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Paltusotine SSTR agonist

Cat.No.E2406

Paltusotine (CRN00808) is an orally active, nonpeptide selective somatostatin type 2 (SST2) receptor agonist, has the potential for maintaining GH and IGF-1 levels after depot somatostatin receptor ligand therapy.
Paltusotine SSTR agonist Chemical Structure

Chemical Structure

Molecular Weight: 456.49

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Quality Control

Batch: E240601 DMSO]91 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.92%
99.92

Solubility

In vitro
Batch:

DMSO : 91 mg/mL (199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 456.49 Formula

C27H22F2N4O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2172870-89-0 -- Storage of Stock Solutions

Synonyms CRN00808 SMILES NC1CCN(CC1)C2=C(C=NC3=C2C=C(C=C3)C4=C(O)C(=CC=C4)C#N)C5=CC(=CC(=C5)F)F

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
SST2
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-04)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07087054 RECRUITING
Carcinoid Syndrome; Carcinoid; Carcinoid Tumor; Carcinoid Tumor of Ileum; Carcinoid Tumor of Cecum; Carcinoid Tumor of Liver; Carcinoid Tumor of Pancreas; Carcinoid Syndrome Diarrhea; Carcinoid Intestine Tumor
Crinetics Pharmaceuticals Inc.
 2025-11-19 PHASE3
NCT04261712 TERMINATED
Acromegaly
Crinetics Pharmaceuticals Inc.
 2020-01-29 PHASE2
NCT05361668 COMPLETED
Carcinoid Syndrome; Carcinoid; Carcinoid Tumor; Carcinoid Tumor of Ileum; Carcinoid Tumor of Cecum; Carcinoid Syndrome Diarrhea; Carcinoid Intestine Tumor; Carcinoid Tumor of Liver; Carcinoid Tumor of Pancreas
Crinetics Pharmaceuticals Inc.
 2022-04-22 PHASE2
NCT05192382 TERMINATED
Acromegaly
Crinetics Pharmaceuticals Inc.
 2021-12-17 PHASE3
NCT04837040 TERMINATED
Acromegaly
Crinetics Pharmaceuticals Inc.
 2021-05-12 PHASE3
NCT03789656 COMPLETED
Acromegaly
Crinetics Pharmaceuticals Inc.
 2019-03-12 PHASE2

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