SMILES:

NC1CCN(CC1)C2=C(C=NC3=C2C=C(C=C3)C4=C(O)C(=CC=C4)C#N)C5=CC(=CC(=C5)F)F
Paltusotine Chemical Structure
Chemical Structure
Check the Paltusotine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[4-(4-aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile
CAS Number 2172870-89-0
Molecular Formula

C27H22F2N4O
Molecular Weight (MW) 456.49
SMILES NC1CCN(CC1)C2=C(C=NC3=C2C=C(C=C3)C4=C(O)C(=CC=C4)C#N)C5=CC(=CC(=C5)F)F
InChIKey GHILNKWBALQPDP-UHFFFAOYSA-N

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 91 mg/mL (199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.