RP-6306

RP-6306 is a Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) inhibitor, which can be used for the research of cancer.

RP-6306 Chemical Structure

RP-6306 Chemical Structure

CAS: 2719793-90-3

Purity & Quality Control

Batch: Purity: 99.68%
99.68

Products often used together with RP-6306

Adavosertib (MK-1775)


RP-6306 and Adavosertib use efficiently kills U2OS cells.

Benada J, et al. NAR Cancer. 2023 Jun 13;5(3):zcad029.

Gemcitabine


RP-6306 and Gemcitabine exhibit synergistic growth defects in HCC1569 cells.

Fourtounis J, et al. Cancer Res (2022) 82 (12_Supplement): 5650.

Carboplatin


RP-6306 and Carboplatin synergistically inhibit cell growth in a CCNE1-amplified ovarian model.

Fourtounis J, et al. European Journal of Cancer 174S1 (2022) S3–S128

Dinaciclib


RP-6306 is more cytotoxic to the CCNE1-amplified cell lines than dinaciclib.

Gallo D, et al. Nature. 2022;604(7907):749-756.

Camonsertib (RP-3500)


RP-6306 and RP-3500 are under clinical trial studies for their use in advanced solid tumors.

https://classic.clinicaltrials.gov/ct2/show/NCT04855656

RP-6306 Related Products

Biological Activity

Description RP-6306 is a Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) inhibitor, which can be used for the research of cancer.
In vitro
In vitro

RP-6306 ((S)-RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC50 of 14 nM. RP-6306 shows a high degree of selectivity over other kinases in cellular binding assays.

In Vivo
In vivo

RP-6306 results in a statistically significant and dose-dependent reduction in OVCAR3 tumor growth in CCNE1-amplified ovarian xenograft model (OVCAR3).

Chemical Information & Solubility

Molecular Weight 324.38 Formula

C18H20N4O2

CAS No. 2719793-90-3 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 65 mg/mL ( (200.38 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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