CAS No. 193746-75-7
Batch:
Purity:99.56
Chemical Structure
Check the
SB 242235
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-methoxypyrimidine | |
|---|---|---|
| CAS Number | 193746-75-7 | |
| Molecular Formula |
C19H20FN5O |
|
| Molecular Weight (MW) | 353.39 | |
| SMILES | COC1=NC=CC(=N1)C2=C(N=CN2C3CCNCC3)C4=CC=C(C=C4)F | |
| InChIKey | PDTYLGXVBIWRIM-UHFFFAOYSA-N |
SB 242235 is a potent and selective p38 MAP kinase inhibitor that suppresses IL-1β-induced p38 MAP kinase activity in primary human chondrocytes. By inhibiting p38 MAPK pathway signaling, SB 242235 downregulates pro-inflammatory gene expression and suppresses cytokine release. This targeted inhibition attenuates downstream inflammatory responses and reduces cellular cartilage degradation mechanisms in preclinical inflammatory models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(200.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 71 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.