
CAS No. 1349719-98-7 Download SDF Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
BET
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03292172 Terminated
Advanced Ovarian Cancer|Triple Negative Breast Cancer
Hoffmann-La Roche
 November 8 2017 Phase 1
NCT03255096 Completed
Diffuse Large B-cell Lymphoma|High-Grade B-cell Lymphoma
Hoffmann-La Roche
 August 28 2017 Phase 1
NCT03068351 Completed
Multiple Myeloma
Hoffmann-La Roche
 June 26 2017 Phase 1
NCT02308761 Completed
Acute Myeloid Leukemia|Myelodysplastic Syndromes
Hoffmann-La Roche
 November 6 2014 Phase 1
NCT01987362 Completed
Solid Tumors Advanced Solid Tumors
Hoffmann-La Roche
 October 16 2013 Phase 1

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