Home MAPK p38 MAPK inhibitor p38-α MAPK-IN-1

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p38-α MAPK-IN-1 p38 MAPK inhibitor

Cat.No.E2372

p38-α MAPK-IN-1 is an inhibitor of p38-α, with IC50 value of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
p38-α MAPK-IN-1 p38 MAPK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 477.60

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Quality Control

Batch: E237201 DMSO]96 mg/mL]false]Ethanol]48 mg/mL]false]Water]Insoluble]false Purity: 99.97%
99.97

Solubility

In vitro
Batch:

DMSO : 96 mg/mL (201.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 48 mg/mL

Water : Insoluble

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 477.60 Formula

C27H35N5O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 443913-15-3 -- Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
p38-α
(EFC displacement assay)
2300 nM
p38-α
(HTRF assay)
5500 nM
p38-α
(HTRF assay)
5500 nM
References

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