Home MAPK Raf inhibitor RG6344 For research use only.

RG6344

Synonyms: B-Raf IN 2

RG6344 (RO7276389) is a brain penetrant inhibitor of BRAF which is designed to overcome the MAPK paradoxical activity. RG6344 can be used for the study of BRAF V600-mutant solid tumors, such as colorectal cancer (CRC).

RG6344 Chemical Structure

RG6344 Chemical Structure

CAS No. 2649372-20-1

Purity & Quality Control

RG6344 Related Products

Signaling Pathway

Raf Signaling Pathways

Raf Signaling Pathway

Biological Activity

Description RG6344 (RO7276389) is a brain penetrant inhibitor of BRAF which is designed to overcome the MAPK paradoxical activity. RG6344 can be used for the study of BRAF V600-mutant solid tumors, such as colorectal cancer (CRC).
  • https://aacrjournals.org/cancerres/article/85/8_Supplement_2/CT017/761335/Abstract-CT017-A-phase-I-study-evaluating-safety?__cf_chl_tk=M9Ichhvn3CkLXTynEW4BZahrFkufJBVAZgAtTbi8a3M-1754891483-1.0.1.1-8TQ3XuGfv2YcaNwWKLKk3ciLgW.G6cG4itRX484RqiI

Chemical Information & Solubility

Molecular Weight 461.44 Formula

C20H17F2N5O4S
CAS No. 2649372-20-1 SDF Download RG6344 SDF
Storage (From the date of receipt)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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