CAS No. 863588-32-3
Batch:
Purity:99.98
Chemical Structure
Check the
ML-180
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione | |
|---|---|---|
| CAS Number | 863588-32-3 | |
| Molecular Formula |
C20H25ClN4O2 |
|
| Molecular Weight (MW) | 388.89 | |
| SMILES | C1CCC(CC1)N2C(=O)C=C(NC2=O)N3CCN(CC3)C4=CC(=CC=C4)Cl | |
| InChIKey | CHMQQIFPOIZPIJ-UHFFFAOYSA-N |
ML-180 is a potent inverse agonist of the orphan nuclear receptor liver receptor homolog-1 (LRH-1/NR5A2). By binding to LRH-1, ML-180 downregulates its transcriptional activity and alters downstream signaling cascades involved in cell proliferation and metabolic regulation. Consequently, LRH-1 inhibition suppresses key downstream target genes such as cyclin D1 and cyclin E1, blocking cell cycle progression and attenuating tumor cell growth.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(25.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.