Orphan Receptor

Other GPCR & G Protein Related Inhibitors

Hedgehog/Smoothened PKA CGRP Receptor Endothelin Receptor S1P Receptor Cannabinoid Receptor SGLT Opioid Receptor GPR CCR

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S0989	ML-180	ML-180 (SR1848) is a potent inverse agonist of orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) with IC50 of 3.7 μM. This compound has the potential for LRH-1-dependent cancers.	J Biol Chem, 2025, 301(7):110405
E7232	1,2-DLPC	1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells.