CAS No. 26993-30-6

Batch: Purity:99.57
Check CoA
Sphingosine-1-phosphate Chemical Structure
Chemical Structure
Check the Sphingosine-1-phosphate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate
CAS Number 26993-30-6
Molecular Formula

C18H38NO5P
Molecular Weight (MW) 379.47
InChIKey DUYSYHSSBDVJSM-KRWOKUGFSA-N

Ordering Information

Biological Activity

Sphingosine-1-phosphate is a bioactive lysophospholipid agonist that targets S1P1–5 receptors and functions as a ligand for GPR3, GPR6, and GPR12. Upon binding, it enhances GPR3-, GPR6-, and GPR12-mediated intracellular Ca²⁺ mobilization and modulates downstream G-protein signaling cascades. These responses drive essential cellular phenotypes, including cell proliferation, cell migration, cytoskeletal reorganization, adherens junction assembly, and tissue morphogenesis.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.