CAS No. 175026-96-7
Batch:
Purity:98.96
Chemical Structure
Check the
NQDI-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | ethyl 8,15-dioxo-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9(17),10,12-heptaene-16-carboxylate | |
|---|---|---|
| CAS Number | 175026-96-7 | |
| Molecular Formula |
C19H13NO4 |
|
| Molecular Weight (MW) | 319.31 | |
| SMILES | CCOC(=O)C1=C2C3=CC=CC=C3C(=O)C4=C2C(=CC=C4)NC1=O | |
| InChIKey | UFJGFNHRMPMALC-UHFFFAOYSA-N |
NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1). By targeted inhibition of ASK1 kinase activity, NQDI-1 suppresses downstream JNK and p38 MAPK signaling cascades, thereby mitigating oxidative stress-induced cell injury and inflammatory responses. In preclinical functional studies, NQDI-1 attenuates acute ischemic renal injury, reduces cellular oxidative stress, and decreases programmed cell death in renal tissues.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
21 mg/mL
(65.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.