Home Peptide Products Mazdutide (IBI362, LY330567)

research use only

Mazdutide (IBI362, LY330567)

Cat.No.P1231

Mazdutide (IBI-362; LY-3305677) is a synthetic long-acting oxyntomodulin analog that functions as a dual agonist of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR). The compound exhibits binding affinity for human and mouse GCGR (Ki values of 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki values of 28.6 nM and 25.1 nM, respectively). In mouse islets, mazdutide stimulates insulin secretion with an EC50 of 5.2 nM. This agent has been investigated in research related to obesity and type 2 diabetes (T2D).

Amino-acid Sequence

Mazdutide (IBI362, LY330567) Amino-acid Sequence

CAS No. 2259884-03-0

Quality Control

Chemical Information & Solubility

Storage (From the date of receipt)

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Biological Activity

Description Mazdutide (IBI-362; LY-3305677) is a synthetic long-acting oxyntomodulin analog that functions as a dual agonist of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR). The compound exhibits binding affinity for human and mouse GCGR (Ki values of 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki values of 28.6 nM and 25.1 nM, respectively). In mouse islets, mazdutide stimulates insulin secretion with an EC50 of 5.2 nM. This agent has been investigated in research related to obesity and type 2 diabetes (T2D).

In Vivo
In vivo Mazdutide (15, 30 nmol/kg; sc; single dose) significantly reduces body weight and physical intake in diabetic mice with diet-induced obesity (DIO).

References
  • https://pubmed.ncbi.nlm.nih.gov/35188373/
  • https://pubmed.ncbi.nlm.nih.gov/35750681/
  • https://diabetesjournals.org/diabetes/article-abstract/70/Supplement_1/682-P/140621

Product Information

Molecular Formula

C210H322N46O67
Molecular Weight 4563.06
CAS No. 2259884-03-0
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)