CAS No. 2212020-52-3
Batch:
Purity:99.00
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Chemical Structure
Check the
Orforglipron (LY3502970)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one | |
|---|---|---|
| CAS Number | 2212020-52-3 | |
| Molecular Formula |
C48H48F2N10O5 |
|
| Molecular Weight (MW) | 882.96 | |
| InChIKey | USUWIEBBBWHKNI-KHIFEHGGSA-N |
Orforglipron (LY3502970) is a non-peptide agonist of the glucagon-like peptide-1 (GLP-1) receptor. Activation of the GLP-1 receptor stimulates intracellular cAMP accumulation and downstream signaling cascades, promoting glucose-dependent insulin secretion. Small-molecule GLP-1 receptor agonists modulate these pathways to improve glycemic control and reduce body weight, providing therapeutic potential in preclinical models of type 2 diabetes mellitus and obesity. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(113.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Orforglipron (LY3502970) Mechanism of Action: GLP-1R Activation in Hypothalamic Neurons Research
- Orforglipron (LY3502970) Clinical Trials
- Orforglipron (LY3502970) Working Concentration | Cell Culture | Treatment
- Orforglipron (LY3502970) Solubility in DMSO
- Orforglipron (LY3502970) Stock Solution
- Orforglipron (LY3502970) Storage
- Orforglipron (LY3502970) Stability
- Orforglipron (LY3502970) Combination Database
- Orforglipron (LY3502970) Molecular Weight
- Orforglipron (LY3502970) Chemical Structure (2D and 3D)
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- Orforglipron (LY3502970) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.