CAS No. 612548-45-5
Batch:
Purity:99.46
Chemical Structure
Check the
Perindopril L-Arginine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid;(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid | |
|---|---|---|
| CAS Number | 612548-45-5 | |
| Molecular Formula |
C19H32N2O5.C6H14N4O2 |
|
| Molecular Weight (MW) | 542.67 | |
| SMILES | CCCC(NC(C)C(=O)N1C2CCCCC2CC1C(O)=O)C(=O)OCC.NC(CCCNC(N)=N)C(O)=O | |
| InChIKey | RYCSJJXKEWBUTI-YDYAIEMNSA-N |
Perindopril L-Arginine is an orally active prodrug metabolized to its diacid metabolite perindoprilat, a high-affinity angiotensin-converting enzyme (ACE) inhibitor. By blocking ACE activity, perindoprilat downregulates vascular endothelial growth factor (VEGF) expression and suppresses endothelial cell tubule formation, leading to the inhibition of angiogenesis and tissue remodeling. Additionally, perindopril arginine demonstrates membrane transport regulated by specific cellular transporters across gastrointestinal epithelial monolayers.[1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| Ethanol | 25 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.