Home Metabolism LDL modulator - ABC Transporter modulator Probucol

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Probucol LDL modulator

Cat.No.S2119

Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
Probucol LDL modulator Chemical Structure

Chemical Structure

Molecular Weight: 516.84

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S211901 DMSO]103 mg/mL]false]Ethanol]103 mg/mL]false]Water]Insoluble]false Purity: 99.99%
99.99

Chemical Information, Storage & Stability

Molecular Weight 516.84 Formula

C31H48O2S2

 Storage (From the date of receipt)
CAS No. 23288-49-5 Download SDF Storage of Stock Solutions

Synonyms DH-581 Smiles CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C

Solubility

In vitro
Batch:

DMSO : 103 mg/mL (199.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 103 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02707458 Completed
Dementia of the Alzheimer Type|Age-related Cognitive Decline|Mild Cognitive Impairment Due to Alzheimer Disease
Douglas Mental Health University Institute|Weston Brain Institute|McGill University
 April 2016 Phase 1|Phase 2
NCT02098460 Unknown status
Severe Hypercholesterolemia
Otsuka Beijing Research Institute
 October 2013 Phase 4

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