Mazdutide (IBI362, LY330567)

Quality Control

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vivo
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Biological Activity

Description	Mazdutide (IBI-362; LY-3305677) is a synthetic long-acting oxyntomodulin analog that functions as a dual agonist of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR). The compound exhibits binding affinity for human and mouse GCGR (Ki values of 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki values of 28.6 nM and 25.1 nM, respectively). In mouse islets, mazdutide stimulates insulin secretion with an EC50 of 5.2 nM. This agent has been investigated in research related to obesity and type 2 diabetes (T2D).

Description

Mazdutide (IBI-362; LY-3305677) is a synthetic long-acting oxyntomodulin analog that functions as a dual agonist of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR). The compound exhibits binding affinity for human and mouse GCGR (Ki values of 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki values of 28.6 nM and 25.1 nM, respectively). In mouse islets, mazdutide stimulates insulin secretion with an EC50 of 5.2 nM. This agent has been investigated in research related to obesity and type 2 diabetes (T2D).

In Vivo
In vivo	Mazdutide (15, 30 nmol/kg; sc; single dose) significantly reduces body weight and physical intake in diabetic mice with diet-induced obesity (DIO).

References
https://pubmed.ncbi.nlm.nih.gov/35188373/ https://pubmed.ncbi.nlm.nih.gov/35750681/ https://diabetesjournals.org/diabetes/article-abstract/70/Supplement_1/682-P/140621

References

https://pubmed.ncbi.nlm.nih.gov/35188373/
https://pubmed.ncbi.nlm.nih.gov/35750681/
https://diabetesjournals.org/diabetes/article-abstract/70/Supplement_1/682-P/140621

Product Information

Molecular Formula	C210H322N46O67
Molecular Weight	4563.06
CAS No.	2259884-03-0
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)