CAS No. 443913-15-3
Batch:
Purity:99.97
Chemical Structure
Check the
p38-α MAPK-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[3-tert-butyl-1-(4-methylphenyl)pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]urea | |
|---|---|---|
| CAS Number | 443913-15-3 | |
| Molecular Formula |
C27H35N5O3 |
|
| Molecular Weight (MW) | 477.60 | |
| SMILES | CC1=CC=C(C=C1)[N]2N=C(C=C2NC(=O)NC3=CC=C(OCCN4CCOCC4)C=C3)C(C)(C)C | |
| InChIKey | FRZNJFWQVYAVCE-UHFFFAOYSA-N |
p38-α MAPK-IN-1 is a small-molecule inhibitor targeting p38-α (IC50 of 2300 nM in an enzyme fragment complementation displacement assay and 5500 nM in a homogeneous time-resolved fluorescence assay). By selectively inhibiting p38-α kinase activity, this compound blocks the p38/MAPK signaling pathway, suppressing downstream transcription factor phosphorylation and reducing cellular pro-inflammatory cytokine secretion.[1][2]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(201.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 48 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.